{ "uniprot_canonical_ac": "A6H603-1", "ptm_annotation": [], "sequence": { "header": "sp|A6H603-1|NWD1_MOUSE Isoform 1 of NACHT domain- and WD repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Nwd1 PE=2 SV=2 CANONICAL=A6H603-1", "length": 1563, "sequence": "MDTEREALQCTAYPEVQSFCQRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGSLVVPGPEEATLTSVLRGGAQEAWRLGLISQEQWMCYHRSVIEWEIELGLLSSARGDQGATVFLRDVQDLNKHILDDCSLKMVDRLVDGCLDTNAQSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKTVVVLRLLGTSKLSLDARSLLRSLSFQVCLAYGLPLPPAQVLEAHSRVGHFFHTLLHTVSQRNFESLVLLLDSVDDLDSICHSPRVSWLPLKCPPRVHLILSTCSGQQVLHNLQQTLKDPSTYWEVKALSGSQGQEFIQLLLAAEKRMLSPGQRDVLWASLPECGHPGRLRLAFEEARKWASFTVPVPLATTAEEATHQLCIRLEETHGALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERAKRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAPQPLWFSSTVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAMIGQLCQQAQSWFRACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAIAWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTAEVKCVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTILDGGSQNPTEPQSWDLHVDERNNVVYSTSGARINMWNLETSKLVFCITGDVSDPWVCVALLAAQGLLLALSKGGQVSLWSSAMGKLQEKHQLSSIKEETPTCAVSIQSRARLVAGFSSGSIALVSAGEDRLLEKLPEAVGFLVVSEDDSLLVAGFGRFVRIFLADSQGFHRFMASDLEHEDMVETAVLGPENNLIITGSRDALIQVWSLSEQGTLLNVLEGVGAPVSLLVRGGTLVVSASRKSSSFKVWDLKSTKKLQSPTPFLDRTGLAAVSHHGSFVYFPKVGDKNKVTIWDLAEGEEQDCLDTSNEVRCLEVAEQAKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARKAVNCMSLSKSENRLAIAYDNIVLVLDISPGDPCPAIEGPTYTFYTQLPETIVSVAVLADYRVVYGMSDGSLFLYDCACSKVFPLEAHGSRVSCVEVSHSEQLAVSGAEDALLCLWDLQACRGMFEMSYENSCCRGVRCACFSRDDKHVFAGMEDRSVTAWSTVDGTLLAVQFVHAVINRIIPTSNGFMAPTSHGYLIRERFQCPSVRASQQDPLKNFKKAVWLVKTRQREELAAAEASQDAEPVAVEGKESKSNKRSQVCLIL" }, "uniprot_id": "NWD1_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H603", "id": "A6H603", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [], "uniprot_ac": "A6H603", "site_annotation": [ { "end_pos": 754, "annotation": "n_glycosylation_sequon", "start_pos": 752 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6H603#A0A2I3BR96-1", "isoform_ac": "A0A2I3BR96-1", "locus": { "end_pos": 72650409, "strand": "-", "start_pos": 72711888, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000228312", "id": "ENSMUST00000228312", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000154488", "id": "ENSMUSP00000154488", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A2I3BR96-1|NWD1_MOUSE Computationally mapped isoform of NACHT domain- and WD repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Nwd1 PE=2 SV=1 CANONICAL=A6H603-1", "length": 1562, "sequence": "MDVGPLSPGTRQRLLQGQAGSLPAPSSSSAVVIFISSTISDMDTEREALQCTAYPEVQSFCQRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGSLVVPGPEEATLTSVLRGGAQEAWRLGLISQEQWMCYHRSVIEWEIELGLLSSARGDQGATVFLRDVQDLNKHILDDCSLKMVDRLVDGCLDTNAQSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKTVVVLRLLGTSKLSLDARSLLRSLSFQVCLAYGLPLPPAQVLEAHSRVGHFFHTLLHTVSQRNFESLVLLLDSVDDLDSICHSPRVSWLPLKCPPRVHLILSTCSGQQVLHNLQQTLKDPSTYWEVKALSGSQGQEFIQLLLAAEKRMLSPGQRDVLWASLPECGHPGRLRLAFEEARKWASFTVPVPLATTAEEATHQLCIRLEETHGALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERAKRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAPQPLWFSSTVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAMIGQLCQQAQSWFRACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAIAWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTAEVKCVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTILDGGSQNPTEPQSWDLHVDERNNVVYSTSGARINMWNLETSKLVFCITGDVSDPWVCVALLAAQGLLLALSKGGQVSLWSSAMGKLQEKHQLSSIKEETPTCAVSIQSRARLVAGFSSGSIALVSAGEDRLLEKLPEAVGFLVVSEDDSLLVAGFGRFVRIFLADSQGFHRFMASDLEHEDMVETAVLGPENNLIITGSRDALIQVWDLKSTKKLQSPTPFLDRTGLAAVSHHGSFVYFPKVGDKNKVTIWDLAEGEEQDCLDTSNEVRCLEVAEQAKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARKAVNCMSLSKSENRLAIAYDNIVLVLDISPGDPCPAIEGPTYTFYTQLPETIVSVAVLADYRVVYGMSDGSLFLYDCACSKVFPLEAHGSRVSCVEVSHSEQLAVSGAEDALLCLWDLQACRGMFEMSYENSCCRGVRCACFSRDDKHVFAGMEDRSVTAWSTVDGTLLAVQFVHAVINRIIPTSNGFMAPTSHGYLIRERFQCPSVRASQQDPLKNFKKAVWLVKTRQREELAAAEASQDAEPVAVEGKESKSNKRSQVCLIL" } }, { "url": "https://www.uniprot.org/uniprot/A6H603#A6H603-1", "isoform_ac": "A6H603-1", "locus": { "end_pos": 