{
    "bcoid": "GLY_000133",
    "title": "Human Protein Function (NCBI Refseq)",
    "description": "The Human Protein Function (NCBI RefSeq) dataset contains biological function annotaion of human [taxid:9606] ...",
    "filename": "human_protein_function_refseq.csv",
    "filetype": "csv",
    "categories": {
        "species": "Homo sapiens",
        "molecule": "Protein",
        "tags": "Protein Function",
        "file_type": "csv",
        "status": "Reviewed",
        "scope": "internal"
    },
    "minitable": {
        "content": [
            [
                "Q9Y5H2-1...",
                "protein_xref..."
            ],
            [
                "Q9Y5H2-1...",
                "protein_xref..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "xref_key..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "xref_key"
                },
                {
                    "type": "string",
                    "label": "xref_id"
                },
                {
                    "type": "string",
                    "label": "evidence"
                },
                {
                    "type": "string",
                    "label": "annotation"
                }
            ],
            [
                "Q9Y5H2-1",
                "protein_xref_refseq",
                "NP_061737.1",
                "20388442",
                "The promoter methylation and mRNA expressions of EMP3 and PCDH-gamma-A11 are closely related with the malignant development of glioma."
            ],
            [
                "Q9Y5H2-1",
                "protein_xref_refseq",
                "NP_061737.1",
                "15799819",
                "PCDH-gamma-A11 is silenced epigenetically in astrocytic gliomas"
            ],
            [
                "Q9BSR8-1",
                "protein_xref_refseq",
                "NP_115688.1",
                "27999994",
                "The significance of YIPF4 protein for the maintenance of the morphology of the Golgi was tested by RNA interference, revealing a number of specific morphological changes to this organelle on their depletion."
            ],
            [
                "Q9BSR8-1",
                "protein_xref_refseq",
                "NP_115688.1",
                "26235900",
                "YIPF4 is a binding partner of the papillomavirus E5 proteins. Publication Status: Online-Only"
            ],
            [
                "Q9BSR8-1",
                "protein_xref_refseq",
                "NP_115688.1",
                "21757827",
                "YIPF4 was detected as a single mobility form consistent with its predicted molecular weight, three different mobility forms of YIPF3 were detected by western blotting."
            ],
            [
                "Q86SG6-1",
                "protein_xref_refseq",
                "NP_835464.1",
                "27892797",
                "NEK8 plays a critical role in replication fork stability through its regulation of the DNA repair and replication fork protection protein RAD51."
            ],
            [
                "Q86SG6-1",
                "protein_xref_refseq",
                "NP_835464.1",
                "15872312",
                "Characterization of the proteome in mice that have a double point mutation in the related gene."
            ],
            [
                "Q86SG6-1",
                "protein_xref_refseq",
                "NP_835464.1",
                "15019993",
                "Data demonstrate for the first time that Nek8 is a novel tumor associated gene, and shares considerable sequence homology with the Nek family of protein kinases and may be involved in G(2)/M progression."
            ],
            [
                "E2RYF6-1",
                "protein_xref_refseq",
                "NP_001185744.1",
                "28262390",
                "Genes TGFB1, TLE4 and MUC22 are associated with the risk of childhood asthma in Chinese population."
            ],
            [
                "E2RYF6-1",
                "protein_xref_refseq",
                "NP_001185744.1",
                "20981447",
                "The mucin-like gene PBMUCL1 is also one of the candidate genes of Diffuse panbronchiolitis susceptibility."
            ],
            [
                "Q8N5H3-3",
                "protein_xref_refseq",
                "NP_001092254.1",
                "25107909",
                "The functional relevance of the LRAP25-MRCK complex in LIMK1-cofilin signaling and the importance of LRAP adaptors as key determinants of MRCK cellular localization and downstream specificities."
