{
    "uniprot_canonical_ac": "A2KF29-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2KF29-1|SMKTR_MOUSE Isoform 1 of Sperm motility kinase Tcr mutant form  OS=Mus musculus OX=10090 GN=Smoktcr PE=2 SV=1 CANONICAL=A2KF29-1", 
        "length": 484, 
        "sequence": "MEKFHAQYEMLETIGQGGCAQVKLARHRLTGTHVAVKVIVKRECWFNPVMSEAELLMMTDHPNIISLLQVIETKKKVYLIMELCEGKSLYQHIQNAGYLQEDEARPLFKQLLSAMNYCHNQGIVHRDLTPDNIMVEKDGKVKIIDFGLGTQEKPGQNHNLFCEIYPFSTPEVLFNRPYDMRKIDVWGLGVVLYFMVTGKILFDTASVEKLRKQIVAEKCSVPCRLSVELQDLIRLLMTDIPELRPTVAEVMVHPWVTEGSGVLPDPCEEHIPLKPDPAIAKAMGFIGFQAQDIEDSLCQRKFNETMASYCLLKKQILKECDRPIRAQPMNPSVTPLSSLVDAPTFHLGLRRTETEPTGLRLSDNKEVPVCGNSTSKKRERSFSGPGVLSRPINTTPTMDQTHTRTWSGPCIYSNVCTIHPNSINESTEGHISTSAEDKPVHSRGWPRGIKGWTRKIGNAMRKLCCCIPSKETSHLGQRRVCPKI"
    }, 
    "uniprot_id": "SMKTR_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "2.7.11.1", 
            "activity": ""
        }, 
        {
            "ec": "2.7.11.1", 
            "activity": "ATP + a protein = ADP + a phosphoprotein."
        }
    ], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2KF29", 
                    "id": "A2KF29", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/10647005", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "10647005"
                }
            ], 
            "title": "A protein kinase encoded by the t complex responder gene causes non-Mendelian inheritance.", 
            "journal": "Nature", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2KF29", 
                    "id": "A2KF29", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Kispert A., Wertz K., Herrmann B.G., Koschorz B., McLaughlin K.J.", 
            "date": "1999"
        }
    ], 
    "uniprot_ac": "A2KF29", 
    "site_annotation": [
        {
            "end_pos": 305, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 303
        }, 
        {
            "end_pos": 374, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 372
        }, 
        {
            "end_pos": 395, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 393
        }, 
        {
            "end_pos": 426, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 424
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2KF29#A2KF29-1", 
            "isoform_ac": "A2KF29-1", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A2KF29-1|SMKTR_MOUSE Isoform 1 of Sperm motility kinase Tcr mutant form  OS=Mus musculus OX=10090 GN=Smoktcr PE=2 SV=1 CANONICAL=A2KF29-1", 
                "length": 484, 
                "sequence": "MEKFHAQYEMLETIGQGGCAQVKLARHRLTGTHVAVKVIVKRECWFNPVMSEAELLMMTDHPNIISLLQVIETKKKVYLIMELCEGKSLYQHIQNAGYLQEDEARPLFKQLLSAMNYCHNQGIVHRDLTPDNIMVEKDGKVKIIDFGLGTQEKPGQNHNLFCEIYPFSTPEVLFNRPYDMRKIDVWGLGVVLYFMVTGKILFDTASVEKLRKQIVAEKCSVPCRLSVELQDLIRLLMTDIPELRPTVAEVMVHPWVTEGSGVLPDPCEEHIPLKPDPAIAKAMGFIGFQAQDIEDSLCQRKFNETMASYCLLKKQILKECDRPIRAQPMNPSVTPLSSLVDAPTFHLGLRRTETEPTGLRLSDNKEVPVCGNSTSKKRERSFSGPGVLSRPINTTPTMDQTHTRTWSGPCIYSNVCTIHPNSINESTEGHISTSAEDKPVHSRGWPRGIKGWTRKIGNAMRKLCCCIPSKETSHLGQRRVCPKI"
            }
        }
    ], 
    "pathway": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2KF29#function", 
            "annotation": "While the main function of Smoks is to control sperm motility, the role of Smok-Tcr, with reduced kinase activity, is to counterbalance a signaling impairment caused by the distorter/sterility loci, giving t-sperm an advantage in reaching the oocytes. Transmission ratio distortion also called segregation distortion is the name given to the phenomenon above-mentioned. Being associated with the T-complex, it allows males heterozygous for a complete t-haplotype to preferentially transmit the t-haplotype chromosome.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2KF29#function", 
                    "id": "A2KF29", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2KF29", 
                                "id": "A2KF29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein serine/threonine kinase activity", 
                        "id": "GO:0004674"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2KF29", 
                                "id": "A2KF29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein tyrosine kinase activity", 
                        "id": "GO:0004713"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2KF29", 
                                "id": "A2KF29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ATP binding", 
                        "id": "GO:0005524"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2KF29", 
                                "id": "A2KF29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2KF29", 
                                "id": "A2KF29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2KF29", 
                                "id": "A2KF29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein phosphorylation", 
                        "id": "GO:0006468"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2KF29", 
                                "id": "A2KF29", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intracellular signal transduction", 
                        "id": "GO:0035556"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2KF29", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Smoktcr"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", 
            "id": "IPR000719", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR008266", 
            "id": "IPR008266", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", 
            "id": "IPR011009", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00069", 
            "id": "PF00069", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2KF29", 
            "id": "PR_A2KF29", 
            "database": "PRO"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 54619.0, 
        "chemical_mass": 54619.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2KF29", 
            "name": "Smoktcr", 
            "locus": {}
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2KF29", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "2.7.11.1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2KF29", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Dominant negative form of Smok"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2KF29", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Responder protein Smok-Tcr"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2KF29", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "SmokTcr"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2KF29", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Sperm motility kinase Tcr mutant form"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2KF29", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Tcr"
        }
    ]
}