{
    "uniprot_canonical_ac": "A1EC95-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A1EC95-1|HEAT6_RAT Isoform 1 of HEAT repeat-containing protein 6  OS=Rattus norvegicus OX=10116 GN=Heatr6 PE=1 SV=1 CANONICAL=A1EC95-1", 
        "length": 1252, 
        "sequence": "MSALPGSKLSERVRTVGWQISRPYFCHFFPIRITAPPATCSANKGFPELEHARPCPKRCPGSISQAIHVGKMAAVQVAASLPCEQPREAPRELSLEQNNGFRRLSARLRALQPDDSTVSRMEIHLLFDQLISENYCEGGGVAPEDVSALLVRACQLVPLNQNHLVSKVSQLIHRLLNRLQVIVDEQNLDFLLTYTISAIQQCSPWTHMEILQALAALVYCNGSKCQKHLPDLLGKSGLLMKLSDVTHSDPEVRRAAVHCMANLCLSVPGQPYLEESYQLVCFQAFLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGKMRLTQTEHLGALLAVLKKAMFHGLPGLNIEMPAVLYPTPLPQYDGRSPVKPQQPESSAARPSANKKKKYKVKPKKTQQGEKAEEEEPYGEVDAAPGLSMDQANTCVESAWCSSPWGSQGLPVDGGRATGREQVSSPFTISSWKRVSSSESDYSDAEGGMQGKMRSYQAKVRQGALACFLSTIKSIEKKVLYGYWSAFVPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHKRAFTPFSVTIASSIRELHRCLLLALVAESSSQTLTQIIKCLANLVSNAPYNRLKLSLLTKVWNHIKPYIRHKDVNVRVSSLTLLGAVVSTHAPLPEVQLLLQQPCSSGRSSSSATPHLSTPDGWKALPAGPSLEEASLSSPKGTAEPCWLIRLCISTVVLPKEDSCSGSDAGSALGSTYEPSPMRLEALQVLAHLARGYFSMAQLYLMELGEVICKCMCEANPSIQLHGVKLLEELGTGLIQQYKPDSSTAPEQRVPVHMVAMFWTAMLNGPLPRALQSTEHPTLQASACDALSSILPEAFSSLPNDKQILCITMLLGLNDSKNHLVKAATSRALGVYVLFPCLRQDVIFVADTANAILMSLQDKSLNVRAKAAWSLGNLTDTLIVNMDTPDPSFQDEFSGLLLLKMLQSAIQASTDKDKVKSNAVRALGNLLHFLQPSHIERPRFAEIIEESIQALISTVVNEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYKALTSVVMSCKNFKVRIRSAAALSVPGRRAQYGSLEQFSQIWSALVTALQRSEDTTDFLEFKYCASLRTHVCQALLHLLGLASASDLPCIQETLTVNGDMIRSYILQFLKSGAGGDDPGAVHSPQERNQMVRVALRHIHSVQALAGDTAKGAIVGFLEDILTVHCDSSGERAVLRGSLDQ"
    }, 
    "uniprot_id": "HEAT6_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EC95", 
                    "id": "A1EC95", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17218081", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17218081"
                }
            ], 
            "title": "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10.", 
            "journal": "Genomics", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EC95", 
                    "id": "A1EC95", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073366.1", 
                    "id": "NP_001073366.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Saad Y., Farms P., Garrett M.R., Joe B., Manickavasagam E., Radecki T., Yerga-Woolwine S.", 
            "date": "2007"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "22673903"
                }
            ], 
            "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", 
            "journal": "Nat. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EC95", 
                    "id": "A1EC95", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", 
            "date": "2012"
        }
    ], 
    "uniprot_ac": "A1EC95", 
    "site_annotation": [
        {
            "end_pos": 223, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 221
        }, 
        {
            "end_pos": 896, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 894
        }, 
        {
            "end_pos": 955, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 953
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1EC95#A1EC95-1", 
            "isoform_ac": "A1EC95-1", 
            "locus": {
                "end_pos": 71054344, 
                "strand": "-", 
                "start_pos": 71083226, 
                "chromosome": "10", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000003492", 
                        "id": "ENSRNOT00000003492", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000003492", 
                        "id": "ENSRNOP00000003492", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A1EC95-1|HEAT6_RAT Isoform 1 of HEAT repeat-containing protein 6  OS=Rattus norvegicus OX=10116 GN=Heatr6 PE=1 SV=1 CANONICAL=A1EC95-1", 
                "length": 1252, 