            ],
            [
                "Q8N5H3-3",
                "protein_xref_refseq",
                "NP_001092254.1",
                "11958456",
                "Identified two human genes, Mtvr1 and Mtvr2, encoding proteins highly related to the Mouse Mammary Tumor Virus receptor [Mtvr1] [Mtvr2]"
            ],
            [
                "Q96LR9-1",
                "protein_xref_refseq",
                "NP_001123887.1",
                "20628086",
                "Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)"
            ],
            [
                "Q96LR9-1",
                "protein_xref_refseq",
                "NP_001123887.1",
                "19913121",
                "Observational study of gene-disease association. (HuGE Navigator)"
            ],
            [
                "O75362-1",
                "protein_xref_refseq",
                "NP_006517.1",
                "31454071",
                "ZNF217 inhibited both COX2 and PGE2 synthesis through estradiol in KGN cells. ZNF217 and aromatase were decreased, whereas COX2 and PGE2 were increased in the GC of women with PCOS"
            ],
            [
                "O75362-1",
                "protein_xref_refseq",
                "NP_006517.1",
                "30898548",
                "Indicated ZNF217 could recruit LSD1 to affect CDH1 epigenetic expression from transcription level."
            ],
            [
                "O75362-1",
                "protein_xref_refseq",
                "NP_006517.1",
                "28607476",
                "ZNF217 contributed to ovarian hyperstimulation syndrome (OHSS) onset through promoting E2 synthesis and the increase of vascular permeability . Increased ZNF217 and decreased TSP-1 provided new targets for the prevention or treatment of OHSS Publication Status: Online-Only"
            ],
            [
                "O75362-1",
                "protein_xref_refseq",
                "NP_006517.1",
                "28207159",
                "The report shows that the ZNF217 oncogene is a crucial mediator and indicator of bone metastasis from breast cancer."
            ],
            [
                "O75362-1",
                "protein_xref_refseq",
                "NP_006517.1",
                "27768596",
                "This study underscored that elevated expression of ZNF217 promotes prostate cancer growth by restraining ferroportin -conducted iron egress"
            ],
            [
                "Q92932-1",
                "protein_xref_refseq",
                "NP_001295196.1",
                "30890718",
                "The association of genetically controlled CpG methylation (cg158269415) of protein tyrosine phosphatase, receptor type N2 (PTPRN2) with childhood obesity. Publication Status: Online-Only"
            ],
            [
                "Q92932-1",
                "protein_xref_refseq",
                "NP_001295196.1",
                "27489308",
                "Copy-number variations are enriched for PTPRN2 and other neurodevelopmental genes in children with developmental coordination disorder."
            ],
            [
                "Q92932-1",
                "protein_xref_refseq",
                "NP_001295196.1",
                "27153397",
                "Haplotype-dependent allele-specific methylation of PTPRN2 gene is associated with neurological disorders."
            ],
            [
                "Q92932-1",
                "protein_xref_refseq",
                "NP_001295196.1",
                "26620550",
                "Reduction in plasma membrane PI(4,5)P2 abundance by PTPRN2 and PLCbeta1 releases the PI(4,5)P2-binding protein cofilin from its inactive membrane-associated state into the cytoplasm where it mediates actin turnover dynamics."
            ],
            [
                "Q92932-1",
                "protein_xref_refseq",
                "NP_001295196.1",
                "20097759",
                "While PTPRN2 shares sequence similarity with protein tyrosine phosphatases, this study in rat suggests that this protein instead functions as a membrane bound phosphatidylinositol phosphatase."
            ],
            [
                "Q8NE22-1",
                "protein_xref_refseq",
                "NP_001165461.1",
                "28029147",
                "SNP variants at the MAP3K1/SETD9 gene boundary associate with somatic PIK3CA variants in breast cancers."
