{ "uniprot_canonical_ac": "A2AF47-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AF47-1|DOC11_MOUSE Isoform 1 of Dedicator of cytokinesis protein 11 OS=Mus musculus OX=10090 GN=Dock11 PE=1 SV=1 CANONICAL=A2AF47-1", "length": 2073, "sequence": "MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKLVEPLDYENVITQRKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLIMLKKIIQINTDSLVQEKKDTVEAIQEEETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFMVNCHDLTFNILGHIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGTSTQLSNDGNAKGFSPESLIHGIAESQLCYIKQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDVQGSLDLDGRFSPLYKQDSSKLSNEDILKLLSEYKKPEKTKLQIIPGQLSITVECVPVDLPNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRVITLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLESYLRSFIKYSFRPEKPSTLQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPEAYHHVLHSLLLAIIPHVTIRYAEIPDESRNGNYSLASFLKRCLTLMDRGFVFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPSSASRDEFPCGFVSPTNRGSLASDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGSTSENTRQSSSRSSVSQYNRLDQYEIRNLLMCYLYIVKMISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKNQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQVNLKPIDVATDEIKDKTAELHKLCSSVDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMNNTLHVFCAISGTSSNRGYGSPRYAEV" }, "uniprot_id": "DOC11_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "taxid": 10090, "name": "Mus musculus", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] } ], "crossref_internal": { "gene": [ "Dock11" ], "site": [ "A2AF47-1.881.883", "A2AF47-1.1237.1237", "A2AF47-1.891.893", "A2AF47-1.1968.1970", "A2AF47-1.16.16", "A2AF47-1.488.490", "A2AF47-1.161.161", "A2AF47-1.1240.1240", "A2AF47-1.12.12", "A2AF47-1.248.248", "A2AF47-1.1024.1026", "A2AF47-1.1358.1360", "A2AF47-1.1380.1382", "A2AF47-1.306.306", "A2AF47-1.445.445", "A2AF47-1.617.619", "A2AF47-1.178.180", "A2AF47-1.2047.2049", "A2AF47-1.23.23" ], "species": [ 10090 ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15710388", "type": [ "PubMed" ], "id": "15710388" } ], "title": "Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.", "journal": "FEBS Lett.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "id": "NP_001009947.2", "database": "RefSeq" } ], "authors": "Maruyama M., Meller N., Nishikimi A., Schwartz M.A., Isobe K., Uekawa N.", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16968698", "type": [ "PubMed" ], "id": "16968698" } ], "title": "Identification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ], "authors": "Yang W., Lin Q., Feng Q., Cerione R.A., Baird D.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "type": [ "PubMed" ], "id": "17242355" } ], "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22494997", "type": [ "PubMed" ], "id": "22494997" } ], "title": "Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells.", "journal": "Immun. Ageing", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "id": "NP_001009947.2", "database": "RefSeq" } ], "authors": "Maruyama M., Sakabe I., Asai A., Iijima J.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23092103", "type": [ "PubMed" ], "id": "23092103" } ], "title": "Restricted expression of new guanine nucleotide exchange factor Zizimin2 in aged acquired immune system.", "journal": "Nagoya journal of medical science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "id": "NP_001009947.2", "database": "RefSeq" } ], "authors": "Jia Y, Sakabe I, Matsuda T, Hayakawa T, Maruyama M", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24194600", "type": [ "PubMed" ], "id": "24194600" } ], "title": "The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "id": "NP_001009947.2", "database": "RefSeq" } ], "authors": "Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25729399", "type": [ "PubMed" ], "id": "25729399" } ], "title": "The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation.", "journal": "Immun. Ageing", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ], "authors": "Maruyama M., Matsuda T., Takaoka A., Yanase S.", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25851601", "type": [ "PubMed" ], "id": "25851601" } ], "title": "The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.", "journal": "Mol. Biol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "id": "NP_001009947.2", "database": "RefSeq" } ], "authors": "Schmidt S., Debant A., Gasman S., Raynaud F., Dusart