{ "uniprot_canonical_ac": "A2TGX5-1", "ptm_annotation": [ { "annotation": "N-glycosylated.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q6SJQ0", "id": "Q6SJQ0", "database": "PubMed" } ] }, { "annotation": "Phosphorylated on tyrosine.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q6SJQ0", "id": "Q6SJQ0", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2TGX5-1|CLM8_RAT Isoform 1 of CMRF35-like molecule 8 OS=Rattus norvegicus OX=10116 GN=Cd300a PE=2 SV=1 CANONICAL=A2TGX5-1", "length": 310, "sequence": "MTQLASAVWPPTLLLLLLFWVPGCVPLRGPSSVTGTVGESLNVTCQYEERFKMNKKYWCRGSLVLLCKDIVRTGGSEEARNGRVSIRDDRDNLTFTVTLQNLTLEDAGTYMCAVDIPLIDHSFKVELSVVPGNIPVSSPGTTRETTVVPTSFSTKGPTQGSIPEGHHEHYEPQGLSLPVLLSVLALLLLLLVGTSLLAWRMFQKRSVKADKHPEMSQNLRQAEEQSESQYVNLQLHTLPLREEPVPPSQVEVEYSTLALPQEELHYTSVVFDSQRQNSHANGDPPCQSPDQKTEYSEIRKPREGLSDPHP" }, "uniprot_id": "CLM8_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A2TGX5", "site_annotation": [ { "end_pos": 103, "annotation": "n_glycosylation_sequon", "start_pos": 101 }, { "end_pos": 44, "annotation": "n_glycosylation_sequon", "start_pos": 42 }, { "end_pos": 94, "annotation": "n_glycosylation_sequon", "start_pos": 92 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5#A0A0G2K2W8-1", "isoform_ac": "A0A0G2K2W8-1", "locus": { "end_pos": 103438303, "strand": "-", "start_pos": 103450911, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000085262", "id": "ENSRNOT00000085262", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072406", "id": "ENSRNOP00000072406", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K2W8-1|CLM8_RAT Computationally mapped isoform of CMRF35-like molecule 8 OS=Rattus norvegicus OX=10116 GN=Cd300a PE=2 SV=1 CANONICAL=A2TGX5-1", "length": 307, "sequence": "MTQLASAVWLPTLLLLLLFWVPGCVPLRGPAVKETVGESLEVELVSMKERFKMNKKWCREVTCLLCKIIVIPGGSEEARNGRVSIRNRDNLAFTSGTYLTLEDAGTYMCAVDIPLIDHSFKVELSVVPGNIPVSSPGTTRETTVVPTSFSTKGPTQGSIPEGHHEHYEPQGLSLPVLLSVLALLLLLLVGTSLLAWRMFQKRSVKADKHPEMSQNLRQAEEQSESQYVNLQLHTLPLREEPVPPSQVEVEYSTLALPQEELHYTSVVFDSQRQNSHANGDPPCQSPDQKTEYSEIRKPREGLSDPHP" } }, { "url": "https://www.uniprot.org/uniprot/A2TGX5#A0A0G2K697-1", "isoform_ac": "A0A0G2K697-1", "locus": { "end_pos": 103441549, "strand": "-", "start_pos": 103450911, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000079545", "id": "ENSRNOT00000079545", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073730", "id": "ENSRNOP00000073730", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K697-1|CLM8_RAT Computationally mapped isoform of CMRF35-like molecule 8 OS=Rattus norvegicus OX=10116 GN=Cd300a PE=2 SV=1 CANONICAL=A2TGX5-1", "length": 288, "sequence": "LCFPGCVPLRGPSVTETVGESLEVACQYEERFKMNKKYCRESLVLCKIIVIPGGSEEARNGRVSIRNDRDNLAFTSGTYLTLEDAGTYMCAVDIPLIDHSFKVELSVVPGNIPVSSPGTTRETTVVPTSFSTKGPTQGSIPEGHHEHYEPQGLSLPVLLSVLALLLLLLVGTSLLAWRMFQKRSVKADKHPEMSQNLRQAEEQSESQYVNLQLHTLPLREEPVPPSQVEVEYSTLALPQEELHYTSVVFDSQRQNSHANGDPPCQSPDQKTEYSEIRKPREGLSDPHP" } }, { "url": "https://www.uniprot.org/uniprot/A2TGX5#A2TGX5-1", "isoform_ac": "A2TGX5-1", "locus": {}, "sequence": { "header": "sp|A2TGX5-1|CLM8_RAT Isoform 1 of CMRF35-like molecule 8 OS=Rattus norvegicus OX=10116 GN=Cd300a PE=2 SV=1 CANONICAL=A2TGX5-1", "length": 310, "sequence": "MTQLASAVWPPTLLLLLLFWVPGCVPLRGPSSVTGTVGESLNVTCQYEERFKMNKKYWCRGSLVLLCKDIVRTGGSEEARNGRVSIRDDRDNLTFTVTLQNLTLEDAGTYMCAVDIPLIDHSFKVELSVVPGNIPVSSPGTTRETTVVPTSFSTKGPTQGSIPEGHHEHYEPQGLSLPVLLSVLALLLLLLVGTSLLAWRMFQKRSVKADKHPEMSQNLRQAEEQSESQYVNLQLHTLPLREEPVPPSQVEVEYSTLALPQEELHYTSVVFDSQRQNSHANGDPPCQSPDQKTEYSEIRKPREGLSDPHP" } } ], "pathway": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5#function", "annotation": "Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5#function", "id": "A2TGX5", "database": "UniProtKB" } ] } ], "orthologs": [], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008429", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "phosphatidylethanolamine binding", "id": "GO:0008429" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001786", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "phosphatidylserine binding", "id": "GO:0001786" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019902", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "phosphatase binding", "id": "GO:0019902" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "signaling receptor activity", "id": "GO:0038023" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014063", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of serotonin secretion", "id": "GO:0014063" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032516", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "positive regulation of phosphoprotein phosphatase activity", "id": "GO:0032516" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048147", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of fibroblast proliferation", "id": "GO:0048147" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006898", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "receptor-mediated