            ],
            [
                "P15121-1",
                "protein_xref_refseq",
                "NP_001619.1",
                "32412859",
                "AKR1B1 plays an important role in the occurrence and development of GC"
            ],
            [
                "P15121-1",
                "protein_xref_refseq",
                "NP_001619.1",
                "31604989",
                "Vitamin K1 prevents diabetic cataract by inhibiting lens aldose reductase 2 (ALR2) activity. Publication Status: Online-Only"
            ],
            [
                "P15121-1",
                "protein_xref_refseq",
                "NP_001619.1",
                "31539366",
                "ALR2 rs759853 and SDH rs2055858 polymorphisms were respectively associated with a higher and lower risk of diabetic retinopathy. Publication Status: Online-Only"
            ],
            [
                "P15121-1",
                "protein_xref_refseq",
                "NP_001619.1",
                "30816220",
                "Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation. Publication Status: Online-Only"
            ],
            [
                "Q9NRY2-1",
                "protein_xref_refseq",
                "NP_067041.1",
                "29150435",
                "INTS3, but not C9ORF80, affects the nucleic acid-binding ability of hNABP1 and hNABP2, indicating that INTS3 might regulate hNABP1/hNABP2 biological function, while the role of C9ORF80 remains unknown. Publication Status: Online-Only"
            ],
            [
                "Q9NRY2-1",
                "protein_xref_refseq",
                "NP_067041.1",
                "19786574",
                "MISE is part of the INTS3/MISE/hSSB1 (IMS1) complex, which controls the DNA damage response"
            ],
            [
                "Q9NRY2-1",
                "protein_xref_refseq",
                "NP_067041.1",
                "19605351",
                "HSSBIP1 forms complexes with INTS3/hSSB1 and INTS3/hSSB2 and participates in the DNA damage response"
            ],
            [
                "Q9NRY2-1",
                "protein_xref_refseq",
                "NP_067041.1",
                "19683501",
                "SOSS-C is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability."
            ],
            [
                "Q15777-1",
                "protein_xref_refseq",
                "NP_001138871.1",
                "32040219",
                "CTN2 (rs6655267) and MPPED2 (rs536007) are not associated with primary dentition caries. MPPED2 (rs11031093, G Allele) is marginally associated."
            ],
            [
                "Q15777-1",
                "protein_xref_refseq",
                "NP_001138871.1",
                "30846004",
                "Findings indicate that epigenetic alterations of MPPED2 promoter region appear sequentially during the colorectal neoplastic progression. Publication Status: Online-Only"
            ],
            [
                "Q15777-1",
                "protein_xref_refseq",
                "NP_001138871.1",
                "21824479",
                "The structures of MPPED2 and two mutants show that the poor activity of MPPED2 is not only a consequence of the substitution of an active-site histidine residue by glycine but also due to binding of AMP or GMP to the active site."
            ],
            [
                "Q15777-1",
                "protein_xref_refseq",
                "NP_001138871.1",
                "19240061",
                "Observational study of gene-disease association. (HuGE Navigator)"
            ],
            [
                "P40424-1",
                "protein_xref_refseq",
                "NP_001191892.1",
                "31488872",
                "HNRPDL transforms hematopoietic cells and a novel HNRPDL/PBX1 axis plays an important role in human CML CD34(+) cells"
            ],
            [
                "P40424-1",
                "protein_xref_refseq",
                "NP_001191892.1",
                "31885790",
                "Findings show that NANOG delays HF-MSC senescence by upregulating PBX1 and activating AKT signaling and that a feedback loop likely exists between PBX1 and AKT signaling. Publication Status: Online-Only"
            ],
            [
                "P40424-1",
                "protein_xref_refseq",
                "NP_001191892.1",
                "31684818",
                "Expression of PBX1 and MMD was higher in the second trimester among lupus patients who experienced a poor pregnancy outcome compared to those who did not.  The pilot study identified two candidate genes that are reflective of the platelet function response to aspirin."