                "sequence": "MSALPGSKLSERVRTVGWQISRPYFCHFFPIRITAPPATCSANKGFPELEHARPCPKRCPGSISQAIHVGKMAAVQVAASLPCEQPREAPRELSLEQNNGFRRLSARLRALQPDDSTVSRMEIHLLFDQLISENYCEGGGVAPEDVSALLVRACQLVPLNQNHLVSKVSQLIHRLLNRLQVIVDEQNLDFLLTYTISAIQQCSPWTHMEILQALAALVYCNGSKCQKHLPDLLGKSGLLMKLSDVTHSDPEVRRAAVHCMANLCLSVPGQPYLEESYQLVCFQAFLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGKMRLTQTEHLGALLAVLKKAMFHGLPGLNIEMPAVLYPTPLPQYDGRSPVKPQQPESSAARPSANKKKKYKVKPKKTQQGEKAEEEEPYGEVDAAPGLSMDQANTCVESAWCSSPWGSQGLPVDGGRATGREQVSSPFTISSWKRVSSSESDYSDAEGGMQGKMRSYQAKVRQGALACFLSTIKSIEKKVLYGYWSAFVPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHKRAFTPFSVTIASSIRELHRCLLLALVAESSSQTLTQIIKCLANLVSNAPYNRLKLSLLTKVWNHIKPYIRHKDVNVRVSSLTLLGAVVSTHAPLPEVQLLLQQPCSSGRSSSSATPHLSTPDGWKALPAGPSLEEASLSSPKGTAEPCWLIRLCISTVVLPKEDSCSGSDAGSALGSTYEPSPMRLEALQVLAHLARGYFSMAQLYLMELGEVICKCMCEANPSIQLHGVKLLEELGTGLIQQYKPDSSTAPEQRVPVHMVAMFWTAMLNGPLPRALQSTEHPTLQASACDALSSILPEAFSSLPNDKQILCITMLLGLNDSKNHLVKAATSRALGVYVLFPCLRQDVIFVADTANAILMSLQDKSLNVRAKAAWSLGNLTDTLIVNMDTPDPSFQDEFSGLLLLKMLQSAIQASTDKDKVKSNAVRALGNLLHFLQPSHIERPRFAEIIEESIQALISTVVNEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYKALTSVVMSCKNFKVRIRSAAALSVPGRRAQYGSLEQFSQIWSALVTALQRSEDTTDFLEFKYCASLRTHVCQALLHLLGLASASDLPCIQETLTVNGDMIRSYILQFLKSGAGGDDPGAVHSPQERNQMVRVALRHIHSVQALAGDTAKGAIVGFLEDILTVHCDSSGERAVLRGSLDQ"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:497972", 
            "resource": "KEGG Pathway", 
            "id": "rno:497972", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6AI08-1", 
            "protein_name": "HEAT repeat-containing protein 6", 
            "sequence": {
                "length": 1181, 
                "sequence": "MAAVQVVGSWPSVQPREAPREAIPERGNGFRLLSARLCALRPDDSSSARTEIHLLFDQLISENYSEGSGVAPEDVSALLVQACRLVPLNQNHLVSKVSQLIHHLLNRLQVIVDEQHLDFLLAYTISAIHQCSSWTHREILQALAALVYCNGSKCQKYLPELLGNTGLLMKLSDLAQSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQNVCFQAFLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGRMKLTQTDELGALLAVLKKFMFHGLPGLNIEMPTVLYPTPLPQYDGRTPIKPQQSESSASRPTLNKKKKSKVKPKKIQQGEEEEKESSGEIEAAPVTGTGRVNLHEGNTWCPSSLGVQSLPLDGSGAAEKDGVSSSFSSSSWKRVSSSESDFSDAEGGMQSKMRSYQAKVRQGALVCFLSTIKSIEKKVLYGYWSAFIPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHRRAFTPFSVMIACSIRELHRCLLLALVAESSSQTVTQIIKCLANLVSNAPYDRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLGNSNSATPHLSPPDWWKKAPAGPSLEETSVSSPKGSSEPCWLIRLCISIVVLPKEDSCSGSDAGSAAGSTYEPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVICKCMGEADPSIQLHGAKLLEELGTGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRALQNSEHPTLQASACDALSSILPEAFSNLPNDRQMLCITVLLGLNDSKNRLVKAATSRALGVYVLFPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQEEFSGLLLLKMLRSAIEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQALISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVTSCKNFKVRIRSAAALSVPGKREQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLLSLASASDLPCMKETLELSGNMVQSYILQFLKSGAEGDDTGAPHSPQERDQMVRMALKHMGSIQAPTGDTARRAIMGFLEEILAVCFDSSGSQGALPGLTNQ"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/11116", 
                    "id": "11116", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A1EC95/", 
                    "id": "A1EC95", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q6P1G0-1", 
            "protein_name": "HEAT repeat-containing protein 6", 
            "sequence": {
                "length": 1184, 
                "sequence": "MAAVQVAASLPCGQPREAPRELSPEQDDGFRRLSARLRALQPDDSTVSRMEIHLLFDQLISENYSEGGGVAPEDVSALLVRACQLVPLNQNHLVSKVCQLIHRLLNRLQVVVDEPNLDFLLTYTISALQQCSSWTHMEILQALAALVYCNGSKCQKHLPDLLGKSGLLMKLSDLSHSDPEVRRAAVHCMANLCLSVPGQPYLEEPYQHVCFQAFLTILQSPKSSDMDDITFCMLLQNALKGIQSLLNGGKMRLTQTEHLGALLAVLKKAMFHGLPGLNIEMPAVLYPTPLPQYDGRSPVKPQQPESTTARSSANKKKKHKVKTKKTQQGEKAEEEEEEPCGEVEAAPGLSMDQANVSGESAWCSSPWGSQGLPVDGGRAAGREQASLPFASSSWKRVSSSESDYSDAEGGMQGKMRSYQAKVRQGALACFLSTIKSIEKKVLYGYWSAFVPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAILEGSKQFLSVAEDTSDHKRAFTPFSVTIASSIRELHRCLLLALVAESSSQTLTQIIKCLANLVSNAPYNRLKLSLLTKVWNHIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQLLLQQPCSSGLSSSSSATPHLSTPDGWKTFPAGSSLEEASLSSPKGSSEPCWLIRLCISTVVLPKEDSCSGSDAGSALGSTYEPSPMRLEALQVLAHLARGYFSTAQLYLMELGEVICKCMCEANPSIQLHGVKLLEELGAGLIQQYKPDSNIAPEQRVPVHLVVVFWTAMLSGPLPRALQSAEHPTLQASACDALSSILPEAFSSLPNDKQILCITVLLGLNDSKNHLVKAATSRALGVYVLFPCLRQDVIFVADTANAILMSLQDKSLNVRAKAAWSLGNLTDTLIVNMDTPDPSFQDEFSGLLLLKMLQCAIQASTDKDKVKSNAVRALGNLLHFLQPSHVERPRFAEIIEESIQALISTVVNEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYKALTSVVMSCKNFKVRIRSAAALSVPSKRGQYGSLEQFIQIWSALVTALQKSEDTTDFLEFKYCASLRTHICQALLHLLSLASASDLPGIQETLKLHGDMIRSYILQFLKSGAEGDDPGAVHTPQERVQMVRVALKHIHRVQTLAGDTARGAIMGFLEDILTVHCDSSGEQVMLRGPSDQ"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/11116", 
                    "id": "11116", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A1EC95/", 
                    "id": "A1EC95", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073366.1", 
        "ac": "NP_001073366.1", 
        "name": "HEAT repeat-containing protein 6", 
        "summary": ""
    }, 
