{ "uniprot_canonical_ac": "A2ABV5-1", "ptm_annotation": [], "sequence": { "header": "sp|A2ABV5-1|MED14_MOUSE Isoform 1 of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1", "length": 1459, "sequence": "MAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDPATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYSTHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYNYYFMSVSTADREDSPVMALLLQQFKDNIQDLMSYTKTGKQTRTGTKHKLSDDPCPIDSKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPEIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHIALGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP" }, "uniprot_id": "MED14_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "taxid": 10090, "name": "Mus musculus", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] } ], "crossref_internal": { "gene": [ "Med14" ], "site": [ "A2ABV5-1.992.992", "A2ABV5-1.1117.1117", "A2ABV5-1.866.868", "A2ABV5-1.623.623", "A2ABV5-1.1411.1413", "A2ABV5-1.1038.1040", "A2ABV5-1.530.532", "A2ABV5-1.1149.1149", "A2ABV5-1.1133.1133", "A2ABV5-1.1263.1265", "A2ABV5-1.1141.1141", "A2ABV5-1.220.222", "A2ABV5-1.738.740", "A2ABV5-1.1124.1124", "A2ABV5-1.723.725", "A2ABV5-1.1450.1452", "A2ABV5-1.432.434" ], "species": [ 10090 ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10512684", "type": [ "PubMed" ], "id": "10512684" } ], "title": "Detection and cloning of an X-linked locus associated with a NotI site that is not methylated on mouse inactivated X chromosome by the RLGS-M method.", "journal": "Genomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673.1", "id": "NP_001041673.1", "database": "RefSeq" } ], "authors": "Muramatsu M., Hayashizaki Y., Shibata H., Takada S., Kamiya M., Wake N., Arima T., Takagi N., Chapman V.M., Kagebayashi H.", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12037571", "type": [ "PubMed" ], "id": "12037571" } ], "title": "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673.1", "id": "NP_001041673.1", "database": "RefSeq" } ], "authors": "Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15340084", "type": [ "PubMed" ], "id": "15340084" } ], "title": "Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673.1", "id": "NP_001041673.1", "database": "RefSeq" } ], "authors": "Malik S, Guermah M, Yuan CX, Wu W, Yamamura S, Roeder RG", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17132730", "type": [ "PubMed" ], "id": "17132730" } ], "title": "The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ], "authors": "Zhang X., Roeder R.G., Rodriguez P., Stumpf M., Guyot B., Borggrefe T., Waskow C., Kroetschel M., van Essen D.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20194623", "type": [ "PubMed" ], "id": "20194623" } ], "title": "MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis.", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673.1", "id": "NP_001041673.1", "database": "RefSeq" } ], "authors": "Grontved L, Madsen MS, Boergesen M, Roeder RG, Mandrup S", "date": "2010" } ], "uniprot_ac": "A2ABV5", "site_annotation": [ { "end_pos": 1040, "annotation": "n_glycosylation_sequon", "start_pos": 1038 }, { "end_pos": 1265, "annotation": "n_glycosylation_sequon", "start_pos": 1263 }, { "end_pos": 1413, "annotation": "n_glycosylation_sequon", "start_pos": 1411 }, { "end_pos": 1452, "annotation": "n_glycosylation_sequon", "start_pos": 1450 }, { "end_pos": 222, "annotation": "n_glycosylation_sequon", "start_pos": 220 }, { "end_pos": 434, "annotation": "n_glycosylation_sequon", "start_pos": 432 }, { "end_pos": 532, "annotation": "n_glycosylation_sequon", "start_pos": 530 }, { "end_pos": 725, "annotation": "n_glycosylation_sequon", "start_pos": 723 }, { "end_pos": 740, "annotation": "n_glycosylation_sequon", "start_pos": 738 }, { "end_pos": 868, "annotation": "n_glycosylation_sequon", "start_pos": 866 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5#A2ABV5-1", "isoform_ac": "A2ABV5-1", "sequence": { "header": "sp|A2ABV5-1|MED14_MOUSE Isoform 1 of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1", "length": 1459, "sequence": "MAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDPATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYSTHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYNYYFMSVSTADREDSPVMALLLQQFKDNIQDLMSYTKTGKQTRTGTKHKLSDDPCPIDSKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPEIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHIALGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP" }, "locus": { "chromosome": "X", "end_pos": 12677581, "start_pos": 12761699, "strand": "+", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000096495", "id": "ENSMUST00000096495", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000094239", "id": "ENSMUSP00000094239", "database": "Ensembl Peptide" } ] } }, { "url": "https://www.uniprot.org/uniprot/A2ABV5#A2ABV5-2", "isoform_ac": "A2ABV5-2", "sequence": { "header": "sp|A2ABV5-2|MED14_MOUSE Isoform 2 of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1", "length": 770, "sequence": "MAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDPATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYSTHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYNYYFMSVSTADREDSPVMALLLQQFKDNIQDLMSYTKTGKQTRTGTKHKLSDDPCPIDSKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGKIFHTVFLLMSIFLKVLVTISFFL" }, "locus": {} }, { "url": "https://www.uniprot.org/uniprot/A2ABV5#A2ABV5-3", "isoform_ac": "A2ABV5-3", "sequence": { "header": "sp|A2ABV5-3|MED14_MOUSE Isoform 3 of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1", "length": 