            ],
            [
                "Q9Y294-1",
                "protein_xref_refseq",
                "NP_054753.1",
                "31286799",
                "ASF1A regulated H4(Y72ph) and promotes autophagy in colon cancer cells via a kinase activity through regulation of ATG"
            ],
            [
                "Q9Y294-1",
                "protein_xref_refseq",
                "NP_054753.1",
                "31229404",
                "We demonstrate that the CIA-targeting complex promotes the ability of FBXL5 to degrade iron regulatory proteins. In addition, the FBXL5-CIA-targeting complex interaction is regulated by oxygen (O2) tension displaying a robust association in 21% O2 that is severely diminished in 1% O2 and contributes to O2-dependent regulation of IRP degradation"
            ],
            [
                "Q9Y294-1",
                "protein_xref_refseq",
                "NP_054753.1",
                "30093638",
                "Faithful transmission of histone variants involves ASF1 and can be impacted by replication stress, with ensuing consequences for cell fate and tumorigenesis Publication Status: Online-Only"
            ],
            [
                "Q9Y294-1",
                "protein_xref_refseq",
                "NP_054753.1",
                "11897662",
                "Model is proposed in which the synergism between hAsf1 and CAF-1 for nucleosome formation during DNA repair is achieved through a transient physical interaction allowing histone delivery from Asf1 to CAF-1"
            ],
            [
                "Q9UQF2-1",
                "protein_xref_refseq",
                "NP_005447.1",
                "30026235",
                "Extensive biochemical characterization of the KLC:JIP1 interaction, as well as identification of potential KLC1-binding partners, improves the understanding of how this growing family of cargos is recruited to kinesin1 by KLC1."
            ],
            [
                "Q9UQF2-1",
                "protein_xref_refseq",
                "NP_005447.1",
                "27891669",
                "All binary complexes (KLC1:APP, KLC1:JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 and JIP1 may take part in APP transport in Alzheimer's disease patients."
            ],
            [
                "Q9UQF2-1",
                "protein_xref_refseq",
                "NP_005447.1",
                "23825109",
                "Analysis of the role of JIP1 in APP transport; knockdown of JIP1 did not affect either amyloid precursor protein transport or amyloid-beta peptide production"
            ],
            [
                "Q3ZCQ2-1",
                "protein_xref_refseq",
                "NP_001014301.1",
                "29694949",
                "Overexpression of AX2R significantly inhibited cell proliferation, migration and tube formation in both types of endothelial cells and increased the expression of KLF2, mediating VEGF and VEGFR2."
            ],
            [
                "Q3ZCQ2-1",
                "protein_xref_refseq",
                "NP_001014301.1",
                "27183438",
                "Data highlighted the crucial role of AXIIR in reducing Mum2C cell viability through inducing apoptosis, while autophagy played a protective role in this process."
            ],
            [
                "Q3ZCQ2-1",
                "protein_xref_refseq",
                "NP_001014301.1",
                "25633185",
                "These subsequent effects might be via suppressing the expression of matrix metalloproteinase 2 and matrix metalloproteinase 9. ... AXIIR participates in angiogenesis, and may be a potential therapeutic target for angiogenesis related diseases"
            ],
            [
                "Q3ZCQ2-1",
                "protein_xref_refseq",
                "NP_001014301.1",
                "23640736",
                "AXIIR acts as a novel inducer of apoptosis in human cells, partially through activating Caspase-8."
            ],
            [
                "Q3ZCQ2-1",
                "protein_xref_refseq",
                "NP_001014301.1",
                "22223826",
                "Results show that AXII and AXIIR play important roles in multiple myeloma (MM) and that targeting the AXII/AXIIR axis may be a novel therapeutic approach for MM."
            ],
            [
                "Q3ZCQ2-1",
                "protein_xref_refseq",
                "NP_001014301.1",
                "18636554",
                "Annexin II and its receptor axis play a central role in prostate cancer metastasis, and prostate cancer utilizes the hematopoietic stem cell homing mechanisms to gain access to the niche."
            ],
            [
                "Q3ZCQ2-1",
                "protein_xref_refseq",
                "NP_001014301.1",
                "16895901",
                "Analysis of the annexin II receptor on human marrow stromal cells"
            ],
            [
                "Q6UXZ0-1",
                "protein_xref_refseq",
                "NP_001306871.1",
                "32508154",
                "Transcriptomic identification of TMIGD1 and its relationship with the ileal epithelial cell differentiation in Crohn's disease."
