{
    "uniprot_canonical_ac": "A2AQ14-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2AQ14-1|MS18B_MOUSE Isoform 1 of Protein Mis18-beta  OS=Mus musculus OX=10090 GN=Oip5 PE=2 SV=1 CANONICAL=A2AQ14-1", 
        "length": 241, 
        "sequence": "MATLSRRSLRFLETQSRRDSCDTPFSLTSSMEWDTQVVEGFSPLGSSESKVKASPVDLRLPAWLEPERCAVFHCARCYAVLGDTLHLAWDLSRSLGALAFSKVTNNVVLLEPFLVGIEGFLKSSTYNLLFCNSCGTPVGFHLYSTHAAMAALRGHFCLSSDKMLCYLLKTNAIVNTSEMDFHNVPLPEKIAELKEKIMLMHTRLNSLTGLLKGKSPHQFKQENQQARKQHILGLTASPKIL"
    }, 
    "uniprot_id": "MS18B_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "taxid": 10090, 
            "name": "Mus musculus", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                    "id": "A2AQ14", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "crossref_internal": {
        "gene": [
            "Oip5"
        ], 
        "site": [
            "A2AQ14-1.42.42", 
            "A2AQ14-1.175.177", 
            "A2AQ14-1.14.14"
        ], 
        "species": [
            10090
        ]
    }, 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "12520002"
                }
            ], 
            "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", 
            "journal": "Nucleic acids research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036118.1", 
                    "id": "NP_001036118.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", 
            "date": "2003"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17284516", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17284516"
                }
            ], 
            "title": "LAP2alpha-binding protein LINT-25 is a novel chromatin-associated protein involved in cell cycle exit.", 
            "journal": "Journal of cell science", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036118.1", 
                    "id": "NP_001036118.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Naetar N, Hutter S, Dorner D, Dechat T, Korbei B, Gotzmann J, Beug H, Foisner R", 
            "date": "2007"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24516558", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24516558"
                }
            ], 
            "title": "Possible involvement of Opa-interacting protein 5 in adipose proliferation and obesity.", 
            "journal": "PloS one", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036118.1", 
                    "id": "NP_001036118.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Inoue K, Maeda N, Mori T, Sekimoto R, Tsushima Y, Matsuda K, Yamaoka M, Suganami T, Nishizawa H, Ogawa Y, Funahashi T, Shimomura I", 
            "date": "2014"
        }
    ], 
    "uniprot_ac": "A2AQ14", 
    "site_annotation": [
        {
            "end_pos": 177, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 175
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AQ14#A2AQ14-1", 
            "isoform_ac": "A2AQ14-1", 
            "sequence": {
                "header": "sp|A2AQ14-1|MS18B_MOUSE Isoform 1 of Protein Mis18-beta  OS=Mus musculus OX=10090 GN=Oip5 PE=2 SV=1 CANONICAL=A2AQ14-1", 
                "length": 241, 
                "sequence": "MATLSRRSLRFLETQSRRDSCDTPFSLTSSMEWDTQVVEGFSPLGSSESKVKASPVDLRLPAWLEPERCAVFHCARCYAVLGDTLHLAWDLSRSLGALAFSKVTNNVVLLEPFLVGIEGFLKSSTYNLLFCNSCGTPVGFHLYSTHAAMAALRGHFCLSSDKMLCYLLKTNAIVNTSEMDFHNVPLPEKIAELKEKIMLMHTRLNSLTGLLKGKSPHQFKQENQQARKQHILGLTASPKIL"
            }, 
            "locus": {
                "chromosome": "2", 
                "end_pos": 119610322, 
                "start_pos": 119618461, 
                "strand": "+", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000123818", 
                        "id": "ENSMUST00000123818", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000115219", 
                        "id": "ENSMUSP00000115219", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:70645", 
            "resource": "KEGG Pathway", 
            "id": "mmu:70645", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-606279", 
            "resource": "Reactome", 
            "id": "R-MMU-606279", 
            "name": "Deposition of new CENPA-containing nucleosomes at the centromere"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036118.1", 
            "annotation": "Increase of Oip5 may associate with development of obesity. Publication Status: Online-Only", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036118.1", 
                    "id": "NP_001036118.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AQ14#function", 
            "annotation": "Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AQ14#function", 
                    "id": "A2AQ14", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A0G2K615-1", 
            "protein_name": "Opa-interacting protein 5", 
            "sequence": {
                "length": 227, 
                "sequence": "MATLSPRGLPVVETQSCSGSCDTPFSSSMEWDTQVVEGFSPLGSSGSEVKASPVDLRLPAWLKPERCAVFHCASCYAVLGDTVHLAWDLSKFLGALAFSRVTNNVVLLEPLLVGIEGSLKSSTYNLLFCNSCGTPVGFHLYSTRAALAALRGHFCLSCDKMLCYLLKTKAIVNTSEMDIYNVPLPEKIAELKEKIMLMHSRLNSLLRVLKEKTPPQSDQENRTSNKQ"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2AQ14/", 
                    "id": "A2AQ14", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "O43482-1", 
            "protein_name": "Protein Mis18-beta", 
            "sequence": {
                "length": 229, 
                "sequence": "MAAQPLRHRSRCATPPRGDFCGGTERAIDQASFTTSMEWDTQVVKGSSPLGPAGLGAEEPAAGPQLPSWLQPERCAVFQCAQCHAVLADSVHLAWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKGSTYNLLFCGSCGIPVGFHLYSTHAALAALRGHFCLSSDKMVCYLLKTKAIVNASEMDIQNVPLSEKIAELKEKIVLTHNRLKSLMKILSEVTPDQSKPEN"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2AQ14/", 
                    "id": "A2AQ14", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/5268", 
                    "id": "5268", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036118.1", 
        "ac": "NP_001036118.1", 
        "name": "protein Mis18-beta", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", 
                        "pmid": "", 
                        "id": "GO:0042802", 
                        "name": "identical protein binding", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", 
                        "pmid": "", 
