{ "uniprot_canonical_ac": "A2AKX3-1", "ptm_annotation": [ { "annotation": "Sumoylated preferentially with SUMO2 or SUMO3.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q7Z333", "id": "Q7Z333", "database": "PubMed" } ] }, { "annotation": "Ubiquitinated.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q7Z333", "id": "Q7Z333", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2AKX3-1|SETX_MOUSE Isoform 1 of Probable helicase senataxin OS=Mus musculus OX=10090 GN=Setx PE=1 SV=1 CANONICAL=A2AKX3-1", "length": 2646, "sequence": "MSTCCWCTPGGSSTIDVLKRYASSTGSSEFQTADEDLCYCLECVAEYHRARDEVPFLHEVLWELETLRLVSHFEKSMKAEAEDDDDLYIVDNNGEEQLFDCSGQDFENKLRVPLFEILKYPYLLLHERVNELCVEALCRMEQNNCSFQVFDKYPGIYLFLVHPNEMVRRWAILTARNLGKVDRDDYYDLQEVLTCLFKVIELGLLESPDIYTSSVLEKGKLILLPAHMYDTTNYKNYWLGICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMEKQSDDDSMDPFWPALHCFMVILDRLGSKVWGQLIDPIEAFQTIINNESYNREIQNIRNSSIRTKLEPEPHFDDMVTCSQIVYNFNPEKTKKDSGWRSAICPDYCPNMYEEMETLANVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIVEVIHHLYSEVKDVLNQTDAVCDKVTEFFILILISVIELHRNKKCLHLLWVSSQQWVEAVVKCAKLPTTAFVRSCEKSPGSTSRGAAIMSSLALHSVQSNSVQLACVQLIRGLLKEGYQLGQQTLCKRFWDKLNLFLRGNLSLGWQLTGQETHELQMCLKQIIRNIKFKMPQYSTFGDSTSTFKTPPSFKEESDKIDRKHKKNIYCLENCSPVSSKEPMKADTHRVLMKVNTTEEENFKQHYIDLNEEEQEPLPAELCLKQKSEALFSESAQEQVKISAEKSGKESSSYAPSNSTSRNGPEWGCDRGVIMSAHSLTDSSSDFMEQVSTSNEDVSLKDGSVGKTSKPSFKLQKDEICAKLSHVIKKQIRKSTLVDNIIDLEENTAISDLENCSGTDGGALKEDSIGHNVPSDPVLDDKHEEQKSQNSSLFKKEIKSEELDNSSSDDEDKLQIQEGRADDDLVSFTEVTDTLVKAPCEGHVKMVVESRDKEMRESTALTSNLVEGQVPHDSSKPLVAGRQIDLCNITLISQTTVIQFPSGLSKQNSFQLQKGDKRCLTANQNSAATCRGQVIVISDSDEEEDEDEDERSSSEENIKQSKACIGKDCSEHRSLAVNASVEKQLVKEEERYPVEFEDSESQVFEFESSSEVFSVWQDHKIDSKNSLQGEQKSYVTHVADSTNNNLGCGDSVSEEVVRNKAEGVKEHAGPHSSVSAEEFCKTGVKKPKRKRYDKVTAEDPQRPSSSVGTDQLPDRRDLTESDLKSADMGMATPSSSVERDSTILQKSTKSRTHSKPVRKVPASKATKKTHSDTRRGQSKSSCYISCRTSPAIVPPKKLRQCPEPTSTVEKLGLKKAPRKAFELSQRSLECIVQLRDHGKTVGVVDAPKKAKLISPQTLSIKNNKKLLTSQDLQFQRLMRSRSHKKRDFDYKNTDTVRVSRIVQGSDVLEADSDEPDDHRVSEPLAISNEKQLAKCMLSKTEVAEASSDPWVTGITCLVNQCESRVLSGGVPTDVVMVSASEDPVDGGAVTVQVGEVASVKAAEPASSSDTDDDDNLFLTQHDPQDMDLCSQLENKTIIVAHKKDTVQREDSLSRPQLESLSITKCKYKDCVETTKNQGEYCPRHSEAKAADDGLFRKPGLPLSVARPLRPTTTKIFSSSSASRTANLSKSLESTTLQQSALKNKSSGAQPNLKVTPPSSMGSQKPVAEVKSLCNIFHFQTPSSSSKQSCKLTFSENRPTSAASPVNILLPSQSIFDTFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRPVPVRFQDCAEYFNVFLPLIILNAFETVAQEWLSSPNKENFYQLQLRKFPADYKKYWEFLIYLNESELAKQLHPKENDLVFLAPEKSYMDRHGMQDCSHYYCGYVHKFRRTSVMRSGKAECSLCIQTQDTLPASVKNLTRCIVISSLVTTQRKLKAMSLLSSRNQLARAVLNPNPMDFCTKDLLTTTSERIVAYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINTEVLKFSLDSQVNHRMKKDLPSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDEHIAIVSKERQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTESIRCSSEWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFDKKGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQKRGAIIKTSDPNYRHDAMKILKLKPVLQRSLTHPPATAPEAPRPQGGLPSNRLDSGLATTSFAASLYHTPSDTVTSKGPERPLLQDRLRDPRLLRRLDAEAKGTFLKDPQPVSPQLPGVVHLLGEPGFPVVFQDLGFVVPPSTAIVAPLGSHRSPMQAEPPPAHPAAAASTSKRKYSDPDAGLSHKREPRAFSGEQGRHGSVTHHVLRSTDWDRRRLDDSSAKRRQFL" }, "uniprot_id": "SETX_MOUSE", "enzyme_annotation": [ { "ec": "3.6.4.