{ "uniprot_canonical_ac": "A2AAY5-1", "ptm_annotation": [ { "annotation": "Phosphorylated in SRC-transformed cells.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144821", "id": "19144821", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2AAY5-1|SPD2B_MOUSE Isoform 1 of SH3 and PX domain-containing protein 2B OS=Mus musculus OX=10090 GN=Sh3pxd2b PE=1 SV=1 CANONICAL=A2AAY5-1", "length": 908, "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP" }, "uniprot_id": "SPD2B_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "taxid": 10090, "name": "Mus musculus", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] } ], "crossref_internal": { "gene": [ "Sh3pxd2b" ], "site": [ "A2AAY5-1.809.811", "A2AAY5-1.279.279", "A2AAY5-1.528.528", "A2AAY5-1.291.291", "A2AAY5-1.185.187", "A2AAY5-1.508.508", "A2AAY5-1.840.840", "A2AAY5-1.457.459", "A2AAY5-1.499.499", "A2AAY5-1.661.661", "A2AAY5-1.25.25", "A2AAY5-1.373.373", "A2AAY5-1.879.881" ], "species": [ 10090 ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15592455", "type": [ "PubMed" ], "id": "15592455" } ], "title": "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.", "journal": "Nat. Biotechnol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ], "authors": "Rush J., Zhang H., Comb M.J., Goss V.L., Guo A., Lee K.A., Moritz A., Polakiewicz R.D., Spek E.J., Zha X.-M., Zha X.M.", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18959745", "type": [ "PubMed" ], "id": "18959745" } ], "title": "A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion.", "journal": "FEBS J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Eguchi T., Osada S., Imagawa M., Nishizuka M., Hishida T.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144319", "type": [ "PubMed" ], "id": "19144319" } ], "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ], "authors": "Thibault P., Trost M., Desjardins M., Courcelles M., English L., Lemieux S.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144821", "type": [ "PubMed" ], "id": "19144821" } ], "title": "The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation.", "journal": "Mol. Biol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Courtneidge S.A., Pass I., Buschman M.D., Cejudo-Martin P., Bromann P.A., Wen F.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19233245", "type": [ "PubMed" ], "id": "19233245" } ], "title": "The role of C/EBPdelta in the early stages of adipogenesis.", "journal": "Biochimie", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Hishida T, Nishizuka M, Osada S, Imagawa M", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19669234", "type": [ "PubMed" ], "id": "19669234" } ], "title": "The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development.", "journal": "Mamm. Genome", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Mao M., Chang B., Johnson K.R., Zheng Q.Y., Donahue L.R., Thedens D.R., Harris B.S., Anderson M.G.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19755710", "type": [ "PubMed" ], "id": "19755710" } ], "title": "Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity.", "journal": "Sci. Signal.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ], "authors": "Bokoch G.M., Fowler B., Courtneidge S.A., Gianni D., Diaz B., Taulet N.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20137777", "type": [ "PubMed" ], "id": "20137777" } ], "title": "Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome.", "journal": "Am. J. Hum. Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Megarbane A., Veltman J.A., van Bokhoven H., de Brouwer A., Alanay Y., Albrecht B., Ben-Neriah Z., Courtneidge S.A., Iqbal Z., van Beusekom E., Hennekam R., van der Zwaag B., Ruiz-Lozano P., Millan J.L., Artuso R., Hamel B., Amenduni M., Cejudo-Martin P., Lindsey J.D., Oudakker A., Scimia M.C., Weinreb R.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21818352", "type": [ "PubMed" ], "id": "21818352" } ], "title": "Sh3pxd2b mice are a model for craniofacial dysmorphology and otitis media.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Yang B, Tian C, Zhang ZG, Han FC, Azem R, Yu H, Zheng Y, Jin G, Arnold JE, Zheng QY", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25259869", "type": [ "PubMed" ], "id": "25259869" } ], "title": "Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Cejudo-Martin P, Yuen A, Vlahovich N, Lock P, Courtneidge SA, Diaz B", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26234751", "type": [ "PubMed" ], "id": "26234751" } ], "title": "Discovery and characterization of spontaneous mouse models of craniofacial dysmorphology.", "journal": "Developmental biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Palmer K, Fairfield H, Borgeia S, Curtain M, Hassan MG, Dionne L, Yong Karst S, Coombs H, Bronson RT, Reinholdt LG, Bergstrom DE, Donahue LR, Cox TC, Murray SA", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27711054", "type": [ "PubMed" ], "id": "27711054" } ], "title": "The scaffold protein Tks4 is required for the differentiation of mesenchymal stromal cells (MSCs) into adipogenic and osteogenic lineages.", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Dulk M, Kudlik G, Fekete A, Ernszt D, Kvell K, Pongracz JE, Mero BL, Szeder B, Radnai L, Geiszt M, Csecsy DE, Kovacs T, Uher F, Lanyi A, Vas V, Buday L", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27802184", "type": [ "PubMed" ], "id": "27802184" } ], "title": "The role of Tks adaptor proteins in invadopodia formation, growth and metastasis of melanoma.", "journal": "Oncotarget", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ], "authors": "Iizuka S, Abdullah C, Buschman MD, Diaz B, Courtneidge SA", "date": "2016" } ], "uniprot_ac": "A2AAY5", "site_annotation": [ { "end_pos": 187, "annotation": "n_glycosylation_sequon", "start_pos": 185 }, { "end_pos": 459, "annotation": "n_glycosylation_sequon", "start_pos": 457 }, { "end_pos": 811, "annotation": "n_glycosylation_sequon", "start_pos": 809 }, { "end_pos": 881, "annotation": "n_glycosylation_sequon", "start_pos": 879 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5#A2AAY5-1", "isoform_ac": "A2AAY5-1", "sequence": { "header": "sp|A2AAY5-1|SPD2B_MOUSE Isoform 1 of SH3 and PX domain-containing protein 2B OS=Mus musculus OX=10090 GN=Sh3pxd2b PE=1 SV=1 CANONICAL=A2AAY5-1", "length": 908, "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP" }, "locus": { "chromosome": "11", "end_pos": 32347894, "start_pos": 32423558, "strand": "-", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000038753", "id": "ENSMUST00000038753", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000044276", "id": "ENSMUSP00000044276", "database": "Ensembl Peptide" } ] } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:268396", "resource": "KEGG Pathway", "id": "mmu:268396", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5#function", "annotation": "Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5#function", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "Induction of the fad49 gene was observed in adipocyte differentiable 3T3-L1 cells, but not in non-adipogenic NIH-3T3 cells.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "SH3PXD2B is a podosomal-adaptor protein required for postnatal growth and development.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "Silencing of C/EBPdelta impaired the expression of factor for adipocyte differentiation (fad) 49, which is up-regulated and plays a crucial role early in adipogenesis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "Suggest the importance of Tks adaptor proteins in melanoma growth and metastasis in vivo is likely via functional invadopodia formation.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "The mouse model with a mutation in the Sh3pxd2b gene (Sh3pxd2b(nee)) mirrors craniofacial dysmorphology and otitis media in humans.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "These findings establish a role for TKS4 in Frank-Ter Haar syndrome and embryonic development.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "Tks4 has a role in the formation and function of podosomes.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "annotation": "Together, these results establish a novel function for Tks4 in the regulation of mesenchymal stromal cells differentiation. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "id": "NP_796338.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A1X283-1", "protein_name": "SH3 and PX domain-containing protein 2B", "sequence": { "length": 911, "sequence": "MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AAY5/", "id": "A2AAY5", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/27952", "id": "27952", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "D3ZAF9-1", "protein_name": "SH3 and PX domains 2B", "sequence": { "length": 804, "sequence": "ALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGSDPTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGVVVEVIQKNLEGWWKIRFQGKEGWAPASYLKKSSGEPLPPKLGPSSSAHSGALDLDGVSRQQNAVGREKELLNNQRDGRFEGRLAPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGEAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPHRGSSPKPPGVILPMIPAKHAPLARDSKKPEPKPDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELPEEKVEPNPQNLFLKSRPQVRPKPTPSPKTEPAQGEDQVDIYNLRSKLRPAKSQEKALLDGESHHAAGGHDTALGRSFLPGEGPGRGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGSQREESRAIPASGRALLVPPKAKPFLSNSSVGQDDIRGKGGLGPRIAGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCRVLSGAPSWEGWIPSNYLRKKP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2AAY5/", "id": "A2AAY5", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796338.2", "ac": "NP_796338.2", "name": "SH3 and PX domain-containing protein 2B", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010314", "pmid": "18959745", "id": "GO:0010314", "name": "phosphatidylinositol-5-phosphate binding", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042169", "pmid": "18959745", "id": "GO:0042169", "name": "SH2 domain binding", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080025", "pmid": "18959745", "id": "GO:0080025", "name": "phosphatidylinositol-3,5-bisphosphate binding", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070273", "pmid": "18959745", "id": "GO:0070273", "name": "phosphatidylinositol-4-phosphate binding", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "pmid": "18959745", "id": "GO:0032266", "name": "phosphatidylinositol-3-phosphate binding", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035091", "pmid": "21873635", "id": "GO:0035091", "name": "phosphatidylinositol binding", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016176", "pmid": "21873635", "id": "GO:0016176", "name": "superoxide-generating NADPH oxidase activator activity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] } ], "total": 7, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "18959745", "id": "GO:0005737", "name": "cytoplasm", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "27711054", "id": "GO:0005737", "name": "cytoplasm", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "19669234", "id": "GO:0005737", "name": "cytoplasm", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "19144821", "id": "GO:0005737", "name": "cytoplasm", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002102", "pmid": "19669234", "id": "GO:0002102", "name": "podosome", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002102", "pmid": "19144821", "id": "GO:0002102", "name": "podosome", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "pmid": "", "id": "GO:0030054", "name": "cell