{
    "uniprot_canonical_ac": "A4D161-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A4D161-1|F221A_HUMAN Isoform 1 of Protein FAM221A  OS=Homo sapiens OX=9606 GN=FAM221A PE=1 SV=1 CANONICAL=A4D161-1", 
        "length": 298, 
        "sequence": "MERLTLPLGGAAAVDEYLEYRRIVGEDDGGKLFTPEEYEEYKRKVLPLRLQNRLFVSWRSPTGMDCKLVGPETLCFCTHRYKQHKTDLEAIPQQCPIDLPCQVTGCQCRAYLYVPLNGSQPIRCRCKHFADQHSAAPGFTCNTCSKCSGFHSCFTCACGQPAYAHDTVVETKQERLAQEKPVGQDIPYAAMGGLTGFSSLAEGYMRLDDSGIGVPSVEFLESPITAVDSPFLKAFQASSSSSPETLTDVGTSSQVSSLRRPEEDDMAFFERRYQERMKMEKAAKWKGKAPLPSATKPS"
    }, 
    "uniprot_id": "F221A_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [
        "glycoprotein", 
        "reported_with_glycan.glygen_ds"
    ], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D161", 
                    "id": "A4D161", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17207965", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17207965"
                }
            ], 
            "title": "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.", 
            "journal": "Genomics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120836.1", 
                    "id": "NP_001120836.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE, Vidal M", 
            "date": "2007"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/28657654", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "28657654"
                }
            ], 
            "title": "Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.", 
            "journal": "The Journal of pathology", 
            "evidence": [
                {
                    "url": "https://data.glygen.org/GLYDS000517", 
                    "id": "GLYDS000517", 
                    "database": "GlyGen"
                }
            ], 
            "authors": "Wang S, Yang F, Petyuk VA, Shukla AK, Monroe ME, Gritsenko MA, Rodland KD, Smith RD, Qian WJ, Gong CX, Liu T", 
            "date": "2017"
        }
    ], 
    "uniprot_ac": "A4D161", 
    "site_annotation": [
        {
            "end_pos": 119, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 117
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D161#A4D161-1", 
            "isoform_ac": "A4D161-1", 
            "locus": {
                "end_pos": 23680219, 
                "strand": "-", 
                "start_pos": 23702161, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000344962", 
                        "id": "ENST00000344962", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000342576", 
                        "id": "ENSP00000342576", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A4D161-1|F221A_HUMAN Isoform 1 of Protein FAM221A  OS=Homo sapiens OX=9606 GN=FAM221A PE=1 SV=1 CANONICAL=A4D161-1", 
                "length": 298, 
                "sequence": "MERLTLPLGGAAAVDEYLEYRRIVGEDDGGKLFTPEEYEEYKRKVLPLRLQNRLFVSWRSPTGMDCKLVGPETLCFCTHRYKQHKTDLEAIPQQCPIDLPCQVTGCQCRAYLYVPLNGSQPIRCRCKHFADQHSAAPGFTCNTCSKCSGFHSCFTCACGQPAYAHDTVVETKQERLAQEKPVGQDIPYAAMGGLTGFSSLAEGYMRLDDSGIGVPSVEFLESPITAVDSPFLKAFQASSSSSPETLTDVGTSSQVSSLRRPEEDDMAFFERRYQERMKMEKAAKWKGKAPLPSATKPS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D161#A4D161-2", 
            "isoform_ac": "A4D161-2", 
            "locus": {
                "end_pos": 23680219, 
                "strand": "-", 
                "start_pos": 23702161, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000409192", 
                        "id": "ENST00000409192", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000386927", 
                        "id": "ENSP00000386927", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A4D161-2|F221A_HUMAN Isoform 2 of Protein FAM221A  OS=Homo sapiens OX=9606 GN=FAM221A PE=1 SV=1 CANONICAL=A4D161-1", 
                "length": 262, 
                "sequence": "MERLTLPLGGAAAVDEYLEYRRIVGEDDGGKLFTPEEYEEYKRKVLPLRLQNRLFVSWRSPTGMDCKLVGPETLCFCTHRYKQHKTDLEAIPQQCPIDLPCQVTGCQCRAYLYVPLNGSQPIRCRCKHFADQHSAAPGFTCNTCSKCSGFHSCFTCACGQPAYAHDTVVETKQERLAQEKPVGQDIPYAAMGGLTGFSSLAEGYMRLDDSGIVGTSSQVSSLRRPEEDDMAFFERRYQERMKMEKAAKWKGKAPLPSATKPS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D161#A4D161-3", 
