{ "uniprot_canonical_ac": "A2AHG0-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AHG0-1|LZTS3_MOUSE Isoform 1 of Leucine zipper putative tumor suppressor 3 OS=Mus musculus OX=10090 GN=Lzts3 PE=1 SV=1 CANONICAL=A2AHG0-1", "length": 700, "sequence": "MAPADLASEGPKLEDPPAPHLFGKCPSGLIMAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLTMGSVGSGVTHAQEFPMKSVGTRTGGGGNQGSFPGPRSGGSGANRERPGRYPSEDKVLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPNHPPKLLTTSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPAGLKGGLDKSRTMTPAGGSGGGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTAGYSSGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRSGHLGSGEGGNGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAQLIRQREELEDKVAVCQKEQADFLPRMEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFGSKQASLELSEGELPPACLKPALTPVDLVEPQEALASCESDEAKMRRQAGVAAAASLVSVDGEVEAGGEGGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGSSTPTPQHGEEKKAWTPSRLERIESTEI" }, "uniprot_id": "LZTS3_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "id": "A2AHG0", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21949185", "type": [ "PubMed" ], "id": "21949185" } ], "title": "The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277956.1", "id": "NP_001277956.1", "database": "RefSeq" } ], "authors": "Peng Y, Clark C, Luong R, Tu WH, Lee J, Johnson DT, Das A, Carroll TJ, Sun Z", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28890345", "type": [ "PubMed" ], "id": "28890345" } ], "title": "Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward.", "journal": "Neuron", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277956.1", "id": "NP_001277956.1", "database": "RefSeq" } ], "authors": "Laguesse S, Morisot N, Shin JH, Liu F, Adrover MF, Sakhai SA, Lopez MF, Phamluong K, Griffin WC 3rd, Becker HC, Bender KJ, Alvarez VA, Ron D", "date": "2017" } ], "uniprot_ac": "A2AHG0", "site_annotation": [ { "end_pos": 216, "annotation": "n_glycosylation_sequon", "start_pos": 214 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0#A2AHG0-1", "isoform_ac": "A2AHG0-1", "locus": { "end_pos": 130634769, "strand": "+", "start_pos": 130637956, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000045761", "id": "ENSMUST00000045761", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000037109", "id": "ENSMUSP00000037109", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AHG0-1|LZTS3_MOUSE Isoform 1 of Leucine zipper putative tumor suppressor 3 OS=Mus musculus OX=10090 GN=Lzts3 PE=1 SV=1 CANONICAL=A2AHG0-1", "length": 700, "sequence": "MAPADLASEGPKLEDPPAPHLFGKCPSGLIMAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLTMGSVGSGVTHAQEFPMKSVGTRTGGGGNQGSFPGPRSGGSGANRERPGRYPSEDKVLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPNHPPKLLTTSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPAGLKGGLDKSRTMTPAGGSGGGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTAGYSSGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRSGHLGSGEGGNGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAQLIRQREELEDKVAVCQKEQADFLPRMEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFGSKQASLELSEGELPPACLKPALTPVDLVEPQEALASCESDEAKMRRQAGVAAAASLVSVDGEVEAGGEGGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGSSTPTPQHGEEKKAWTPSRLERIESTEI" } }, { "url": "https://www.uniprot.org/uniprot/A2AHG0#A2AHG0-2", "isoform_ac": "A2AHG0-2", "locus": { "end_pos": 130634769, "strand": "+", "start_pos": 130637956, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000110260", "id": "ENSMUST00000110260", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000105889", "id": "ENSMUSP00000105889", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AHG0-2|LZTS3_MOUSE Isoform 2 of Leucine zipper putative tumor suppressor 3 OS=Mus musculus OX=10090 GN=Lzts3 PE=1 SV=1 CANONICAL=A2AHG0-1", "length": 586, "sequence": "MAPADLASEGPKLEDPPAPHLFGKCPSGLIMAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLTMGSCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPAGLKGGLDKSRTMTPAGGSGGGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTAGYSSGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRSGHLGSGEGGNGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAQLIRQREELEDKVAVCQKEQADFLPRMEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFGSKQASLELSEGELPPACLKPALTPVDLVEPQEALASCESDEAKMRRQAGVAAAASLVSVDGEVEAGGEGGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGSSTPTPQHGEEKKAWTPSRLERIESTEI" } }, { "url": "https://www.uniprot.org/uniprot/A2AHG0#A2AHG0-3", "isoform_ac": "A2AHG0-3", "locus": {}, "sequence": { "header": "sp|A2AHG0-3|LZTS3_MOUSE Isoform 3 of Leucine zipper putative tumor suppressor 3 OS=Mus musculus OX=10090 GN=Lzts3 PE=1 SV=1 CANONICAL=A2AHG0-1", "length": 591, "sequence": "MAPADLASEGPKLEDPPAPHLFGKCPSGLIMAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLTMGSVGSGVTHAQEFPMKSVGTRTGGGGNQGSFPGPRSGGSGANRERPGRYPSEDKVLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPNHPPKLLTTSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPAGLKGGLDKSRTMTPAGGSGGGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTAGYSSGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRSGHLGSGEGGNGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAQLIRQREELEDKVAVCQKEQADFLPRMEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFGSKQASLELSEGELPPACLKPALTPVDLVEPQEALASCESDEAKMRRQAGVAAAASLVSVDGEIAG" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:241638", "resource": "KEGG Pathway", "id": "mmu:241638", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277956.1", "annotation": "Data suggest that Prosapip1 in the NAc is a molecular transducer of structural and synaptic alterations that drive and/or maintain excessive alcohol use.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277956.1", "id": "NP_001277956.