junction", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042995", "pmid": "", "id": "GO:0042995", "name": "cell projection", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] } ], "total": 8, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904888", "pmid": "27711054", "id": "GO:1904888", "name": "cranial skeletal system development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002051", "pmid": "27711054", "id": "GO:0002051", "name": "osteoblast fate commitment", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904179", "pmid": "27711054", "id": "GO:1904179", "name": "positive regulation of adipose tissue development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060378", "pmid": "27711054", "id": "GO:0060378", "name": "regulation of brood size", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "pmid": "20137777", "id": "GO:0007507", "name": "heart development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "pmid": "27711054", "id": "GO:0010628", "name": "positive regulation of gene expression", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045600", "pmid": "27711054", "id": "GO:0045600", "name": "positive regulation of fat cell differentiation", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045600", "pmid": "18959745", "id": "GO:0045600", "name": "positive regulation of fat cell differentiation", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060612", "pmid": "20137777", "id": "GO:0060612", "name": "adipose tissue development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001501", "pmid": "20137777", "id": "GO:0001501", "name": "skeletal system development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051496", "pmid": "27711054", "id": "GO:0051496", "name": "positive regulation of stress fiber assembly", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": 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"https://www.ebi.ac.uk/interpro/entry/IPR035477", "id": "IPR035477", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035478", "id": "IPR035478", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035479", "id": "IPR035479", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035480", "id": "IPR035480", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "id": "IPR036028", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036871", "id": "IPR036871", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037961", "id": "IPR037961", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:268396", "id": "mmu:268396", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2442062", "id": "2442062", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/GGQDDMR/", 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Almost complete loss of phosphorylation; when associated with F-25 and F-373." } ], "disease": [], "phosphorylation": [ { "residue": "Tyr", "position": "25", "kinase_gene_name": "Atxn7l3b", "kinase_uniprot_canonical_ac": "Q3UD01-1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144821", "id": "19144821", "database": "PubMed" } ] }, { "residue": "Tyr", "position": "25", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "279", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "291", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "499", "kinase_gene_name": "Atxn7l3b", "kinase_uniprot_canonical_ac": "Q3UD01-1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ] }, { "residue": "Ser", "position": "499", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "528", "kinase_gene_name": "Atxn7l3b", "kinase_uniprot_canonical_ac": "Q3UD01-1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ] }, { "residue": "Ser", "position": "528", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "residue": "Tyr", "position": "661", "kinase_gene_name": "Atxn7l3b", "kinase_uniprot_canonical_ac": "Q3UD01-1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15592455", "id": "15592455", "database": "PubMed" } ] }, { "residue": "Tyr", "position": "661", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] }, { "residue": "Ser", "position": "840", "kinase_gene_name": "Atxn7l3b", "kinase_uniprot_canonical_ac": "Q3UD01-1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144319", "id": "19144319", "database": "PubMed" } ] }, { "residue": "Ser", "position": "840", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "id": "A2AAY5", "database": "UniProtKB" } ] } ], "mass": { "monoisotopic_mass": 101517.0, "chemical_mass": 101517.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "name": "Sh3pxd2b", "locus": { "chromosome": "11", "end_pos": 32428173, "start_pos": 32347820, "strand": "+", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000040711", "id": "ENSMUSG00000040711", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AAY5", "resource": "UniProtKB", "type": "synonym", "name": "Factor for adipocyte differentiation 49" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AAY5", "resource": "RefSeq", "type": "synonym", "name": "SH3 and PX domain-containing protein 2B" }, { "url": "https://www.uniprot.org/uniprot/A2AAY5", "resource": "UniProtKB", "type": "recommended", "name": "SH3 and PX domain-containing protein 2B" }, { "url": "https://www.uniprot.org/uniprot/A2AAY5", "resource": "UniProtKB", "type": "synonym", "name": "Tyrosine kinase substrate with four SH3 domains" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AAY5", "resource": "RefSeq", "type": "synonym", "name": "tyrosine kinase substrate with four SH3 domains; factor for adipocyte differentiation 49" } ] }