{ "uniprot_canonical_ac": "A2APY7-1", "ptm_annotation": [], "sequence": { "header": "sp|A2APY7-1|NDUF5_MOUSE Isoform 1 of Arginine-hydroxylase NDUFAF5, mitochondrial OS=Mus musculus OX=10090 GN=Ndufaf5 PE=1 SV=1 CANONICAL=A2APY7-1", "length": 343, "sequence": "MLRKVVLLRLCPLLGRPAVSASSGSRREVASGVPPSGSTSPRALNIFDRELKRKQKNWAARQPDPMKFDYLKEEVGSRIADRVYDIARDFPLALDIGCGRGYIAQHLDKETVGKIFQTDIAEHALKNSLETDIPTVNILADEEFLPFQENTFDLVVSSLSLHWVNDLPRALEQIHYVLKPDGVFVGAMFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLKGMGESNCSWNRKALLHRDTMLAAAAVYREMYRNEDGSIPATFQIYHMIGWKYHDSQARPAERGSATVSFGELAKLNDVMSHEKK" }, "uniprot_id": "NDUF5_MOUSE", "enzyme_annotation": [ { "ec": "1.-.-.-", "activity": "" }, { "ec": "2.1.1.-", "activity": "" } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APY7", "id": "A2APY7", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [], "uniprot_ac": "A2APY7", "site_annotation": [ { "end_pos": 267, "annotation": "n_glycosylation_sequon", "start_pos": 265 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2APY7#A2APY7-1", "isoform_ac": "A2APY7-1", "locus": { "end_pos": 140170712, "strand": "-", "start_pos": 140203615, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000044825", "id": "ENSMUST00000044825", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000035325", "id": "ENSMUSP00000035325", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2APY7-1|NDUF5_MOUSE Isoform 1 of Arginine-hydroxylase NDUFAF5, mitochondrial OS=Mus musculus OX=10090 GN=Ndufaf5 PE=1 SV=1 CANONICAL=A2APY7-1", "length": 343, "sequence": "MLRKVVLLRLCPLLGRPAVSASSGSRREVASGVPPSGSTSPRALNIFDRELKRKQKNWAARQPDPMKFDYLKEEVGSRIADRVYDIARDFPLALDIGCGRGYIAQHLDKETVGKIFQTDIAEHALKNSLETDIPTVNILADEEFLPFQENTFDLVVSSLSLHWVNDLPRALEQIHYVLKPDGVFVGAMFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLKGMGESNCSWNRKALLHRDTMLAAAAVYREMYRNEDGSIPATFQIYHMIGWKYHDSQARPAERGSATVSFGELAKLNDVMSHEKK" } }, { "url": "https://www.uniprot.org/uniprot/A2APY7#A2APY7-2", "isoform_ac": "A2APY7-2", "locus": {}, "sequence": { "header": "sp|A2APY7-2|NDUF5_MOUSE Isoform 2 of Arginine-hydroxylase NDUFAF5, mitochondrial OS=Mus musculus OX=10090 GN=Ndufaf5 PE=1 SV=1 CANONICAL=A2APY7-1", "length": 156, "sequence": "MFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLKGMGESNCSWNRKALLHRDTMLAAAAVYREMYRNEDGSIPATFQIYHMIGWKYHDSQARPAERGSATVSFGELAKLNDVMSHEKK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69487", "resource": "KEGG Pathway", "id": "mmu:69487", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6799198", "resource": "Reactome", "id": "R-MMU-6799198", "name": "Complex I biogenesis" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2APY7#function", "annotation": "Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. Acts by mediating hydroxylation of 'Arg-111' of NDUFS7. May also have methyltransferase activity.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APY7#function", "id": "A2APY7", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "B2GV71-1", "protein_name": "Arginine-hydroxylase NDUFAF5, mitochondrial", "sequence": { "length": 343, "sequence": "MLRRVVLSRLYARLGGPAVSAGRGGRRGVASSVPPSGSTSPRALNIFDRELKRKQKNWAARQPEPMKFDYLKEEIGSRIADRVYDIARDFPLALDIGCGRGYIAQHLNKETVGKIFQTDIAEHALKNSIETDIPTVNILADEEFLPFPENTFDLVVSSLSLHWVNDLPRALEQIHYVLKPDGVFVGAMFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLKGMGESNCSWNRKALLHRDTMLAAAAVYREMYSNEDGSIPATYQIYHMIGWKYHDSQARPAERGSATVSFGDLARLNDTMSQGKK" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2APY7/", "id": "A2APY7", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/11474", "id": "11474", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q5TEU4-1", "protein_name": "Arginine-hydroxylase NDUFAF5, mitochondrial", "sequence": { "length": 345, "sequence": "MLRPAGLWRLCRRPWAARVPAENLGRREVTSGVSPRGSTSPRTLNIFDRDLKRKQKNWAARQPEPTKFDYLKEEVGSRIADRVYDIPRNFPLALDLGCGRGYIAQYLNKETIGKFFQADIAENALKNSSETEIPTVSVLADEEFLPFKENTFDLVVSSLSLHWVNDLPRALEQIHYILKPDGVFIGAMFGGDTLYELRCSLQLAETEREGGFSPHISPFTAVNDLGHLLGRAGFNTLTVDTDEIQVNYPGMFELMEDLQGMGESNCAWNRKALLHRDTMLAAAAVYREMYRNEDGSVPATYQIYYMIGWKYHESQARPAERGSATVSFGELGKINNLMPPGKKSQ" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2APY7/", "id": "A2APY7", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/11474", "id": "11474", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081369.2", "ac": "NP_081369.2", "name": "arginine-hydroxylase