            ],
            [
                "Q6UXZ0-1",
                "protein_xref_refseq",
                "NP_001306871.1",
                "32303178",
                "The mitochondrial outer membrane protein SYNJ2BP interacts with the cell adhesion molecule TMIGD1 and can recruit it to mitochondria. Publication Status: Online-Only"
            ],
            [
                "Q6UXZ0-1",
                "protein_xref_refseq",
                "NP_001306871.1",
                "26342724",
                "Identified TMIGD1 as a novel cell adhesion molecule expressed in kidney epithelial cells that protects kidney epithelial cells from oxidative cell injury to promote cell survival"
            ],
            [
                "Q9H1X1-1",
                "protein_xref_refseq",
                "NP_001180270.1",
                "22448264",
                "Mutations in RSPH9 leads to ultrastructural cilia defects and ciliary dyskinesia."
            ],
            [
                "Q9H1X1-1",
                "protein_xref_refseq",
                "NP_001180270.1",
                "20070851",
                "Study focused on an extended 5 generation Bedouin family, analysed mutation segregation, and calculated the age of the mutated allele in 2 families based on haplotypes and haplotype+microsatellite in an attempt to define the source of the mutation."
            ],
            [
                "Q9H4G0-1",
                "protein_xref_refseq",
                "NP_001245258.1",
                "29428502",
                "4.1N, betaII spectrin and ankyrin G are structural components of the lateral membrane skeleton and this skeleton plays an essential role in the assembly of a fully functional lateral membrane."
            ],
            [
                "Q9H4G0-1",
                "protein_xref_refseq",
                "NP_001245258.1",
                "27448302",
                "Data show that overexpression of 4.1N protein decreased expression of flotillin-1, decreased activation of beta-catenin/Wnt pathway in non-small-cell lung cancer (NSCLC) cells."
            ],
            [
                "Q9H4G0-1",
                "protein_xref_refseq",
                "NP_001245258.1",
                "26575790",
                "Data suggest that repression of JNK-c-Jun signaling through pancreatic polypeptide receptor 1 (PP1) is one of the key anti-tumor mechanisms of neuronal membrane cytoskeletal protein 4.1 (4.1N). Erratum:[Oncotarget. 2019 Oct 22;10(58):6285. PMID: 31692885]"
            ],
            [
                "Q9H4G0-1",
                "protein_xref_refseq",
                "NP_001245258.1",
                "26648170",
                "The data of the current study identified 4.1N as an inhibitor of hypoxiainduced tumor progression in epithelial ovarian cancer cells."
            ],
            [
                "Q18PE1-1",
                "protein_xref_refseq",
                "NP_001158145.1",
                "32238315",
                "Congenital myasthenic syndrome due to DOK7 mutation in a cohort of patients with 'unexplained' limb-girdle muscular weakness."
            ],
            [
                "Q18PE1-1",
                "protein_xref_refseq",
                "NP_001158145.1",
                "31453852",
                "2 unrelated adult patients who presented with a limb-girdle congenital myasthenic syndrome, caused by 2 compound heterozygous pathogenic sequence variants in DOK7: c.1124_1127dupTGCC (P.Ala378Serfs*30) and c.480C> A (p.Tyr160*)"
            ],
            [
                "Q18PE1-1",
                "protein_xref_refseq",
                "NP_001158145.1",
                "30829272",
                "This study shows hypermethylation of DOK7 gene in DNA from patients affected with breast cancer"
            ],
            [
                "Q18PE1-1",
                "protein_xref_refseq",
                "NP_001158145.1",
                "20603078",
                "The crystal structure of the Dok7 PH-PTB domains in complex with a phosphopeptide representing the Dok7-binding site on MuSK, is presented."