471, "sequence": "MAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSKHSRAGEMAQQLRVPTALPKVLSSNPINHMVAHNHL" }, "locus": {} }, { "url": "https://www.uniprot.org/uniprot/A2ABV5#A2ABV5-4", "isoform_ac": "A2ABV5-4", "sequence": { "header": "sp|A2ABV5-4|MED14_MOUSE Isoform 4 of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1", "length": 362, "sequence": "MVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANES" }, "locus": {} }, { "url": "https://www.uniprot.org/uniprot/A2ABV5#A2BDN7-1", "isoform_ac": "A2BDN7-1", "sequence": { "header": "tr|A2BDN7-1|MED14_MOUSE Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1", "length": 700, "sequence": "MAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDPATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYSTHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYNYYFMSVSTADREDSPVMALLLQQFKDNIQDLMSYTKTGKQTRTGTKHKLSDDPCPIDSKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKVPIMEGEN" }, "locus": { "chromosome": "X", "end_pos": 12709216, "start_pos": 12761699, "strand": "+", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000076016", "id": "ENSMUST00000076016", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000075395", "id": "ENSMUSP00000075395", "database": "Ensembl Peptide" } ] } }, { "url": "https://www.uniprot.org/uniprot/A2ABV5#A2BDP0-1", "isoform_ac": "A2BDP0-1", "sequence": { "header": "tr|A2BDP0-1|MED14_MOUSE Computationally mapped isoform of Mediator of RNA polymerase II transcription subunit 14 OS=Mus musculus OX=10090 GN=Med14 PE=1 SV=1 CANONICAL=A2ABV5-1", "length": 798, "sequence": "MCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFNHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPEIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHIALGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGT" }, "locus": { "chromosome": "X", "end_pos": 12680239, "start_pos": 12716027, "strand": "+", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000115481", "id": "ENSMUST00000115481", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000111143", "id": "ENSMUSP00000111143", "database": "Ensembl Peptide" } ] } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:26896", "resource": "KEGG Pathway", "id": "mmu:26896", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436", "resource": "Reactome", "id": "R-MMU-212436", "name": "Generic Transcription Pathway" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5#function", "annotation": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5#function", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673.1", "annotation": "MED14 constitutes a novel anchoring point between Mediator and the N-terminal domain of PPARgamma that is necessary for functional PPARgamma-mediated recruitment of Mediator and transactivation of PPARgamma subtype-specific target genes.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673.1", "id": "NP_001041673.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D4A020-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 14", "sequence": { "length": 1459, "sequence": "MAPVQLENHQLIPPGGGGGSGGGGGSSSGSASVPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQIDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRSFNANENSSIETALPALIVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLEDMEKSLNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTITTETLQLANYATHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVSTADRDDSPAMALLLQQFKDNIQDLMSCTNTGKQTRTGTKHKLSDDSCPVECKKAKRSGETCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPEIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPPASYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGALDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDVSHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/22082", "id": "22082", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2ABV5/", "id": "A2ABV5", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "O60244-1", "protein_name": "Mediator of RNA polymerase II transcription subunit 14", "sequence": { "length": 1454, "sequence": "MAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/22082", "id": "22082", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2ABV5/", "id": "A2ABV5", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673.1", "ac": "NP_001041673.1", "name": "mediator of RNA polymerase II transcription subunit 14 isoform a", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003713", "pmid": "", "id": "GO:0003713", "name": "transcription coactivator activity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "pmid": "", "id": "GO:0003712", "name": "transcription coregulator activity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "pmid": "20508642", "id": "GO:0016592", "name": "mediator complex", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016592", "pmid": "15340084", "id": "GO:0016592", "name": "mediator complex", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070847", "pmid": "21873635", "id": "GO:0070847", "name": "core mediator complex", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "id": "GO:0005634", "name": "nucleus", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "id": "GO:0005654", "name": "nucleoplasm", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] } ], "total": 5, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "pmid": "21873635", "id": "GO:0006357", "name": "regulation of transcription by RNA polymerase II", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019827", "pmid": "20720539", "id": "GO:0019827", "name": "stem