{ "uniprot_canonical_ac": "A2RRU2-1", "ptm_annotation": [], "sequence": { "header": "tr|A2RRU2-1|A2RRU2_RAT Isoform 1 of Transmembrane protein 127 OS=Rattus norvegicus OX=10116 GN=Tmem127 PE=2 SV=1 CANONICAL=A2RRU2-1", "length": 238, "sequence": "MYAPGGAGLPGGRRRRSPGSSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENDPYPAEYEVINQFQPPPAYTP" }, "uniprot_id": "A2RRU2_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU2", "id": "A2RRU2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20154675", "type": [ "PubMed" ], "id": "20154675" } ], "title": "Germline mutations in TMEM127 confer susceptibility to pheochromocytoma.", "journal": "Nature genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448.1", "id": "NP_001094448.1", "database": "RefSeq" } ], "authors": "Qin Y, Yao L, King EE, Buddavarapu K, Lenci RE, Chocron ES, Lechleiter JD, Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G, Toledo RA, Toledo SP, Stiles C, Aguiar RC, Dahia PL", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24334765", "type": [ "PubMed" ], "id": "24334765" } ], "title": "The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function.", "journal": "Human molecular genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448.1", "id": "NP_001094448.1", "database": "RefSeq" } ], "authors": "Qin Y, Deng Y, Ricketts CJ, Srikantan S, Wang E, Maher ER, Dahia PL", "date": "2014" } ], "uniprot_ac": "A2RRU2", "site_annotation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RRU2#A2RRU2-1", "isoform_ac": "A2RRU2-1", "locus": { "end_pos": 119678179, "strand": "-", "start_pos": 119686931, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000031577", "id": "ENSRNOT00000031577", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000030631", "id": "ENSRNOP00000030631", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2RRU2-1|A2RRU2_RAT Isoform 1 of Transmembrane protein 127 OS=Rattus norvegicus OX=10116 GN=Tmem127 PE=2 SV=1 CANONICAL=A2RRU2-1", "length": 238, "sequence": "MYAPGGAGLPGGRRRRSPGSSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENDPYPAEYEVINQFQPPPAYTP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:311405", "resource": "KEGG Pathway", "id": "rno:311405", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O75204-1", "protein_name": "Transmembrane protein 127", "sequence": { "length": 238, "sequence": "MYAPGGAGLPGGRRRRSPGGSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENEPYPAEYEVINQFQPPPAYTP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/9877", "id": "9877", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8BGP5-1", "protein_name": "Transmembrane protein 127", "sequence": { "length": 238, "sequence": "MYAPGGAGLPGGRRRRSPGSSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVNPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENDPYPAEYEVINQFQPPPAYTP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/9877", "id": "9877", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448.1", "ac": "NP_001094448.1", "name": "transmembrane protein 127", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU2", "id": "A2RRU2", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU2", "id": "A2RRU2", "database": "UniProtKB" } ], "name": "negative regulation of cell population proliferation", "id": "GO:0008285" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032007", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RRU2", "id": "A2RRU2", "database": "UniProtKB" } ], "name": "negative regulation of TOR signaling", "id": "GO:0032007" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RRU2", "type": "synonym", "resource": "RefSeq", "name": "RGD1309744" }, { "url": "https://www.uniprot.org/uniprot/A2RRU2", "type": "synonym", "resource": "UniProtKB", "name": "RGD1309744" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RRU2", "type": "synonym", "resource": "RefSeq", "name": "Tmem127" }, { "url": "https://www.uniprot.org/uniprot/A2RRU2", "type": "recommended", "resource": "UniProtKB", "name": "Tmem127" }, { "url": "https://www.uniprot.org/uniprot/A2RRU2", "type": "synonym", "resource": "UniProtKB", "name": "rCG_26229" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000022727", "id": "ENSRNOG00000022727", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/311405", "id": "311405", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033331", "id": "IPR033331", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:311405", "id": "rno:311405", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/WISVDAN/", "id": "WISVDAN", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1422066at2759", "id": "1422066at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28358", "id": "PTHR28358", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RRU2", "id": "PR_A2RRU2", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094448.1", "id": "NP_001094448.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309744", "id": "1309744", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 25858.0, "chemical_mass": 25858.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2RRU2", "name": "Tmem127", "locus": { "end_pos": 119690366, "strand": "+", "start_pos": 119677575, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000022727", "id": "ENSRNOG00000022727", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2RRU2", "type": "synonym", "resource": "UniProtKB", "name": "RCG26229, isoform CRA_a" }, { "url": "https://www.uniprot.org/uniprot/A2RRU2", "type": "synonym", "resource": "UniProtKB", "name": "Transmembrane protein 127" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RRU2", "type": "synonym", "resource": "RefSeq", "name": "transmembrane protein 127" } ] }