{
    "uniprot_canonical_ac": "A2AF31-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A2AF31-1|A2AF31_MOUSE Isoform 1 of Thymosin beta  OS=Mus musculus OX=10090 GN=Tmsb15b2 PE=1 SV=1 CANONICAL=A2AF31-1", 
        "length": 45, 
        "sequence": "MSDKPDLSEVETFDKAKLKKTNTEVKNTLPSKETIQQEKEHNERT"
    }, 
    "uniprot_id": "A2AF31_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AF31", 
                    "id": "A2AF31", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19233202", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "19233202"
                }
            ], 
            "title": "The mouse thymosin beta15 gene family displays unique complexity and encodes a functional thymosin repeat.", 
            "journal": "Journal of molecular biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074436.1", 
                    "id": "NP_001074436.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Dhaese S, Vandepoele K, Waterschoot D, Vanloo B, Vandekerckhove J, Ampe C, Van Troys M", 
            "date": "2009"
        }
    ], 
    "uniprot_ac": "A2AF31", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AF31#A2AF31-1", 
            "isoform_ac": "A2AF31-1", 
            "locus": {
                "end_pos": 136955448, 
                "strand": "+", 
                "start_pos": 136956834, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000069803", 
                        "id": "ENSMUST00000069803", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000063549", 
                        "id": "ENSMUSP00000063549", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2AF31-1|A2AF31_MOUSE Isoform 1 of Thymosin beta  OS=Mus musculus OX=10090 GN=Tmsb15b2 PE=1 SV=1 CANONICAL=A2AF31-1", 
                "length": 45, 
                "sequence": "MSDKPDLSEVETFDKAKLKKTNTEVKNTLPSKETIQQEKEHNERT"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AF31#Q8C0W0-1", 
            "isoform_ac": "Q8C0W0-1", 
            "locus": {
                "end_pos": 136955448, 
                "strand": "+", 
                "start_pos": 136975497, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000127404", 
                        "id": "ENSMUST00000127404", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000118704", 
                        "id": "ENSMUSP00000118704", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|Q8C0W0-1|A2AF31_MOUSE Computationally mapped isoform of Thymosin beta  OS=Mus musculus OX=10090 GN=Tmsb15b2 PE=1 SV=1 CANONICAL=A2AF31-1", 
                "length": 80, 
                "sequence": "MSDKPDLSEVETFDKSKLKKTNTEVKNTLPSNENKMSDKPDLSEVETFDKAKLKKTNTEVKNTLPSKETIQQEKEHNERT"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:100034363", 
            "resource": "KEGG Pathway", 
            "id": "mmu:100034363", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AF31#function", 
            "annotation": "Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AF31#function", 
                    "id": "A2AF31", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074436.1", 
        "ac": "NP_001074436.1", 
        "name": "thymosin beta-like", 
        "summary": "This gene is part of tandem duplication; the other copy of this gene is about 1.5 kb away. Readthrough transcripts that include two exons transcribed from each gene exist. [provided by RefSeq, Jul 2008]."
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003785", 
                        "pmid": "19233202", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AF31", 
                                "id": "A2AF31", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "actin monomer binding", 
                        "id": "GO:0003785"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001725", 
                        "pmid": "19233202", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AF31", 
                                "id": "A2AF31", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "stress fiber", 
                        "id": "GO:0001725"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031941", 
                        "pmid": "19233202", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AF31", 
                                "id": "A2AF31", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "filamentous actin", 
                        "id": "GO:0031941"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AF31", 
                                "id": "A2AF31", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042989", 
                        "pmid": "19233202", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AF31", 
                                "id": "A2AF31", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "sequestering of actin monomers", 
                        "id": "GO:0042989"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051497", 
                        "pmid": "19233202", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AF31", 
                                "id": "A2AF31", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of stress fiber assembly", 
                        "id": "GO:0051497"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030837", 
                        "pmid": "19233202", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AF31", 
                                "id": "A2AF31", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of actin filament polymerization", 
                        "id": "GO:0030837"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AF31", 
                                "id": "A2AF31", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "actin filament organization", 
                        "id": "GO:0007015"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AF31", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Tb15c"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AF31", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Tmsb15b2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AF31", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Tmsb15b2"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000089996", 
            "id": "ENSMUSG00000089996", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/100034363", 
            "id": "100034363", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001152", 
            "id": "IPR001152", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038386", 
            "id": "IPR038386", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:100034363", 
            "id": "mmu:100034363", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:3843061", 
            "id": "3843061", 
            "database": "MGI"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12021", 
            "id": "PTHR12021", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01290", 
            "id": "PF01290", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074436", 
            "id": "NP_001074436", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074436.1", 
            "id": "NP_001074436.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AF31", 
            "id": "A2AF31", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 5247.0, 
        "chemical_mass": 5247.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AF31", 
            "name": "Tmsb15b2", 
            "locus": {
                "end_pos": 136955265, 
                "strand": "-", 
                "start_pos": 136975497, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000089996", 
                        "id": "ENSMUSG00000089996", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AF31#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Thymosin beta"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2AF31", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "thymosin beta-like"
        }
    ]
}