{
    "uniprot_canonical_ac": "A2RSX7-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2RSX7-1|TYW5_MOUSE Isoform 1 of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=2 CANONICAL=A2RSX7-1", 
        "length": 315, 
        "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISEDEKYYLRSLGEDPRKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYDTTDTYGNKDPVAASRAVQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNFE"
    }, 
    "uniprot_id": "TYW5_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "1.14.11.42", 
            "activity": ""
        }, 
        {
            "ec": "1.14.11.42", 
            "activity": "7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2)."
        }
    ], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                    "id": "A2RSX7", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "12520002"
                }
            ], 
            "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", 
            "journal": "Nucleic acids research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831.2", 
                    "id": "NP_001032831.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", 
            "date": "2003"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20972222", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20972222"
                }
            ], 
            "title": "Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.", 
            "journal": "Nucleic acids research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831.2", 
                    "id": "NP_001032831.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kato M, Araiso Y, Noma A, Nagao A, Suzuki T, Ishitani R, Nureki O", 
            "date": "2011"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26073538", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "26073538"
                }
            ], 
            "title": "Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs.", 
            "journal": "American journal of reproductive immunology (New York, N.Y. : 1989)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831.2", 
                    "id": "NP_001032831.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Pan J, Mor G, Ju W, Zhong J, Luo X, Aldo PB, Zhong M, Yu Y, Jenkins EC, Brown WT, Zhong N", 
            "date": "2015"
        }
    ], 
    "uniprot_ac": "A2RSX7", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7#A2RSX7-1", 
            "isoform_ac": "A2RSX7-1", 
            "locus": {
                "end_pos": 57388499, 
                "strand": "+", 
                "start_pos": 57406461, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000162686", 
                        "id": "ENSMUST00000162686", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000125427", 
                        "id": "ENSMUSP00000125427", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2RSX7-1|TYW5_MOUSE Isoform 1 of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=2 CANONICAL=A2RSX7-1", 
                "length": 315, 
                "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISEDEKYYLRSLGEDPRKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYDTTDTYGNKDPVAASRAVQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNFE"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7#A2RSX7-2", 
            "isoform_ac": "A2RSX7-2", 
            "locus": {
                "end_pos": 57393454, 
                "strand": "+", 
                "start_pos": 57406461, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000079998", 
                        "id": "ENSMUST00000079998", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000078912", 
                        "id": "ENSMUSP00000078912", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2RSX7-2|TYW5_MOUSE Isoform 2 of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=2 CANONICAL=A2RSX7-1", 
                "length": 121, 
                "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFIKLYLLTSWSREQPKKHIKNSSFQRMRNTTYGHLEKTQGRMLQTSDSSSHH"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7#E0CZH0-1", 
            "isoform_ac": "E0CZH0-1", 
            "locus": {
                "end_pos": 57393631, 
                "strand": "+", 
                "start_pos": 57406461, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000160118", 
                        "id": "ENSMUST00000160118", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000125386", 
                        "id": "ENSMUSP00000125386", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|E0CZH0-1|TYW5_MOUSE Computationally mapped isoform of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=1 CANONICAL=A2RSX7-1", 
                "length": 131, 
                "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFIKLYLLTSWSREQPKKHIKNSSFQRMRNTTYGHLEKTQGSRKNSFTGKVGCCCWAFPIIGL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7#G3UW53-1", 
            "isoform_ac": "G3UW53-1", 
            "locus": {
                "end_pos": 57388667, 
                "strand": "+", 
                "start_pos": 57406443, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000160837", 
                        "id": "ENSMUST00000160837", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000128576", 
                        "id": "ENSMUSP00000128576", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|G3UW53-1|TYW5_MOUSE Computationally mapped isoform of tRNA wybutosine-synthesizing protein 5  OS=Mus musculus OX=10090 GN=Tyw5 PE=2 SV=1 CANONICAL=A2RSX7-1", 
                "length": 255, 
                "sequence": "PVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVPQMDFIKLYLLTSWSREQPKKHIKNSSFQRMRNTTYGHLEKTQGSRKNSFTGKDVADIRQQFPSLGGDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFNPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNIFWKHLPSECYD"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68736", 
            "resource": "KEGG Pathway", 