            ],
            [
                "Q18PE1-1",
                "protein_xref_refseq",
                "NP_001158145.1",
                "17439981",
                "Study of patients with congenital myasthenic syndromes with mutations in DOK7; none with DOK7 mutations had tubular aggregates in muscle biopsy, implying 'limb-girdle myasthenia with tubular aggregates' may be distinct from CMS caused by DOK7 mutations"
            ],
            [
                "Q18PE1-1",
                "protein_xref_refseq",
                "NP_001158145.1",
                "16917026",
                "Findings showed that recessive inheritance of mutations in Dok-7, which result in a defective structure of the neuromuscular junction, is a cause of congenital myasthenic syndromes with proximal muscle weakness"
            ],
            [
                "Q18PE1-1",
                "protein_xref_refseq",
                "NP_001158145.1",
                "16794080",
                "Dok-7 is essential for neuromuscular synaptogenesis through its interaction with MuSK"
            ],
            [
                "O14810-1",
                "protein_xref_refseq",
                "NP_006642.1",
                "29118371",
                "Findings do not support microRNA137 (MIR137) and complexin 1 (CPLX1) conferring susceptibility to schizophrenia in Han Chinese. Publication Status: Online-Only"
            ],
            [
                "O14810-1",
                "protein_xref_refseq",
                "NP_006642.1",
                "28422131",
                "Homozygous CPLX1 variants were identified in three patients with severe infantile myoclonic epilepsy and ID."
            ],
            [
                "O14810-1",
                "protein_xref_refseq",
                "NP_006642.1",
                "28108469",
                "Data define CPLX1 as a PD risk factor and provide functional insights into the role and regulation of blood SNCA levels. The new blood biomarkers of PARK4 in this Turkish family might become useful for PD prediction"
            ],
            [
                "O14810-1",
                "protein_xref_refseq",
                "NP_006642.1",
                "27866231",
                "This study demonstrated that complexin-I influence cognitive function in early and late stages of Alzheimer's disease."
            ],
            [
                "O14810-1",
                "protein_xref_refseq",
                "NP_006642.1",
                "26603934",
                "Collectively these results demonstrate that CPX-1 is a secreted collagen-binding glycoprotein and provide a foundation for future studies investigating the function of CPX-1."
            ],
            [
                "Q86VF2-1",
                "protein_xref_refseq",
                "NP_001158058.1",
                "30335789",
                "Study results in UOK146 renal cell carcinoma cell line provide evidence of novel splicing in intron 15 of IGFN1 leading to the formation of two more alternative spliced isoforms. Potential G-quadruplex forming sequence (PQS) in this intron forms a stable G-quadruplex which is involved in the alternative splicing and regulates splicing efficiency. Publication Status: Online-Only"
            ],
            [
                "Q86VF2-1",
                "protein_xref_refseq",
                "NP_001158058.1",
                "29323771",
                "A novel variant, c.6196A>G in the IGFN1 gene, was significantly associated with only Polypoidal choroidal vasculopathy (combined p = 7.1 x 10(-11) , odds ratio = 9.44), but not with neovascular age-related macular degeneration(combined p = 0.683, odds ratio = 1.30)."
            ],
            [
                "Q86VF2-1",
                "protein_xref_refseq",
                "NP_001158058.1",
                "18756455",
                "A model in which this increased expression of IGFN1 serves to down-regulate protein synthesis via interaction with eEF1A during denervation."
            ],
            [
                "P46821-1",
                "protein_xref_refseq",
                "NP_005900.2",
                "31492158",
                "Knockdown of microtubule-associated protein 1B light chain (MAP 1B-LC1) represses E-cadherin downregulation, vimentin upregulation and actin filament remodeling, decreases cell migration and invasion during TGF-beta1-induced epithelial to mesenchymal transition (EMT) in A549 cells. Heterogeneous nuclear ribonucleoprotein K (hnRNP K) promotes the EMT of lung cancer cells induced by TGF-beta1 through interacting with MAP... Publication Status: Online-Only"
            ],
            [
                "P46821-1",
                "protein_xref_refseq",
                "NP_005900.2",
                "31235589",
                "These neuritic defects result from impaired Nrf2 activity on antioxidant response elements (AREs) localized to a microtubule-associated protein (Map1b) gene enhancer and are rescued by forced expression of Map1b as well as by both Nrf2 overexpression and pharmaceutical activation in Parkinson's disease (PD) neurons"
            ],
            [
                "P46821-1",
                "protein_xref_refseq",
                "NP_005900.2",
                "30425305",
                "Calpain-10 regulates actin dynamics by proteolysis of microtubule-associated protein 1B Publication Status: Online-Only"
            ],
            [
                "P46821-1",
                "protein_xref_refseq",
                "NP_005900.2",
                "29925525",
                "MAP1B-LC1 links microtubules and Stx17 in fed cells, and starvation causes the dephosphorylation of MAP1B-LC1 at Thr217, allowing Stx17 to dissociate from MAP1B-LC1 and bind to Atg14L."
