{
    "uniprot_canonical_ac": "A2IBE2-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A2IBE2-1|A2IBE2_RAT Isoform 1 of Carbonic anhydrase  OS=Rattus norvegicus OX=10116 GN=Ca12 PE=2 SV=1 CANONICAL=A2IBE2-1", 
        "length": 354, 
        "sequence": "MPHCSLHATVVLLLVILKEQPSSSAPLNGSKWTYIGPAGEKNWSKKYPSCGGLLQSPIDLHSDILQYDASLAPLQFQGYNVSVEKLLNLTNDGHSVRLNLNSDMYIQGLQPHQYRAEQLHLHWGNRNDPHGSEHTVSGKHFAAELHIVHYNSDLYSDFGSASDKSEGLAVLAVLIEIGSVNPSYDKIFSHLQHVKYKGQQVLIPGFNIEELLPESPGEYYRYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALETALYFTHMDDPSPREMVNNFRQVQKFDERLVYISFRQGLLTDTGLSLGIILSVALAGVLGISIVLAVSVWLFKRKKSKKGDNKGVIYKPAIKKEAEVHA"
    }, 
    "uniprot_id": "A2IBE2_RAT", 
    "enzyme_annotation": [
        {
            "ec": "4.2.1.1", 
            "activity": ""
        }, 
        {
            "ec": "4.2.1.1", 
            "activity": "H(2)CO(3) = CO(2) + H(2)O."
        }
    ], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2IBE2", 
                    "id": "A2IBE2", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/14660577", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "14660577"
                }
            ], 
            "title": "Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes.", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074225.1", 
                    "id": "NP_001074225.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Whittington DA, Grubb JH, Waheed A, Shah GN, Sly WS, Christianson DW", 
            "date": "2004"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/16831598", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "16831598"
                }
            ], 
            "title": "Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum.", 
            "journal": "Gastroenterology", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2IBE2", 
                    "id": "A2IBE2", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Takeuchi T., Akiba Y., Engel E., Ghayouri S., Guth P.H., Kaunitz J.D., Mizumori M., Swenson E.R.", 
            "date": "2006"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/28940640", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "28940640"
                }
            ], 
            "title": "Bicarbonate Recycling by HIF-1-Dependent Carbonic Anhydrase Isoforms 9 and 12 Is Critical in Maintaining Intracellular pH and Viability of Nucleus Pulposus Cells.", 
            "journal": "Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074225.1", 
                    "id": "NP_001074225.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Silagi ES, Schoepflin ZR, Seifert EL, Merceron C, Schipani E, Shapiro IM, Risbud MV", 
            "date": "2018"
        }
    ], 
    "uniprot_ac": "A2IBE2", 
    "site_annotation": [
        {
            "end_pos": 30, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 28
        }, 
        {
            "end_pos": 44, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 42
        }, 
        {
            "end_pos": 82, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 80
        }, 
        {
            "end_pos": 90, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 88
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2IBE2#A2IBE2-1", 
            "isoform_ac": "A2IBE2-1", 
            "locus": {
                "end_pos": 72405923, 
                "strand": "-", 
                "start_pos": 72458895, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000023952", 
                        "id": "ENSRNOT00000023952", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000023952", 
                        "id": "ENSRNOP00000023952", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2IBE2-1|A2IBE2_RAT Isoform 1 of Carbonic anhydrase  OS=Rattus norvegicus OX=10116 GN=Ca12 PE=2 SV=1 CANONICAL=A2IBE2-1", 
                "length": 354, 
                "sequence": "MPHCSLHATVVLLLVILKEQPSSSAPLNGSKWTYIGPAGEKNWSKKYPSCGGLLQSPIDLHSDILQYDASLAPLQFQGYNVSVEKLLNLTNDGHSVRLNLNSDMYIQGLQPHQYRAEQLHLHWGNRNDPHGSEHTVSGKHFAAELHIVHYNSDLYSDFGSASDKSEGLAVLAVLIEIGSVNPSYDKIFSHLQHVKYKGQQVLIPGFNIEELLPESPGEYYRYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALETALYFTHMDDPSPREMVNNFRQVQKFDERLVYISFRQGLLTDTGLSLGIILSVALAGVLGISIVLAVSVWLFKRKKSKKGDNKGVIYKPAIKKEAEVHA"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:363085", 
            "resource": "KEGG Pathway", 
            "id": "rno:363085", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1475029", 
            "resource": "Reactome", 
            "id": "R-RNO-1475029", 
            "name": "Reversible hydration of carbon dioxide"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074225.1", 
            "annotation": "Binding of HIF-1alpha to select hypoxia-responsive elements on CA9/12 promoters, was observed.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074225.1", 
                    "id": "NP_001074225.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2IBE2#function", 
            "annotation": "Reversible hydration of carbon dioxide.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2IBE2#function", 
                    "id": "A2IBE2", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "O43570-1", 
            "protein_name": "Carbonic anhydrase 12", 
            "sequence": {
                "length": 354, 