I., Wehrle R., Vodjdani G., Bellanger J.M., Doulazmi M., Fagni L., Jaudon F.", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29099971", "type": [ "PubMed" ], "id": "29099971" } ], "title": "Involvement of Zizimin2/3 in the age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM.", "journal": "International immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "id": "NP_001009947.2", "database": "RefSeq" } ], "authors": "Sakamoto A, Matsuda T, Kawaguchi K, Takaoka A, Maruyama M", "date": "2017" } ], "uniprot_ac": "A2AF47", "site_annotation": [ { "end_pos": 1026, "annotation": "n_glycosylation_sequon", "start_pos": 1024 }, { "end_pos": 1360, "annotation": "n_glycosylation_sequon", "start_pos": 1358 }, { "end_pos": 1382, "annotation": "n_glycosylation_sequon", "start_pos": 1380 }, { "end_pos": 180, "annotation": "n_glycosylation_sequon", "start_pos": 178 }, { "end_pos": 1970, "annotation": "n_glycosylation_sequon", "start_pos": 1968 }, { "end_pos": 2049, "annotation": "n_glycosylation_sequon", "start_pos": 2047 }, { "end_pos": 490, "annotation": "n_glycosylation_sequon", "start_pos": 488 }, { "end_pos": 619, "annotation": "n_glycosylation_sequon", "start_pos": 617 }, { "end_pos": 883, "annotation": "n_glycosylation_sequon", "start_pos": 881 }, { "end_pos": 893, "annotation": "n_glycosylation_sequon", "start_pos": 891 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AF47#A2AF47-1", "isoform_ac": "A2AF47-1", "sequence": { "header": "sp|A2AF47-1|DOC11_MOUSE Isoform 1 of Dedicator of cytokinesis protein 11 OS=Mus musculus OX=10090 GN=Dock11 PE=1 SV=1 CANONICAL=A2AF47-1", "length": 2073, "sequence": "MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKLVEPLDYENVITQRKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLIMLKKIIQINTDSLVQEKKDTVEAIQEEETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFMVNCHDLTFNILGHIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGTSTQLSNDGNAKGFSPESLIHGIAESQLCYIKQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDVQGSLDLDGRFSPLYKQDSSKLSNEDILKLLSEYKKPEKTKLQIIPGQLSITVECVPVDLPNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRVITLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLESYLRSFIKYSFRPEKPSTLQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPEAYHHVLHSLLLAIIPHVTIRYAEIPDESRNGNYSLASFLKRCLTLMDRGFVFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPSSASRDEFPCGFVSPTNRGSLASDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGSTSENTRQSSSRSSVSQYNRLDQYEIRNLLMCYLYIVKMISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKNQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQVNLKPIDVATDEIKDKTAELHKLCSSVDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMNNTLHVFCAISGTSSNRGYGSPRYAEV" }, "locus": { "chromosome": "X", "end_pos": 35888931, "start_pos": 36076215, "strand": "-", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000033419", "id": "ENSMUST00000033419", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000033419", "id": "ENSMUSP00000033419", "database": "Ensembl Peptide" } ] } }, { "url": "https://www.uniprot.org/uniprot/A2AF47#A2AF65-1", "isoform_ac": "A2AF65-1", "sequence": { "header": "tr|A2AF65-1|DOC11_MOUSE Computationally mapped isoform of Dedicator of cytokinesis protein 11 OS=Mus musculus OX=10090 GN=Dock11 PE=1 SV=1 CANONICAL=A2AF47-1", "length": 527, "sequence": "MRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQVNLKPIDVATDEIKDKTAELHKLCSSVDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDIIHEQL" }, "locus": { "chromosome": "X", "end_pos": 36041238, "start_pos": 36075919, "strand": "-", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000115264", "id": "ENSMUST00000115264", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000110919", "id": "ENSMUSP00000110919", "database": "Ensembl Peptide" } ] } }, { "url": "https://www.uniprot.org/uniprot/A2AF47#A2AF67-1", "isoform_ac": "A2AF67-1", "sequence": { "header": "tr|A2AF67-1|DOC11_MOUSE Computationally mapped isoform of Dedicator of cytokinesis protein 11 OS=Mus musculus OX=10090 GN=Dock11 PE=1 SV=1 CANONICAL=A2AF47-1", "length": 