{ "uniprot_canonical_ac": "A2A9F4-1", "ptm_annotation": [], "sequence": { "header": "sp|A2A9F4-1|KDF1_MOUSE Isoform 1 of Keratinocyte differentiation factor 1 OS=Mus musculus OX=10090 GN=Kdf1 PE=1 SV=1 CANONICAL=A2A9F4-1", "length": 397, "sequence": "MPRPGQPRPSSGPPRLGPWERPSELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRGCSPCLSAGDPIEGSAEAAWAKEHNGVPPSPDRAPPSRRDGQRLKTSMGSSFSYPDVKLKGIPVYPYRHATSPVPDVDSCCKEPLAEPPPTRHSLPSTFTNSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRSRPQTSEGRSARSTAPAAAPDSGHETMLGSGLSQDELTVQISQETTADAIARKLRPYGAPGYPASQDSSFQGTDTDSSGAPLLQVYC" }, "uniprot_id": "KDF1_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "taxid": 10090, "name": "Mus musculus", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] } ], "crossref_internal": { "gene": [ "Kdf1" ], "site": [ "A2A9F4-1.218.218" ], "species": [ 10090 ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12819125", "type": [ "PubMed" ], "id": "12819125" } ], "title": "Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.", "journal": "Genome research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385.1", "id": "NP_001077385.1", "database": "RefSeq" } ], "authors": "Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T, Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA, Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts P, Muramatsu M, Okazaki Y, Kawai J, Hayashizaki Y", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24075906", "type": [ "PubMed" ], "id": "24075906" } ], "title": "Forward genetics identifies Kdf1/1810019J16Rik as an essential regulator of the proliferation-differentiation decision in epidermal progenitor cells.", "journal": "Dev. Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385.1", "id": "NP_001077385.1", "database": "RefSeq" } ], "authors": "Lee S., Kong Y., Weatherbee S.D.", "date": "2013" } ], "uniprot_ac": "A2A9F4", "site_annotation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4#A2A9F2-1", "isoform_ac": "A2A9F2-1", "sequence": { "header": "tr|A2A9F2-1|KDF1_MOUSE Computationally mapped isoform of Keratinocyte differentiation factor 1 OS=Mus musculus OX=10090 GN=Kdf1 PE=1 SV=8 CANONICAL=A2A9F4-1", "length": 172, "sequence": "MPRPGQPRPSSGPPRLGPWERPSELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRGCSPCLSAGDPIEGSAEAAWAKEHNGVPPSPDRAPPSRRDGQRLKTSMGSSFSYPDVKLKGIPVY" }, "locus": { "chromosome": "4", "end_pos": 133527974, "start_pos": 133528489, "strand": "-", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000153811", "id": "ENSMUST00000153811", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122170", "id": "ENSMUSP00000122170", "database": "Ensembl Peptide" } ] } }, { "url": "https://www.uniprot.org/uniprot/A2A9F4#A2A9F3-1", "isoform_ac": "A2A9F3-1", "sequence": { "header": "tr|A2A9F3-1|KDF1_MOUSE Computationally mapped isoform of Keratinocyte differentiation factor 1 OS=Mus musculus OX=10090 GN=Kdf1 PE=1 SV=1 CANONICAL=A2A9F4-1", "length": 265, "sequence": "MPRPGQPRPSSGPPRLGPWERPSELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRGCSPCLSAGDPIEGSAEAAWAKEHNGVPPSPDRAPPSRRDGQRLKTSMGSSFSYPDVKLKGIPVYPYRHATSPVPDVDSCCKEPLAEPPPTRHSLPSTFTNSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSD" }, "locus": { "chromosome": "4", "end_pos": 133527974, "start_pos": 133528768, "strand": "-", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000149807", "id": "ENSMUST00000149807", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119014", "id": "ENSMUSP00000119014", "database": "Ensembl Peptide" } ] } }, { "url": "https://www.uniprot.org/uniprot/A2A9F4#A2A9F4-1", "isoform_ac": "A2A9F4-1", "sequence": { "header": "sp|A2A9F4-1|KDF1_MOUSE Isoform 1 of Keratinocyte differentiation factor 1 OS=Mus musculus OX=10090 GN=Kdf1 PE=1 SV=1 CANONICAL=A2A9F4-1", "length": 