            "isoform_ac": "A4D161-3", 
            "locus": {
                "end_pos": 23680219, 
                "strand": "-", 
                "start_pos": 23702161, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000409994", 
                        "id": "ENST00000409994", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000386631", 
                        "id": "ENSP00000386631", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A4D161-3|F221A_HUMAN Isoform 3 of Protein FAM221A  OS=Homo sapiens OX=9606 GN=FAM221A PE=1 SV=1 CANONICAL=A4D161-1", 
                "length": 204, 
                "sequence": "MERLTLPLGGAAAVDEYLEYRRYKQHKTDLEAIPQQCPIDLPCQVTGCQCRAYLYVPLNGSQPIRCRCKHFADQHSAAPGFTCNTCSKCSGFHSCFTCACGQPAYAHDTVVETKQERLAQEKPVGQDIPYAAMGGLTGFSSLAEGYMRLDDSGIVGTSSQVSSLRRPEEDDMAFFERRYQERMKMEKAAKWKGKAPLPSATKPS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D161#B8ZZQ8-1", 
            "isoform_ac": "B8ZZQ8-1", 
            "locus": {
                "end_pos": 23680219, 
                "strand": "-", 
                "start_pos": 23702161, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000409653", 
                        "id": "ENST00000409653", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000386900", 
                        "id": "ENSP00000386900", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|B8ZZQ8-1|F221A_HUMAN Computationally mapped isoform of Protein FAM221A  OS=Homo sapiens OX=9606 GN=FAM221A PE=1 SV=1 CANONICAL=A4D161-1", 
                "length": 240, 
                "sequence": "MERLTLPLGGAAAVDEYLEYRRYKQHKTDLEAIPQQCPIDLPCQVTGCQCRAYLYVPLNGSQPIRCRCKHFADQHSAAPGFTCNTCSKCSGFHSCFTCACGQPAYAHDTVVETKQERLAQEKPVGQDIPYAAMGGLTGFSSLAEGYMRLDDSGIGVPSVEFLESPITAVDSPFLKAFQASSSSSPETLTDVGTSSQVSSLRRPEEDDMAFFERRYQERMKMEKAAKWKGKAPLPSATKPS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D161#F8WCP2-1", 
            "isoform_ac": "F8WCP2-1", 
            "locus": {
                "end_pos": 23680219, 
                "strand": "-", 
                "start_pos": 23688282, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000446234", 
                        "id": "ENST00000446234", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000404551", 
                        "id": "ENSP00000404551", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|F8WCP2-1|F221A_HUMAN Computationally mapped isoform of Protein FAM221A  OS=Homo sapiens OX=9606 GN=FAM221A PE=1 SV=1 CANONICAL=A4D161-1", 
                "length": 98, 
                "sequence": "MERLTLPLGGAAAVDEYLEYRRIVGEDDGGKLFTPEEYEEYKRKVLPLRLQNRLFVSWRSPTGMDCKLVGPETLCFCTHSRDGGFHRVSQDGLDLLTL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D161#F8WCP3-1", 
            "isoform_ac": "F8WCP3-1", 
            "locus": {
                "end_pos": 23680219, 
                "strand": "-", 
                "start_pos": 23686391, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000429719", 
                        "id": "ENST00000429719", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000416525", 
                        "id": "ENSP00000416525", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|F8WCP3-1|F221A_HUMAN Computationally mapped isoform of Protein FAM221A  OS=Homo sapiens OX=9606 GN=FAM221A PE=1 SV=1 CANONICAL=A4D161-1", 
                "length": 114, 
                "sequence": "MERLTLPLGGAAAVDEYLEYRRIVGEDDGGKLFTPEEYEEYKRKVLPLRLQNRLFVSWRSPTGMDCKLVGPETLCFCTHRVLLCHSGWSAVARSWLIAASTSWAQAILRPQPPK"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:340277", 
            "resource": "KEGG Pathway", 
            "id": "hsa:340277", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q4V8D7-1", 
            "protein_name": "Protein FAM221A", 
            "sequence": {
                "length": 296, 
                "sequence": "MERLTLPPGGAQAVDEYLEYRRIVGEDDGGKLFTPEEYEEYKKKVLPMRLQNRLFVSWRSPTGMDCKLVGPETLCFCTHRYKQHKTDFETVPQQRPIDLPCRVTGCQCKAYHYVPLNGTQPIRCRCKHFADQHSPALGFTCNACSKCSGFHSCFTCACGQPAYAHDTVVETRQERLAQGKPVGQDVPYAAMGGLTGFSSLAEGYMRLDDSGIGAPSVDVLDSPVSVMDHPFLRAMQPPSTSSPQPLAVGPSTQISSLRKPEEDDMAYFERQYQERIKMEKAAKKGKALPPPSTQPS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/18214", 
