{ "uniprot_canonical_ac": "A6H6A4-1", "ptm_annotation": [], "sequence": { "header": "sp|A6H6A4-1|LRIQ4_MOUSE Isoform 1 of Leucine-rich repeat and IQ domain-containing protein 4 OS=Mus musculus OX=10090 GN=Lrriq4 PE=2 SV=1 CANONICAL=A6H6A4-1", "length": 596, "sequence": "MHHSSSGSRCVLQNGLELTVILPRLHRFDIIDTFKTLTKELLRQEHLPKVLQKKEPHQLTDRTFFIDGSNQGLKTIPSEILALKELEEVHLENNQIAEIPQGIQQLQNTKVLYLHNNSLQDLCPELGALSSLESLDLSGNPLVISSLHVVSRLRTLRELRLYRTGLTEIPTGICKSLHHLELFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKLKSIPGDIGHLVRLQKFYVASNHLMSLPESLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRLEKVPRLLCSWVSLHLLYLRNTSLHGLRDSFKRLINLRFLDLSQNHIEHFPVQICALKNLEILALDDNKVRQLPPSISLLSNLKILGLTGNDLLSFPEEIFSLISLEKLYIGQDQGSKLSSLPENIKRLMNLKELYIENNRLEQLPASLGLMPNLEVLDCRHNLLKQLPDAICRTRNLRELLLEDNLLCCLPENLDHLVNLKVLTLMNNPMVDPPIYVCNQGNEAIWKHLKENRIRKMMATTIQAWWRGIMVRKGYGSYEELLKARKKGKSPPKDKKGKKAAKGKPEKGNKK" }, "uniprot_id": "LRIQ4_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A4", "id": "A6H6A4", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [], "uniprot_ac": "A6H6A4", "site_annotation": [ { "end_pos": 118, "annotation": "n_glycosylation_sequon", "start_pos": 116 }, { "end_pos": 201, "annotation": "n_glycosylation_sequon", "start_pos": 199 }, { "end_pos": 327, "annotation": "n_glycosylation_sequon", "start_pos": 325 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6H6A4#A6H6A4-1", "isoform_ac": "A6H6A4-1", "locus": { "end_pos": 30645330, "strand": "-", "start_pos": 30672290, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000172350", "id": "ENSMUST00000172350", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000127052", "id": "ENSMUSP00000127052", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H6A4-1|LRIQ4_MOUSE Isoform 1 of Leucine-rich repeat and IQ domain-containing protein 4 OS=Mus musculus OX=10090 GN=Lrriq4 PE=2 SV=1 CANONICAL=A6H6A4-1", "length": 596, "sequence": "MHHSSSGSRCVLQNGLELTVILPRLHRFDIIDTFKTLTKELLRQEHLPKVLQKKEPHQLTDRTFFIDGSNQGLKTIPSEILALKELEEVHLENNQIAEIPQGIQQLQNTKVLYLHNNSLQDLCPELGALSSLESLDLSGNPLVISSLHVVSRLRTLRELRLYRTGLTEIPTGICKSLHHLELFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKLKSIPGDIGHLVRLQKFYVASNHLMSLPESLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRLEKVPRLLCSWVSLHLLYLRNTSLHGLRDSFKRLINLRFLDLSQNHIEHFPVQICALKNLEILALDDNKVRQLPPSISLLSNLKILGLTGNDLLSFPEEIFSLISLEKLYIGQDQGSKLSSLPENIKRLMNLKELYIENNRLEQLPASLGLMPNLEVLDCRHNLLKQLPDAICRTRNLRELLLEDNLLCCLPENLDHLVNLKVLTLMNNPMVDPPIYVCNQGNEAIWKHLKENRIRKMMATTIQAWWRGIMVRKGYGSYEELLKARKKGKSPPKDKKGKKAAKGKPEKGNKK" } }, { "url": "https://www.uniprot.org/uniprot/A6H6A4#A6H6A4-2", "isoform_ac": "A6H6A4-2", "locus": { "end_pos": 30648226, "strand": "-", "start_pos": 30672290, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000108265", "id": "ENSMUST00000108265", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000103900", "id": "ENSMUSP00000103900", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H6A4-2|LRIQ4_MOUSE Isoform 2 of Leucine-rich repeat and IQ domain-containing protein 4 OS=Mus musculus OX=10090 GN=Lrriq4 PE=2 SV=1 CANONICAL=A6H6A4-1", "length": 581, "sequence": "MAYPSAKLQMHRFDIIDTFKTLTKELLRQEHLPKVLQKKEPHQLTDRTFFIDGSNQGLKTIPSEILALKELEEVHLENNQIAEIPQGIQQLQNTKVLYLHNNSLQDLCPELGALSSLESLDLSGNPLVISSLHVVSRLRTLRELRLYRTGLTEIPTGICKSLHHLELFGLSENFLESLPEEIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKLKSIPGDIGHLVRLQKFYVASNHLMSLPESLSQCSKLSVLDLTHNSIHSLPSSLELLTELTEVGLSGNRLEKVPRLLCSWVSLHLLYLRNTSLHGLRDSFKRLINLRFLDLSQNHIEHFPVQICALKNLEILALDDNKVRQLPPSISLLSNLKILGLTGNDLLSFPEEIFSLISLEKLYIGQDQGSKLSSLPENIKRLMNLKELYIENNRLEQLPASLGLMPNLEVLDCRHNLLKQLPDAICRTRNLRELLLEDNLLCCLPENLDHLVNLKVLTLMNNPMVDPPIYVCNQGNEAIWKHLKENRIRKMMATTIQAWWRGIMVRKGYGSYEELLKARKKGKSPPKDKKGKKAAKGKPEKGNKK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68307", "resource": "KEGG