{
    "uniprot_canonical_ac": "A5H300-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A5H300-1|A5H300_RAT Isoform 1 of Toll-like receptor 8  OS=Rattus norvegicus OX=10116 GN=Tlr8 PE=2 SV=1 CANONICAL=A5H300-1", 
        "length": 1029, 
        "sequence": "MSPQSWILTCFCLLSSGTSAVFLKGNFSRSYPCDEKRHNALVTAECNHRQLHEVPQTIGKYVTDVDLSDNTIMHITNESFQKFRNLTKINLNHNAKQQHPNENKNGMNITEGAFLSLRNLTELLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLRNLERLYLGWNCYFKCNQIFKVEDGAFNNLINLKLLSLSFNNLFSVPPKLPSSLSKLFLSNAKISTITQEDFKGLEHLILLDLSGNCPRCFNAPFPCESCNLSASIRIHPLAFQNLTQLRFLNLSSTSLRTIPSTWFDNLTNLKELHLEFNYLVQEIASGAFLTKLPSLQTLDLSFNFIHKEYLQYITISPNFSMLRSLRKLHLKGYVFRELKKEHFKPLQNLPNLTTINLGINFIEKIDFKAFQDFPNLKVIYLSGNRIASVIDGTDHSSWRNRLRKPLSTDYDEFDPHMNFYHSTEPLIKPQCTTYGKALDLSLNNIFVIGKSQFEGFQDIACLNLSFNANGQVLNGTEFSSMPHIKYLDLTNNRLDFDDNQTFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLIKLKVLNLSHNGIYTLTDEYKLQSKSLKELVFSGNRLDRLWNANDGKYWSIFTSLETLTRLDLSYNNLQQIPNEAFLNLPQSLQELHINDNRLRFFNWTLLQYFPHLHVLDLGRNELYFLTNCLSKFTHSLKTLLLNHNHFSHLPAGFLSEARNLVYLDLSFNTIKMINKSSLQTETKTNLSVLDLQGNHFDCTCDISDFRSWLEENPHVRIPRLVDVICSNPGDQRWKSVMSLDLTTCVSDTTAAILFFFTFLTTSTVLLAALVHHLFYWDVWFIYHMCSAKLRGYRSSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLKNVVLTENDSRYDNLYIDSIRQY"
    }, 
    "uniprot_id": "A5H300_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5H300", 
                    "id": "A5H300", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/12032557", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "12032557"
                }
            ], 
            "title": "Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.", 
            "journal": "Nature immunology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479.1", 
                    "id": "NP_001094479.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S", 
            "date": "2002"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/14976262", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "14976262"
                }
            ], 
            "title": "Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.", 
            "journal": "Science (New York, N.Y.)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479.1", 
                    "id": "NP_001094479.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S", 
            "date": "2004"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/16111635", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "16111635"
                }
            ], 
            "title": "Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.", 
            "journal": "Immunity", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479.1", 
                    "id": "NP_001094479.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kariko K, Buckstein M, Ni H, Weissman D", 
            "date": "2005"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/16123302", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "16123302"
                }
            ], 
            "title": "Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function.", 
            "journal": "Science (New York, N.Y.)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479.1", 
                    "id": "NP_001094479.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Peng G, Guo Z, Kiniwa Y, Voo KS, Peng W, Fu T, Wang DY, Li Y, Wang HY, Wang RF", 
            "date": "2005"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/16188996", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "16188996"
                }
            ], 
            "title": "Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner.", 
            "journal": "Journal of virology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479.1", 
                    "id": "NP_001094479.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Melchjorsen J, Jensen SB, Malmgaard L, Rasmussen SB, Weber F, Bowie AG, Matikainen S, Paludan SR", 
            "date": "2005"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20004021", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20004021"
                }
            ], 
            "title": "A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition.", 
            "journal": "Mol. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A5H300", 
                    "id": "A5H300", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Liu J., Xu C., Luo Y., Hsu L.C., Xiang R., Chuang T.H.", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/23520111", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "23520111"
                }
            ], 
            "title": "Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands.", 
            "journal": "Science (New York, N.Y.)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479.1", 
                    "id": "NP_001094479.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Tanji H, Ohto U, Shibata T, Miyake K, Shimizu T", 
            "date": "2013"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24091496", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24091496"
                }
            ], 
            "title": "Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.", 
            "journal": "Angiogenesis", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479.1", 
                    "id": "NP_001094479.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Aplin AC, Ligresti G, Fogel E, Zorzi P, Smith K, Nicosia RF", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24942581", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24942581"