397, "sequence": "MPRPGQPRPSSGPPRLGPWERPSELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRGCSPCLSAGDPIEGSAEAAWAKEHNGVPPSPDRAPPSRRDGQRLKTSMGSSFSYPDVKLKGIPVYPYRHATSPVPDVDSCCKEPLAEPPPTRHSLPSTFTNSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRSRPQTSEGRSARSTAPAAAPDSGHETMLGSGLSQDELTVQISQETTADAIARKLRPYGAPGYPASQDSSFQGTDTDSSGAPLLQVYC" }, "locus": { "chromosome": "4", "end_pos": 133527974, "start_pos": 133530366, "strand": "-", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000042919", "id": "ENSMUST00000042919", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000048768", "id": "ENSMUSP00000048768", "database": "Ensembl Peptide" } ] } }, { "url": "https://www.uniprot.org/uniprot/A2A9F4#A8Y5H9-1", "isoform_ac": "A8Y5H9-1", "sequence": { "header": "tr|A8Y5H9-1|KDF1_MOUSE Computationally mapped isoform of Keratinocyte differentiation factor 1 OS=Mus musculus OX=10090 GN=Kdf1 PE=1 SV=1 CANONICAL=A2A9F4-1", "length": 375, "sequence": "MPRPGQPRPSSGPPRLGPWERPSELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRGCSPCLSAGDPIEGSAEAAWAKEHNGVPPSPDRAPPSRRDGQRLKTSMGSSFSYPDVKLKGIPVYPYRHATSPVPDVDSCCKEPLAEPPPTRHSLPSTFTNSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRSRPQTSEGRSARSTAPAAAPDSGHETMLGSGLSQDELTVQISQETTADAIARKLRPYGAPGVVLT" }, "locus": { "chromosome": "4", "end_pos": 133527974, "start_pos": 133529919, "strand": "-", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000121797", "id": "ENSMUST00000121797", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000113590", "id": "ENSMUSP00000113590", "database": "Ensembl Peptide" } ] } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69073", "resource": "KEGG Pathway", "id": "mmu:69073", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4#function", "annotation": "Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4#function", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385.1", "annotation": "The Keratinocyte differentiation factor 1 is an essential regulator of the proliferation-differentiation balance in epidermal progenitor cells.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385.1", "id": "NP_001077385.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q6AY88-1", "protein_name": "Keratinocyte differentiation factor 1", "sequence": { "length": 397, "sequence": "MPRPGQPRPSSGPPRLGPWERPTELCLETNDERSQPPPGRRTRRPDPKDPGHHGPESITFISGSAEPANEPPTCCLLWRPWGWDWCRAAFCFRRCRDCLQRCGACVRSCSPCLSAGDPIEGSSEAAWAKEHNGVPPSPDRAPPSRRDGQKLKTSMGSSFSYPDVKLKGIPVYPYRHATSPVPDADSCCKEPLADPPPTRHSLPSTFTSSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRSRPQTSEGRSARSTAPAAAPDSGHETMVGSGLSQDELTVQISQETTADAIARKLRPYGAPGYPASQDSSFQGTDTDSSGAPLLQVYC" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/17563", "id": "17563", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2A9F4/", "id": "A2A9F4", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q8NAX2-1", "protein_name": "Keratinocyte differentiation factor 1", "sequence": { "length": 398, "sequence": "MPRPGHPRPASGPPRLGPWERPTELCLETYDKPPQPPPSRRTRRPDPKDPGHHGPESITFISGSAEPALESPTCCLLWRPWVWEWCRAAFCFRRCRDCLQRCGACVRGCSPCLSTEDSTEGTAEANWAKEHNGVPPSPDRAPPSRRDGQRLKSTMGSSFSYPDVKLKGIPVYPYPRATSPAPDADSCCKEPLADPPPMRHSLPSTFASSPRGSEEYYSFHESDLDLPEMGSGSMSSREIDVLIFKKLTELFSVHQIDELAKCTSDTVFLEKTSKISDLISSITQDYHLDEQDAEGRLVRGIIRISTRKSRARPQTSEGRSTRAAAPTAAAPDSGHETMVGSGLSQDELTVQISQETTADAIARKLRPYGAPGYPASHDSSFQGTDTDSSGAPLLQVYC" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/17563", "id": "17563", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2A9F4/", "id": "A2A9F4", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385.1", "ac": "NP_001077385.1", "name": "keratinocyte differentiation factor 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "24075906", "id": "GO:0005737", "name": "cytoplasm", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "pmid": "24075906", "id": "GO:0005938", "name": "cell cortex", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "pmid": "24075906", "id": "GO:0030054", "name": "cell junction", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031252", "pmid": "24075906", "id": "GO:0031252", "name": "cell