72653488, "strand": "-", "start_pos": 72711888, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000093427", "id": "ENSMUST00000093427", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000091135", "id": "ENSMUSP00000091135", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H603-1|NWD1_MOUSE Isoform 1 of NACHT domain- and WD repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Nwd1 PE=2 SV=2 CANONICAL=A6H603-1", "length": 1563, "sequence": "MDTEREALQCTAYPEVQSFCQRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGSLVVPGPEEATLTSVLRGGAQEAWRLGLISQEQWMCYHRSVIEWEIELGLLSSARGDQGATVFLRDVQDLNKHILDDCSLKMVDRLVDGCLDTNAQSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKTVVVLRLLGTSKLSLDARSLLRSLSFQVCLAYGLPLPPAQVLEAHSRVGHFFHTLLHTVSQRNFESLVLLLDSVDDLDSICHSPRVSWLPLKCPPRVHLILSTCSGQQVLHNLQQTLKDPSTYWEVKALSGSQGQEFIQLLLAAEKRMLSPGQRDVLWASLPECGHPGRLRLAFEEARKWASFTVPVPLATTAEEATHQLCIRLEETHGALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERAKRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAPQPLWFSSTVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAMIGQLCQQAQSWFRACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAIAWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTAEVKCVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTILDGGSQNPTEPQSWDLHVDERNNVVYSTSGARINMWNLETSKLVFCITGDVSDPWVCVALLAAQGLLLALSKGGQVSLWSSAMGKLQEKHQLSSIKEETPTCAVSIQSRARLVAGFSSGSIALVSAGEDRLLEKLPEAVGFLVVSEDDSLLVAGFGRFVRIFLADSQGFHRFMASDLEHEDMVETAVLGPENNLIITGSRDALIQVWSLSEQGTLLNVLEGVGAPVSLLVRGGTLVVSASRKSSSFKVWDLKSTKKLQSPTPFLDRTGLAAVSHHGSFVYFPKVGDKNKVTIWDLAEGEEQDCLDTSNEVRCLEVAEQAKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARKAVNCMSLSKSENRLAIAYDNIVLVLDISPGDPCPAIEGPTYTFYTQLPETIVSVAVLADYRVVYGMSDGSLFLYDCACSKVFPLEAHGSRVSCVEVSHSEQLAVSGAEDALLCLWDLQACRGMFEMSYENSCCRGVRCACFSRDDKHVFAGMEDRSVTAWSTVDGTLLAVQFVHAVINRIIPTSNGFMAPTSHGYLIRERFQCPSVRASQQDPLKNFKKAVWLVKTRQREELAAAEASQDAEPVAVEGKESKSNKRSQVCLIL" } }, { "url": "https://www.uniprot.org/uniprot/A6H603#A6H603-2", "isoform_ac": "A6H603-2", "locus": {}, "sequence": { "header": "sp|A6H603-2|NWD1_MOUSE Isoform 2 of NACHT domain- and WD repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Nwd1 PE=2 SV=2 CANONICAL=A6H603-1", "length": 1435, "sequence": "MDTEREALQCTAYPEVQSFCQRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGSLVVPGPEEATLTSVLRGGAQEAWRLGLISQEQWMCYHRSVIEWEIELGLLSSARGDQGATVFLRDVQDLNKHILDDCSLKMVDRLVDGCLDTNAQSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKTVVVLRLLGTSKLSLDARSLLRSLSFQVCLAYGLPLPPAQVLEAHSRVGHFFHTLLHTVSQRNFESLVLLLDSVDDLDSICHSPRVSWLPLKCPPRVHLILSTCSGQQVLHNLQQTLKDPSTYWEVKALSGSQGQEFIQLLLAAEKRMLSPGQRDVLWASLPECGHPGRLRLAFEEARKWASFTVPVPLATTAEEATHQLCIRLEETHGALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERAKRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAPQPLWFSSTVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAMIGQLCQQAQSWFRACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAIAWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTAEVKCVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTILDGGSQNPTEPQSWDLHVDERNNVVYSTSGARINMWNLETSKLVFCITGDVSDPWVCVALLAAQGLLLALSKGGQVSLWSSAMGKLQEKHQLSSIKEETPTCAVSIQSRARLVAGFSSGSIALVSAGEDRLLEKLPEAVGFLVVSEDDSLLVAGFGRFVRIFLADSQGFHRFMASDLEHEDMVETAVLGPENNLIITGSRDALIQVWSLSEQGTLLNVLEGVGAPVSLLVRGGTLVVSASRKSSSFKVWDLKSTKKLQSPTPFLDRTGLAAVSHHGSFVYFPKVGDKNKVTIWDLAEGEEQDCLDTSNEVRCLEVAEQAKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARKAVNCMSLSKSENRLAIAYDNIVLVLDISPGDPCPAIEGPTYTFYTQLPETIVSVAVLADYRVVYGMSDGSLFLYDCACSKVFPLEAHGSRVSCVEVSHSEQLAVSGAEDALLCLWDLQACRGMFEMSYEVGGLDN" } }, { "url": "https://www.uniprot.org/uniprot/A6H603#A6H603-3", "isoform_ac": "A6H603-3", "locus": {}, "sequence": { "header": "sp|A6H603-3|NWD1_MOUSE