                }
            ], 
            "title": "CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.", 
            "journal": "Journal of virology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479.1", 
                    "id": "NP_001094479.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Zhen A, Krutzik SR, Levin BR, Kasparian S, Zack JA, Kitchen SG", 
            "date": "2014"
        }
    ], 
    "uniprot_ac": "A5H300", 
    "site_annotation": [
        {
            "end_pos": 1016, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 1014
        }, 
        {
            "end_pos": 110, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 108
        }, 
        {
            "end_pos": 121, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 119
        }, 
        {
            "end_pos": 159, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 157
        }, 
        {
            "end_pos": 265, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 263
        }, 
        {
            "end_pos": 28, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 26
        }, 
        {
            "end_pos": 279, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 277
        }, 
        {
            "end_pos": 287, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 285
        }, 
        {
            "end_pos": 303, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 301
        }, 
        {
            "end_pos": 356, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 354
        }, 
        {
            "end_pos": 389, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 387
        }, 
        {
            "end_pos": 501, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 499
        }, 
        {
            "end_pos": 512, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 510
        }, 
        {
            "end_pos": 537, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 535
        }, 
        {
            "end_pos": 580, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 578
        }, 
        {
            "end_pos": 670, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 668
        }, 
        {
            "end_pos": 742, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 740
        }, 
        {
            "end_pos": 753, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 751
        }, 
        {
            "end_pos": 79, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 77
        }, 
        {
            "end_pos": 87, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 85
        }, 
        {
            "end_pos": 927, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 925
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A5H300#A5H300-1", 
            "isoform_ac": "A5H300-1", 
            "locus": {
                "end_pos": 28559564, 
                "strand": "-", 
                "start_pos": 28562650, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000073535", 
                        "id": "ENSRNOT00000073535", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000066040", 
                        "id": "ENSRNOP00000066040", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A5H300-1|A5H300_RAT Isoform 1 of Toll-like receptor 8  OS=Rattus norvegicus OX=10116 GN=Tlr8 PE=2 SV=1 CANONICAL=A5H300-1", 
                "length": 1029, 
                "sequence": "MSPQSWILTCFCLLSSGTSAVFLKGNFSRSYPCDEKRHNALVTAECNHRQLHEVPQTIGKYVTDVDLSDNTIMHITNESFQKFRNLTKINLNHNAKQQHPNENKNGMNITEGAFLSLRNLTELLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLRNLERLYLGWNCYFKCNQIFKVEDGAFNNLINLKLLSLSFNNLFSVPPKLPSSLSKLFLSNAKISTITQEDFKGLEHLILLDLSGNCPRCFNAPFPCESCNLSASIRIHPLAFQNLTQLRFLNLSSTSLRTIPSTWFDNLTNLKELHLEFNYLVQEIASGAFLTKLPSLQTLDLSFNFIHKEYLQYITISPNFSMLRSLRKLHLKGYVFRELKKEHFKPLQNLPNLTTINLGINFIEKIDFKAFQDFPNLKVIYLSGNRIASVIDGTDHSSWRNRLRKPLSTDYDEFDPHMNFYHSTEPLIKPQCTTYGKALDLSLNNIFVIGKSQFEGFQDIACLNLSFNANGQVLNGTEFSSMPHIKYLDLTNNRLDFDDNQTFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLIKLKVLNLSHNGIYTLTDEYKLQSKSLKELVFSGNRLDRLWNANDGKYWSIFTSLETLTRLDLSYNNLQQIPNEAFLNLPQSLQELHINDNRLRFFNWTLLQYFPHLHVLDLGRNELYFLTNCLSKFTHSLKTLLLNHNHFSHLPAGFLSEARNLVYLDLSFNTIKMINKSSLQTETKTNLSVLDLQGNHFDCTCDISDFRSWLEENPHVRIPRLVDVICSNPGDQRWKSVMSLDLTTCVSDTTAAILFFFTFLTTSTVLLAALVHHLFYWDVWFIYHMCSAKLRGYRSSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLKNVVLTENDSRYDNLYIDSIRQY"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:684440", 
            "resource": "KEGG Pathway", 
            "id": "rno:684440", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1679131", 
            "resource": "Reactome", 
            "id": "R-RNO-1679131", 
            "name": "Trafficking and processing of endosomal TLR"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-168181", 
            "resource": "Reactome", 
            "id": "R-RNO-168181", 
            "name": "Toll Like Receptor 7/8 (TLR7/8) Cascade"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975110", 
            "resource": "Reactome", 
            "id": "R-RNO-975110", 
            "name": "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975138", 
            "resource": "Reactome", 
            "id": "R-RNO-975138", 
            "name": "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975155", 
            "resource": "Reactome", 
            "id": "R-RNO-975155", 
            "name": "MyD88 dependent cascade initiated on endosome"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479.1", 
