{ "uniprot_canonical_ac": "A0A0G2KAI2-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KAI2-1|A0A0G2KAI2_RAT Isoform 1 of PHD finger protein 2 OS=Rattus norvegicus OX=10116 GN=Phf2 PE=1 SV=1 CANONICAL=A0A0G2KAI2-1", "length": 1073, "sequence": "MPASDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQTPDMKPVQNGSQLFIKELRSRTFPSAEDVVSRVPGSQLTVGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPASANLSLYECWRSASNHSEMFFADQVDKCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFRPSQLIKDLAKEIRLSENASKTVRPEVNAVASSDEVCDGDREKEEPPSPIESTPPRSLLEKVSKKKTSKTVKMPKPSKTPKPPKPPKPPKTLKLKDGSKKKGKKCKESASPTIPNLDLLEAHTKEALTKMEPPKKGKTPKSVLSVPNKDTVHTQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLRMEEEQRLEKSPLAGNKDKFSFSFSNRKLLGSKPLRPPSSPGVFGTLQSFKEDKAKPVRDEYEYVSDDGELKIDEFPIRRKKNPPKRDLSFLLDKKETLLIPTSKPKLDSTAYKSDDSSDEGSLHIDTDTKPSRNAKVKKESGSSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGTGQAKGGSLAAHGARKNGGSSKGTGKRLLKRTAKNSVDLEDYEEQDHLDACFKDSDYVYPSLESDEDNPVFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKNRKKKNTKRKPTPNTASPSVSTSASASTGTTSASTTPASTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSGLADHEYTAAGTFAGAQAGRASQPMAPGVFLTQRRPSASSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL" }, "uniprot_id": "A0A0G2KAI2_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2KAI2", "site_annotation": [ { "end_pos": 1041, "annotation": "n_glycosylation_sequon", "start_pos": 1039 }, { "end_pos": 170, "annotation": "n_glycosylation_sequon", "start_pos": 168 }, { "end_pos": 256, "annotation": "n_glycosylation_sequon", "start_pos": 254 }, { "end_pos": 268, "annotation": "n_glycosylation_sequon", "start_pos": 266 }, { "end_pos": 423, "annotation": "n_glycosylation_sequon", "start_pos": 421 }, { "end_pos": 63, "annotation": "n_glycosylation_sequon", "start_pos": 61 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2#A0A0G2KAI2-1", "isoform_ac": "A0A0G2KAI2-1", "locus": { "end_pos": 16204525, "strand": "-", "start_pos": 16272779, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087692", "id": "ENSRNOT00000087692", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075406", "id": "ENSRNOP00000075406", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KAI2-1|A0A0G2KAI2_RAT Isoform 1 of PHD finger protein 2 OS=Rattus norvegicus OX=10116 GN=Phf2 PE=1 SV=1 CANONICAL=A0A0G2KAI2-1", "length": 1073, "sequence": "MPASDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQTPDMKPVQNGSQLFIKELRSRTFPSAEDVVSRVPGSQLTVGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPASANLSLYECWRSASNHSEMFFADQVDKCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFRPSQLIKDLAKEIRLSENASKTVRPEVNAVASSDEVCDGDREKEEPPSPIESTPPRSLLEKVSKKKTSKTVKMPKPSKTPKPPKPPKPPKTLKLKDGSKKKGKKCKESASPTIPNLDLLEAHTKEALTKMEPPKKGKTPKSVLSVPNKDTVHTQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLRMEEEQRLEKSPLAGNKDKFSFSFSNRKLLGSKPLRPPSSPGVFGTLQSFKEDKAKPVRDEYEYVSDDGELKIDEFPIRRKKNPPKRDLSFLLDKKETLLIPTSKPKLDSTAYKSDDSSDEGSLHIDTDTKPSRNAKVKKESGSSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGTGQAKGGSLAAHGARKNGGSSKGTGKRLLKRTAKNSVDLEDYEEQDHLDACFKDSDYVYPSLESDEDNPVFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKNRKKKNTKRKPTPNTASPSVSTSASASTGTTSASTTPASTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSGLADHEYTAAGTFAGAQAGRASQPMAPGVFLTQRRPSASSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2#F1LWX5-1", "isoform_ac": "F1LWX5-1", "locus": { "end_pos": 