{ "uniprot_canonical_ac": "A6H5Y3-1", "ptm_annotation": [], "sequence": { "header": "sp|A6H5Y3-1|METH_MOUSE Isoform 1 of Methionine synthase OS=Mus musculus OX=10090 GN=Mtr PE=1 SV=1 CANONICAL=A6H5Y3-1", "length": 1253, "sequence": "MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEEHFQGQEFKDHSRPLKGNNDILSITQPDIIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKCSADVARKAAEEITLQTGVKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVDAYQEQAKGLLDGRVDILLIETIFDTANAKAALFAIQNLFEENYAPPRPIFISGTIVDKSGRTLSGQTGEAFVTSVSHSDPLCIGLNCSLGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPSTMATHLKDFAVDGLVNIVGGCCGSTPDHIREIAEAVKKCKPRVPPASVFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALSIAKAQVEMGAQVLDINMDDGMLDGPSAMTRFCNSIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEGDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVNVCTRAYHLLVDKVGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKFGMDMGIVNAGNLPVYDAIHKDLLQLCEDLIWNKDSEATEKLLRYAQTHGTGGKKVIQTDEWRNGSIEERLEYALVKGIEKHIVEDTEEARLNGEKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREEARLINGSVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLACNNFRVIDLGVMTPCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLRDDYFEEILEEYEDIRQDHYESLKERKYVPLSQARKHGFHIDWLSEPHPVKPTFIGTQVFEDYNLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYNDAQNMLNILISQKKLQARGVVGFWPAQSVQDDIHLYAEGVVPQAAEPIATFYGLRQQAEKDSSSTDPYHCLSDFIAPLHSGVCDYLGLFAVACFGVEELSKTYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYSRSEQLGVPDLRRLRYEGIRPAPGYPSQPDHTEKLTMWRLASIEQATGIRLTESLAMAPASAVSGLYFSNVKAKYFAVGKISKDQTEDYALRKNMPVAEVEKWLGPILGYDTD" }, "uniprot_id": "METH_MOUSE", "enzyme_annotation": [ { "ec": "2.1.1.13", "activity": "" }, { "ec": "2.1.1.13", "activity": "5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11110696", "type": [ "PubMed" ], "id": "11110696" } ], "title": "Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism.", "journal": "Blood", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074597.1", "id": "NP_001074597.1", "database": "RefSeq" } ], "authors": "Gwynn B, Ciciotte SL, Hunter SJ, Washburn LL, Smith RS, Andersen SG, Swank RT, Dell'Angelica EC, Bonifacino JS, Eicher EM, Peters LL", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11440986", "type": [ "PubMed" ], "id": "11440986" } ], "title": "Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.", "journal": "Human molecular genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074597.1", "id": "NP_001074597.1", "database": "RefSeq" } ], "authors": "Mills M, Yang N, Weinberger R, Vander Woude DL, Beggs AH, Easteal S, North K", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074597.1", "id": "NP_001074597.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17937387", "type": [ "PubMed" ], "id": "17937387" } ], "title": "Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.", "journal": "Hepatology (Baltimore, Md.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074597.1", "id": "NP_001074597.1", "database": "RefSeq" } ], "authors": "Liu SP, Li YS, Chen YJ, Chiang EP, Li AF, Lee YH, Tsai TF, Hsiao M, Huang SF, Chen YM", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19158324", "type": [ "PubMed" ], "id": "19158324" } ], "title": "Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha.", "journal": "American journal of physiology. Endocrinology and metabolism", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074597.1", "id": "NP_001074597.1", "database": "RefSeq" } ], "authors": "Li S, Arning E, Liu C, Vitvitsky V, Hernandez C, Banerjee R, Bottiglieri T, Lin JD", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22365888", "type": [ "PubMed" ], "id": "22365888" } ], "title": "Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development.", "journal": "Placenta", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074597.1", "id": "NP_001074597.1", "database": "RefSeq" } ], "authors": "Cherukad J, Wainwright V, Watson ED", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30753104", "type": [ "PubMed" ], "id": "30753104" } ], "title": "Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074597.1", "id": "NP_001074597.1", "database": "RefSeq" } ], "authors": "Partearroyo T, Murillo-Cuesta S, Vallecillo N, Bermudez-Munoz JM, Rodriguez-de la Rosa L, Mandruzzato G, Celaya AM, Zeisel SH, Pajares MA, Varela-Moreiras G, Varela-Nieto I", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9321480", "type": [ "PubMed" ], "id": "9321480" } ], "title": "The methionine synthase (Mtr) gene maps to proximal mouse chromosome 13.", "journal": "Mammalian genome : official journal of the International Mammalian Genome Society", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074597.1", "id": "NP_001074597.1", "database": "RefSeq" } ], "authors": "Zhang ZX, Leclerc D, Gravel R, Rozen R", "date": "1997" } ], "uniprot_ac": "A6H5Y3", "site_annotation": [ { "end_pos": 139, "annotation": "n_glycosylation_sequon", "start_pos": 137 }, { "end_pos": 155, "annotation": "n_glycosylation_sequon", "start_pos": 153 }, { "end_pos": 