{ "bcoid": "GLY_000324", "title": "Mouse Protein Enzyme Annotation (UniProtKB)", "description": "The Mouse Protein Enzyme Annotation (UniProtKB) dataset contains mouse [taxid:10090] enzyme annotations ...", "filename": "mouse_protein_enzyme_annotation_uniprotkb.csv", "filetype": "csv", "categories": { "species": "Mus musculus", "molecule": "Protein", "tags": "enzyme annotation", "file_type": "csv", "status": "Reviewed", "scope": "internal" }, "minitable": { "content": [ [ "A2RSX7-1...", "1.14.11.42..." ], [ "A2RSX7-1...", "1.14.11.42..." ] ], "headers": [ "uniprotkb_ca...", "enzyme_ec..." ], "colwidth": [ "40%", "20%" ] }, "sampledata": { "type": "table", "data": [ [ { "type": "string", "label": "uniprotkb_canonical_ac" }, { "type": "string", "label": "enzyme_ec" }, { "type": "string", "label": "enzyme_activity" } ], [ "A2RSX7-1", "1.14.11.42", "7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2)." ], [ "A2RSX7-1", "1.14.11.42", "" ], [ "Q6NSR3-1", "2.7.11.-", "" ], [ "Q6NSR3-1", "2.7.11.-", "" ], [ "Q6NSR8-1", "3.4.11.-", "" ], [ "Q6NSR8-1", "3.4.11.-", "" ], [ "P83855-1", "4.6.1.1", "ATP = 3',5'-cyclic AMP + diphosphate." ], [ "P83855-1", "4.6.1.1", "" ], [ "O70250-1", "5.4.2.11", "2-phospho-D-glycerate = 3-phospho-D-glycerate." ], [ "O70250-1", "5.4.2.4", "3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." ], [ "O70250-1", "5.4.2.4", "" ], [ "O70250-1", "5.4.2.11", "" ], [ "O70252-1", "1.14.14.18", "Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = biliverdin + Fe(2+) + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O." ], [ "O70252-1", "1.14.14.18", "" ], [ "Q9WUD1-1", "2.3.2.27", "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine." ], [ "Q9WUD1-1", "2.3.2.27", "" ], [ "O54785-1", "2.7.11.1", "ATP + a protein = ADP + a phosphoprotein." ], [ "O54785-1", "2.7.11.1", "" ], [ "O54784-1", "2.7.11.1", "ATP + a protein = ADP + a phosphoprotein." ], [ "O54784-1", "2.7.11.1", "" ], [ "Q811W2-1", "1.14.13.-", "" ], [ "Q811W2-1", "1.14.13.-", "" ], [ "Q9CXG3-1", "5.2.1.8", "Peptidylproline (omega=180) = peptidylproline (omega=0)." ], [ "Q9CXG3-1", "5.2.1.8", "" ], [ "O55047-1", "2.7.11.1", "ATP + a protein = ADP + a phosphoprotein." ], [ "O55047-1", "2.7.11.1", "" ], [ "P03899-1", "7.1.1.2", "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)." ], [ "P03899-1", "7.1.1.2", "" ], [ "P48964-1", "3.1.3.48", "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." ], [ "P48964-1", "3.1.3.48", "" ], [ "P48967-1", "3.1.3.48", "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." ], [ "P48967-1", "3.1.3.48", "" ], [ "P03893-1", "7.1.1.2", "NADH + ubiquinone + 5 H(+)(Side 1) = NAD(+) + ubiquinol + 4 H(+)(Side 2)." ], [ "P03893-1", "7.1.1.2", "" ], [ "Q9Z0S1-1", "3.1.3.7", "Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate." ], [ "Q9Z0S1-1", "3.1.3.7", "" ], [ "P52479-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "P52479-1", "3.4.19.12", "" ], [ "Q8BLF1-1", "3.1.1.-", "" ], [ "Q8BLF1-1", "3.1.1.-", "" ], [ "Q8BLF2-1", "2.7.11.22", "ATP + a protein = ADP + a phosphoprotein." ], [ "Q8BLF2-1", "2.7.11.22", "" ], [ "Q8BTW8-1", "2.8.4.3", "N(6)-(3-methylbut-2-en-1-yl)-adenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + reduced electron acceptor = N(6)-(3-methylbut-2-en-1-yl)-2-(methylsulfanyl)adenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine + electron acceptor." ], [ "Q8BTW8-1", "2.8.4.3", "" ], [ "Q8BTW9-1", "2.7.11.1", "ATP + a protein = ADP + a phosphoprotein." ], [ "Q8BTW9-1", "2.7.11.1", "" ], [ "Q61409-1", "3.1.4.17", "Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate." ], [ "Q61409-1", "3.1.4.17", "" ], [ "Q9JKK8-1", "2.7.11.1", "ATP + a protein = ADP + a phosphoprotein." ], [ "Q9JKK8-1", "2.7.11.1", "" ], [ "Q80YU0-1", "3.-.-.-", "" ], [ "Q80YU0-1", "3.-.-.-", "" ], [ "P21180-1", "3.4.21.43", "Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b." ], [ "P21180-1", "3.4.21.43", "" ], [ "Q14BT6-1", "2.4.1.-", "" ], [ "Q14BT6-1", "2.4.1.-", "" ], [ "Q8BUM9-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "Q8BUM9-1", "3.4.19.12", "" ], [ "Q99MQ3-1", "2.7.11.1", "ATP + a protein = ADP + a phosphoprotein." ], [ "Q99MQ3-1", "2.7.11.1", "" ], [ "P70419-1", "2.4.1.41", "UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-threonine." ], [ "P70419-1", "2.4.1.41", "" ], [ "Q8C078-1", "2.7.11.17", "ATP + a protein = ADP + a phosphoprotein." ], [ "Q8C078-1", "2.7.11.17", "" ], [ "Q9EP78-1", "2.8.2.