{ "uniprot_canonical_ac": "A0A1B0GTL2-1", "ptm_annotation": [], "sequence": { "header": "sp|A0A1B0GTL2-1|CT204_HUMAN Isoform 1 of Uncharacterized protein C20orf204 OS=Homo sapiens OX=9606 GN=C20orf204 PE=3 SV=1 CANONICAL=A0A1B0GTL2-1", "length": 189, "sequence": "MVPPKPALWALLLALLGTAPSRAYSPACSVPDVLRHYRAIIFEDLQAAVKWGGAGAEKTRPGSRHFHFIQKNLTRPGSSGRRGRPRASCGAQKEHSILLSISSLGRTLRGAVAGGRRGALERAAWTVAVRTEAVMRRHCRTLRQRSRRPKMRPARRRGGRRQLLLRALDAVATCWEKLFALRAPASRDS" }, "uniprot_id": "CT204_HUMAN", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Human", "taxid": 9606, "name": "Homo sapiens", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GTL2", "id": "A0A1B0GTL2", "database": "UniProtKB" } ] } ], "crossref_internal": { "gene": [ "C20orf204" ], "site": [ "A0A1B0GTL2-1.72.74", "A0A1B0GTL2-1.101.101", "A0A1B0GTL2-1.72.72" ], "species": [ 9606 ] }, "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28869604", "type": [ "PubMed" ], "id": "28869604" } ], "title": "Myc target gene, long intergenic noncoding RNA, Linc00176 in hepatocellular carcinoma regulates cell cycle and cell survival by titrating tumor suppressor microRNAs.", "journal": "Oncogene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335019.1", "id": "NP_001335019.1", "database": "RefSeq" } ], "authors": "Tran DDH, Kessler C, Niehus SE, Mahnkopf M, Koch A, Tamura T", "date": "2018" } ], "uniprot_ac": "A0A1B0GTL2", "site_annotation": [ { "end_pos": 74, "annotation": "n_glycosylation_sequon", "start_pos": 72 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GTL2#A0A1B0GTL2-1", "isoform_ac": "A0A1B0GTL2-1", "sequence": { "header": "sp|A0A1B0GTL2-1|CT204_HUMAN Isoform 1 of Uncharacterized protein C20orf204 OS=Homo sapiens OX=9606 GN=C20orf204 PE=3 SV=1 CANONICAL=A0A1B0GTL2-1", "length": 189, "sequence": "MVPPKPALWALLLALLGTAPSRAYSPACSVPDVLRHYRAIIFEDLQAAVKWGGAGAEKTRPGSRHFHFIQKNLTRPGSSGRRGRPRASCGAQKEHSILLSISSLGRTLRGAVAGGRRGALERAAWTVAVRTEAVMRRHCRTLRQRSRRPKMRPARRRGGRRQLLLRALDAVATCWEKLFALRAPASRDS" }, "locus": { "chromosome": "20", "end_pos": 64036324, "start_pos": 64038756, "strand": "-", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000636176", "id": "ENST00000636176", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000489747", "id": "ENSP00000489747", "database": "Ensembl Peptide" } ] } }, { "url": "https://www.uniprot.org/uniprot/A0A1B0GTL2#A0A1B0GVI8-1", "isoform_ac": "A0A1B0GVI8-1", "sequence": { "header": "tr|A0A1B0GVI8-1|CT204_HUMAN Computationally mapped isoform of Uncharacterized protein C20orf204 OS=Homo sapiens OX=9606 GN=C20orf204 PE=3 SV=1 CANONICAL=A0A1B0GTL2-1", "length": 69, "sequence": "XKNLTRPGSSGRRGRPRASCGAQKRSRRPKMRPARRRGGRRQLLLRALDAVATCWEKLFALRAPASRDS" }, "locus": { "chromosome": "20", "end_pos": 64038132, "start_pos": 64038757, "strand": "-", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000463337", "id": "ENST00000463337", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000490531", "id": "ENSP00000490531", "database": "Ensembl Peptide" } ] } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:284739", "resource": "KEGG Pathway", "id": "hsa:284739", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335019.1", "annotation": "Study identified a novel long intergenic noncoding RNA, Linc00176, that plays a role in proliferation and survival of hepatocellular carcinoma.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335019.1", "id": "NP_001335019.