            "annotation": "Aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479.1", 
                    "id": "NP_001094479.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "P58682-1", 
            "protein_name": "Toll-like receptor 8", 
            "sequence": {
                "length": 1032, 
                "sequence": "MENMPPQSWILTCFCLLSSGTSAIFHKANYSRSYPCDEIRHNSLVIAECNHRQLHEVPQTIGKYVTNIDLSDNAITHITKESFQKLQNLTKIDLNHNAKQQHPNENKNGMNITEGALLSLRNLTVLLLEDNQLYTIPAGLPESLKELSLIQNNIFQVTKNNTFGLRNLERLYLGWNCYFKCNQTFKVEDGAFKNLIHLKVLSLSFNNLFYVPPKLPSSLRKLFLSNAKIMNITQEDFKGLENLTLLDLSGNCPRCYNAPFPCTPCKENSSIHIHPLAFQSLTQLLYLNLSSTSLRTIPSTWFENLSNLKELHLEFNYLVQEIASGAFLTKLPSLQILDLSFNFQYKEYLQFINISSNFSKLRSLKKLHLRGYVFRELKKKHFEHLQSLPNLATINLGINFIEKIDFKAFQNFSKLDVIYLSGNRIASVLDGTDYSSWRNRLRKPLSTDDDEFDPHVNFYHSTKPLIKPQCTAYGKALDLSLNNIFIIGKSQFEGFQDIACLNLSFNANTQVFNGTEFSSMPHIKYLDLTNNRLDFDDNNAFSDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLINLRVLNLSHNGIYTLTEESELKSISLKELVFSGNRLDRLWNANDGKYWSIFKSLQNLIRLDLSYNNLQQIPNGAFLNLPQSLQELLISGNKLRFFNWTLLQYFPHLHLLDLSRNELYFLPNCLSKFAHSLETLLLSHNHFSHLPSGFLSEARNLVHLDLSFNTIKMINKSSLQTKMKTNLSILELHGNYFDCTCDISDFRSWLDENLNITIPKLVNVICSNPGDQKSKSIMSLDLTTCVSDTTAAVLFFLTFLTTSMVMLAALVHHLFYWDVWFIYHMCSAKLKGYRTSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLKNVVLTENDSRYDDLYIDSIRQY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/44054", 
                    "id": "44054", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q9NR97-1", 
            "protein_name": "Toll-like receptor 8", 
            "sequence": {
                "length": 1041, 
                "sequence": "MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYVDSIKQY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/44054", 
                    "id": "44054", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094479.1", 
        "ac": "NP_001094479.1", 
        "name": "toll-like receptor 8 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008144", 
                        "pmid": "16973131", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "drug binding", 
                        "id": "GO:0008144"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003727", 
                        "pmid": "16973131", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "single-stranded RNA binding", 
                        "id": "GO:0003727"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008329", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "signaling pattern recognition receptor activity", 
                        "id": "GO:0008329"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA binding", 
                        "id": "GO:0003677"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "transmembrane signaling receptor activity", 
                        "id": "GO:0004888"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "double-stranded RNA binding", 
                        "id": "GO:0003725"
                    }
                ], 
                "total": 6, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "external side of plasma membrane", 
                        "id": "GO:0009897"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045359", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of interferon-beta biosynthetic process", 
                        "id": "GO:0045359"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001774", 
                        "pmid": "16973131", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "microglial cell activation", 
                        "id": "GO:0001774"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immune response", 
                        "id": "GO:0006955"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "defense response to virus", 
                        "id": "GO:0051607"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of interleukin-6 production", 
                        "id": "GO:0032755"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045416", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of interleukin-8 biosynthetic process", 
                        "id": "GO:0045416"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007249", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "I-kappaB kinase/NF-kappaB signaling", 
                        "id": "GO:0007249"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002224", 
                        "pmid": "16973131", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "toll-like receptor signaling pathway", 
                        "id": "GO:0002224"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045078", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of interferon-gamma biosynthetic process", 
                        "id": "GO:0045078"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045356", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of interferon-alpha biosynthetic process", 
                        "id": "GO:0045356"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "innate immune response", 
                        "id": "GO:0045087"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050718", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of interleukin-1 beta secretion", 
                        "id": "GO:0050718"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular response to mechanical stimulus", 
                        "id": "GO:0071260"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001932", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of protein phosphorylation", 