Isoform 3 of NACHT domain- and WD repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Nwd1 PE=2 SV=2 CANONICAL=A6H603-1", "length": 1228, "sequence": "MVDRLVDGCLDTNAQSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKTVVVLRLLGTSKLSLDARSLLRSLSFQVCLAYGLPLPPAQVLEAHSRVGHFFHTLLHTVSQRNFESLVLLLDSVDDLDSICHSPRVSWLPLKCPPRVHLILSTCSGQQVLHNLQQTLKDPSTYWEVKALSGSQGQEFIQLLLAAEKRMLSPGQRDVLWASLPECGHPGRLRLAFEEARKWASFTVPVPLATTAEEATHQLCIRLEETHGALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERAKRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAPQPLWFSSTVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAMIGQLCQQAQSWFRACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAIAWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTAEVKCVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTILDGGSQNPTEPQSWDLHVDERNNVVYSTSGARINMWNLETSKLVFCITGDVSDPWVCVALLAAQGLLLALSKGGQVSLWSSAMGKLQEKHQLSSIKEETPTCAVSIQSRARLVAGFSSGSIALVSAGEDRLLEKLPEAVGFLVVSEDDSLLVAGFGRFVRIFLADSQGFHRFMASDLEHEDMVETAVLGPENNLIITGSRDALIQVWSLSEQGTLLNVLEGVGAPVSLLVRGGTLVVSASRKSSSFKVWDLKSTKKLQSPTPFLDRTGLAAVSHHGSFVYFPKVGDKNKVTIWDLAEGEEQDCLDTSNEVRCLEVAEQAKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARKAVNCMSLSKSENRLAIAYDNIVLVLDISPGDPCPAIEGPTYTFYTQLPETIVSVAVLADYRVVYGMSDGSLFLYDCACSKVFPLEAHGSRVSCVEVSHSEQLAVSGAEDALLCLWDLQACRGMFEMSYEVGGLDN" } }, { "url": "https://www.uniprot.org/uniprot/A6H603#A6H603-4", "isoform_ac": "A6H603-4", "locus": {}, "sequence": { "header": "sp|A6H603-4|NWD1_MOUSE Isoform 4 of NACHT domain- and WD repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Nwd1 PE=2 SV=2 CANONICAL=A6H603-1", "length": 911, "sequence": "MDTEREALQCTAYPEVQSFCQRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGSLVVPGPEEATLTSVLRGGAQEAWRLGLISQEQWMCYHRSVIEWEIELGLLSSARGDQGATVFLRDVQDLNKHILDDCSLKMVDRLVDGCLDTNAQSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKTVVVLRLLGTSKLSLDARSLLRSLSFQVCLAYGLPLPPAQVLEAHSRVGHFFHTLLHTVSQRNFESLVLLLDSVDDLDSICHSPRVSWLPLKCPPRVHLILSTCSGQQVLHNLQQTLKDPSTYWEVKALSGSQGQEFIQLLLAAEKRMLSPGQRDVLWASLPECGHPGRLRLAFEEARKWASFTVPVPLATTAEEATHQLCIRLEETHGALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERAKRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAPQPLWFSSTVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAMIGQLCQQAQSWFRACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAIAWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTV" } }, { "url": "https://www.uniprot.org/uniprot/A6H603#E0CX99-1", "isoform_ac": "E0CX99-1", "locus": { "end_pos": 72653488, "strand": "-", "start_pos": 72711888, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000161254", "id": "ENSMUST00000161254", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000124804", "id": "ENSMUSP00000124804", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E0CX99-1|NWD1_MOUSE Computationally mapped isoform of NACHT domain- and WD repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Nwd1 PE=2 SV=1 CANONICAL=A6H603-1", "length": 