{ "uniprot_canonical_ac": "A2RSG8-1", "ptm_annotation": [], "sequence": { "header": "tr|A2RSG8-1|A2RSG8_MOUSE Isoform 1 of A disintegrin and metallopeptidase domain 34 OS=Mus musculus OX=10090 GN=Adam34 PE=2 SV=1 CANONICAL=A2RSG8-1", "length": 714, "sequence": "MSGAKALVHKRNMFLKFCLWTMFFFSAWSSIGHAKYSSLPEVVTPLRVTVTRGNNISPGWLSYSLNIEGQRHIITMKPKKNLISRNFLLFTYSDQGDLLEEQPFVQNDCYYHGYVDEDPESLVIVNTCFGSLQGTLEINGTTYEIMPKSTTSTFEHLAYKMDNGESEPSPMRCGLSEEEIAQQMKLQESNASTLLQIPYENWWTHHRFIDYFVVIDHNRYVHRNNNTTTCIQDMLQVVNGINGYYLQIQTDVVLTKLEVWSQNNLINVEQEIRKVLGAFCNWKINAIGNRVRHDIIHLFVRRSYGTYLGLANVGTVCLTLNCAVNSFLSDSLSDMAFIIAHEMGHNLGMMHDGSSCTCGLSSCIMAPYKSNSPKFSNCSYEEMFSVVTKRSCLYDIPDALKTINLMPTMCGNNLVEEGEECDCGSTESCLQDPCCSSDCVLKPGAQCAFGLCCKNCQFLKTGTVCREEKNECDLPEWCNGTSAECPGDVYKADGIPCSGEGYCYKMECHQRDEQCRKIFGNGSRSADEICYMEMNRRGDRFGNCGNDSSMYRRCNLADVLCGRIQCENVIQLPQRRNHETVHYTHFSNVTCWTTDYHFGITIDDVGAVSDGTTCGPDYLCVHRKCVSKSVLVRNCTPQLCHMQGVCNNKDHCHCNNTWEPPDCQLRGHGGSIDSGPPPVPLSPSNWSMYFLAFIIMYVLGFIALYGIRELKKKS" }, "uniprot_id": "A2RSG8_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSG8", "id": "A2RSG8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12034510", "type": [ "PubMed" ], "id": "12034510" } ], "title": "Molecular cloning and expression analysis of a novel member of the Disintegrin and Metalloprotease-Domain (ADAM) family.", "journal": "Gene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665688.2", "id": "NP_665688.2", "database": "RefSeq" } ], "authors": "Brachvogel B, Reichenberg D, Beyer S, Jehn B, von der Mark K, Bielke W", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12838346", "type": [ "PubMed" ], "id": "12838346" } ], "title": "Human and mouse proteases: a comparative genomic approach.", "journal": "Nature reviews. Genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665688.2", "id": "NP_665688.2", "database": "RefSeq" } ], "authors": "Puente XS, Sanchez LM, Overall CM, Lopez-Otin C", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8146185", "type": [ "PubMed" ], "id": "8146185" } ], "title": "A family of cellular proteins related to snake venom disintegrins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665688.2", "id": "NP_665688.2", "database": "RefSeq" } ], "authors": "Weskamp G, Blobel CP", "date": "1994" } ], "uniprot_ac": "A2RSG8", "site_annotation": [ { "end_pos": 141, "annotation": "n_glycosylation_sequon", "start_pos": 139 }, { "end_pos": 192, "annotation": "n_glycosylation_sequon", "start_pos": 190 }, { "end_pos": 227, "annotation": "n_glycosylation_sequon", "start_pos": 225 }, { "end_pos": 228, "annotation": "n_glycosylation_sequon", "start_pos": 226 }, { "end_pos": 379, "annotation": "n_glycosylation_sequon", "start_pos": 377 }, { "end_pos": 481, "annotation": "n_glycosylation_sequon", "start_pos": 479 }, { "end_pos": 523, "annotation": "n_glycosylation_sequon", "start_pos": 521 }, { "end_pos": 548, "annotation": "n_glycosylation_sequon", "start_pos": 546 }, { "end_pos": 57, "annotation": "n_glycosylation_sequon", "start_pos": 55 }, { "end_pos": 590, "annotation": "n_glycosylation_sequon", "start_pos": 588 }, { "end_pos": 636, "annotation": "n_glycosylation_sequon", "start_pos": 634 }, { "end_pos": 657, "annotation": "n_glycosylation_sequon", "start_pos": 655 }, { "end_pos": 687, "annotation": "n_glycosylation_sequon", "start_pos": 685 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RSG8#A2RSG8-1", "isoform_ac": "A2RSG8-1", "locus": { "end_pos": 43650465, "strand": "+", "start_pos": 43652606, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000110411", "id": "ENSMUST00000110411", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000106041", "id": "ENSMUSP00000106041", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2RSG8-1|A2RSG8_MOUSE Isoform 1 of A disintegrin and metallopeptidase domain 34 OS=Mus musculus OX=10090 GN=Adam34 PE=2 SV=1 CANONICAL=A2RSG8-1", "length": 714, "sequence": "MSGAKALVHKRNMFLKFCLWTMFFFSAWSSIGHAKYSSLPEVVTPLRVTVTRGNNISPGWLSYSLNIEGQRHIITMKPKKNLISRNFLLFTYSDQGDLLEEQPFVQNDCYYHGYVDEDPESLVIVNTCFGSLQGTLEINGTTYEIMPKSTTSTFEHLAYKMDNGESEPSPMRCGLSEEEIAQQMKLQESNASTLLQIPYENWWTHHRFIDYFVVIDHNRYVHRNNNTTTCIQDMLQVVNGINGYYLQIQTDVVLTKLEVWSQNNLINVEQEIRKVLGAFCNWKINAIGNRVRHDIIHLFVRRSYGTYLGLANVGTVCLTLNCAVNSFLSDSLSDMAFIIAHEMGHNLGMMHDGSSCTCGLSSCIMAPYKSNSPKFSNCSYEEMFSVVTKRSCLYDIPDALKTINLMPTMCGNNLVEEGEECDCGSTESCLQDPCCSSDCVLKPGAQCAFGLCCKNCQFLKTGTVCREEKNECDLPEWCNGTSAECPGDVYKADGIPCSGEGYCYKMECHQRDEQCRKIFGNGSRSADEICYMEMNRRGDRFGNCGNDSSMYRRCNLADVLCGRIQCENVIQLPQRRNHETVHYTHFSNVTCWTTDYHFGITIDDVGAVSDGTTCGPDYLCVHRKCVSKSVLVRNCTPQLCHMQGVCNNKDHCHCNNTWEPPDCQLRGHGGSIDSGPPPVPLSPSNWSMYFLAFIIMYVLGFIALYGIRELKKKS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:252866", "resource": "KEGG Pathway", "id": "mmu:252866", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q7M766-1", "protein_name": "A