            "id": "mmu:68736", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7#function", 
            "annotation": "tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RSX7#function", 
                    "id": "A2RSX7", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A2RUC4-1", 
            "protein_name": "tRNA wybutosine-synthesizing protein 5", 
            "sequence": {
                "length": 315, 
                "sequence": "MAGQHLPVPRLEGVSREQFMQHLYPQRKPLVLEGIDLGPCTSKWTVDYLSQVGGKKEVKIHVAAVAQMDFISKNFVYRTLPFDQLVQRAAEEKHKEFFVSEDEKYYLRSLGEDPRKDVADIRKQFPLLKGDIKFPEFFKEEQFFSSVFRISSPGLQLWTHYDVMDNLLIQVTGKKRVVLFSPRDAQYLYLKGTKSEVLNIDNPDLAKYPLFSKARRYECSLEAGDVLFIPALWFHNVISEEFGVGVNIFWKHLPSECYDKTDTYGNKDPTAASRAAQILDRALKTLAELPEEYRDFYARRMVLHIQDKAYSKNSE"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2RSX7/", 
                    "id": "A2RSX7", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/72085", 
                    "id": "72085", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "D3ZY75-1", 
            "protein_name": "tRNA-yW synthesizing protein 5", 
            "sequence": {
                "length": 315, 
                "sequence": "MAEQRLPVPRLRGVSREQFMEHLYPQRKPLVLEGLDLGSCTSKWTVDYLSQVGGTKEVKIHVAAVAQMDFISKNFVYRTLPFNKLVQRAAEETHKEFFISQDERYYLRSLGEDPRKDIADIRQQFPSLGEDITFPMFFREEQFFSSVFRISSPGLQLWTHYDVMDNFLIQVTGKKRITLFSPRDAQYLYLSGSKSEVLNIDSPDLDKYPLFPKARRYECSLEAGDVLFIPALWFHNVVSEEFGVGVNVFLKHLPSECYDTTDTYGNKDPVAASRAMQILDRALKTLAELPEEYRDFYARQMVLRIQDKAYSKNSE"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2RSX7/", 
                    "id": "A2RSX7", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/72085", 
                    "id": "72085", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831.2", 
        "ac": "NP_001032831.2", 
        "name": "tRNA wybutosine-synthesizing protein 5 isoform 1", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                                "id": "A2RSX7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "iron ion binding", 
                        "id": "GO:0005506"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                                "id": "A2RSX7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein homodimerization activity", 
                        "id": "GO:0042803"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                                "id": "A2RSX7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "tRNA binding", 
                        "id": "GO:0000049"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016706", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                                "id": "A2RSX7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "2-oxoglutarate-dependent dioxygenase activity", 
                        "id": "GO:0016706"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102524", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                                "id": "A2RSX7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity", 
                        "id": "GO:0102524"
                    }
                ], 
                "total": 5, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031591", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RSX7", 
                                "id": "A2RSX7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "wybutosine biosynthetic process", 
                        "id": "GO:0031591"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSX7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "1110034B05Rik"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSX7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Tyw5"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Tyw5"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000048495", 
            "id": "ENSMUSG00000048495", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/68736", 
            "id": "68736", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003347", 
            "id": "IPR003347", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR029612", 
            "id": "IPR029612", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041667", 
            "id": "IPR041667", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68736", 
            "id": "mmu:68736", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1915986", 
            "id": "1915986", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/PLYDDRP/", 
            "id": "PLYDDRP", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1385616at2759", 
            "id": "1385616at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12461:SF50", 
            "id": "PTHR12461:SF50", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF13621", 
            "id": "PF13621", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RSX7", 
            "id": "PR_A2RSX7", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032831.2", 
            "id": "NP_001032831.2", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 36633.0, 
        "chemical_mass": 36633.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7", 
            "name": "Tyw5", 
            "locus": {
                "end_pos": 57388237, 
                "strand": "-", 
                "start_pos": 57407101, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000048495", 
                        "id": "ENSMUSG00000048495", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "1.14.11.42"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSX7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "jmjC domain-containing protein C2orf60 homolog; tRNA yW-synthesizing enzyme 5; tRNA wybutosine-synthesizing protein 5; tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSX7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "tRNA wybutosine-synthesizing protein 5 isoform 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "tRNA wybutosine-synthesizing protein 5"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RSX7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase"
        }
    ]
}