{
    "uniprot_canonical_ac": "A6H6T1-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A6H6T1-1|PRS40_MOUSE Isoform 1 of Serine protease 40  OS=Mus musculus OX=10090 GN=Prss40 PE=2 SV=2 CANONICAL=A6H6T1-1", 
        "length": 365, 
        "sequence": "MCGIRAKKSGLGGYGAGLLAALLGVSFLSQHAQTAEHVTNAANNTTIQIMKSTLSLSEVCGKTKFQGKIYGGQIAGAERWPWQASLRLYGRHICGAVLIDKNWVLSAAHCFQRSQEPSDYHVMLGYTDLNSPTRYSRTMSVQKVIVHKDYNRFHTQGSDIVLLQLRSSVEYSSHILPACVPEENIKIPKEKACWASGWGYLREDVRIPLPNELYEAELIIMSNDQCKGFFPPPVPGSGRSYYIYDDMVCAADYDMSKSICAGDSGGPLVCLLEGSWYVVGLTSWSSTCEEPIVSPSVFARVSYFDKWIKDNKKSSSNSKPGESPHHPGSPENENPEGDNKNQGAVIKPTVCTALLLSQILLQQLI"
    }, 
    "uniprot_id": "PRS40_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "3.4.21.-", 
            "activity": ""
        }
    ], 
    "glycation": [], 
    "keywords": [
        "glycoprotein", 
        "predicted.uniprotkb_gly"
    ], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6H6T1", 
                    "id": "A6H6T1", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24194600", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24194600"
                }
            ], 
            "title": "The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.", 
            "journal": "Nucleic acids research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033382.2", 
                    "id": "NP_033382.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/9588171", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "9588171"
                }
            ], 
            "title": "Two novel testicular serine proteases, TESP1 and TESP2, are present in the mouse sperm acrosome.", 
            "journal": "Biochem. Biophys. Res. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6H6T1", 
                    "id": "A6H6T1", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Yamada S., Yamagata K., Sakai Y., Baba T., Kashiwabara S., Kohno N.", 
            "date": "1998"
        }
    ], 
    "uniprot_ac": "A6H6T1", 
    "site_annotation": [
        {
            "end_pos": 45, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 43
        }, 
        {
            "end_pos": 46, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 44
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H6T1#A0A087WS39-1", 
            "isoform_ac": "A0A087WS39-1", 
            "locus": {
                "end_pos": 34552682, 
                "strand": "+", 
                "start_pos": 34558111, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000190790", 
                        "id": "ENSMUST00000190790", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000140885", 
                        "id": "ENSMUSP00000140885", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A087WS39-1|PRS40_MOUSE Computationally mapped isoform of Serine protease 40  OS=Mus musculus OX=10090 GN=Prss40 PE=2 SV=1 CANONICAL=A6H6T1-1", 
                "length": 147, 
                "sequence": "DYHVMLGYTDLNSPTRYSRTMSVQKVIVHKDYNRFHTQGSDIVLLQLRSSVEYSSHILPACVPEENIKIPKEKACWASGWGYLREDVRIPLPNELYEAELIIMSNDQCKGFFPPPVPGSGRSYYIYDDMVCAADYDMSKSICAGLLL"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H6T1#A6H6T1-1", 
            "isoform_ac": "A6H6T1-1", 
            "locus": {
                "end_pos": 34552498, 
                "strand": "+", 
                "start_pos": 34560904, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000047840", 
                        "id": "ENSMUST00000047840", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000045118", 
                        "id": "ENSMUSP00000045118", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A6H6T1-1|PRS40_MOUSE Isoform 1 of Serine protease 40  OS=Mus musculus OX=10090 GN=Prss40 PE=2 SV=2 CANONICAL=A6H6T1-1", 
                "length": 365, 
                "sequence": "MCGIRAKKSGLGGYGAGLLAALLGVSFLSQHAQTAEHVTNAANNTTIQIMKSTLSLSEVCGKTKFQGKIYGGQIAGAERWPWQASLRLYGRHICGAVLIDKNWVLSAAHCFQRSQEPSDYHVMLGYTDLNSPTRYSRTMSVQKVIVHKDYNRFHTQGSDIVLLQLRSSVEYSSHILPACVPEENIKIPKEKACWASGWGYLREDVRIPLPNELYEAELIIMSNDQCKGFFPPPVPGSGRSYYIYDDMVCAADYDMSKSICAGDSGGPLVCLLEGSWYVVGLTSWSSTCEEPIVSPSVFARVSYFDKWIKDNKKSSSNSKPGESPHHPGSPENENPEGDNKNQGAVIKPTVCTALLLSQILLQQLI"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H6T1#E9Q9Y0-1", 
            "isoform_ac": "E9Q9Y0-1", 
            "locus": {
                "end_pos": 34558096, 
                "strand": "+", 
                "start_pos": 34560904, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000115071", 
                        "id": "ENSMUST00000115071", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000110723", 
                        "id": "ENSMUSP00000110723", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|E9Q9Y0-1|PRS40_MOUSE Computationally mapped isoform of Serine protease 40  OS=Mus musculus OX=10090 GN=Prss40 PE=2 SV=2 CANONICAL=A6H6T1-1", 
                "length": 133, 
                "sequence": "MCGIRAKKSGLGGYGAGLLAALLGVSFLSQHAQTAEHVTNAANNTTIQIMKSTLSLSEGAWRLGLSLQYVARPNSKGRSMAVRLQGLSGGRGRPVCAYMAGTSVEQFSSTKTGYSALPTASKDLKNQVTTMSC"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:21756", 