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AHG0#function", "annotation": "May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0#function", "id": "A2AHG0", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "O60299-1", "protein_name": "Leucine zipper putative tumor suppressor 3", "sequence": { "length": 673, "sequence": "MAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLAMGSVGSGVAHAQEFAMKSVGTRTGGGGSQGSFPGPRGSGSGASRERPGRYPSEDKGLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSHPPKLLATSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTPAGGSGSGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSGGGSGYQDLGTSDSGRASSKSGSSSSMGRPGHLGSGEGGGGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFSSKQASLELGEGELPAACLKPALTPVDPAEPQDALATCESDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGASTPTPQHGEEKKAWTPSRLERIESTEI" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8824", "id": "8824", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8K1Q4-1", "protein_name": "Leucine zipper putative tumor suppressor 3", "sequence": { "length": 703, "sequence": "MAPADLASEGPKLEDPPAPHLFGKCPSGLIMANVETLPVRADPGRDPLLAFAPRPAELGPPDPRLTMGSVGGGVTHAQEFPMKSVGTRTGGGGSQGSFPGPRSSGSGTNRERPGPGRYPSEDKVLANSLYLNGELRGSDHTDVCGNVVGSSGGSSSSGGSDKAPPQYREPNHPPKLLTTSGKLDQCSEPLVRPSAFKPVVPKNFHSMQNLCPPQTNGTPEGRQGPAGLKGGLEKSRTMTPAGGSGGGGLSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTPGYSSGGGGGGSGYQDLGTSDSGRASSKSGSSSSMGRSGHLGSGEGGNGGLPFAACSPPSPSALIQELEERLWEKEQEVAALRRSQEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAAQLIRQREELEDKVAACQKEQADFLPRMEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSLRDSFGSKQASLELSEGELPPACLKPALTPVDLVEPQEALASCESDEAKMRRQAGVAAAASLVSVDGEVDAGGEGGTRALRREVGRLQAELAAERRARERQGASFAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRERGAAGGSRTPTPQHGEEEKAWTPSRLERIESTEI" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8824", "id": "8824", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277956.1", "ac": "NP_001277956.1", "name": "leucine zipper putative tumor suppressor 3 isoform b", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043621", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "id": "A2AHG0", "database": "UniProtKB" } ], "name": "protein self-association", "id": "GO:0043621" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030165", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "id": "A2AHG0", "database": "UniProtKB" } ], "name": "PDZ domain binding", "id": "GO:0030165" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "id": "A2AHG0", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "id": "A2AHG0", "database": "UniProtKB" } ], "name": "cytoskeleton", "id": "GO:0005856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "id": "A2AHG0", "database": "UniProtKB" } ], "name": "postsynaptic density", "id": "GO:0014069" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "id": "A2AHG0", "database": "UniProtKB" } ], "name": "dendritic spine", "id": "GO:0043197" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "id": "A2AHG0", "database": "UniProtKB" } ], "name": "synapse", "id": "GO:0045202" } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "id": "A2AHG0", "database": "UniProtKB" } ], "name": "protein homooligomerization", "id": "GO:0051260" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061001", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "id": "A2AHG0", "database": "UniProtKB" } ], "name": "regulation of dendritic spine morphogenesis", "id": "GO:0061001" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AHG0", "type": "synonym", "resource": "RefSeq", "name": "Lzts3" }, { "url": "https://www.uniprot.org/uniprot/A2AHG0", "type": "recommended", "resource": "UniProtKB", "name": "Lzts3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AHG0", "type": "synonym", "resource": "RefSeq", "name": "P; Prosapip1" }, { "url": "https://www.uniprot.org/uniprot/A2AHG0", "type": "synonym", "resource": "UniProtKB", "name": "Prosapip1" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037703", "id": "ENSMUSG00000037703", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/241638", "id": "241638", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AHG0*", "id": "A2AHG0", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033295", "id": "IPR033295", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:241638", "id": "mmu:241638", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2656976", "id": "2656976", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/SVNLEIC/", "id": "SVNLEIC", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=363339at2759", "id": "363339at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19354:SF6", "id": "PTHR19354:SF6", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AHG0", "id": "PR_A2AHG0", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277956.1", "id": "NP_001277956.1", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": "343", "end_pos": "343", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "id": "A2AHG0", "database": "UniProtKB" } ], "start_pos": "343", "end_pos": "343", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": "345", "end_pos": "345", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "id": "A2AHG0", "database": "UniProtKB" } ], "start_pos": "345", "end_pos": "345", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 74986.0, "chemical_mass": 74986.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "name": "Lzts3", "locus": { "end_pos": 130632839, "strand": "-", "start_pos": 130642803, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000037703", "id": "ENSMUSG00000037703", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AHG0", "type": "recommended", "resource": "UniProtKB", "name": "Leucine zipper putative tumor suppressor 3" }, { "url": "https://www.uniprot.org/uniprot/A2AHG0", "type": "synonym", "resource": "UniProtKB", "name": "ProSAP-interacting protein 1" }, { "url": "https://www.uniprot.org/uniprot/A2AHG0", "type": "synonym", "resource": "UniProtKB", "name": "ProSAPiP1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AHG0", "type": "synonym", "resource": "RefSeq", "name": "leucine zipper putative tumor suppressor 3 isoform b" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AHG0", "type": "synonym", "resource": "RefSeq", "name": "proSAP-interacting protein 1; proline rich synapse associated protein interacting protein 1 (Prosapip1); leucine zipper putative tumor suppressor 3" } ] }