            ],
            [
                "P46821-1",
                "protein_xref_refseq",
                "NP_005900.2",
                "29738522",
                "All of the patients with a microtubule associated protein 1B (MAP1B) variant had a similar brain abnormality, and at least one of the parents who transmitted the variant to their child was also similarly affected. Publication Status: Online-Only"
            ],
            [
                "Q9Y6N9-1",
                "protein_xref_refseq",
                "NP_001284693.1",
                "31644917",
                "Myosin VII, USH1C, and ANKS4B or USH1G Together Form Condensed Molecular Assembly via Liquid-Liquid Phase Separation."
            ]
        ]
    },
    "readme": "Name\n   - Human Protein Function (NCBI Refseq)\n\nVersion\n   - 1.8.25\n\nCreated on\n  - 2019-03-16T15:35:15.248632\n\nModified on\n   - 2020-04-10T11:41:20.232299\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu]\n\nAuthors\n   - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n   - \n\nUsability Domain\n   - The Human Protein Function (NCBI RefSeq) dataset contains biological function annotaion of human [taxid:9606] genes from GeneRIF section in the NCBI RefSeq database. The dataset is downloaded from NCBI RefSeq Release 96, September 9, 2019. If you use this dataset please provide proper attribution to NCBI RefSeq and GlyGen\n\nDescription Domain\n   Keywords\n   - protein function\n   - NCBI RefSeq\n   - geneRIF\n   - PMID\n\n   Pipeline Steps\n   - Step-1: The script parses the NCBI RefSeq gpff files to extract the geneRIFs that contain protein function. The script also maps RefSeq accesion to the UniProtKB Canonical accessions\n\nExecution Domain\n   Scripts   - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: refseq_protein_all_9606.gpff\n      URI: https://data.glygen.org/ln2data/releases/data/v-1.8.25/source/source/refseq_protein_all_9606.gpff\n      Name: human_protein_xref_refseq.csv\n      URI: https://data.glygen.org/ln2data/releases/data/v-1.8.25/reviewed/human_protein_xref_refseq.csv\n   Output Subdomain\n      Name: human_protein_function_refseq.csv\n      URI: http://data.glygen.org/ln2data/releases/data/v-1.8.25/reviewed/human_protein_function_refseq.csv\n      Name: human_protein_function_refseq.stat.csv\n      URI: http://data.glygen.org/ln2data/releases/data/v-1.8.25/reviewed/human_protein_function_refseq.stat.csv\n\nFields\n      Name: \"src_xref_key\"\n     Description: \"Source Xref  key\"\n      Unique Values: \"1\"\n      Name: \"xref_id\"\n     Description: \"ID of the X-ref\"\n      Unique Values: \"119\"\n      Name: \"title\"\n     Description: \"Title of the published article in the journal\"\n      Unique Values: \"119\"\n      Name: \"src_xref_id\"\n     Description: \"Source X-ref ID\"\n      Unique Values: \"120\"\n      Name: \"journal_name\"\n     Description: \"The name of the journal in which the article is published\"\n      Unique Values: \"49\"\n      Name: \"authors\"\n     Description: \"NA\"\n      Unique Values: \"118\"\n      Name: \"publication_date\"\n     Description: \"Contains the full date on which the issue of the journal was published. Sourced from MEDLINE/PubMed data element(fields) description.\"\n      Unique Values: \"117\"\n      Name: \"glytoucan_ac\"\n     Description: \"Unique accession assigned to the registered glycan structure in GlyTouCan database\"\n      Unique Values: \"115\"\n      Name: \"xref_key\"\n     Description: \"Source key associated to the  xref_id\"\n      Unique Values: \"1\"",
    "downloadurl": "/ln2data/releases/data/v-1.8.25/reviewed/human_protein_function_refseq.csv"
}