                        "id": "GO:0001932"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000778", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of interleukin-6 secretion", 
                        "id": "GO:2000778"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001183", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of interleukin-12 secretion", 
                        "id": "GO:2001183"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002755", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "MyD88-dependent toll-like receptor signaling pathway", 
                        "id": "GO:0002755"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034158", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A5H300", 
                                "id": "A5H300", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "toll-like receptor 8 signaling pathway", 
                        "id": "GO:0034158"
                    }
                ], 
                "total": 18, 
                "name": "Biological Process"
            }
        ]
    }, 
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        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A5H300", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Tlr8"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A5H300", 
            "type": "recommended", 
            "resource": "UniProtKB", 
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        }
    ], 
    "pro_annotation": [], 
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        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000045992", 
            "id": "ENSRNOG00000045992", 
            "database": "Bgee"
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        {
            "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4105765", 
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            "database": "ChEMBL"
        }, 
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        }, 
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            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000157", 
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            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", 
            "id": "IPR000483", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", 
            "id": "IPR001611", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", 
            "id": "IPR003591", 
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        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027175", 
            "id": "IPR027175", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", 
            "id": "IPR032675", 
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        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035897", 
            "id": "IPR035897", 
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        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:684440", 
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        }, 
        {
            "url": "https://omabrowser.org/oma/group/HDIACLN/", 
            "id": "HDIACLN", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=96378at2759", 
            "id": "96378at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47410:SF1", 
            "id": "PTHR47410:SF1", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00560", 
            "id": "PF00560", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01582", 
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        }, 
        {
            "url": "http://pfam.xfam.org/family/PF13855", 
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        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A5H300", 
            "id": "PR_A5H300", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1679131", 
            "id": "R-RNO-1679131", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-168181", 
            "id": "R-RNO-168181", 
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        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975110", 
            "id": "R-RNO-975110", 
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        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975138", 
            "id": "R-RNO-975138", 
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        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975155", 
            "id": "R-RNO-975155", 
            "database": "Reactome"
        }, 
        {
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        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1590327", 
            "id": "1590327", 
            "database": "RGD"
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    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
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        "chemical_mass": 119272.0
    }, 
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                "strand": "+", 
                "start_pos": 28539158, 
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        }
    ], 
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            "url": "https://www.uniprot.org/uniprot/A5H300", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Toll-like receptor 8"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A5H300", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "toll-like receptor 8 precursor"
        }
    ]
}