1902, "sequence": "MKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLIMLKKIIQINTDSLVQEKKDTVEAIQEEETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFMVNCHDLTFNILGHIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGTSTQLSNDGNAKGFSPESLIHGIAESQLCYIKQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDVQGSLDLDGRFSPLYKQDSSKLSNEDILKLLSEYKKPEKTKLQIIPGQLSITVECVPVDLPNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRVITLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLESYLRSFIKYSFRPEKPSTLQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPEAYHHVLHSLLLAIIPHVTIRYAEIPDESRNGNYSLASFLKRCLTLMDRGFVFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDFFSFAVDRLTSVDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPSSASRDEFPCGFVSPTNRGSLASDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGSTSENTRQSSSRSSVSQYNRLDQYEIRNLLMCYLYIVKMISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKNQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQVNLKPIDVATDEIKDKTAELHKLCSSVDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMNNTLHVFCAISGTSSNRGYGSPRYAEV" }, "locus": { "chromosome": "X", "end_pos": 35947397, "start_pos": 36076215, "strand": "-", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000115266", "id": "ENSMUST00000115266", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000110921", "id": "ENSMUSP00000110921", "database": "Ensembl Peptide" } ] } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75974", "resource": "KEGG Pathway", "id": "mmu:75974", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983231", "resource": "Reactome", "id": "R-MMU-983231", "name": "Factors involved in megakaryocyte development and platelet production" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "annotation": "Cloning of zizimin2; expressed predominantly in lymphocytes with an opposite pattern than zizimin1 [zizimin2]", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "id": "NP_001009947.2", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AF47#function", "annotation": "Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:15710388, PubMed:16968698, PubMed:25851601). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (PubMed:25729399). Facilitates filopodia formation through the activation of CDC42 (PubMed:22494997).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47#function", "id": "A2AF47", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "annotation": "These data suggested that Zizimin2 is associated with the reduction of immune response in acquired immunity along with aging.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "id": "NP_001009947.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "annotation": "This study shows that Zizimin2 is involved in age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "id": "NP_001009947.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JV16-1", "protein_name": "Dedicator of cytokinesis 11", "sequence": { "length": 2086, "sequence": "MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKLVEPLDYENVITQRKTQIYSDPLRDLLMFPMEDISLSVIGRQLRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLITLKKIIQINTDSLVQEKKETVEAIQEEETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDVKPFEEKCNKRFLVNCHDLTFNILGHIGDNAKGPPTNVEPFFITLALFDVKNNCKISADFHVDLNPPSVREMLWGMSTQLANDGNTKGSSPESLIHGIAESRLCYIRQGIFSVTNPHPEIFLVVRIEKVLQGNITHCAEPYIKNSDPIKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDLQGSLDLDGKFSPLYKQDSSKLSNEDILKLLSEYKKPEKTKLQIIPGQLNITVECVPVDLPNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKSFAKARNIAVCVEFRDSDESDTSALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRVTTLEQQLPVSANLPPGYLNVNDAESRRQSNADIKWVDGAKPLLKIKTHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLESYLRSFIKYSFRPEKPSTLQAQLIHETLATTMIAILKQSADFLAINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPEAYHHILHSLLLAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFVFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDFFSFAVDRLTSVDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSASRDEFPCGFVSPTSRGSLATDKEPAYGSFQNGHGIKREDSRGSLIPEGATGFPDPGSTGENTRQSSSRTSVSQYNRLDQYEIRNLLMCYLYIVKMISEDTLLTYWNKVSPQELINILVLLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSATTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKSQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRSFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPTEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHIKNGDFSEAAMCYVHVAALVAEFLHRKKLFPSGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEVISEISKLIIPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISFRLVKLYGEKFGTENIKIIQDSDKVNAKELDPKFAHIQVTYVKPYFDDKELTERKTEFERNHNINRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPITCEQQVNLKPIDVATDEIKDKTAELHKLCSSADVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNESQANKYPPKKVNELKDMFRKFIQACSIALELNERLIKEDQIEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMNNTLHVFCAISGTSSNRGYGSPRYSEV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/70950", "id": "70950", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q5JSL3-1", "protein_name": "Dedicator