-", "activity": "" } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14770181", "type": [ "PubMed" ], "id": "14770181" } ], "title": "Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2.", "journal": "Nat. Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Aubourg P., Brice A., Warter J.-M., Watanabe M., Bouslam N., Stevanin G., Calvas P., Koenig M., Pandolfo M., Tazir M., Tanaka M., Tranchant C., Barbot C., Coutinho P., Duerr A., Le Ber I., Mendonca P., Moreira M.-C., Sequeiros J., Schoels L., Dunne E., Izatt L., Pouget J., Nemeth A.H., Guimaraes J., Benhassine T., Shizuka-Ikeda M., Shaw C.E., Schulz J.B., Bomont P., Shoji M., Klur S., M'Zahem A., Moniz J.-C.", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16644229", "type": [ "PubMed" ], "id": "16644229" } ], "title": "Senataxin, the yeast Sen1p orthologue: characterization of a unique protein in which recessive mutations cause ataxia and dominant mutations cause motor neuron disease.", "journal": "Neurobiol. Dis.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "authors": "Huang Y., Bennett C.L., Chance P.F., Glass I.A., Moreira M.-C., Lynch D.R., Anderson S.K., Hashemi S.H., Chen Y.-Z.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22767893", "type": [ "PubMed" ], "id": "22767893" } ], "title": "Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex.", "journal": "Science", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Padmanabhan K., Weitz C.J., Westerling T., Robles M.S.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23593030", "type": [ "PubMed" ], "id": "23593030" } ], "title": "Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing.", "journal": "PLoS Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Xu X., Becherel O.J., Lavin M.F., Deng C., Fleming J., McKinney K., Woods R., Carrie D., Heng E.Y., Luff J., Stellati A., Suraweera A.M., Yeo A.J.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29497044", "type": [ "PubMed" ], "id": "29497044" } ], "title": "Elongator and codon bias regulate protein levels in mammalian peripheral neurons.", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Goffena J, Lefcort F, Zhang Y, Lehrmann E, Chaverra M, Felig J, Walters J, Buksch R, Becker KG, George L", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29725819", "type": [ "PubMed" ], "id": "29725819" } ], "title": "Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients.", "journal": "Acta neuropathologica", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Bennett CL, Dastidar SG, Ling SC, Malik B, Ashe T, Wadhwa M, Miller DB, Lee C, Mitchell MB, van Es MA, Grunseich C, Chen Y, Sopher BL, Greensmith L, Cleveland DW, La Spada AR", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29968717", "type": [ "PubMed" ], "id": "29968717" } ], "title": "A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links.", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Andrews AM, McCartney HJ, Errington TM, D'Andrea AD, Macara IG", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30010942", "type": [ "PubMed" ], "id": "30010942" } ], "title": "Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ], "authors": "Kannan A, Bhatia K, Branzei D, Gangwani L", "date": "2018" } ], "uniprot_ac": "A2AKX3", "site_annotation": [ { "end_pos": 1044, "annotation": "n_glycosylation_sequon", "start_pos": 1042 }, { "end_pos": 146, "annotation": "n_glycosylation_sequon", "start_pos": 144 }, { "end_pos": 1500, "annotation": "n_glycosylation_sequon", "start_pos": 1498 }, { "end_pos": 1592, "annotation": "n_glycosylation_sequon", "start_pos": 1590 }, { "end_pos": 1609, "annotation": "n_glycosylation_sequon", "start_pos": 1607 }, { "end_pos": 1778, "annotation": "n_glycosylation_sequon", "start_pos": 1776 }, { "end_pos": 1851, "annotation": "n_glycosylation_sequon", "start_pos": 1849 }, { "end_pos": 2289, "annotation": "n_glycosylation_sequon", "start_pos": 2287 }, { "end_pos": 2387, "annotation": "n_glycosylation_sequon", "start_pos": 2385 }, { "end_pos": 323, "annotation": "n_glycosylation_sequon", "start_pos": 321 }, { "end_pos": 335, "annotation": "n_glycosylation_sequon", "start_pos": 333 }, { "end_pos": 407, "annotation": "n_glycosylation_sequon", "start_pos": 405 }, { "end_pos": 447, "annotation": "n_glycosylation_sequon", "start_pos": 445 }, { "end_pos": 571, "annotation": "n_glycosylation_sequon", "start_pos": 569 }, { "end_pos": 640, "annotation": "n_glycosylation_sequon", "start_pos": 638 }, { "end_pos": 662, "annotation": "n_glycosylation_sequon", "start_pos": 660 }, { "end_pos": 724, "annotation": "n_glycosylation_sequon", "start_pos": 722 }, { "end_pos": 821, "annotation": "n_glycosylation_sequon", "start_pos": 819 }, { "end_pos": 856, "annotation": "n_glycosylation_sequon", "start_pos": 854 }, { "end_pos": 871, "annotation": "n_glycosylation_sequon", "start_pos": 869 }, { "end_pos": 954, "annotation": "n_glycosylation_sequon", "start_pos": 952 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3#A0A0A0MQJ0-1", "isoform_ac": "A0A0A0MQJ0-1", "locus": { "end_pos": 29126887, "strand": "-", "start_pos": 29130245, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000129544", "id": "ENSMUST00000129544", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119521", "id": "ENSMUSP00000119521", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A0MQJ0-1|SETX_MOUSE Computationally mapped isoform of Probable helicase senataxin OS=Mus musculus OX=10090 GN=Setx PE=1 SV=1 CANONICAL=A2AKX3-1", "length": 81, "sequence": "MSTCCWCTPGGSSTIDVLKRYASSTGSSEFQTADEDLCYCLECVAEYHRARDEVPFLHEVLWELETLRLVSHFEKSMKAEA" } }, { "url": "https://www.uniprot.org/uniprot/A2AKX3#A2AKX3-1", "isoform_ac": "A2AKX3-1", "locus": { "end_pos": 29126887, "strand": "-", "start_pos": 29180122, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000061578", "id": "ENSMUST00000061578", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000051492", "id": "ENSMUSP00000051492", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AKX3-1|SETX_MOUSE Isoform 1 of Probable helicase senataxin OS=Mus musculus OX=10090 GN=Setx PE=1 SV=1 