{ "uniprot_canonical_ac": "A6JFQ6-1", "ptm_annotation": [], "sequence": { "header": "sp|A6JFQ6-1|CLVS1_RAT Isoform 1 of Clavesin-1 OS=Rattus norvegicus OX=10116 GN=Clvs1 PE=1 SV=1 CANONICAL=A6JFQ6-1", "length": 354, "sequence": "MGPVSVLPKPQSISTWEGDLAKMTHLQAGLSPDTIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMYVKHTCSNLERECSPKPMKRSQSVVEAGTLKHEEKGENENTQPLLALD" }, "uniprot_id": "CLVS1_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19651769", "type": [ "PubMed" ], "id": "19651769" } ], "title": "The clavesin family: neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102439.1", "id": "NP_001102439.1", "database": "RefSeq" } ], "authors": "Katoh Y., McPherson P.S., Ritter B., Blondeau F., Gaffry T., Honing S.", "date": "2009" } ], "uniprot_ac": "A6JFQ6", "site_annotation": [ { "end_pos": 190, "annotation": "n_glycosylation_sequon", "start_pos": 188 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6#A0A0G2K5H2-1", "isoform_ac": "A0A0G2K5H2-1", "locus": { "end_pos": 22392732, "strand": "-", "start_pos": 22578098, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000087182", "id": "ENSRNOT00000087182", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000073425", "id": "ENSRNOP00000073425", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K5H2-1|CLVS1_RAT Computationally mapped isoform of Clavesin-1 OS=Rattus norvegicus OX=10116 GN=Clvs1 PE=1 SV=1 CANONICAL=A6JFQ6-1", "length": 352, "sequence": "MGPVSVPKPQSITTWKRFAKMTHLQAGLSPDTIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMYVKHTCSNLERECSPKPMKRSQSVVEAGTLKHEEKGENENTQPLLALD" } }, { "url": "https://www.uniprot.org/uniprot/A6JFQ6#A6JFQ6-1", "isoform_ac": "A6JFQ6-1", "locus": {}, "sequence": { "header": "sp|A6JFQ6-1|CLVS1_RAT Isoform 1 of Clavesin-1 OS=Rattus norvegicus OX=10116 GN=Clvs1 PE=1 SV=1 CANONICAL=A6JFQ6-1", "length": 354, "sequence": "MGPVSVLPKPQSISTWEGDLAKMTHLQAGLSPDTIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMYVKHTCSNLERECSPKPMKRSQSVVEAGTLKHEEKGENENTQPLLALD" } }, { "url": "https://www.uniprot.org/uniprot/A6JFQ6#F1LRF3-1", "isoform_ac": "F1LRF3-1", "locus": { "end_pos": 22392795, "strand": "-", "start_pos": 22578098, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000009744", "id": "ENSRNOT00000009744", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000009744", "id": "ENSRNOP00000009744", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F1LRF3-1|CLVS1_RAT Computationally mapped isoform of Clavesin-1 OS=Rattus norvegicus OX=10116 GN=Clvs1 PE=1 SV=3 CANONICAL=A6JFQ6-1", "length": 332, "sequence": "MTHLQAGLSPDTIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMYVKHTCSNLERECSPKPMKRSQSVVEAGTLKHEEKGENENTQPLLALD" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:366311", "resource": "KEGG Pathway", "id": "rno:366311", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-432720", "resource": "Reactome", "id": "R-RNO-432720", "name": "Lysosome Vesicle Biogenesis" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6#function", "annotation": "Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6#function", "id": "A6JFQ6", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8IUQ0-1", "protein_name": "Clavesin-1", "sequence": { "length": 354, "sequence": "MGPVSLLPKYQKLNTWNGDLAKMTHLQAGLSPETIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMHVKHTSSNLERECSPKLMKRSQSVVEAGTLKHEEKGENENTQPLLALD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/65267", "id": "65267", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "CLVS1", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9D4C9-1", "protein_name": "Clavesin-1", "sequence": { "length": 354, "sequence": "MGPVSVLPSPQSLSTWEGDLAKMTHLQAGLSPDTIEKARLELNENPDILHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMHVKHTCSNLERECSPKPMKRSQSVVEAGTLKHEEKGENENTQPLLALD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/65267", "id": "65267", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Clvs1", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102439.1", "ac": "NP_001102439.1", "name": "clavesin-1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902936", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "phosphatidylinositol bisphosphate binding", "id": "GO:1902936" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080025", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "phosphatidylinositol-3,5-bisphosphate binding", "id": "GO:0080025" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030136", "pmid": "19651769", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "clathrin-coated vesicle", "id": "GO:0030136" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "pmid": "19651769", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "trans-Golgi network", "id": "GO:0005802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "endosome", "id": "GO:0005768" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "early endosome membrane", "id": "GO:0031901" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007040", "pmid": "19651769", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "name": "lysosome organization", "id": "GO:0007040" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A6JFQ6", "type": "synonym", "resource": "RefSeq", "name": "Clavesin-1; RGD1564200; Rlbp1l1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A6JFQ6", "type": "synonym", "resource": "RefSeq", "name": "Clvs1" }, { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "type": "recommended", "resource": "UniProtKB", "name": "Clvs1" }, { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "type": "synonym", "resource": "UniProtKB", "name": "Rlbp1l1" } ], "pro_annotation": [], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00170", "id": "cd00170", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/366311", "id": "366311", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001251", "id": "IPR001251", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011074", "id": "IPR011074", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028634", "id": "IPR028634", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036273", "id": "IPR036273", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036865", "id": "IPR036865", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:366311", "id": "rno:366311", "database": "KEGG Pathway" }, { "url": "http://www.orthodb.org/?query=1182715at2759", "id": "1182715at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10174:SF72", "id": "PTHR10174:SF72", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00650", "id": "PF00650", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF03765", "id": "PF03765", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A6JFQ6", "id": "PR_A6JFQ6", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-432720", "id": "R-RNO-432720", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001102439.1", "id": "NP_001102439.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1564200", "id": "1564200", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "id": "A6JFQ6", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 40667.0, "chemical_mass": 40667.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6", "name": "Clvs1", "locus": { "end_pos": 22578297, "strand": "+", "start_pos": 22380334, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000006919", "id": "ENSRNOG00000006919", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A6JFQ6#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Clavesin-1" }, { "url": "https://www.uniprot.org/uniprot/A6JFQ6#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Retinaldehyde-binding protein 1-like 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A6JFQ6", "type": "synonym", "resource": "RefSeq", "name": "Retinaldehyde-binding protein 1-like protein 1; retinaldehyde-binding protein 1-like 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A6JFQ6", "type": "synonym", "resource": "RefSeq", "name": "clavesin-1" } ] }