    "go_annotation": {}, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1EC95", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Heatr6"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1EC95", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Heatr6"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1EC95", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "RGD1566204"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002542", 
            "id": "ENSRNOG00000002542", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/497972", 
            "id": "497972", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011989", 
            "id": "IPR011989", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", 
            "id": "IPR016024", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR025283", 
            "id": "IPR025283", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:497972", 
            "id": "rno:497972", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/DYGCLTG/", 
            "id": "DYGCLTG", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=106835at2759", 
            "id": "106835at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF13251", 
            "id": "PF13251", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1EC95", 
            "id": "PR_A1EC95", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073366.1", 
            "id": "NP_001073366.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1566204", 
            "id": "1566204", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [
        {
            "residue": "Ser", 
            "position": "471", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EC95", 
                    "id": "A1EC95", 
                    "database": "UniProtKB"
                }
            ], 
            "kinase_uniprot_canonical_ac": "", 
            "kinase_gene_name": ""
        }, 
        {
            "residue": "Ser", 
            "position": "474", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EC95", 
                    "id": "A1EC95", 
                    "database": "UniProtKB"
                }
            ], 
            "kinase_uniprot_canonical_ac": "", 
            "kinase_gene_name": ""
        }, 
        {
            "residue": "Thr", 
            "position": "689", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", 
                    "id": "22673903", 
                    "database": "PubMed"
                }
            ], 
            "kinase_uniprot_canonical_ac": "Q703I1-1", 
            "kinase_gene_name": "Oser1"
        }, 
        {
            "residue": "Thr", 
            "position": "689", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EC95", 
                    "id": "A1EC95", 
                    "database": "UniProtKB"
                }
            ], 
            "kinase_uniprot_canonical_ac": "", 
            "kinase_gene_name": ""
        }, 
        {
            "residue": "Ser", 
            "position": "714", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", 
                    "id": "22673903", 
                    "database": "PubMed"
                }
            ], 
            "kinase_uniprot_canonical_ac": "Q703I1-1", 
            "kinase_gene_name": "Oser1"
        }, 
        {
            "residue": "Ser", 
            "position": "714", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EC95", 
                    "id": "A1EC95", 
                    "database": "UniProtKB"
                }
            ], 
            "kinase_uniprot_canonical_ac": "", 
            "kinase_gene_name": ""
        }
    ], 
    "mass": {
        "monoisotopic_mass": 136505.0, 
        "chemical_mass": 136505.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1EC95", 
            "name": "Heatr6", 
            "locus": {
                "end_pos": 71083536, 
                "strand": "+", 
                "start_pos": 71054344, 
                "chromosome": "10", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000002542", 
                        "id": "ENSRNOG00000002542", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1EC95", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "2700008B19Rik-like protein"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1EC95", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "HEAT repeat-containing protein 6"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1EC95", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "HEAT repeat-containing protein 6"
        }
    ]
}