                    "id": "18214", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A4D161/", 
                    "id": "A4D161", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q8C790-1", 
            "protein_name": "Protein FAM221A", 
            "sequence": {
                "length": 301, 
                "sequence": "MERLTLPPGGAEAVDEYLEYRRIVGEDDGGKLFTPEEYEEYKKKVLPMRLQNRLFVSWRSPTGMDCKLVGPETLCFCTHRYKQHKTDFETIPQQRPIALPCRVSGCRCKAYHYVPLNGTQPIRCRCKHFADQHSAALGFTCNACSKCSGFHSCYTCACGQPAYAHDTVVETRQERLAQGKPVGRDVPYAAMGGLTGFSSLAEGYMRLDDSGIGAPSVEVLDSAVSAMDHPFLRAMHAPSTSSPQPLAGGNEVGPSTQLSSLRKPEEDDMAYFERQYQERIKLEKAAKQKGKVPPLPSTKPS"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/18214", 
                    "id": "18214", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [
        {
            "sequence_org": "S", 
            "start_pos": 119, 
            "alt_nt": "T", 
            "chr_id": "7", 
            "ref_nt": "G", 
            "chr_pos": "23729004", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D161", 
                    "id": "A4D161", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [
                "n-glyco-site-loss", 
                "o-glyco-site-loss"
            ], 
            "frequency": "2.0", 
            "sequence_mut": "I", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 119, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
            "sequence_org": "H", 
            "alt_nt": "A", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "23691452", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1453242665", 
                    "id": "rs1453242665", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "http://gnomad.broadinstitute.org/awesome?query=rs1453242665", 
                    "id": "rs1453242665", 
                    "database": "gnomAD"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-gain"
            ], 
            "sequence_mut": "N", 
            "start_pos": 165, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 165, 
            "minor_allelic_frequency": "", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (HDT->NDT)."
        }, 
        {
            "sequence_org": "S", 
            "start_pos": 199, 
            "alt_nt": "T", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "23731174", 
            "disease": [
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "id": "DOID:1324", 
                        "url": "http://disease-ontology.org/term/DOID:1324", 
                        "resource": "Disease Ontology", 
                        "name": "lung cancer", 
                        "description": "A respiratory system cancer that is located_in the lung."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D161", 
                    "id": "A4D161", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [
                "o-glyco-site-loss"
            ], 
            "frequency": "2.6", 
            "sequence_mut": "L", 
            "subjects_tested": "38", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.6%).", 
            "end_pos": 199, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
            "sequence_org": "S", 
            "alt_nt": "A", 
            "chr_id": "7", 
            "ref_nt": "G", 
            "chr_pos": "23698273", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs141261638", 
                    "id": "rs141261638", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/snp/rs141261638#frequency_tab", 
                    "id": "rs141261638", 
                    "database": "TOPMed"
                }, 
                {
                    "url": "http://gnomad.broadinstitute.org/awesome?query=rs141261638", 
                    "id": "rs141261638", 
                    "database": "gnomAD"
                }
            ], 
            "glycoeffect": [
                "n-glyco-sequon-gain", 
                "o-glyco-sequon-loss"
            ], 
            "sequence_mut": "N", 
            "start_pos": 240, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 240, 
            "minor_allelic_frequency": "", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SSS->NSS)."