Pathway", "id": "mmu:68307", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "A6NIV6-1", "protein_name": "Leucine-rich repeat and IQ domain-containing protein 4", "sequence": { "length": 560, "sequence": "MSKDIKSVEHSPKIHQRNDPQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNIMATKIQAWWRGTMVQRGFGKFGELLKPQKKGKTSPKDKKGKKDVKGKPGKGKKK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12260", "id": "12260", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "LRRIQ4", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277439.1", "ac": "NP_001277439.1", "name": "leucine-rich repeat and IQ domain-containing protein 4 isoform 2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004722", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A4", "id": "A6H6A4", "database": "UniProtKB" } ], "name": "protein serine/threonine phosphatase activity", "id": "GO:0004722" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A4", "id": "A6H6A4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A4", "id": "A6H6A4", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H6A4", "id": "A6H6A4", "database": "UniProtKB" } ], "name": "signal transduction", "id": "GO:0007165" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H6A4", "type": "synonym", "resource": "RefSeq", "name": "4930558O21Rik" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H6A4", "type": "synonym", "resource": "RefSeq", "name": "Lrriq4" }, { "url": "https://www.uniprot.org/uniprot/A6H6A4", "type": "recommended", "resource": "UniProtKB", "name": "Lrriq4" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000027703", "id": "ENSMUSG00000027703", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/68307", "id": "68307", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "id": "IPR000048", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "id": "IPR001611", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "id": "IPR003591", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "id": "IPR032675", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:68307", "id": "mmu:68307", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1915557", "id": "1915557", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/ELCVLYN/", "id": "ELCVLYN", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=826997at2759", "id": "826997at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00612", "id": "PF00612", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13855", "id": "PF13855", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A6H6A4", "id": "PR_A6H6A4", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277439.1", "id": "NP_001277439.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A6H6A4", "id": "A6H6A4", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 68010.0, "chemical_mass": 68010.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6H6A4", "name": "Lrriq4", "locus": { "end_pos": 30672431, "strand": "+", "start_pos": 30644507, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000027703", "id": "ENSMUSG00000027703", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A6H6A4#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Leucine-rich repeat and IQ domain-containing protein 4" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H6A4", "type": "synonym", "resource": "RefSeq", "name": "leucine-rich repeat and IQ domain-containing protein 4 isoform 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H6A4", "type": "synonym", "resource": "RefSeq", "name": "leucine-rich repeat and IQ domain-containing protein 4" } ] }