disintegrin and metallopeptidase domain 34-like", "sequence": { "length": 736, "sequence": "MTGAKVVVHKRNMFLKFCLWTMFFFSAYSPIGHAKYSSLPEVVTPLRVTVTRGNNSSPGWLSYSLSIGGQRHIITMKPKENLISRNFLLFTYSDQGDLLEEHPFVQNDCYYHGYVDEDPESLVIVNTCFGSLQGTLEINGTIYEIMPRSKTSTFEHLAYKMDSGESEPSPMRCGLSEEEIAQQMNLQESNASTLLQIPYENWWTHHRFIDYFVVIDHNCYVHRNNNTTTCIQDMLQVVNGINGYFLQIQTDVVLTKVEVWSQNNLINVEEEMSAALDAFCSWKKNAIGNRVRHDIIHLFVRHNYVKFLGMAKLGQVCLTLNCAVNSFLTDSLSYLAFIVAHEMGHNLGMKHDGSACTCGLHTCIMYPYAYISPKFSNCSYEEMFSVVNRRSCLYNIPDALKTITLVPTMCGNNLVEEGEQCDCGNSESCLQDPCCSSDCVLKPGAKCAFGLCCKDCQFLQTGTVCRQEKNECDLPEWCNGTSGECPGDVYKADGIRCSRGGYCYKMECQRHDRQCREIFGKRSRSADEICYMEMNRRGDRFGNCGNDSSMYKRCELTDVLCGRIQCENVIKLPQRRNHETVHYTHFSNNTCWTMDYHFGITIDDVGAVSDGTPCAPDHICLDRKCVSKSVLVSNCTPHLCHMQGVCNNKHHCHCTNTWEPPDCQLHGHGGSIDSGPPPVPLSPSNWSMYFLAFIIMYVLGFIALYGIRELRKKLLKESVPESDSGDKNLTRKQQDL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/78104", "id": "78104", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665688.2", "ac": "NP_665688.2", "name": "a disintegrin and metallopeptidase domain 34", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSG8", "id": "A2RSG8", "database": "UniProtKB" } ], "name": "metalloendopeptidase activity", "id": "GO:0004222" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSG8", "id": "A2RSG8", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007229", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSG8", "id": "A2RSG8", "database": "UniProtKB" } ], "name": "integrin-mediated signaling pathway", "id": "GO:0007229" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSG8", "type": "synonym", "resource": "RefSeq", "name": "Adam34" }, { "url": "https://www.uniprot.org/uniprot/A2RSG8", "type": "recommended", "resource": "UniProtKB", "name": "Adam34" }, { "url": "https://www.uniprot.org/uniprot/A2RSG8", "type": "synonym", "resource": "UniProtKB", "name": "mCG_141116" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000079058", "id": "ENSMUSG00000079058", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04269", "id": "cd04269", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/252866", "id": "252866", "database": "GeneID" }, { "url": "https://acgg.asia/gpdb2/GPDB0001755", "id": "GPDB0001755", "database": "GlycoProtDB" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "id": "IPR000742", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001590", "id": "IPR001590", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001762", "id": "IPR001762", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002870", "id": "IPR002870", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006586", "id": "IPR006586", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018358", "id": "IPR018358", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", "id": "IPR024079", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR034027", "id": "IPR034027", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036436", "id": "IPR036436", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:252866", "id": "mmu:252866", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2181992", "id": "2181992", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/NASKCIM/", "id": "NASKCIM", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=162519at2759", "id": "162519at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00200", "id": "PF00200", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01421", "id": "PF01421", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01562", "id": "PF01562", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF08516", "id": "PF08516", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_665688.2", "id": "NP_665688.2", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 80572.0, "chemical_mass": 80572.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2RSG8", "name": "Adam34", "locus": { "end_pos": 43650309, "strand": "-", "start_pos": 43710049, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000079058", "id": "ENSMUSG00000079058", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2RSG8", "type": "synonym", "resource": "UniProtKB", "name": "A disintegrin and metallopeptidase domain 34, isoform CRA_a" }, { "url": "https://www.uniprot.org/uniprot/A2RSG8", "type": "synonym", "resource": "UniProtKB", "name": "A disintegrin and metallopeptidase domain 34" }, { "url": "https://www.uniprot.org/uniprot/A2RSG8", "type": "synonym", "resource": "UniProtKB", "name": "Adam34 protein" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSG8", "type": "synonym", "resource": "RefSeq", "name": "a disintegrin and metallopeptidase domain 34" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSG8", "type": "synonym", "resource": "RefSeq", "name": "testase 4" } ] }