of cytokinesis protein 11", "sequence": { "length": 2073, "sequence": "MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKVVEPLDYENVIAQRKTQIYSDPLRDLLMFPMEDISISVIGRQRRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYKYEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSSSLCSQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLTQLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKMRRHAFELKMLDKYSHYLAAETEQEMEEWLITLKKIIQINTDSLVQEKKETVETAQDDETSSQGKAENIMASLERSMHPELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGIEPDIKPFEEKCNKRFLVNCHDLTFNILGQIGDNAKGPPTNVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWGSSTQLASDGSPKGSSPESYIHGIAESQLRYIQQGIFSVTNPHPEIFLVARIEKVLQGNITHCAEPYIKNSDPVKTAQKVHRTAKQVCSRLGQYRMPFAWAARPIFKDTQGSLDLDGRFSPLYKQDSSKLSSEDILKLLSEYKKPEKTKLQIIPGQLNITVECVPVDLSNCITSSYVPLKPFEKNCQNITVEVEEFVPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKTFAKARNIAVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSHHNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTKGTTKKQDTVETPVGFAWVPLLKDGRIITFEQQLPVSANLPPGYLNLNDAESRRQCNVDIKWVDGAKPLLKIKSHLESTIYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAMEIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLHIVSKCHEEGLDSYLRSFIKYSFRPEKPSAPQAQLIHETLATTMIAILKQSADFLSINKLLKYSWFFFEIIAKSMATYLLEENKIKLPRGQRFPETYHHVLHSLLLAIIPHVTIRYAEIPDESRNVNYSLASFLKRCLTLMDRGFIFNLINDYISGFSPKDPKVLAEYKFEFLQTICNHEHYIPLNLPMAFAKPKLQRVQDSNLEYSLSDEYCKHHFLVGLLLRETSIALQDNYEIRYTAISVIKNLLIKHAFDTRYQHKNQQAKIAQLYLPFVGLLLENIQRLAGRDTLYSCAAMPNSASRDEFPCGFTSPANRGSLSTDKDTAYGSFQNGHGIKREDSRGSLIPEGATGFPDQGNTGENTRQSSTRSSVSQYNRLDQYEIRSLLMCYLYIVKMISEDTLLTYWNKVSPQELINILILLEVCLFHFRYMGKRNIARVHDAWLSKHFGIDRKSQTMPALRNRSGVMQARLQHLSSLESSFTLNHSSTTTEADIFHQALLEGNTATEVSLTVLDTISFFTQCFKTQLLNNDGHNPLMKKVFDIHLAFLKNGQSEVSLKHVFASLRAFISKFPSAFFKGRVNMCAAFCYEVLKCCTSKISSTRNEASALLYLLMRNNFEYTKRKTFLRTHLQIIIAVSQLIADVALSGGSRFQESLFIINNFANSDRPMKATAFPAEVKDLTKRIRTVLMATAQMKEHEKDPEMLIDLQYSLAKSYASTPELRKTWLDSMAKIHVKNGDFSEAAMCYVHVAALVAEFLHRKKLFPNGCSAFKKITPNIDEEGAMKEDAGMMDVHYSEEVLLELLEQCVDGLWKAERYEIISEISKLIVPIYEKRREFEKLTQVYRTLHGAYTKILEVMHTKKRLLGTFFRVAFYGQSFFEEEDGKEYIYKEPKLTGLSEISLRLVKLYGEKFGTENVKIIQDSDKVNAKELDPKYAHIQVTYVKPYFDDKELTERKTEFERNHNISRFVFEAPYTLSGKKQGCIEEQCKRRTILTTSNSFPYVKKRIPINCEQQINLKPIDVATDEIKDKTAELQKLCSSTDVDMIQLQLKLQGCVSVQVNAGPLAYARAFLNDSQASKYPPKKVSELKDMFRKFIQACSIALELNERLIKEDQVEYHEGLKSNFRDMVKELSDIIHEQILQEDTMHSPWMSNTLHVFCAISGTSSDRGYGSPRYAEV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/70950", "id": "70950", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "ac": "NP_001009947.2", "name": "dedicator of cytokinesis protein 11", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "pmid": "22494997", "id": "GO:0005085", "name": "guanyl-nucleotide exchange factor activity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "pmid": "25851601", "id": "GO:0005085", "name": "guanyl-nucleotide exchange factor activity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005089", "pmid": "15710388", "id": "GO:0005089", "name": "Rho guanyl-nucleotide exchange factor activity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017048", "pmid": "15710388", "id": "GO:0017048", "name": "Rho GTPase binding", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547", "pmid": "22494997", "id": "GO:0043547", "name": "positive regulation of GTPase activity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043547", "pmid": "25851601", "id": "GO:0043547", "name": "positive regulation of GTPase activity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051491", "pmid": "22494997", "id": "GO:0051491", "name": "positive regulation of filopodium assembly", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001782", "pmid": "25729399", "id": "GO:0001782", "name": "B cell homeostasis", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002315", "pmid": "25729399", "id": "GO:0002315", "name": "marginal zone B cell differentiation", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007264", "pmid": "", "id": "GO:0007264", "name": "small GTPase mediated signal transduction", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] } ], "total": 6, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AF47", "resource": "RefSeq", "type": "synonym", "name": "5033414A21Rik; 8030476J24; sph238; Zizimin2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AF47", "resource": "RefSeq", "type": "synonym", "name": "Dock11" }, { "url": "https://www.uniprot.org/uniprot/A2AF47", "resource": "UniProtKB", "type": "recommended", "name": "Dock11" }, { "url": "https://www.uniprot.org/uniprot/A2AF47", "resource": "UniProtKB", "type": "synonym", "name": "Ziz2" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000031093", "id": "ENSMUSG00000031093", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08697", "id": "cd08697", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/75974", "id": "75974", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AF47*", "id": "A2AF47", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "id": "IPR001849", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR010703", "id": "IPR010703", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR021816", "id": "IPR021816", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026791", "id": "IPR026791", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027007", "id": "IPR027007", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027357", "id": "IPR027357", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "id": "IPR035892", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037809", "id": "IPR037809", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75974", "id": "mmu:75974", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1923224", "id": "1923224", "database": "MGI" }, { "url": "http://www.orthodb.org/?query=20156at2759", "id": "20156at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23317", "id": "PTHR23317", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00169", "id": "PF00169", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF06920", "id": "PF06920", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF11878", "id": "PF11878", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF14429", "id": "PF14429", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AF47", "id": "PR_A2AF47", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983231", "id": "R-MMU-983231", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009947.2", "id": "NP_001009947.2", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "1237", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "1240", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "12", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "161", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "residue": "Thr", "position": "16", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "23", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "residue": "Tyr", "position": "248", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "306", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "445", "kinase_gene_name": "Atxn7l3b", "kinase_uniprot_canonical_ac": "Q3UD01-1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ] }, { "residue": "Ser", "position": "445", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "id": "A2AF47", "database": "UniProtKB" } ] } ], "mass": { "monoisotopic_mass": 237771.0, "chemical_mass": 237771.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "name": "Dock11", "locus": { "chromosome": "X", "end_pos": 36076562, "start_pos": 35888832, "strand": "+", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000031093", "id": "ENSMUSG00000031093", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AF47", "resource": "UniProtKB", "type": "synonym", "name": "ACG" }, { "url": "https://www.uniprot.org/uniprot/A2AF47", "resource": "UniProtKB", "type": "synonym", "name": "Activated Cdc42-associated guanine nucleotide exchange factor" }, { "url": "https://www.uniprot.org/uniprot/A2AF47", "resource": "UniProtKB", "type": "recommended", "name": "Dedicator of cytokinesis protein 11" }, { "url": "https://www.uniprot.org/uniprot/A2AF47", "resource": "UniProtKB", "type": "synonym", "name": "Zizimin-2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AF47", "resource": "RefSeq", "type": "synonym", "name": "dedicator of cytokinesis protein 11" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AF47", "resource": "RefSeq", "type": "synonym", "name": "spleen specific 238 kDa protein with PH domain; ACG; zizimin-2; activated Cdc42-associated guanine nucleotide exchange factor" } ] }