                        "id": "GO:0046872", 
                        "name": "metal ion binding", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "pmid": "17284516", 
                        "id": "GO:0005634", 
                        "name": "nucleus", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000775", 
                        "pmid": "21873635", 
                        "id": "GO:0000775", 
                        "name": "chromosome, centromeric region", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", 
                        "pmid": "17284516", 
                        "id": "GO:0000785", 
                        "name": "chromatin", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015030", 
                        "pmid": "17284516", 
                        "id": "GO:0015030", 
                        "name": "Cajal body", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010369", 
                        "pmid": "17284516", 
                        "id": "GO:0010369", 
                        "name": "chromocenter", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", 
                        "pmid": "", 
                        "id": "GO:0005654", 
                        "name": "nucleoplasm", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "pmid": "", 
                        "id": "GO:0005829", 
                        "name": "cytosol", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", 
                        "pmid": "", 
                        "id": "GO:0016607", 
                        "name": "nuclear speck", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }
                ], 
                "total": 8, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007059", 
                        "pmid": "21873635", 
                        "id": "GO:0007059", 
                        "name": "chromosome segregation", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034080", 
                        "pmid": "21873635", 
                        "id": "GO:0034080", 
                        "name": "CENP-A containing nucleosome assembly", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", 
                        "pmid": "", 
                        "id": "GO:0051301", 
                        "name": "cell division", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007049", 
                        "pmid": "", 
                        "id": "GO:0007049", 
                        "name": "cell cycle", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                                "id": "A2AQ14", 
                                "database": "UniProtKB"
                            }
                        ]
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AQ14", 
            "resource": "RefSeq", 
            "type": "synonym", 
            "name": "5730547N13Rik; Lint-25; Ms18b"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AQ14", 
            "resource": "UniProtKB", 
            "type": "synonym", 
            "name": "Ms18b"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AQ14", 
            "resource": "RefSeq", 
            "type": "synonym", 
            "name": "Oip5"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AQ14", 
            "resource": "UniProtKB", 
            "type": "recommended", 
            "name": "Oip5"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000072980", 
            "id": "ENSMUSG00000072980", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/70645", 
            "id": "70645", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR004910", 
            "id": "IPR004910", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR034752", 
            "id": "IPR034752", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:70645", 
            "id": "mmu:70645", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1917895", 
            "id": "1917895", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/KIMLTHT/", 
            "id": "KIMLTHT", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1253924at2759", 
            "id": "1253924at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF03226", 
            "id": "PF03226", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AQ14", 
            "id": "PR_A2AQ14", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-606279", 
            "id": "R-MMU-606279", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036118.1", 
            "id": "NP_001036118.1", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [
        {
            "residue": "Thr", 
            "position": "14", 
            "kinase_gene_name": "", 
            "kinase_uniprot_canonical_ac": "", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                    "id": "A2AQ14", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "residue": "Ser", 
            "position": "42", 
            "kinase_gene_name": "", 
            "kinase_uniprot_canonical_ac": "", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AQ14", 
                    "id": "A2AQ14", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "mass": {
        "monoisotopic_mass": 26861.0, 
        "chemical_mass": 26861.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AQ14", 
            "name": "Oip5", 
            "locus": {
                "chromosome": "2", 
                "end_pos": 119609512, 
                "start_pos": 119618469, 
                "strand": "-", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000072980", 
                        "id": "ENSMUSG00000072980", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AQ14", 
            "resource": "UniProtKB", 
            "type": "synonym", 
            "name": "Opa-interacting protein 5 homolog"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AQ14", 
            "resource": "UniProtKB", 
            "type": "recommended", 
            "name": "Protein Mis18-beta"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AQ14", 
            "resource": "RefSeq", 
            "type": "synonym", 
            "name": "opa-interacting protein 5 homolog"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AQ14", 
            "resource": "RefSeq", 
            "type": "synonym", 
            "name": "protein Mis18-beta"
        }
    ]
}