1521, "sequence": "MDTEREALQCTAYPEVQSFCQRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGSLVVPGPEEATLTSVLRGGAQEAWRLGLISQEQWMCYHRSVIEWEIELGLLSSARGDQGATVFLRDVQDLNKHILDDCSLKMVDRLVDGCLDTNAQSLLSGLKGRILDAQPGALKSHHLSWSRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIRHHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQVPELLGHKTVVVLRLLGTSKLSLDARSLLRSLSFQVCLAYGLPLPPAQVLEAHSRVGHFFHTLLHTVSQRNFESLVLLLDSVDDLDSICHSPRVSWLPLKCPPRVHLILSTCSGQQVLHNLQQTLKDPSTYWEVKALSGSQGQEFIQLLLAAEKRMLSPGQRDVLWASLPECGHPGRLRLAFEEARKWASFTVPVPLATTAEEATHQLCIRLEETHGALLVAHVLGYIVSSRYGLSEAELKDVLSLDDEVLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQVRYLSGPERAKRHGVLAEFFSGAWSQGIKKLITLPLVGKPLNLDRKVAPQPLWFSSTVANLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNSPEVDLVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAMIGQLCQQAQSWFRACPYPMLVPLAGFLQPPGGPLRATLTGCHKGITAIAWSLEEKLLVVGTQDGAMVVWDVEEQQVVHVLMGHTAEVKCVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTILDGGSQNPTEPQSWDLHVDERNNVVYSTSGARINMWNLETSKLVFCITGDVSDPWVCVALLAAQGLLLALSKGGQVSLWSSAMGKLQEKHQLSSIKEETPTCAVSIQSRARLVAGFSSGSIALVSAGEDRLLEKLPEAVGFLVVSEDDSLLVAGFGRFVRIFLADSQGFHRFMASDLEHEDMVETAVLGPENNLIITGSRDALIQVWDLKSTKKLQSPTPFLDRTGLAAVSHHGSFVYFPKVGDKNKVTIWDLAEGEEQDCLDTSNEVRCLEVAEQAKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARKAVNCMSLSKSENRLAIAYDNIVLVLDISPGDPCPAIEGPTYTFYTQLPETIVSVAVLADYRVVYGMSDGSLFLYDCACSKVFPLEAHGSRVSCVEVSHSEQLAVSGAEDALLCLWDLQACRGMFEMSYENSCCRGVRCACFSRDDKHVFAGMEDRSVTAWSTVDGTLLAVQFVHAVINRIIPTSNGFMAPTSHGYLIRERFQCPSVRASQQDPLKNFKKAVWLVKTRQREELAAAEASQDAEPVAVEGKESKSNKRSQVCLIL" } }, { "url": "https://www.uniprot.org/uniprot/A6H603#E0CY71-1", "isoform_ac": "E0CY71-1", "locus": { "end_pos": 72653488, "strand": "-", "start_pos": 72666639, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000161557", "id": "ENSMUST00000161557", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000125470", "id": "ENSMUSP00000125470", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E0CY71-1|NWD1_MOUSE Computationally mapped isoform of NACHT domain- and WD repeat-containing protein 1 OS=Mus musculus OX=10090 GN=Nwd1 PE=2 SV=1 CANONICAL=A6H603-1", "length": 77, "sequence": "MDTEREALQCTAYPEVQSFCQRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIGPAFVLLSGRSSLAY" } } ], "pathway": [], "function": [ { "url": "https://www.uniprot.org/uniprot/A6H603#function", "annotation": "May play a role in the control of androgen receptor (AR) protein steady-state levels.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H603#function", "id": "A6H603", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q149M9-1", "protein_name": "NACHT domain- and WD repeat-containing protein 1", "sequence": { "length": 1564, "sequence": "MQRGKPCRALPTLKCQTFCQRHGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDRCWKTSIGPAFVALIGDQYGPCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVLQAPGTGEACEPEEATLTSVLRSGAQEARRLGLITQEQWQHYHRSVIEWEIERSLLSSEDREQGATVFLREIQDLHKHILEDCALRMVDRLADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWSRDLVNPKNKTHACYLKELGEQFVVRANHQVLTRLRELDTAGQELAWLYQEIRHHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQMPRLLGHKTVTVLRLLGTSQMSSDARGLLKSICFQVCLAYGLPLPPAQVLDAHTRVVQFFHTLLHTVSCRNFESLVLLLDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALGVLDTLQRVLLDPEAYWEVKPLSGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGRLRLAFEEARKWASFTVPVPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQDVYRDWTPPSKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERAKRHGVLADFFSGTWSQGTKKLITLPLVGKPLNLDRKVAPQPLWFSHTVANLRKLKELPYHLLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQLCRPAVELRGMERSLLYTELLARLHFFATSHPALVGQLCQQAQSWFQLCAHPVLVPLGGFLQPPGGPLRATLSGCHKGITAMAWGVEEKLLVIGTQDGIMAVWDMEEQHVIHMLTGHTGEVRCVKIFAKGTLANSASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQIWNLHVDEAHKVVYSASGSKINAWNLETAEPVFHILGDASDPWMCMAVLASQATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKLVTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDLEHEDMVETAVFGTENNLIITGSLDALIQVWSLSEQGTLLDILEGVGAPVSLLARGGALVASASPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSHNGSYVYFPKIGDKNKVTIWDLAEGEEQDSLDTSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARKAINCMSLSKCEDRLAIAYDNIVLVLDITSGDPCPVIDGPRYTFYTQLPETLSSVAILTDYRVVYSMTNGDLFLYECATSKAFPLETHRSRVACVEVSHKEQLVVSGSEDALLCLWDLQARKWKFEMSYTSSYCRGVQCACFSKDDKYVYVGLKDRSILVWSVLDGTLLTVQFVHAVVNRIIPTTSGFIAPTRHGYLIRENFQCLSAKASPQDPLKNFKKAMWMVKSRQREELVAAAGAPQDLESESAQGNETKSNKCSQVCLIV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/72261", "id": "72261", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "NWD1", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006531150.1", "ac": "XP_006531150.1", "name": "NACHT domain- and WD repeat-containing protein 1 isoform X2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H603", "id": "A6H603", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H603", "id": "A6H603", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H603", "id": "A6H603", "database": "UniProtKB" } ], "name": "positive regulation of gene expression", "id": "GO:0010628" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032088", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H603", "id": "A6H603", "database": "UniProtKB" } ], "name": "negative regulation of NF-kappaB transcription factor activity", "id": "GO:0032088" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H603", "type": "synonym", "resource": "RefSeq", "name": "A230063L24Rik" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H603", "type": "synonym", "resource": "RefSeq", "name": "Nwd1" }, { "url": "https://www.uniprot.org/uniprot/A6H603", "type": "recommended", "resource": "UniProtKB", "name": "Nwd1" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000048148", "id": "ENSMUSG00000048148", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/319555", "id": "319555", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007111", "id": "IPR007111", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "id": "IPR019775", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR024977", "id": "IPR024977", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR043365", "id": "IPR043365", "database": "InterPro" }, { "url": "http://www.informatics.jax.org/marker/MGI:2442268", "id": "2442268", "database": "MGI" }, { "url": "http://www.orthodb.org/?query=20367at2759", "id": "20367at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45013", "id": "PTHR45013", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00400", "id": "PF00400", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF05729", "id": "PF05729", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12894", "id": "PF12894", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A6H603", "id": "PR_A6H603", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006531150.1", "id": "XP_006531150.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A6H603", "id": "A6H603", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 173270.0, "chemical_mass": 173270.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6H603", "name": "Nwd1", "locus": { "end_pos": 72717876, "strand": "+", "start_pos": 72646711, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000048148", "id": "ENSMUSG00000048148", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H603", "type": "synonym", "resource": "RefSeq", "name": "NACHT domain- and WD repeat-containing protein 1 isoform X2" }, { "url": "https://www.uniprot.org/uniprot/A6H603#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "NACHT domain- and WD repeat-containing protein 1" } ] }