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A0A140LIA7-1", "protein_name": "Uncharacterized protein C20orf204 homolog", "sequence": { "length": 188, "sequence": "MVRPKLAFYILPLLLAFLGSALGWPGSQSCSVQEVLRHYQAVIFQDLQTAMQWAGLGVQHTQPGSRHHRFIQKNLTGAGGGQGQPGTSCDAQKESSILLSIESLGQTLLGSVAGVPHNALEKAAWTVAVRTEAVMRRHCGTSYRIQQPRKHAVQLRNSRRRLLLRALYAVATCWEKLFALSAMATGEF" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A1B0GTL2/", "id": "A0A1B0GTL2", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "D3ZCA7-1", "protein_name": "Long intergenic non-protein coding RNA 176", "sequence": { "length": 188, "sequence": "MVPLKPAFYLLLLLLAFLGSALGWPGSQSCSVQEVLRHYQAVIFQDLQAAMQWAGMGVQRTEPGSRHHRFIQKNLTGAGGGQGQPGTSCGAQKESSILLSIESLGQTLLGSVAGVPHNAFEKAAWTVAVRTEAVMRRHCRISYRIQQPKKQAVQPRSSRRRLLLRALYAVATCWEKLFALSALATGEF" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A1B0GTL2/", "id": "A0A1B0GTL2", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [ { "sequence_org": "I", "alt_nt": "A", "chr_id": "20", "ref_nt": "T", "chr_pos": "64038318", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1406266195", "id": "rs1406266195", "database": "dbSNP" }, { "url": "https://www.ncbi.nlm.nih.gov/snp/rs1406266195#frequency_tab", "id": "rs1406266195", "database": "TOPMed" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "sequence_mut": "N", "start_pos": 101, "keywords": [ "ebi", "germline" ], "end_pos": 101, "minor_allelic_frequency": "", "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (ISS->NSS)." } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335019.1", "ac": "NP_001335019.1", "name": "uncharacterized protein C20orf204 precursor", "summary": "" }, "go_annotation": {}, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A1B0GTL2", "resource": "RefSeq", "type": "synonym", "name": "C20orf204" }, { "url": "https://www.uniprot.org/uniprot/A0A1B0GTL2", "resource": "UniProtKB", "type": "recommended", "name": "C20orf204" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A1B0GTL2", "resource": "RefSeq", "type": "synonym", "name": "LINC00176; NCRNA00176; PRR17" }, { "url": "https://www.uniprot.org/uniprot/A0A1B0GTL2", "resource": "UniProtKB", "type": "synonym", "name": "PRR17" } ], "pro_annotation": [], "crossref": [ { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=C20orf204", "id": "C20orf204", "database": "GeneCards" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/284739", "id": "284739", "database": "GeneID" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=27655", "id": "27655", "database": "HGNC" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:284739", "id": "hsa:284739", "database": "KEGG Pathway" }, { "url": "https://www.nextprot.org/entry/NX_A0A1B0GTL2", "id": "NX_A0A1B0GTL2", "database": "neXtProt" }, { "url": "https://omabrowser.org/oma/group/EKAAWTV/", "id": "EKAAWTV", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1480156at2759", "id": "1480156at2759", "database": "OrthoDB" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0A1B0GTL2", "id": "PR_A0A1B0GTL2", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335019.1", "id": "NP_001335019.1", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [ { "residue": "Asn", "site_category": "predicted", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GTL2#ptm_processing", "id": "A0A1B0GTL2", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "position": 72, "glytoucan_ac": "", "type": "N-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 20914.0, "chemical_mass": 20914.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GTL2", "name": "C20orf204", "locus": { "chromosome": "20", "end_pos": 64039962, "start_pos": 64034344, "strand": "+", "evidence": [ { "url": "https://www.ensembl.org/id/ENSG00000196421", "id": "ENSG00000196421", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A1B0GTL2", "resource": "UniProtKB", "type": "recommended", "name": "Uncharacterized protein C20orf204" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A1B0GTL2", "resource": "RefSeq", "type": "synonym", "name": "proline rich 17; putative proline-rich protein 17; long intergenic non-protein coding RNA 176; uncharacterized protein C20orf204" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A1B0GTL2", "resource": "RefSeq", "type": "synonym", "name": "uncharacterized protein C20orf204 precursor" } ] }