                "sequence": "MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/20327", 
                    "id": "20327", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q8CI85-1", 
            "protein_name": "Carbonic anhydrase 12", 
            "sequence": {
                "length": 354, 
                "sequence": "MPHRSLRATVVLLLVILKKQPSSSAPLNGSKWTYVGPAGEKNWSKKYPSCGGLLQSPIDLHSDILQYDASLAPLQFQGYNVSVEKLLNLTNDGHSVRLNLNSDMYIQGLQPHHYRAEQLHLHWGNRNDPHGSEHTVSGKHFAAELHIVHYNSDLYPDFSTASDKSEGLAVLAVLIEIGSANPSYDKIFSHLQHVKYKGQQVLIPGFNIEELLPESPGEYYRYEGSLTTPPCYPTVLWTVFRNPVQISQEQLLALETALYFTHMDDPTPREMINNFRQVQKFDERLVYISFRQGLLTDTGLSLGIILSVALAGVLGISIVLAVSIWLFKRKKSKKGDNKGVIYKPAIKKEAEVHA"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/20327", 
                    "id": "20327", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074225.1", 
        "ac": "NP_001074225.1", 
        "name": "carbonic anhydrase 12 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2IBE2", 
                                "id": "A2IBE2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "zinc ion binding", 
                        "id": "GO:0008270"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004089", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2IBE2", 
                                "id": "A2IBE2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "carbonate dehydratase activity", 
                        "id": "GO:0004089"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016836", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2IBE2", 
                                "id": "A2IBE2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "hydro-lyase activity", 
                        "id": "GO:0016836"
                    }
                ], 
                "total": 3, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2IBE2", 
                                "id": "A2IBE2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2IBE2", 
                                "id": "A2IBE2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006730", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2IBE2", 
                                "id": "A2IBE2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "one-carbon metabolic process", 
                        "id": "GO:0006730"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055064", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2IBE2", 
                                "id": "A2IBE2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "chloride ion homeostasis", 
                        "id": "GO:0055064"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2IBE2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Ca12"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2IBE2", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Ca12"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2IBE2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Car12"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2IBE2", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Car12"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000017766", 
            "id": "ENSRNOG00000017766", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/363085", 
            "id": "363085", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001148", 
            "id": "IPR001148", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018338", 
            "id": "IPR018338", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018430", 
            "id": "IPR018430", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023561", 
            "id": "IPR023561", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036398", 
            "id": "IPR036398", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:363085", 
            "id": "rno:363085", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/TALYCTD/", 
            "id": "TALYCTD", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1377476at2759", 
            "id": "1377476at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952", 
            "id": "PTHR18952", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR18952:SF19", 
            "id": "PTHR18952:SF19", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00194", 
            "id": "PF00194", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1475029", 
            "id": "R-RNO-1475029", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074225.1", 
            "id": "NP_001074225.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306612", 
            "id": "1306612", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 39561.0, 
        "chemical_mass": 39561.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2IBE2", 
            "name": "Ca12", 
            "locus": {}
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2IBE2", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "4.2.1.1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2IBE2", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Carbonic anhydrase"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2IBE2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "carbonic anhydrase 12 precursor"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2IBE2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "membrane-bound carbonic anhydrase 12; carbonic anyhydrase 12"
        }
    ]
}