            "resource": "KEGG Pathway", 
            "id": "mmu:21756", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H6T1#function", 
            "annotation": "May play an important role in the sperm/egg interaction; released during the acrosome reaction.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6H6T1#function", 
                    "id": "A6H6T1", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033382.2", 
        "ac": "NP_033382.2", 
        "name": "serine protease 40 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H6T1", 
                                "id": "A6H6T1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "serine-type endopeptidase activity", 
                        "id": "GO:0004252"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H6T1", 
                                "id": "A6H6T1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular space", 
                        "id": "GO:0005615"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001669", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H6T1", 
                                "id": "A6H6T1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "acrosomal vesicle", 
                        "id": "GO:0001669"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6H6T1", 
                                "id": "A6H6T1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "proteolysis", 
                        "id": "GO:0006508"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A6H6T1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Prss40"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H6T1", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Prss40"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A6H6T1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Tes; Tesp2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H6T1", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Tesp2"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000037529", 
            "id": "ENSMUSG00000037529", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00190", 
            "id": "cd00190", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/21756", 
            "id": "21756", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001254", 
            "id": "IPR001254", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001314", 
            "id": "IPR001314", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009003", 
            "id": "IPR009003", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018114", 
            "id": "IPR018114", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033116", 
            "id": "IPR033116", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043504", 
            "id": "IPR043504", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:21756", 
            "id": "mmu:21756", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1270857", 
            "id": "1270857", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/LLEGSWY/", 
            "id": "LLEGSWY", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1314811at2759", 
            "id": "1314811at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00089", 
            "id": "PF00089", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A6H6T1", 
            "id": "PR_A6H6T1", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_033382.2", 
            "id": "NP_033382.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H6T1", 
            "id": "A6H6T1", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "site_category": "predicted", 
            "end_pos": 44, 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6H6T1#ptm_processing", 
                    "id": "A6H6T1", 
                    "database": "UniProtKB"
                }
            ], 
            "subtype": "", 
            "relation": "attached", 
            "start_pos": 44, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 40146.0, 
        "chemical_mass": 40146.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H6T1", 
            "name": "Prss40", 
            "locus": {
                "end_pos": 34543968, 
                "strand": "-", 
                "start_pos": 34560943, 
                "chromosome": "1", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000037529", 
                        "id": "ENSMUSG00000037529", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A6H6T1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "3.4.21.-"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H6T1#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Serine protease 40"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6H6T1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Testicular serine protease 2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A6H6T1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "serine protease 40 precursor"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A6H6T1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "serine protease 40; testicular serine protease 2"
        }
    ]
}