{ "uniprot_canonical_ac": "A0A0G2JVC2-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2JVC2-1|A0A0G2JVC2_RAT Isoform 1 of SCY1-like pseudokinase 2 OS=Rattus norvegicus OX=10116 GN=Scyl2 PE=1 SV=1 CANONICAL=A0A0G2JVC2-1", "length": 934, "sequence": "MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSSISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNVTPENIILNKSGAWKIMGFDFCVSSSNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGAVMYAVFNKGRPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTSIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYIKLILPELGPVFKQQEPIQASNMILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLNLNQFSSFIAVIKEMLSRLESEHRTKLEQLHIMQEQQRSLDIGNQMSTSEETKVTPSGTQQIDKVFNNIGADLLSGGESENREDGLQGKQKRGSLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPIAPVKQTKDLTDTLMENMSSLTSLSVSTPKISASSTFTSVPSTGLSMMFSTPIDNTKRNLTNGLNANMGFQTSGFNMPVNPNQNFFSGTSTAGVTTMTLGAPPTMSNFSPLSIPPASVKQTQQRPPDMSALNNLFGPQKPKVSMNQLSQQKPNQWLNQFVPPQGSPGMGSAAMGTQVNVMGQAAFGMQGNPFFNPQSFAQPPPTTMTSSSSASNDLKDLFG" }, "uniprot_id": "A0A0G2JVC2_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "id": "A0A0G2JVC2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "id": "A0A0G2JVC2", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2JVC2", "site_annotation": [ { "end_pos": 180, "annotation": "n_glycosylation_sequon", "start_pos": 178 }, { "end_pos": 189, "annotation": "n_glycosylation_sequon", "start_pos": 187 }, { "end_pos": 311, "annotation": "n_glycosylation_sequon", "start_pos": 309 }, { "end_pos": 53, "annotation": "n_glycosylation_sequon", "start_pos": 51 }, { "end_pos": 732, "annotation": "n_glycosylation_sequon", "start_pos": 730 }, { "end_pos": 774, "annotation": "n_glycosylation_sequon", "start_pos": 772 }, { "end_pos": 822, "annotation": "n_glycosylation_sequon", "start_pos": 820 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2#A0A0G2JVC2-1", "isoform_ac": "A0A0G2JVC2-1", "locus": { "end_pos": 30292782, "strand": "+", "start_pos": 30333387, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000082016", "id": "ENSRNOT00000082016", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069426", "id": "ENSRNOP00000069426", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JVC2-1|A0A0G2JVC2_RAT Isoform 1 of SCY1-like pseudokinase 2 OS=Rattus norvegicus OX=10116 GN=Scyl2 PE=1 SV=1 CANONICAL=A0A0G2JVC2-1", "length": 934, "sequence": "MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSSISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNVTPENIILNKSGAWKIMGFDFCVSSSNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGAVMYAVFNKGRPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTSIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYIKLILPELGPVFKQQEPIQASNMILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLNLNQFSSFIAVIKEMLSRLESEHRTKLEQLHIMQEQQRSLDIGNQMSTSEETKVTPSGTQQIDKVFNNIGADLLSGGESENREDGLQGKQKRGSLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPIAPVKQTKDLTDTLMENMSSLTSLSVSTPKISASSTFTSVPSTGLSMMFSTPIDNTKRNLTNGLNANMGFQTSGFNMPVNPNQNFFSGTSTAGVTTMTLGAPPTMSNFSPLSIPPASVKQTQQRPPDMSALNNLFGPQKPKVSMNQLSQQKPNQWLNQFVPPQGSPGMGSAAMGTQVNVMGQAAFGMQGNPFFNPQSFAQPPPTTMTSSSSASNDLKDLFG" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2#D4A1Y0-1", "isoform_ac": "D4A1Y0-1", "locus": { "end_pos": 30292782, "strand": "+", "start_pos": 30333387, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000002638", "id": "ENSRNOT00000002638", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000002638", "id": "ENSRNOP00000002638", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4A1Y0-1|A0A0G2JVC2_RAT Computationally mapped isoform of SCY1-like pseudokinase 2 OS=Rattus norvegicus OX=10116 GN=Scyl2 PE=1 SV=1 CANONICAL=A0A0G2JVC2-1", "length": 930, "sequence": "MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSSISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNVTPENIILNKSGAWKIMGFDFCVSSSNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGAVMYAVFNKGRPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTSIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYIKLILPELGPVFKQQEPIQILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLNLNQFSSFIAVIKEMLSRLESEHRTKLEQLHIMQEQQRSLDIGNQMSTSEETKVTPSGTQQIDKVFNNIGADLLSGGESENREDGLQGKQKRGSLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPIAPVKQTKDLTDTLMENMSSLTSLSVSTPKISASSTFTSVPSTGLSMMFSTPIDNTKRNLTNGLNANMGFQTSGFNMPVNPNQNFFSGTSTAGVTTMTLGAPPTMSNFSPLSIPPASVKQTQQRPPDMSALNNLFGPQKPKVSMNQLSQQKPNQWLNQFVPPQGSPGMGSAAMGTQVNVMGQAAFGMQGNPFFNPQSFAQPPPTTMTSSSSASNDLKDLFG" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q6P3W7-1", "protein_name": "SCY1-like protein 2", "sequence": { "length": 929, "sequence": "MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSPISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNITPENIILNKSGAWKIMGFDFCVSSTNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTNIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYVKLILPELGPVFKQQEPIQILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLNLNQFNSFISVIKEMLNRLESEHKTKLEQLHIMQEQQKSLDIGNQMNVSEEMKVTNIGNQQIDKVFNNIGADLLTGSESENKEDGLQNKHKRASLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPVATVKQTKDLTDTLMDNMSSLTSLSVSTPKSSASSTFTSVPSMGIGMMFSTPTDNTKRNLTNGLNANMGFQTSGFNMPVNTNQNFYSSPSTVGVTKMTLGTPPTLPNFNALSVPPAGAKQTQQRPTDMSALNNLFGPQKPKVSMNQLSQQKPNQWLNQFVPPQGSPTMGSSVMGTQMNVIGQSAFGMQGNPFFNPQNFAQPPTTMTNSSSASNDLKDLFG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/13349", "id": "13349", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8CFE4-1", "protein_name": "SCY1-like