NDUFAF5, mitochondrial precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APY7", "id": "A2APY7", "database": "UniProtKB" } ], "name": "oxidoreductase activity", "id": "GO:0016491" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APY7", "id": "A2APY7", "database": "UniProtKB" } ], "name": "methyltransferase activity", "id": "GO:0008168" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "pmid": "18614015", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APY7", "id": "A2APY7", "database": "UniProtKB" } ], "name": "mitochondrion", "id": "GO:0005739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031314", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APY7", "id": "A2APY7", "database": "UniProtKB" } ], "name": "extrinsic component of mitochondrial inner membrane", "id": "GO:0031314" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APY7", "id": "A2APY7", "database": "UniProtKB" } ], "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032259", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APY7", "id": "A2APY7", "database": "UniProtKB" } ], "name": "methylation", "id": "GO:0032259" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030961", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APY7", "id": "A2APY7", "database": "UniProtKB" } ], "name": "peptidyl-arginine hydroxylation", "id": "GO:0030961" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2APY7", "type": "synonym", "resource": "RefSeq", "name": "2310003L22Rik" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2APY7", "type": "synonym", "resource": "RefSeq", "name": "Ndufaf5" }, { "url": "https://www.uniprot.org/uniprot/A2APY7", "type": "recommended", "resource": "UniProtKB", "name": "Ndufaf5" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000027384", "id": "ENSMUSG00000027384", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/69487", "id": "69487", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013216", "id": "IPR013216", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "id": "IPR029063", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69487", "id": "mmu:69487", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1916737", "id": "1916737", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/IYFVGWK/", "id": "IYFVGWK", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=691814at2759", "id": "691814at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF08241", "id": "PF08241", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2APY7", "id": "PR_A2APY7", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6799198", "id": "R-MMU-6799198", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081369.2", "id": "NP_081369.2", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 38405.0, "chemical_mass": 38405.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2APY7", "name": "Ndufaf5", "locus": { "end_pos": 140203689, "strand": "+", "start_pos": 140170649, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000027384", "id": "ENSMUSG00000027384", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2APY7", "type": "synonym", "resource": "UniProtKB", "name": "1.-.-.-" }, { "url": "https://www.uniprot.org/uniprot/A2APY7", "type": "synonym", "resource": "UniProtKB", "name": "2.1.1.-" }, { "url": "https://www.uniprot.org/uniprot/A2APY7", "type": "recommended", "resource": "UniProtKB", "name": "Arginine-hydroxylase NDUFAF5, mitochondrial" }, { "url": "https://www.uniprot.org/uniprot/A2APY7", "type": "synonym", "resource": "UniProtKB", "name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5" }, { "url": "https://www.uniprot.org/uniprot/A2APY7", "type": "synonym", "resource": "UniProtKB", "name": "Putative methyltransferase NDUFAF5" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2APY7", "type": "synonym", "resource": "RefSeq", "name": "arginine-hydroxylase NDUFAF5, mitochondrial precursor" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2APY7", "type": "synonym", "resource": "RefSeq", "name": "probable methyltransferase C20orf7 homolog, mitochondrial; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5; putative methyltransferase NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial; NADH dehydrogenase (ubiquinone) complex I, assembly factor 5" } ] }