-", "" ], [ "Q9EP78-1", "2.8.2.17", "3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." ], [ "Q9EP78-1", "2.8.2.-", "" ], [ "Q9EP78-1", "2.8.2.17", "" ], [ "P56399-1", "3.4.19.12", "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)." ], [ "P56399-1", "3.4.19.12", "" ], [ "Q9EP75-1", "1.14.14.94", "(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + [reduced NADPH--hemoprotein reductase] + O(2) = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + [oxidized NADPH--hemoprotein reductase] + H(2)O." ], [ "Q9EP75-1", "1.14.14.94", "" ], [ "O88455-1", "1.3.1.21", "Cholesterol + NADP(+) = cholesta-5,7-dien-3-beta-ol + NADPH." ], [ "O88455-1", "1.3.1.21", "" ], [ "O88451-1", "1.1.1.105", "All-trans-retinol-[cellular-retinol-binding-protein] + NAD(+) = all-trans-retinal-[cellular-retinol-binding-protein] + NADH." ], [ "O88451-1", "1.1.1.105", "" ], [ "Q9R0Q7-1", "5.3.99.3", "(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate." ], [ "Q9R0Q7-1", "5.3.99.3", "" ], [ "Q80W65-1", "3.4.21.-", "" ], [ "Q80W65-1", "3.4.21.-", "" ], [ "Q8VCW8-1", "6.2.1.2", "ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium-chain acyl-CoA." ], [ "Q8VCW8-1", "6.2.1.2", "" ], [ "P19096-1", "2.3.1.85", "Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+)." ], [ "P19096-1", "2.3.1.39", "Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein]." ] ] }, "readme": "Name\n - Mouse Protein Enzyme Annotation (UniProtKB)\n\nVersion\n - 1.8.25\n\nCreated on\n - 2019-12-01T15:59:48.968222\n\nModified on\n - 2020-04-10T12:48:22.718557\n\nCreated by\n - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu]\n\nAuthors\n - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n - \n\nUsability Domain\n - The Mouse Protein Enzyme Annotation (UniProtKB) dataset contains mouse [taxid:10090] enzyme annotations for UniProtKB canonical accessions. The dataset contains ec numbers and enzyme activity that describes the enzymatic reactions. The dataset is derived form 2019-09 UniprotKB release. If you use this dataset please give proper attribution to UniProtKB and GlyGen\n\nDescription Domain\n Keywords\n - enzyme annotation\n - enzyme \n - UniProtKB\n - enzyme activity\n - EC number\n\n Pipeline Steps\n - Step-1: The script extracts the enzyme annotation triples from the triplestore for the UniProtKB canonical sequnces asnd extracts as a dataset in a csv format\n\nExecution Domain\n Scripts - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n Software Prerequisites\n Name: Python\n Version: 2.7.5\n URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n Input Subdomain\n Name: uniprot-proteome-mus-musculus.nt\n URI: https://data.glygen.org/ln2wwwdata/reviewed/uniprot-proteome-mus-musculus.nt\n Name: mouse_protein_masterlist.csv\n URI: https://data.glygen.org/ln2wwwdata/reviewed/mouse_protein_masterlist.csv\n Output Subdomain\n Name: mouse_protein_enzyme_annotation_uniprotkb.csv\n URI: http://data.glygen.org/ln2wwwdata/reviewed/mouse_protein_enzyme_annotation_uniprotkb.csv\n Name: mouse_protein_enzyme_annotation_uniprotkb.stat.csv\n URI: http://data.glygen.org/ln2wwwdata/reviewed/mouse_protein_enzyme_annotation_uniprotkb.stat.csv\n\nFields\n Name: \"src_xref_key\"\n Description: \"Source Xref key\"\n Unique Values: \"1\"\n Name: \"xref_id\"\n Description: \"ID of the X-ref\"\n Unique Values: \"119\"\n Name: \"title\"\n Description: \"Title of the published article in the journal\"\n Unique Values: \"119\"\n Name: \"src_xref_id\"\n Description: \"Source X-ref ID\"\n Unique Values: \"120\"\n Name: \"journal_name\"\n Description: \"The name of the journal in which the article is published\"\n Unique Values: \"49\"\n Name: \"authors\"\n Description: \"NA\"\n Unique Values: \"118\"\n Name: \"publication_date\"\n Description: \"Contains the full date on which the issue of the journal was published. Sourced from MEDLINE/PubMed data element(fields) description.\"\n Unique Values: \"117\"\n Name: \"glytoucan_ac\"\n Description: \"Unique accession assigned to the registered glycan structure in GlyTouCan database\"\n Unique Values: \"115\"\n Name: \"xref_key\"\n Description: \"Source key associated to the xref_id\"\n Unique Values: \"1\"", "downloadurl": "/ln2data/releases/data/v-1.8.25/reviewed/mouse_protein_enzyme_annotation_uniprotkb.csv" }