        }, 
        {
            "sequence_org": "A", 
            "start_pos": 90, 
            "alt_nt": "A", 
            "chr_id": "7", 
            "ref_nt": "G", 
            "chr_pos": "23728916", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D161", 
                    "id": "A4D161", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "2.0", 
            "sequence_mut": "T", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 90, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }
    ], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120836.1", 
        "ac": "NP_001120836.1", 
        "name": "protein FAM221A isoform 2", 
        "summary": ""
    }, 
    "go_annotation": {}, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4D161", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "C7orf46"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D161", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "C7orf46"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4D161", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "FAM221A"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D161", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "FAM221A"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
            "id": "ENSG00000188732", 
            "database": "Bgee"
        }, 
        {
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D161", 
            "id": "A4D161", 
            "database": "BioMuta"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=FAM221A", 
            "id": "FAM221A", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/340277", 
            "id": "340277", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=27977", 
            "id": "27977", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A4D161*", 
            "id": "A4D161", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026755", 
            "id": "IPR026755", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:340277", 
            "id": "hsa:340277", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A4D161", 
            "id": "NX_A4D161", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/PGGIDCK/", 
            "id": "PGGIDCK", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=973186at2759", 
            "id": "973186at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR31214", 
            "id": "PTHR31214", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF14753", 
            "id": "PF14753", 
            "database": "Pfam"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A4D161", 
            "id": "A4D161", 
            "database": "PHAROS"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A4D161", 
            "id": "PR_A4D161", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120836.1", 
            "id": "NP_001120836.1", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [
        {
            "residue": "Thr", 
            "site_category": "reported_with_glycan", 
            "evidence": [
                {
                    "url": "https://data.glygen.org/GLYDS000517", 
                    "id": "GLYDS000517", 
                    "database": "GlyGen"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/28657654", 
                    "id": "28657654", 
                    "database": "PubMed"
                }
            ], 
            "subtype": "O-GlcNAcylation", 
            "relation": "attached", 
            "position": 295, 
            "glytoucan_ac": "G49108TO", 
            "type": "O-linked"
        }
    ], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 33083.0, 
        "chemical_mass": 33083.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000007", 
                "uberon": "0000007", 
                "name": "Pituitary gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178", 
                "uberon": "0000178", 
                "name": "Blood"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000955", 
                "uberon": "0000955", 
                "name": "Brain"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000996", 
                "uberon": "0000996", 
                "name": "Vagina"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043", 
                "uberon": "0001043", 
                "name": "Esophagus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001150", 
                "uberon": "0001150", 
                "name": "Body of pancreas"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155", 
                "uberon": "0001155", 
                "name": "Colon"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001160", 
                "uberon": "0001160", 
                "name": "Fundus of stomach"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001161", 
                "uberon": "0001161", 
                "name": "Body of stomach"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255", 
                "uberon": "0001255", 
                "name": "Urinary bladder"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001987", 
                "uberon": "0001987", 
                "name": "Placenta"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046", 
                "uberon": "0002046", 
                "name": "Thyroid gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002048", 
                "uberon": "0002048", 
                "name": "Lung"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107", 
                "uberon": "0002107", 
                "name": "Liver"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367", 
                "uberon": "0002367", 
                "name": "Prostate gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000188732", 
                    "id": "ENSG00000188732", 
                    "database": "Bgee"
                }
            ]
        }
    ], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D161", 
            "name": "FAM221A", 
            "locus": {
                "end_pos": 23703249, 
                "strand": "+", 
                "start_pos": 23680130, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000188732", 
                        "id": "ENSG00000188732", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D161", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Protein FAM221A"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4D161", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "protein FAM221A isoform 2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4D161", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "uncharacterized protein C7orf46; protein FAM221A"
        }
    ]
}