cell population maintenance", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "pmid": "", "id": "GO:0045944", "name": "positive regulation of transcription by RNA polymerase II", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "pmid": "", "id": "GO:0045893", "name": "positive regulation of transcription, DNA-templated", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006367", "pmid": "", "id": "GO:0006367", "name": "transcription initiation from RNA polymerase II promoter", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] } ], "total": 5, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2ABV5", "resource": "RefSeq", "type": "synonym", "name": "9930001L01Rik; AU041628; Crsp2; Gm641; ORF1; Trap170" }, { "url": "https://www.uniprot.org/uniprot/A2ABV5", "resource": "UniProtKB", "type": "synonym", "name": "Crsp2" }, { "url": "https://www.uniprot.org/uniprot/A2ABV5", "resource": "UniProtKB", "type": "synonym", "name": "Gm641" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2ABV5", "resource": "RefSeq", "type": "synonym", "name": "Med14" }, { "url": "https://www.uniprot.org/uniprot/A2ABV5", "resource": "UniProtKB", "type": "recommended", "name": "Med14" }, { "url": "https://www.uniprot.org/uniprot/A2ABV5", "resource": "UniProtKB", "type": "synonym", "name": "Trap170" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000064127", "id": "ENSMUSG00000064127", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/26896", "id": "26896", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2ABV5*", "id": "A2ABV5", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013947", "id": "IPR013947", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:26896", "id": "mmu:26896", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1349442", "id": "1349442", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/HLDCPIT/", "id": "HLDCPIT", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1215335at2759", "id": "1215335at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12809", "id": "PTHR12809", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF08638", "id": "PF08638", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2ABV5", "id": "PR_A2ABV5", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-212436", "id": "R-MMU-212436", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041673.1", "id": "NP_001041673.1", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "1117", "kinase_gene_name": "Atxn7l3b", "kinase_uniprot_canonical_ac": "Q3UD01-1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ] }, { "residue": "Ser", "position": "1117", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "1124", "kinase_gene_name": "Atxn7l3b", "kinase_uniprot_canonical_ac": "Q3UD01-1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ] }, { "residue": "Ser", "position": "1124", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "1133", "kinase_gene_name": "Atxn7l3b", "kinase_uniprot_canonical_ac": "Q3UD01-1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ] }, { "residue": "Ser", "position": "1133", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "1141", "kinase_gene_name": "Atxn7l3b", "kinase_uniprot_canonical_ac": "Q3UD01-1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ] }, { "residue": "Ser", "position": "1141", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "1149", "kinase_gene_name": "Atxn7l3b", "kinase_uniprot_canonical_ac": "Q3UD01-1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ] }, { "residue": "Ser", "position": "1149", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "623", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "992", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "id": "A2ABV5", "database": "UniProtKB" } ] } ], "mass": { "monoisotopic_mass": 160966.0, "chemical_mass": 160966.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "name": "Med14", "locus": { "chromosome": "X", "end_pos": 12675369, "start_pos": 12762073, "strand": "-", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000064127", "id": "ENSMUSG00000064127", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2ABV5", "resource": "UniProtKB", "type": "synonym", "name": "CRSP complex subunit 2" }, { "url": "https://www.uniprot.org/uniprot/A2ABV5", "resource": "UniProtKB", "type": "synonym", "name": "Cofactor required for Sp1 transcriptional activation subunit 2" }, { "url": "https://www.uniprot.org/uniprot/A2ABV5", "resource": "UniProtKB", "type": "synonym", "name": "Mediator complex subunit 14" }, { "url": "https://www.uniprot.org/uniprot/A2ABV5", "resource": "UniProtKB", "type": "recommended", "name": "Mediator of RNA polymerase II transcription subunit 14" }, { "url": "https://www.uniprot.org/uniprot/A2ABV5", "resource": "UniProtKB", "type": "synonym", "name": "Thyroid hormone receptor-associated protein complex 170 kDa component" }, { "url": "https://www.uniprot.org/uniprot/A2ABV5", "resource": "UniProtKB", "type": "synonym", "name": "Trap170" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2ABV5", "resource": "RefSeq", "type": "synonym", "name": "cofactor required for Sp1 transcriptional activation, subunit 2; mediator of RNA polymerase II transcription subunit 14; CRSP complex subunit 2; thyroid hormone receptor-associated protein complex 170 kDa component; cofactor required for Sp1 transcriptional activation subunit 2 (150 kDa)" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2ABV5", "resource": "RefSeq", "type": "synonym", "name": "mediator of RNA polymerase II transcription subunit 14 isoform a" } ] }