endocytosis", "id": "GO:0006898" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043407", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of MAP kinase activity", "id": "GO:0043407" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030889", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of B cell proliferation", "id": "GO:0030889" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034125", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of MyD88-dependent toll-like receptor signaling pathway", "id": "GO:0034125" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050856", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "regulation of T cell receptor signaling pathway", "id": "GO:0050856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033007", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of mast cell activation involved in immune response", "id": "GO:0033007" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043305", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of mast cell degranulation", "id": "GO:0043305" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050859", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of B cell receptor signaling pathway", "id": "GO:0050859" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051134", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of NK T cell activation", "id": "GO:0051134" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060101", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of phagocytosis, engulfment", "id": "GO:0060101" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902564", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of neutrophil activation", "id": "GO:1902564" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902567", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of eosinophil activation", "id": "GO:1902567" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902569", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of activation of Janus kinase activity", "id": "GO:1902569" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000417", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "negative regulation of eosinophil migration", "id": "GO:2000417" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002552", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "name": "serotonin secretion by mast cell", "id": "GO:0002552" } ], "total": 18, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "type": "recommended", "resource": "UniProtKB", "name": "Cd300a" } ], "pro_annotation": [], "crossref": [ { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "id": "IPR003599", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "id": "IPR007110", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013106", "id": "IPR013106", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "id": "IPR013783", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "id": "IPR036179", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF07686", "id": "PF07686", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2TGX5", "id": "PR_A2TGX5", "database": "PRO" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1583719", "id": "1583719", "database": "RGD" } ], "expression_disease": [], "glycosylation": [ { "residue": "Asn", "site_category": "predicted", "end_pos": 101, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5#ptm_processing", "id": "A2TGX5", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 101, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "site_category": "predicted", "end_pos": 42, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5#ptm_processing", "id": "A2TGX5", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 42, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "site_category": "predicted", "end_pos": 92, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5#ptm_processing", "id": "A2TGX5", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 92, "glytoucan_ac": "", "type": "N-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Tyr", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "id": "A2TGX5", "database": "UniProtKB" } ], "start_pos": "295", "end_pos": "295", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 34495.0, "chemical_mass": 34495.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "name": "Cd300a", "locus": { "end_pos": 103450947, "strand": "+", "start_pos": 103438303, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000057058", "id": "ENSRNOG00000057058", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2TGX5", "type": "synonym", "resource": "UniProtKB", "name": "CD300 antigen-like family member A" }, { "url": "https://www.uniprot.org/uniprot/A2TGX5", "type": "synonym", "resource": "UniProtKB", "name": "CLM-8" }, { "url": "https://www.uniprot.org/uniprot/A2TGX5", "type": "recommended", "resource": "UniProtKB", "name": "CMRF35-like molecule 8" } ] }