CANONICAL=A2AKX3-1", "length": 2646, "sequence": "MSTCCWCTPGGSSTIDVLKRYASSTGSSEFQTADEDLCYCLECVAEYHRARDEVPFLHEVLWELETLRLVSHFEKSMKAEAEDDDDLYIVDNNGEEQLFDCSGQDFENKLRVPLFEILKYPYLLLHERVNELCVEALCRMEQNNCSFQVFDKYPGIYLFLVHPNEMVRRWAILTARNLGKVDRDDYYDLQEVLTCLFKVIELGLLESPDIYTSSVLEKGKLILLPAHMYDTTNYKNYWLGICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMEKQSDDDSMDPFWPALHCFMVILDRLGSKVWGQLIDPIEAFQTIINNESYNREIQNIRNSSIRTKLEPEPHFDDMVTCSQIVYNFNPEKTKKDSGWRSAICPDYCPNMYEEMETLANVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIVEVIHHLYSEVKDVLNQTDAVCDKVTEFFILILISVIELHRNKKCLHLLWVSSQQWVEAVVKCAKLPTTAFVRSCEKSPGSTSRGAAIMSSLALHSVQSNSVQLACVQLIRGLLKEGYQLGQQTLCKRFWDKLNLFLRGNLSLGWQLTGQETHELQMCLKQIIRNIKFKMPQYSTFGDSTSTFKTPPSFKEESDKIDRKHKKNIYCLENCSPVSSKEPMKADTHRVLMKVNTTEEENFKQHYIDLNEEEQEPLPAELCLKQKSEALFSESAQEQVKISAEKSGKESSSYAPSNSTSRNGPEWGCDRGVIMSAHSLTDSSSDFMEQVSTSNEDVSLKDGSVGKTSKPSFKLQKDEICAKLSHVIKKQIRKSTLVDNIIDLEENTAISDLENCSGTDGGALKEDSIGHNVPSDPVLDDKHEEQKSQNSSLFKKEIKSEELDNSSSDDEDKLQIQEGRADDDLVSFTEVTDTLVKAPCEGHVKMVVESRDKEMRESTALTSNLVEGQVPHDSSKPLVAGRQIDLCNITLISQTTVIQFPSGLSKQNSFQLQKGDKRCLTANQNSAATCRGQVIVISDSDEEEDEDEDERSSSEENIKQSKACIGKDCSEHRSLAVNASVEKQLVKEEERYPVEFEDSESQVFEFESSSEVFSVWQDHKIDSKNSLQGEQKSYVTHVADSTNNNLGCGDSVSEEVVRNKAEGVKEHAGPHSSVSAEEFCKTGVKKPKRKRYDKVTAEDPQRPSSSVGTDQLPDRRDLTESDLKSADMGMATPSSSVERDSTILQKSTKSRTHSKPVRKVPASKATKKTHSDTRRGQSKSSCYISCRTSPAIVPPKKLRQCPEPTSTVEKLGLKKAPRKAFELSQRSLECIVQLRDHGKTVGVVDAPKKAKLISPQTLSIKNNKKLLTSQDLQFQRLMRSRSHKKRDFDYKNTDTVRVSRIVQGSDVLEADSDEPDDHRVSEPLAISNEKQLAKCMLSKTEVAEASSDPWVTGITCLVNQCESRVLSGGVPTDVVMVSASEDPVDGGAVTVQVGEVASVKAAEPASSSDTDDDDNLFLTQHDPQDMDLCSQLENKTIIVAHKKDTVQREDSLSRPQLESLSITKCKYKDCVETTKNQGEYCPRHSEAKAADDGLFRKPGLPLSVARPLRPTTTKIFSSSSASRTANLSKSLESTTLQQSALKNKSSGAQPNLKVTPPSSMGSQKPVAEVKSLCNIFHFQTPSSSSKQSCKLTFSENRPTSAASPVNILLPSQSIFDTFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRPVPVRFQDCAEYFNVFLPLIILNAFETVAQEWLSSPNKENFYQLQLRKFPADYKKYWEFLIYLNESELAKQLHPKENDLVFLAPEKSYMDRHGMQDCSHYYCGYVHKFRRTSVMRSGKAECSLCIQTQDTLPASVKNLTRCIVISSLVTTQRKLKAMSLLSSRNQLARAVLNPNPMDFCTKDLLTTTSERIVAYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINTEVLKFSLDSQVNHRMKKDLPSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDEHIAIVSKERQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTESIRCSSEWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFDKKGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQKRGAIIKTSDPNYRHDAMKILKLKPVLQRSLTHPPATAPEAPRPQGGLPSNRLDSGLATTSFAASLYHTPSDTVTSKGPERPLLQDRLRDPRLLRRLDAEAKGTFLKDPQPVSPQLPGVVHLLGEPGFPVVFQDLGFVVPPSTAIVAPLGSHRSPMQAEPPPAHPAAAASTSKRKYSDPDAGLSHKREPRAFSGEQGRHGSVTHHVLRSTDWDRRRLDDSSAKRRQFL" } }, { "url": "https://www.uniprot.org/uniprot/A2AKX3#A2AKX3-2", "isoform_ac": "A2AKX3-2", "locus": {}, "sequence": { "header": "sp|A2AKX3-2|SETX_MOUSE Isoform 2 of Probable helicase senataxin OS=Mus musculus OX=10090 GN=Setx PE=1 SV=1 CANONICAL=A2AKX3-1", "length": 