{ "uniprot_canonical_ac": "A2AIR5-1", "ptm_annotation": [], "sequence": { "header": "tr|A2AIR5-1|A2AIR5_MOUSE Isoform 1 of Glutamate receptor OS=Mus musculus OX=10090 GN=Grin3a PE=1 SV=1 CANONICAL=A2AIR5-1", "length": 1135, "sequence": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQDGGRAGAQRDEPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGTETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNMGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQTHQDIPLPPRRRELPASLTTNGKADSLNVARNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTNRTCES" }, "uniprot_id": "A2AIR5_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "reported_with_glycan.glyconnect" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11735224", "type": [ "PubMed" ], "id": "11735224" } ], "title": "Nucleotide sequence, genomic organization, and chromosomal localization of genes encoding the human NMDA receptor subunits NR3A and NR3B.", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Andersson O, Stenqvist A, Attersand A, von Euler G", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14983056", "type": [ "PubMed" ], "id": "14983056" } ], "title": "Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Kattenstroth G, Tantalaki E, Sudhof TC, Gottmann K, Missler M", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30635555", "type": [ "PubMed" ], "id": "30635555" } ], "title": "Single-cell transcriptomic analysis of mouse neocortical development.", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Loo L, Simon JM, Xing L, McCoy ES, Niehaus JK, Guo J, Anton ES, Zylka MJ", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30734226", "type": [ "PubMed" ], "id": "30734226" } ], "title": "Immuno-Pharmacological Characterization of Presynaptic GluN3A-Containing NMDA Autoreceptors: Relevance to Anti-NMDA Receptor Autoimmune Diseases.", "journal": "Molecular neurobiology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Olivero G, Vergassola M, Cisani F, Usai C, Pittaluga A", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "type": [ "PubMed" ], "id": "30899004" } ], "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "journal": "Nature communications", "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2354", "id": "2354", "database": "GlyConnect" } ], "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31601771", "type": [ "PubMed" ], "id": "31601771" } ], "title": "Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula.", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Otsu Y, Darcq E, Pietrajtis K, Matyas F, Schwartz E, Bessaih T, Abi Gerges S, Rousseau CV, Grand T, Dieudonne S, Paoletti P, Acsady L, Agulhon C, Kieffer BL, Diana MA", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31712124", "type": [ "PubMed" ], "id": "31712124" } ], "title": "Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation.", "journal": "Experimental neurology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Giralt A, Brito V, Pardo M, Rubio SE, Marion-Poll L, Martin-Ibanez R, Zamora-Moratalla A, Bosch C, Ballesteros JJ, Blasco E, Garcia-Torralba A, Pascual M, Pumarola M, Alberch J, Gines S, Martin ED, Segovia J, Soriano E, Canals JM", "date": "2020" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7306792", "type": [ "PubMed" ], "id": "7306792" } ], "title": "Hypomyelinated mutant mice IV: peripheral myelin in jp msd.", "journal": "Brain research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Billings-Gagliardi S, Adcock LH", "date": "1981" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9620802", "type": [ "PubMed" ], "id": "9620802" } ], "title": "Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A.", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ], "authors": "Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, Nakanishi N", "date": "1998" } ], "uniprot_ac": "A2AIR5", "site_annotation": [ { "end_pos": 1037, "annotation": "n_glycosylation_sequon", "start_pos": 1035 }, { "end_pos": 1040, "annotation": "n_glycosylation_sequon", "start_pos": 1038 }, { "end_pos": 1132, "annotation": "n_glycosylation_sequon", "start_pos": 1130 }, { "end_pos": 147, "annotation": "n_glycosylation_sequon", "start_pos": 145 }, { "end_pos": 266, "annotation": "n_glycosylation_sequon", "start_pos": 264 }, { "end_pos": 277, "annotation": "n_glycosylation_sequon", "start_pos": 275 }, { "end_pos": 287, "annotation": "n_glycosylation_sequon", "start_pos": 285 }, { "end_pos": 298, "annotation": "n_glycosylation_sequon", "start_pos": 296 }, { "end_pos": 302, "annotation": "n_glycosylation_sequon", "start_pos": 300 }, { "end_pos": 322, "annotation": "n_glycosylation_sequon", "start_pos": 320 }, { "end_pos": 428, "annotation": "n_glycosylation_sequon", "start_pos": 426 }, { "end_pos": 441, "annotation": "n_glycosylation_sequon", "start_pos": 439 }, { "end_pos": 551, "annotation": "n_glycosylation_sequon", "start_pos": 549 }, { "end_pos": 567, "annotation": "n_glycosylation_sequon", "start_pos": 565 }, { "end_pos": 888, "annotation": "n_glycosylation_sequon", "start_pos": 886 }, { "end_pos": 967, "annotation": "n_glycosylation_sequon", "start_pos": 965 }, { "end_pos": 986, "annotation": "n_glycosylation_sequon", "start_pos": 984 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5#A2AIR4-1", "isoform_ac": "A2AIR4-1", "locus": { "end_pos": 49665229, "strand": "+", "start_pos": 49845081, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000076674", "id": "ENSMUST00000076674", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000075970", "id": "ENSMUSP00000075970", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AIR4-1|A2AIR5_MOUSE Computationally