{
    "uniprot_canonical_ac": "A0A0G2JVC4-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A0A0G2JVC4-1|A0A0G2JVC4_RAT Isoform 1 of Cyclic GMP-AMP synthase  OS=Rattus norvegicus OX=10116 GN=Cgas PE=1 SV=1 CANONICAL=A0A0G2JVC4-1", 
        "length": 510, 
        "sequence": "MEDPRRRTTAPRAKKPSAKRAPTRPSGTRATVSHAGSCGPQRGARSRRVERDGDTTEKPHTPAPRVRPRRAAERTEDAQPLATDAAGASERPAVREPQRQVILDPEPPAVPEPQAPEDPEAPTVARGPVRRRGARSIRQPRASQGSRKEPDKLKKVLDKLRLKRKEISAAAETVNKVVDQLLRRMQRRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELEEYYETGAFYRVKFKRIPRGNPLSHFLEGEVLSATKVLSKFRELIKEEVKEIKDTDVTVEEEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKGGLPIQDWLGTKVRTNLRREPFYLVPKNAKDGNRFQGYDVECVFGLGVLYILCGHGQGRVLYEKSGIQCCVKECLKLMKYLLEQLKREFQELDAFCSYHVKTAIFHMWTKDPQDSQWDPRNLSTCFDKFLTFFLECLRTEKLDHYFIPKFNLFSQELIDKKSKEFLSEKIEYERNNGFPIFNKF"
    }, 
    "uniprot_id": "A0A0G2JVC4_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                    "id": "A0A0G2JVC4", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [], 
    "uniprot_ac": "A0A0G2JVC4", 
    "site_annotation": [
        {
            "end_pos": 449, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 447
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4#A0A0G2JVC4-1", 
            "isoform_ac": "A0A0G2JVC4-1", 
            "locus": {
                "end_pos": 85789766, 
                "strand": "+", 
                "start_pos": 85803433, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000081544", 
                        "id": "ENSRNOT00000081544", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000069428", 
                        "id": "ENSRNOP00000069428", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2JVC4-1|A0A0G2JVC4_RAT Isoform 1 of Cyclic GMP-AMP synthase  OS=Rattus norvegicus OX=10116 GN=Cgas PE=1 SV=1 CANONICAL=A0A0G2JVC4-1", 
                "length": 510, 
                "sequence": "MEDPRRRTTAPRAKKPSAKRAPTRPSGTRATVSHAGSCGPQRGARSRRVERDGDTTEKPHTPAPRVRPRRAAERTEDAQPLATDAAGASERPAVREPQRQVILDPEPPAVPEPQAPEDPEAPTVARGPVRRRGARSIRQPRASQGSRKEPDKLKKVLDKLRLKRKEISAAAETVNKVVDQLLRRMQRRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELEEYYETGAFYRVKFKRIPRGNPLSHFLEGEVLSATKVLSKFRELIKEEVKEIKDTDVTVEEEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKGGLPIQDWLGTKVRTNLRREPFYLVPKNAKDGNRFQGYDVECVFGLGVLYILCGHGQGRVLYEKSGIQCCVKECLKLMKYLLEQLKREFQELDAFCSYHVKTAIFHMWTKDPQDSQWDPRNLSTCFDKFLTFFLECLRTEKLDHYFIPKFNLFSQELIDKKSKEFLSEKIEYERNNGFPIFNKF"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4#M0R8I6-1", 
            "isoform_ac": "M0R8I6-1", 
            "locus": {
                "end_pos": 85795523, 
                "strand": "+", 
                "start_pos": 85803433, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000073286", 
                        "id": "ENSRNOT00000073286", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000065782", 
                        "id": "ENSRNOP00000065782", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|M0R8I6-1|A0A0G2JVC4_RAT Computationally mapped isoform of Cyclic GMP-AMP synthase  OS=Rattus norvegicus OX=10116 GN=Cgas PE=1 SV=1 CANONICAL=A0A0G2JVC4-1", 
                "length": 358, 
                "sequence": "MEDPRRRTTAPRAKKPSAKRAPTRPSGTRATVSHAGSCGPQRGARSRRVERDGDTTEKPHTPAPRVRPRRAAERTEDAQPLATDAAGASERPAVREPQRQVILDPEPPAVPEPQAPEDPEAPTVARGPVRRRGARSIRQPRASQGSRKEPDKLKKVLDKLRLKRKEISAAAETVNKVVDQLLRRMQRRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELEEYYETGAFYRVKFKRIPRGNPLSHFLEGEVLSATKVLSKFRELIKEEVKEIKDTDVTVEEEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKGGLPIQDWLGTKVRTNLRRAVLSCTQECKRWK"
            }
        }
    ], 
    "pathway": [], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8C6L5-1", 
            "protein_name": "Cyclic GMP-AMP synthase", 
            "sequence": {
                "length": 507, 
                "sequence": "MEDPRRRTTAPRAKKPSAKRAPTQPSRTRAHAESCGPQRGARSRRAERDGDTTEKPRAPGPRVHPARATELTKDAQPSAMDAAGATARPAVRVPQQQAILDPELPAVREPQPPADPEARKVVRGPSHRRGARSTGQPRAPRGSRKEPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A0G2JVC4/", 
                    "id": "A0A0G2JVC4", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q8N884-1", 
            "protein_name": "Cyclic GMP-AMP synthase", 
            "sequence": {
                "length": 522, 
                "sequence": "MQPWHGKAMQRASEAGATAPKASARNARGAPMDPTESPAAPEAALPKAGKFGPARKSGSRQKKSAPDTQERPPVRATGARAKKAPQRAQDTQPSDATSAPGAEGLEPPAAREPALSRAGSCRQRGARCSTKPRPPPGPWDVPSPGLPVSAPILVRRDAAPGASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A0A0G2JVC4/", 
                    "id": "A0A0G2JVC4", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061501", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cyclic-GMP-AMP synthase activity", 
                        "id": "GO:0061501"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA binding", 