2265, "sequence": "MYEEMETLANVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIVEVIHHLYSEVKDVLNQTDAVCDKVTEFFILILISVIELHRNKKCLHLLWVSSQQWVEAVVKCAKLPTTAFVRSCEKSPGSTSRGAAIMSSLALHSVQSNSVQLACVQLIRGLLKEGYQLGQQTLCKRFWDKLNLFLRGNLSLGWQLTGQETHELQMCLKQIIRNIKFKMPQYSTFGDSTSTFKTPPSFKEESDKIDRKHKKNIYCLENCSPVSSKEPMKADTHRVLMKVNTTEEENFKQHYIDLNEEEQEPLPAELCLKQKSEALFSESAQEQVKISAEKSGKESSSYAPSNSTSRNGPEWGCDRGVIMSAHSLTDSSSDFMEQVSTSNEDVSLKDGSVGKTSKPSFKLQKDEICAKLSHVIKKQIRKSTLVDNIIDLEENTAISDLENCSGTDGGALKEDSIGHNVPSDPVLDDKHEEQKSQNSSLFKKEIKSEELDNSSSDDEDKLQIQEGRADDDLVSFTEVTDTLVKAPCEGHVKMVVESRDKEMRESTALTSNLVEGQVPHDSSKPLVAGRQIDLCNITLISQTTVIQFPSGLSKQNSFQLQKGDKRCLTANQNSAATCRGQVIVISDSDEEEDEDEDERSSSEENIKQSKACIGKDCSEHRSLAVNASVEKQLVKEEERYPVEFEDSESQVFEFESSSEVFSVWQDHKIDSKNSLQGEQKSYVTHVADSTNNNLGCGDSVSEEVVRNKAEGVKEHAGPHSSVSAEEFCKTGVKKPKRKRYDKVTAEDPQRPSSSVGTDQLPDRRDLTESDLKSADMGMATPSSSVERDSTILQKSTKSRTHSKPVRKVPASKATKKTHSDTRRGQSKSSCYISCRTSPAIVPPKKLRQCPEPTSTVEKLGLKKAPRKAFELSQRSLECIVQLRDHGKTVGVVDAPKKAKLISPQTLSIKNNKKLLTSQDLQFQRLMRSRSHKKRDFDYKNTDTVRVSRIVQGSDVLEADSDEPDDHRVSEPLAISNEKQLAKCMLSKTEVAEASSDPWVTGITCLVNQCESRVLSGGVPTDVVMVSASEDPVDGGAVTVQVGEVASVKAAEPASSSDTDDDDNLFLTQHDPQDMDLCSQLENKTIIVAHKKDTVQREDSLSRPQLESLSITKCKYKDCVETTKNQGEYCPRHSEAKAADDGLFRKPGLPLSVARPLRPTTTKIFSSSSASRTANLSKSLESTTLQQSALKNKSSGAQPNLKVTPPSSMGSQKPVAEVKSLCNIFHFQTPSSSSKQSCKLTFSENRPTSAASPVNILLPSQSIFDTFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRPVPVRFQDCAEYFNVFLPLIILNAFETVAQEWLSSPNKENFYQLQLRKFPADYKKYWEFLIYLNESELAKQLHPKENDLVFLAPEKSYMDRHGMQDCSHYYCGYVHKFRRTSVMRSGKAECSLCIQTQDTLPASVKNLTRCIVISSLVTTQRKLKAMSLLSSRNQLARAVLNPNPMDFCTKDLLTTTSERIVAYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINTEVLKFSLDSQVNHRMKKDLPSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDEHIAIVSKERQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTESIRCSSEWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFDKKGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQKRGAIIKTSDPNYRHDAMKILKLKPVLQRSLTHPPATAPEAPRPQGGLPSNRLDSGLATTSFAASLYHTPSDTVTSKGPERPLLQDRLRDPRLLRRLDAEAKGTFLKDPQPVSPQLPGVVHLLGEPGFPVVFQDLGFVVPPSTAIVAPLGSHRSPMQAEPPPAHPAAAASTSKRKYSDPDAGLSHKREPRAFSGEQGRHGSVTHHVLRSTDWDRRRLDDSSAKRRQFL" } }, { "url": "https://www.uniprot.org/uniprot/A2AKX3#F6R186-1", "isoform_ac": "F6R186-1", "locus": { "end_pos": 29164458, "strand": "-", "start_pos": 29179540, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000145422", "id": "ENSMUST00000145422", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119176", "id": "ENSMUSP00000119176", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6R186-1|SETX_MOUSE Computationally mapped isoform of Probable helicase senataxin OS=Mus musculus OX=10090 GN=Setx PE=1 SV=1 CANONICAL=A2AKX3-1", "length": 381, "sequence": "XCCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTESIRCSSEWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFDKKGLLQPIMMGESRQQDSEASKQQQKSSEFMHASDELGSSTVTQSGISSLENGATHTGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQKRGAIIKTSDPNYRHDAMKILKLKPVLQRSLTHP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269254", "resource": "KEGG Pathway", "id": "mmu:269254", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3#function", "annotation": "Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription. Contributes to the mRNA splicing efficiency and splice site selection. Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (By similarity). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (PubMed:22767893). Involved in DNA double-strand breaks damage response generated by oxidative stress. In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (By similarity). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (PubMed:23593030). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis. May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3#function", "id": "A2AKX3", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "annotation": "SETX ALS4 mice thus recapitulated ALS disease phenotypes in association with TDP-43 mislocalization and provided insight into the basis for TDP-43 histopathology, linking SETX dysfunction to common pathways of ALS motor neuron degeneration.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "annotation": "Senataxin (SETX)-deficiency results in increased RNA-DNA hybrids (R-loops) and DNA double-strand breaks (DSBs), and deficiency of DNA-activated protein kinase-catalytic subunit (DNA-PKcs), which impairs DSB repair. SETX overexpression in SMA neurons reduces R-loops and DNA damage, and rescues neurodegeneration.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "annotation": "Study report a previously uncharacterized protein, SAN1, the Fam120b gene product, as a 5' exonuclease that acts independently of the Fanconi anemia pathway in response to inter-strand DNA cross-links (ICLs). Deletion of SAN1 in HeLa cells and mouse embryonic fibroblasts causes sensitivity to ICLs. SAN1 binds to senataxin (SETX). SAN1-SETX binding is increased by ICLs and is required to prevent cross-link sensitivity. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "annotation": "These data support key roles for senataxin in coordinating meiotic crossing-over with transcription and in gene silencing to protect the integrity of the genome.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "id": "NP_932150.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D4AEB3-1", "protein_name": "Senataxin", "sequence": { "length": 2647, "sequence": "MSTCCWCTPGGSSTIDVLKCYASSTGSSEFQTADEDLCYCLECVAEYHRARDEVPFLHEVLWELETLRLISHFEKSMKAEAEDDDELYIVDNNGEEQLFDCSGQDFENRLRVPLFEILKYPYLLLHERVNELCVEALCRMEQNNCSFQVFDKYPGIYLFLVHPNEMVRRWAILTARNLGKVDRDDYYDLQEVLTCLFKVIELGLLESPDIYTSSVLEKGKLILLPAHMYDTTNYKNYWLGICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMEKQSDDDSMDPFWPALHCFMVILDRLGSKVWGQLIDPIEAFQTIINNESYNREIQNIRNSSIRTKLEPEPHFDDMVTCSQIVYNYNPEKTKKDSGWRSAICPDYCPNMYEEMETLANVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIVEVIHHLYSEVKDVLNQTDAVCDKVTEFFILILVSVIELHRNKKCLHLLWVSSQQWVDAVVKCAKLPTTAFVRSCEKSPGSTPRGAAIMSSLALHSVPSNSVQLACVQLIRGLLKEGYQLGQQTLCKRFWDKLNLFLRGNSSLGWQLTGQETHELQMCLKQIIRNIKIKMPQYSTFGDTTSTFKTPPSFKEESEQIDRKPKKDIHSLGNCSPIPSKEPMKADSHRVPTKASATEEEDFTQHYIDLNEEEPLPAELGVKQKSEALLSESAPEQVKISTEKSGKENSSYTAPNSTSRSGPEWGCDRGVIISTHSLTDSSSDFLEKVSTSNGDVPLKDGTVGKTSKPNFKVQKDEICAKLSHVLKKQHRKSTLVNNIIDLEENAATSDLENCSGTDRGALKKDTIEHDVSSDSVLNDDHEEQKSKNSSLFKKEIKSEKLDNSSFDDEDKLQIQEGHADDDLISFTEVTDTLVKKTPCEGSVKVAVESRDNEMRVLTSNLEGQVPHDSNKALVAGPQVDLCNITLISQTTVIQFPSGLSKQNSFQLQKDDKKCLTANHNRDATCHEQVIIISDSDDEDDADEQDEDKRCGIEGNIEQSKVSRENDCSEQHDLVVNTSVEKKLVKEEETNCPIEFEDSESQVFEFESSSEVFSVWQDHKIDSKSSLQEDQKSCIAHVADSTNNNLGCGADSVSEEVVRNKEKGVKEHAEPHSSVSAEGFCKIGVRKPKRKRCDKVTAEDPQRPSSSVRTEQLAEHRDLPERDLESADVDMAAPSSSVERDSTVLQKKSTKPRPHSKPVRKVPASKATKKTHPDTRRGQTKSSCYISCRTSPAIVPPKKFRQCPEPTSTVEKLGLKKGPRKAFELSQRSLECIVQLRDHGKTVGVVEAPKKTKLISPQTLSIKNNKKLLTSQDLQFQRLMRSRSHQKRDFDYKNTDSVRAVSRVVQGSDVLAADSDEPDNPGGSEPLAISSEKQLAKGTLSKAEVAEAASGPWGTGITCLVNQCESRVLSGGVPTDVLMGSASEDPVGGGALTVQVGEVAAVRAAEPESSSDTDDDDNLFLTQHDPQDMDLCSQLENSKAIIVAHKDTVQREDSLSRPQLESLSIIKCKYKDCVETTKNQGEYCPKHSEAKAADDDVFRKPGLPLSVARSSRPTTTKIFSSSSASRTANLSKSLESTTLQSALKNKSSGAQSNLKMTPSSSLGSQKPVAEVKSLCNIFHFQTPSSSSKQSYKFTFSENRPASAASSVDILLPSQSIFDTFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRPVPVRFQDCAEYFNVFLPLIILNAFETVAQEWLNSPNKENFYQLHLRKFPADYKKYWEFLIYLEESELAKQLHPKENDLVFLVPEKKYMDRHSVQDRSHYYCGYVHKFRRTSVMRSGKTECSLCIQTQDNMPASVKELTKCIVISSLVTTQRKLKAMSLLSGRNQLARAVLNPNPMDFCTKDLLTTTSERIIAYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTESQRKGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINTEVLKFSLDSQVSHRMKKDLPSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDEHIVIVSKERQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEVETLSPLIHRCNKLVLVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQNMIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTETIRCSSEWPFQPYLVFDVGDGSEQRDNDSYINVQEIKLVMEIIKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFDKKGPAEVDTVDAFQGRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQKRGAIIKTCDPNYRHDAMKILKLKPVLQRSLTHPPATAPEAPRPQGGLPSNRLDSGLATTSFAPSLYHTPSDTVTSKEPERPLLQDRLRDPRLLRRLDAEAKGTFLRDPQPESPQLPGVVHLLGESGCPVLFQDLGFVVPPSTAIVAPLGSHRSPIQAEPRPAHPAAAASTSKRKYSDPDAGLSHRREPRAFAGEQGRHGSVTHHALRSTDLDRRRLDDSSAKRRRFL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/41003", "id": "41003", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q7Z333-1", "protein_name": "Probable helicase senataxin", "sequence": { "length": 2677, "sequence": "MSTCCWCTPGGASTIDFLKRYASNTPSGEFQTADEDLCYCLECVAEYHKARDELPFLHEVLWELETLRLINHFEKSMKAEIGDDDELYIVDNNGEMPLFDITGQDFENKLRVPLLEILKYPYLLLHERVNELCVEALCRMEQANCSFQVFDKHPGIYLFLVHPNEMVRRWAILTARNLGKVDRDDYYDLQEVLLCLFKVIELGLLESPDIYTSSVLEKGKLILLPSHMYDTTNYKSYWLGICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMEREADDDSVDPFWPALHCFMVILDRLGSKVWGQLMDPIVAFQTIINNASYNREIRHIRNSSVRTKLEPESYLDDMVTCSQIVYNYNPEKTKKDSGWRTAICPDYCPNMYEEMETLASVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIAQVVNHLYSEVKEVLNQTDAVCDKVTEFFLLILVSVIELHRNKKCLHLLWVSSQQWVEAVVKCAKLPTTAFTRSSEKSSGNCSKGTAMISSLSLHSMPSNSVQLAYVQLIRSLLKEGYQLGQQSLCKRFWDKLNLFLRGNLSLGWQLTSQETHELQSCLKQIIRNIKFKAPPCNTFVDLTSACKISPASYNKEESEQMGKTSRKDMHCLEASSPTFSKEPMKVQDSVLIKADNTIEGDNNEQNYIKDVKLEDHLLAGSCLKQSSKNIFTERAEDQIKISTRKQKSVKEISSYTPKDCTSRNGPERGCDRGIIVSTRLLTDSSTDALEKVSTSNEDFSLKDDALAKTSKRKTKVQKDEICAKLSHVIKKQHRKSTLVDNTINLDENLTVSNIESFYSRKDTGVQKGDGFIHNLSLDPSGVLDDKNGEQKSQNNVLPKEKQLKNEELVIFSFHENNCKIQEFHVDGKELIPFTEMTNASEKKSSPFKDLMTVPESRDEEMSNSTSVIYSNLTREQAPDISPKSDTLTDSQIDRDLHKLSLLAQASVITFPSDSPQNSSQLQRKVKEDKRCFTANQNNVGDTSRGQVIIISDSDDDDDERILSLEKLTKQDKICLEREHPEQHVSTVNSKEEKNPVKEEKTETLFQFEESDSQCFEFESSSEVFSVWQDHPDDNNSVQDGEKKCLAPIANTTNGQGCTDYVSEVVKKGAEGIEEHTRPRSISVEEFCEIEVKKPKRKRSEKPMAEDPVRPSSSVRNEGQSDTNKRDLVGNDFKSIDRRTSTPNSRIQRATTVSQKKSSKLCTCTEPIRKVPVSKTPKKTHSDAKKGQNRSSNYLSCRTTPAIVPPKKFRQCPEPTSTAEKLGLKKGPRKAYELSQRSLDYVAQLRDHGKTVGVVDTRKKTKLISPQNLSVRNNKKLLTSQELQMQRQIRPKSQKNRRRLSDCESTDVKRAGSHTAQNSDIFVPESDRSDYNCTGGTEVLANSNRKQLIKCMPSEPETIKAKHGSPATDDACPLNQCDSVVLNGTVPTNEVIVSTSEDPLGGGDPTARHIEMAALKEGEPDSSSDAEEDNLFLTQNDPEDMDLCSQMENDNYKLIELIHGKDTVEVEEDSVSRPQLESLSGTKCKYKDCLETTKNQGEYCPKHSEVKAADEDVFRKPGLPPPASKPLRPTTKIFSSKSTSRIAGLSKSLETSSALSPSLKNKSKGIQSILKVPQPVPLIAQKPVGEMKNSCNVLHPQSPNNSNRQGCKVPFGESKYFPSSSPVNILLSSQSVSDTFVKEVLKWKYEMFLNFGQCGPPASLCQSISRPVPVRFHNYGDYFNVFFPLMVLNTFETVAQEWLNSPNRENFYQLQVRKFPADYIKYWEFAVYLEECELAKQLYPKENDLVFLAPERINEEKKDTERNDIQDLHEYHSGYVHKFRRTSVMRNGKTECYLSIQTQENFPANLNELVNCIVISSLVTTQRKLKAMSLLGSRNQLARAVLNPNPMDFCTKDLLTTTSERIIAYLRDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENSNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINSEVLKFSLDSQVNHRMKKELPSHVQAMHKRKEFLDYQLDELSRQRALCRGGREIQRQELDENISKVSKERQELASKIKEVQGRPQKTQSIIILESHIICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEIETLTPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCRLLEENVEHNMISRLPILQLTVQYRMHPDICLFPSNYVYNRNLKTNRQTEAIRCSSDWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKDKRKDVSFRNIGIITHYKAQKTMIQKDLDKEFDRKGPAEVDTVDAFQGRQKDCVIVTCVRANSIQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWNQLIQDAQKRGAIIKTCDKNYRHDAVKILKLKPVLQRSLTHPPTIAPEGSRPQGGLPSSKLDSGFAKTSVAASLYHTPSDSKEITLTVTSKDPERPPVHDQLQDPRLLKRMGIEVKGGIFLWDPQPSSPQHPGATPPTGEPGFPVVHQDLSHIQQPAAVVAALSSHKPPVRGEPPAASPEASTCQSKCDDPEEELCHRREARAFSEGEQEKCGSETHHTRRNSRWDKRTLEQEDSSSKKRKLL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/41003", "id": "41003", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_932150.2", "ac": "NP_932150.2", "name": "probable helicase senataxin", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "RNA binding", "id": "GO:0003723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "helicase activity", "id": "GO:0004386" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001147", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "transcription termination site sequence-specific DNA binding", "id": "GO:0001147" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "nucleolus", "id": "GO:0005730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "axon", "id": "GO:0030424" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "growth cone", "id": "GO:0030426" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "intercellular bridge", "id": "GO:0045171" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "nuclear body", "id": "GO:0016604" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000228", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AKX3", "id": "A2AKX3", "database": "UniProtKB" } ], "name": "nuclear chromosome", "id": "GO:0000228" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "pmid": "", "evidence": [ { "url": 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