{
    "uniprot_canonical_ac": "A2RT60-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2RT60-1|HTRA4_MOUSE Isoform 1 of Serine protease HTRA4  OS=Mus musculus OX=10090 GN=Htra4 PE=2 SV=1 CANONICAL=A2RT60-1", 
        "length": 483, 
        "sequence": "MSFQRLWAVRTQFLLLWLLLPAVPVPWAEARRSRVSLPCPDACDPTRCPTLPTCSAGLAPVPDRCGCCRVCAAAEGQECGGARGRPCAPRLRCGAPFSRDPSGGAWLGTCGCAEGAEDAVVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQKGACEEAGTTRAGRLRRKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQSGARYEATVKDIDHKLDLALIKIEPDTELPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGRELGLKNSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLEDYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMKRQDPEFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTTTTDVIEAVKDNDFLSIIVLRGSQTLFLTVTPEIIN"
    }, 
    "uniprot_id": "HTRA4_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "3.4.21.-", 
            "activity": ""
        }
    ], 
    "glycation": [], 
    "keywords": [
        "enzyme"
    ], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RT60", 
                    "id": "A2RT60", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24194600", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24194600"
                }
            ], 
            "title": "The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.", 
            "journal": "Nucleic acids research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", 
                    "id": "NP_001074656.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26353049", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "26353049"
                }
            ], 
            "title": "Generation and characterization of mice with a conditional null allele of the HtrA4 gene.", 
            "journal": "Molecular medicine reports", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", 
                    "id": "NP_001074656.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Liu J, Li Y, Hoh J", 
            "date": "2015"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "27626380"
                }
            ], 
            "title": "High-throughput discovery of novel developmental phenotypes.", 
            "journal": "Nature", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", 
                    "id": "NP_001074656.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", 
            "date": "2016"
        }
    ], 
    "uniprot_ac": "A2RT60", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RT60#A2RT60-1", 
            "isoform_ac": "A2RT60-1", 
            "locus": {
                "end_pos": 25025572, 
                "strand": "+", 
                "start_pos": 25038874, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000084031", 
                        "id": "ENSMUST00000084031", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000081044", 
                        "id": "ENSMUSP00000081044", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2RT60-1|HTRA4_MOUSE Isoform 1 of Serine protease HTRA4  OS=Mus musculus OX=10090 GN=Htra4 PE=2 SV=1 CANONICAL=A2RT60-1", 
                "length": 483, 
                "sequence": "MSFQRLWAVRTQFLLLWLLLPAVPVPWAEARRSRVSLPCPDACDPTRCPTLPTCSAGLAPVPDRCGCCRVCAAAEGQECGGARGRPCAPRLRCGAPFSRDPSGGAWLGTCGCAEGAEDAVVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQKGACEEAGTTRAGRLRRKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQSGARYEATVKDIDHKLDLALIKIEPDTELPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGRELGLKNSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLEDYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMKRQDPEFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTTTTDVIEAVKDNDFLSIIVLRGSQTLFLTVTPEIIN"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:330723", 
            "resource": "KEGG Pathway", 
            "id": "mmu:330723", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", 
            "annotation": "Mice, featuring a conditional null allele of HtrA4, may provide a valuable tool to investigate the role of HtrA4 in development and pathogenesis of coronary heart disease and preeclampsia.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", 
                    "id": "NP_001074656.1", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RT60#function", 
            "annotation": "Serine protease.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RT60#function", 
                    "id": "A2RT60", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZKF5-1", 
            "protein_name": "Serine protease HTR4", 
            "sequence": {
                "length": 488, 
                "sequence": "MSRSKMSSQRLWAVRAQFLLLWLLLWAAPVPWAEARRSRVSLPCPDACDPTRCPPLPSCSAGSALVPDRCGCCQVCAAVEGQECGGARGRPCVPGLRCGAPFSREPSGRAWLGTCGCAEGAEGAAVCGSDGRTYPSLCALRKENRAARQRGALPAVPVQKGACGDSGTTRAGRLRTKYNFIAAVVEKVAPSVVHLQLFRRSPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQQKIQVELQNGAQYEATVKDIDHKLDLALIKIEPDTDLPVLLLGRSSDLRAGEFVVALGSPFSLQNTVTAGIVSTTQRGGKELGLKDSDIDYIQTDAIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLADYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMKRQDPDFPDVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTTTTDVIEAVKDNAFLSIIVLRGSQTLFLTVTPEIIN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/17801", 
                    "id": "17801", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "Htra4", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "P83105-1", 
            "protein_name": "Serine protease HTRA4", 
            "sequence": {
                "length": 476, 
                "sequence": "MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2RT60/", 
                    "id": "A2RT60", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/17801", 
                    "id": "17801", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "HTRA4", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", 
        "ac": "NP_001074656.1", 
        "name": "serine protease HTRA4 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004175", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT60", 
                                "id": "A2RT60", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endopeptidase activity", 
                        "id": "GO:0004175"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT60", 
                                "id": "A2RT60", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "serine-type endopeptidase activity", 
                        "id": "GO:0004252"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT60", 
                                "id": "A2RT60", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "identical protein binding", 
                        "id": "GO:0042802"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005520", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT60", 
                                "id": "A2RT60", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "insulin-like growth factor binding", 
                        "id": "GO:0005520"
                    }
                ], 
                "total": 4, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT60", 
                                "id": "A2RT60", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular region", 
                        "id": "GO:0005576"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RT60", 
                                "id": "A2RT60", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "proteolysis", 
                        "id": "GO:0006508"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RT60", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "B430206E18Rik"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RT60", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Htra4"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RT60", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Htra4"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037406", 
            "id": "ENSMUSG00000037406", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/330723", 
            "id": "330723", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000867", 
            "id": "IPR000867", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", 
            "id": "IPR001478", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001940", 
            "id": "IPR001940", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002350", 
            "id": "IPR002350", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", 
            "id": "IPR009003", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", 
            "id": "IPR009030", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", 
            "id": "IPR036034", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036058", 
            "id": "IPR036058", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR041489", 
            "id": "IPR041489", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:330723", 
            "id": "mmu:330723", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:3036260", 
            "id": "3036260", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/NQQWIEV/", 
            "id": "NQQWIEV", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=630723at2759", 
            "id": "630723at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00219", 
            "id": "PF00219", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07648", 
            "id": "PF07648", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF17820", 
            "id": "PF17820", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A2RT60", 
            "id": "PR_A2RT60", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656", 
            "id": "NP_001074656", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074656.1", 
            "id": "NP_001074656.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RT60", 
            "id": "A2RT60", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 51988.0, 
        "chemical_mass": 51988.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RT60", 
            "name": "Htra4", 
            "locus": {
                "end_pos": 25024929, 
                "strand": "-", 
                "start_pos": 25038962, 
                "chromosome": "8", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000037406", 
                        "id": "ENSMUSG00000037406", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RT60#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "3.4.21.-"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RT60#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "High-temperature requirement factor A4"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RT60#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Serine protease HTRA4"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RT60", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "high-temperature requirement factor A4; serine protease HTRA4"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RT60", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "serine protease HTRA4 precursor"
        }
    ]
}