16249350, "strand": "-", "start_pos": 16272779, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000022669", "id": "ENSRNOT00000022669", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000022669", "id": "ENSRNOP00000022669", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F1LWX5-1|A0A0G2KAI2_RAT Computationally mapped isoform of PHD finger protein 2 OS=Rattus norvegicus OX=10116 GN=Phf2 PE=1 SV=2 CANONICAL=A0A0G2KAI2-1", "length": 979, "sequence": "MEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPASANLSLYECWRSASNHSEMFFADQVDKCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFRPSQLIKDLAKEIRLSENASKTVRPEVNAVASSDEVCDGDREKEEPPSPIESTPPRSLLEKVSKKKTSKTVKMPKPSKTPKPPKPPKPPKTLKLKDGSKKKGKKCKESASPTIPNLDLLEAHTKEALTKMEPPKKGKTPKSVLSVPNKDTVHTQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLRMEEEQRLEKSPLAGNKDKFSFSFSNRKLLGSKPLRPPSSPGVFGTLQSFKEDKAKPVRDEYEYVSDDGELKIDEFPIRRKKNPPKRDLSFLLDKKETLLIPTSKPKLDSTAYKSDDSSDEGSLHIDTDTKPSRNAKVKKESGSSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGTGQAKGGSLAAHGARKNGGSSKGTGKRLLKRTAKNSVDLEDYEEQDHLDACFKDSDYVYPSLESDEDNPVFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKNRKKKNTKRKPTPNTASPSVSTSASASTGTTSASTTPASTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSGLADHEYTAAGTFAGAQAGRASQPMAPGVFLTQRRPSASSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O75151-1", "protein_name": "Lysine-specific demethylase PHF2", "sequence": { "length": 1096, "sequence": "MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGQAPDVKPVQNGSQLFIKELRSRTFPSAEDVVARVPGSQLTLGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKTFYLIRPASANISLYERWRSASNHSEMFFADQVDKCYKCIVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFKPSQLIKDLAKEIRLSENASKAVRPEVNTVASSDEVCDGDREKEEPPSPIEATPPQSLLEKVSKKKTPKTVKMPKPSKIPKPPKPPKPPRPPKTLKLKDGGKKKGKKSRESASPTIPNLDLLEAHTKEALTKMEPPKKGKATKSVLSVPNKDVVHMQNDVERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQKLEKSPLAGNKDNKFSFSFSNKKLLGSKALRPPTSPGVFGALQNFKEDKPKPVRDEYEYVSDDGELKIDEFPIRRKKNAPKRDLSFLLDKKAVLPTPVTKPKLDSAAYKSDDSSDEGSLHIDTDTKPGRNARVKKESGSSAAGILDLLQASEEVGALEYNPSSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGAGQAKGSSLAAHGARKNGGGSGKSAGKRLLKRAAKNSVDLDDYEEEQDHLDACFKDSDYVYPSLESDEDNPIFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKSKKKKSAKRKLTPNTTSPSTSTSISAGTTSTSTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLADHEYTAAGTFTGAQAGRTSQPMAPGVFLTQRRPSASSPNNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2KAI2/", "id": "A0A0G2KAI2", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9WTU0-1", "protein_name": "Lysine-specific demethylase PHF2", "sequence": { "length": 1096, "sequence": "MATVPVYCVCRLPYDVTRFMIECDACKDWFHGSCVGVEEEEAPDIDIYHCPNCEKTHGKSTLKKKRTWHKHGPGPTPDVKPVQNGSQLFIKELRSRTFPSAEDVVSRVPGSQLTVGYMEEHGFTEPILVPKKDGLGLAVPAPTFYVSDVENYVGPERSVDVTDVTKQKDCKMKLKEFVDYYYSTNRKRVLNVTNLEFSDTRMSSFVEPPDIVKKLSWVENYWPDDALLAKPKVTKYCLICVKDSYTDFHIDSGGASAWYHVLKGEKIFYLIRPASANISLYERWRSASNHSEMFFADQVDRCYKCTVKQGQTLFIPSGWIYATLTPVDCLAFAGHFLHSLSVEMQMRAYEVERRLKLGSLTQFPNFETACWYMGKHLLEAFKGSHKSGKQLPPHLVQGAKILNGAFRSWTKKQALAEHEDELPEHFRPSQLIKDLAKEIRLSENASKTVRPEVNAAASSDEVCDGDREKEEPPSPVETTPPRSLLEKVSKKKTSKTVKMPKPSKIPKPPKSPKPPKTLKLKDGSKKKGKKCKESASPTIPNLDLLEAHTKEALTKMEPPKKGKTPKSVLSVPNKDTVHTQNDMERLEIREQTKSKSEAKWKYKNSKPDSLLKMEEEQRLEKSPLAGNKDKFSFSFSNRKLLGSKALRPPSSPGVFGALQSFKEDKAKPVRDEYEYVSDDGELKIDEFPIRRKKSAPKRDLSFLLDKKEALLMPTSKPKLDSAVYKSDDSSDEGSLHIDTDTKPGRNAKVKKESGSSAAGILDLLQASEEVGALEYNPNSQPPASPSTQEAIQGMLSMANLQASDSCLQTTWGTGQAKGGSLAAHGARKIGGGNKGTGKRLLKRTAKNSVDLEDYEEQDHLDACFKDSDYVYPSLESDEDNPVFKSRSKKRKGSDDAPYSPTARVGPSVPRQDRPVREGTRVASIETGLAAAAAKLSQQEEQKNRKKKNTKRKPAPNTASPSISTSASASTGTTSASTTPASTTPASTTPASTTPASTSTASSQASQEGSSPEPPPESHSSSLADHEYTAAGTFSGSQAGRASQPMAPGVFLTQRRPSASSPNNTAAKGKRTKKGMATAKQRLGKILKIHRNGKLLL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2KAI2/", "id": "A0A0G2KAI2", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "transcription coactivator activity", "id": "GO:0003713" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "iron ion binding", "id": "GO:0005506" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "zinc ion binding", "id": "GO:0008270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051213", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "dioxygenase activity", "id": "GO:0051213" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035064", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "methylated histone binding", "id": "GO:0035064" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032454", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "histone demethylase activity (H3-K9 specific)", "id": "GO:0032454" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "nucleolus", "id": "GO:0005730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000776", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "kinetochore", "id": "GO:0000776" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006482", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "protein demethylation", "id": "GO:0006482" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061188", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "negative regulation of ribosomal DNA heterochromatin assembly", "id": "GO:0061188" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033169", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "id": "A0A0G2KAI2", "database": "UniProtKB" } ], "name": "histone H3-K9 demethylation", "id": "GO:0033169" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "type": "recommended", "resource": "UniProtKB", "name": "Phf2" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000016816", "id": "ENSRNOG00000016816", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003347", "id": "IPR003347", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "id": "IPR011011", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "id": "IPR013083", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041070", "id": "IPR041070", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/KKCRGSA/", "id": "KKCRGSA", "database": "OMA" }, { "url": "http://pfam.xfam.org/family/PF02373", "id": "PF02373", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17811", "id": "PF17811", "database": "Pfam" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305228", "id": "1305228", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 118206.0, "chemical_mass": 118206.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "name": "Phf2", "locus": { "end_pos": 16274624, "strand": "+", "start_pos": 16204427, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000016816", "id": "ENSRNOG00000016816", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI2", "type": "synonym", "resource": "UniProtKB", "name": "PHD finger protein 2" } ] }