protein 2", "sequence": { "length": 930, "sequence": "MESMLNKLKSTVTKVTADVTSAVMGNPVTREFDVGRHIASGGNGLAWKIFNGTKKSTKQEVAVFVFDKKLIDKYQKFEKDQIIDSLKRGVQQLTRLRHPRLLTVQHPLEESRDCLAFCTEPVFASLANVLGNWENLPSSISPDIKDYKLYDVETKYGLLQVSEGLSFLHSSVKMVHGNVTPENVILNKSGAWKIMGFDFCVSSSNPSEQEPKFPCKEWDPNLPSLCLPNPEYLAPEYILSVSCETASDMYSLGAVMYAVFNQGRPIFEVNKQDIYKSFSRQLDQLSRLGSSSLTSIPEEVREHVKLLLNVTPTVRPDADQMTKIPFFDDVGAVTLQYFDTLFQRDNLQKSQFFKGLPKVLPKLPKRVIVQRILPCLTSEFVNPDMVPFVLPNVLLIAEECTKEEYIKLILPELGPVFKQQEPIQILLIFLQKMDLLLTKTPPDEIKNSVLPMVYRALEAPSIQIQELCLNIIPTFANLIDYPSMKNALIPRIKNACLQTSSLAVRVNSLVCLGKILEYLDKWFVLDDILPFLQQIPSKEPAVLMGILGIYKCTFTHKKLGITKEQLAGKVLPHLIPLSIENNLNLNQFSSFIAVIKEMLSRLESEHRTKLEQLHVMQEQQRSLDIGNQMSTSEETKVAHSGSQQIDKVFNNIGADLLSGSESENREDGMQGKQKRGSLTLEEKQKLAKEQEQAQKLKSQQPLKPQVHTPIAPIKQTKDLTDTLMENMSSLTSLSVSTPKISASSTFTPVPSTGLGMMFSTPIDNTKRNLTNGLNANMGFQTSGFSMPVNPNQNFFSGTGTAGVTTMSLGAPPTMSNFSPLTIPPASVKQPQQRPTDMSALNNLFGPQKPKVSMNQLSQQKPNQWLNQFAPPQGSPVMGSAAMGTQGNVMGQAAFGMQGNPFFNPQNFAQPPPTTMTSSSSASNDLKDLFG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/13349", "id": "13349", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241303.1", "ac": "XP_006241303.1", "name": "SCY1-like protein 2 isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "id": "A0A0G2JVC2", "database": "UniProtKB" } ], "name": "protein kinase activity", "id": "GO:0004672" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "id": "A0A0G2JVC2", "database": "UniProtKB" } ], "name": "signaling receptor binding", "id": "GO:0005102" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "id": "A0A0G2JVC2", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000286", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "id": "A0A0G2JVC2", "database": "UniProtKB" } ], "name": "receptor internalization involved in canonical Wnt signaling pathway", "id": "GO:2000286" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090090", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "id": "A0A0G2JVC2", "database": "UniProtKB" } ], "name": "negative regulation of canonical Wnt signaling pathway", "id": "GO:0090090" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "id": "A0A0G2JVC2", "database": "UniProtKB" } ], "name": "brain development", "id": "GO:0007420" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008333", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "id": "A0A0G2JVC2", "database": "UniProtKB" } ], "name": "endosome to lysosome transport", "id": "GO:0008333" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002092", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "id": "A0A0G2JVC2", "database": "UniProtKB" } ], "name": "positive regulation of receptor internalization", "id": "GO:0002092" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021860", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "id": "A0A0G2JVC2", "database": "UniProtKB" } ], "name": "pyramidal neuron development", "id": "GO:0021860" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000370", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "id": "A0A0G2JVC2", "database": "UniProtKB" } ], "name": "positive regulation of clathrin-dependent endocytosis", "id": "GO:2000370" } ], "total": 7, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JVC2", "type": "synonym", "resource": "RefSeq", "name": "RGD1305665" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JVC2", "type": "synonym", "resource": "RefSeq", "name": "Scyl2" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "type": "recommended", "resource": "UniProtKB", "name": "Scyl2" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000024955", "id": "ENSRNOG00000024955", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/314717", "id": "314717", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "id": "IPR000719", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "id": "IPR011009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", "id": "IPR011989", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/QLTKIRH/", "id": "QLTKIRH", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=196028at2759", "id": "196028at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00069", "id": "PF00069", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006241303.1", "id": "XP_006241303.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305665", "id": "1305665", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 103769.0, "chemical_mass": 103769.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "name": "Scyl2", "locus": { "end_pos": 30291087, "strand": "-", "start_pos": 30344445, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000024955", "id": "ENSRNOG00000024955", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JVC2", "type": "synonym", "resource": "RefSeq", "name": "SCY1-like protein 2 isoform X1" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JVC2", "type": "synonym", "resource": "UniProtKB", "name": "SCY1-like pseudokinase 2" } ] }