mapped isoform of Glutamate receptor OS=Mus musculus OX=10090 GN=Grin3a PE=1 SV=1 CANONICAL=A2AIR5-1", "length": 1115, "sequence": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQDGGRAGAQRDEPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGTETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSKTKRVEKRSNMGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQTHQDIPLPPRRRELPASLTTNGKADSLNVARNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTNRTCES" } }, { "url": "https://www.uniprot.org/uniprot/A2AIR5#A2AIR5-1", "isoform_ac": "A2AIR5-1", "locus": { "end_pos": 49665229, "strand": "+", "start_pos": 49845081, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000093859", "id": "ENSMUST00000093859", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000091381", "id": "ENSMUSP00000091381", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AIR5-1|A2AIR5_MOUSE Isoform 1 of Glutamate receptor OS=Mus musculus OX=10090 GN=Grin3a PE=1 SV=1 CANONICAL=A2AIR5-1", "length": 1135, "sequence": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQDGGRAGAQRDEPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGTETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPDLHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWNLQYDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNMGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQTHQDIPLPPRRRELPASLTTNGKADSLNVARNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTNRTCES" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9609736", "resource": "Reactome", "id": "R-MMU-9609736", "name": "Assembly and cell surface presentation of NMDA receptors" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "annotation": "Decrease in NMDA-receptor activity in alpha-neurexin-deficient synapses", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AIR5#function", "annotation": "Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5#function", "id": "A2AIR5", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "annotation": "Study found GluN1/GluN3A receptors are operational in neurons of the medial habenula (MHb), an epithalamic area controlling aversive physiological states; in the absence of glycinergic neuronal specializations in the MHb, glial cells tuned neuronal activity via GluN1/GluN3A receptors; reducing GluN1/GluN3A receptor levels in the MHb prevented place-aversion conditioning", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "annotation": "Thsese findings confirm the existence of presynaptic GluN3A-containing release-regulating NMDARs in mouse hippocampal glutamatergic nerve endings.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "id": "NP_001263284.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8TCU5-1", "protein_name": "Glutamate receptor ionotropic, NMDA 3A", "sequence": { "length": 1115, "sequence": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAPDDSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAEALWPRDALLFAVDNLNRVEGLLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSLVLHIPVISIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPPELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRKYIFSDEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128613", "id": "128613", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "GRIN3A", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9R1M7-1", "protein_name": "Glutamate receptor ionotropic, NMDA 3A", "sequence": { "length": 1135, "sequence": "MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAQEGGRAGAQRDDPESGTWRPPAPSQGARWLGSALHGRGPPGSRKLGEGAGAETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPRSKTKRVEKSRWRRWTCKTEGDSELSLFPRSNLGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQAHQDIPLPQRRRELPASLTTNGKADSLNVTRSSVIQELSELEKQIQVIRQELQLAVSRKTELEEYQKTNRTCES" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128613", "id": "128613", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Grin3a", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263284.1", "ac": "NP_001263284.1", "name": "glutamate receptor ionotropic, NMDA 3A isoform 1 precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005262", "pmid": "9620802", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "calcium channel activity", "id": "GO:0005262" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015276", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "ligand-gated ion channel activity", "id": "GO:0015276" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038023", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "signaling receptor activity", "id": "GO:0038023" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904315", "pmid": "24183704", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential", "id": "GO:1904315" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004972", "pmid": "14507892", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "NMDA glutamate receptor activity", "id": "GO:0004972" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "identical protein binding", "id": "GO:0042802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051721", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "protein phosphatase 2A binding", "id": "GO:0051721" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004970", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "ionotropic glutamate receptor activity", "id": "GO:0004970" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016594", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIR5", "id": "A2AIR5", "database": "UniProtKB" } ], "name": "glycine binding", "id": "GO:0016594" }, { "url": 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