                        "id": "GO:0003677"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "chromatin binding", 
                        "id": "GO:0003682"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phosphatidylinositol-4,5-bisphosphate binding", 
                        "id": "GO:0005546"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003690", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "double-stranded DNA binding", 
                        "id": "GO:0003690"
                    }
                ], 
                "total": 5, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "site of double-strand break", 
                        "id": "GO:0035861"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071360", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to exogenous dsRNA", 
                        "id": "GO:0071360"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000042", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of double-strand break repair via homologous recombination", 
                        "id": "GO:2000042"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002637", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of immunoglobulin production", 
                        "id": "GO:0002637"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "defense response to virus", 
                        "id": "GO:0051607"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of immune response", 
                        "id": "GO:0050776"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to DNA damage stimulus", 
                        "id": "GO:0006974"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002230", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of defense response to virus by host", 
                        "id": "GO:0002230"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043950", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cAMP-mediated signaling", 
                        "id": "GO:0043950"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002218", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "activation of innate immune response", 
                        "id": "GO:0002218"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000774", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cellular senescence", 
                        "id": "GO:2000774"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032481", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of type I interferon production", 
                        "id": "GO:0032481"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038001", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "paracrine signaling", 
                        "id": "GO:0038001"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008340", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "determination of adult lifespan", 
                        "id": "GO:0008340"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050863", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of T cell activation", 
                        "id": "GO:0050863"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032479", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of type I interferon production", 
                        "id": "GO:0032479"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010753", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
                                "id": "A0A0G2JVC4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cGMP-mediated signaling", 
                        "id": "GO:0010753"
                    }
                ], 
                "total": 16, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Cgas"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000046191", 
            "id": "ENSRNOG00000046191", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024810", 
            "id": "IPR024810", 
            "database": "InterPro"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/VKCCRKE/", 
            "id": "VKCCRKE", 
            "database": "OMA"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF03281", 
            "id": "PF03281", 
            "database": "Pfam"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1586939", 
            "id": "1586939", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 58497.0, 
        "chemical_mass": 58497.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
            "name": "Cgas", 
            "locus": {
                "end_pos": 85789763, 
                "strand": "-", 
                "start_pos": 85803433, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000046191", 
                        "id": "ENSRNOG00000046191", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A0G2JVC4", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Cyclic GMP-AMP synthase"
        }
    ]
}