leading edge", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "id": "GO:0005654", "name": "nucleoplasm", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "pmid": "", "id": "GO:0072686", "name": "mitotic spindle", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060887", "pmid": "24075906", "id": "GO:0060887", "name": "limb epidermis development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000647", "pmid": "24075906", "id": "GO:2000647", "name": "negative regulation of stem cell proliferation", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061436", "pmid": "24075906", "id": "GO:0061436", "name": "establishment of skin barrier", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016331", "pmid": "24075906", "id": "GO:0016331", "name": "morphogenesis of embryonic epithelium", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003334", "pmid": "24075906", "id": "GO:0003334", "name": "keratinocyte development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010482", "pmid": "24075906", "id": "GO:0010482", "name": "regulation of epidermal cell division", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010839", "pmid": "24075906", "id": "GO:0010839", "name": "negative regulation of keratinocyte proliferation", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045606", "pmid": "24075906", "id": "GO:0045606", "name": "positive regulation of epidermal cell differentiation", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048589", "pmid": "24075906", "id": "GO:0048589", "name": "developmental growth", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] } ], "total": 9, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A9F4", "resource": "RefSeq", "type": "synonym", "name": "1810019J16Rik" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A9F4", "resource": "RefSeq", "type": "synonym", "name": "Kdf1" }, { "url": "https://www.uniprot.org/uniprot/A2A9F4", "resource": "UniProtKB", "type": "recommended", "name": "Kdf1" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037600", "id": "ENSMUSG00000037600", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/69073", "id": "69073", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028003", "id": "IPR028003", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:69073", "id": "mmu:69073", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1916323", "id": "1916323", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/DQLAKCT/", "id": "DQLAKCT", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=896286at2759", "id": "896286at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR35085", "id": "PTHR35085", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF15551", "id": "PF15551", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A9F4", "id": "PR_A2A9F4", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077385.1", "id": "NP_001077385.1", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "218", "kinase_gene_name": "Atxn7l3b", "kinase_uniprot_canonical_ac": "Q3UD01-1", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ] }, { "residue": "Ser", "position": "218", "kinase_gene_name": "", "kinase_uniprot_canonical_ac": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "id": "A2A9F4", "database": "UniProtKB" } ] } ], "mass": { "monoisotopic_mass": 43496.0, "chemical_mass": 43496.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "name": "Kdf1", "locus": { "chromosome": "4", "end_pos": 133530790, "start_pos": 133518963, "strand": "+", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000037600", "id": "ENSMUSG00000037600", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2A9F4", "resource": "UniProtKB", "type": "recommended", "name": "Keratinocyte differentiation factor 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A9F4", "resource": "RefSeq", "type": "synonym", "name": "keratinocyte differentiation factor 1" } ] }