249, "annotation": "n_glycosylation_sequon", "start_pos": 247 }, { "end_pos": 569, "annotation": "n_glycosylation_sequon", "start_pos": 567 }, { "end_pos": 658, "annotation": "n_glycosylation_sequon", "start_pos": 656 }, { "end_pos": 752, "annotation": "n_glycosylation_sequon", "start_pos": 750 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3#A0A1Y7VM88-1", "isoform_ac": "A0A1Y7VM88-1", "locus": { "end_pos": 12241658, "strand": "+", "start_pos": 12253973, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000221290", "id": "ENSMUST00000221290", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000152579", "id": "ENSMUSP00000152579", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1Y7VM88-1|METH_MOUSE Computationally mapped isoform of Methionine synthase OS=Mus musculus OX=10090 GN=Mtr PE=1 SV=1 CANONICAL=A6H5Y3-1", "length": 222, "sequence": "MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEEHFQGQEFKDHSRPLKGNNDILSITQPDIIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLESRGLWLELWVRLIRHFLSPHLWKGQIIGTSHLMSLLTHTRSRPRDCWMAGSTSYSLKQFLIQLMPKQPCLRSRTSLKRIMLLLGLSLFLGPLLIKVEGLFLGRRERLLSPACLIRTPCALD" } }, { "url": "https://www.uniprot.org/uniprot/A6H5Y3#A6H5Y3-1", "isoform_ac": "A6H5Y3-1", "locus": { "end_pos": 12187008, "strand": "+", "start_pos": 12253973, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000099856", "id": "ENSMUST00000099856", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000097442", "id": "ENSMUSP00000097442", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A6H5Y3-1|METH_MOUSE Isoform 1 of Methionine synthase OS=Mus musculus OX=10090 GN=Mtr PE=1 SV=1 CANONICAL=A6H5Y3-1", "length": 1253, "sequence": "MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEEHFQGQEFKDHSRPLKGNNDILSITQPDIIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKCSADVARKAAEEITLQTGVKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVDAYQEQAKGLLDGRVDILLIETIFDTANAKAALFAIQNLFEENYAPPRPIFISGTIVDKSGRTLSGQTGEAFVTSVSHSDPLCIGLNCSLGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPSTMATHLKDFAVDGLVNIVGGCCGSTPDHIREIAEAVKKCKPRVPPASVFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALSIAKAQVEMGAQVLDINMDDGMLDGPSAMTRFCNSIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEGDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVNVCTRAYHLLVDKVGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKFGMDMGIVNAGNLPVYDAIHKDLLQLCEDLIWNKDSEATEKLLRYAQTHGTGGKKVIQTDEWRNGSIEERLEYALVKGIEKHIVEDTEEARLNGEKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREEARLINGSVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLACNNFRVIDLGVMTPCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLRDDYFEEILEEYEDIRQDHYESLKERKYVPLSQARKHGFHIDWLSEPHPVKPTFIGTQVFEDYNLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYNDAQNMLNILISQKKLQARGVVGFWPAQSVQDDIHLYAEGVVPQAAEPIATFYGLRQQAEKDSSSTDPYHCLSDFIAPLHSGVCDYLGLFAVACFGVEELSKTYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYSRSEQLGVPDLRRLRYEGIRPAPGYPSQPDHTEKLTMWRLASIEQATGIRLTESLAMAPASAVSGLYFSNVKAKYFAVGKISKDQTEDYALRKNMPVAEVEKWLGPILGYDTD" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:238505", "resource": "KEGG Pathway", "id": "mmu:238505", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-156581", "resource": "Reactome", "id": "R-MMU-156581", "name": "Methylation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1614635", "resource": "Reactome", "id": "R-MMU-1614635", "name": "Sulfur amino acid metabolism" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-196741", "resource": "Reactome", "id": "R-MMU-196741", "name": "Cobalamin (Cbl, vitamin B12) transport and metabolism" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3#function", "annotation": "Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3#function", "id": "A6H5Y3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q99707-1", "protein_name": "Methionine synthase", "sequence": { "length": 1265, "sequence": "MSPALQDLSQPEGLKKTLRDEINAILQKRIMVLDGGMGTMIQREKLNEEHFRGQEFKDHARPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNMCSAGVARKAAEEVTLQTGIKRFVAGALGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQNLFEEKYAPRPIFISGTIVDKSGRTLSGQTGEGFVISVSHGEPLCIGLNCALGAAEMRPFIEIIGKCTTAYVLCYPNAGLPNTFGDYDETPSMMAKHLKDFAMDGLVNIVGGCCGSTPDHIREIAEAVKNCKPRVPPATAFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSRKFAKLIMAGNYEEALCVAKVQVEMGAQVLDVNMDDGMLDGPSAMTRFCNLIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEDDFLEKARKIKKYGAAMVVMAFDEEGQATETDTKIRVCTRAYHLLVKKLGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATKVIKETLPGARISGGLSNLSFSFRGMEAIREAMHGVFLYHAIKSGMDMGIVNAGNLPVYDDIHKELLQLCEDLIWNKDPEATEKLLRYAQTQGTGGKKVIQTDEWRNGPVEERLEYALVKGIEKHIIEDTEEARLNQKKYPRPLNIIEGPLMNGMKIVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREETRVLNGTVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILKAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIRIPLLIGGATTSKTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPHPVKPTFIGTQVFEDYDLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKTVGGEARKVYDDAHNMLNTLISQKKLRARGVVGFWPAQSIQDDIHLYAEAAVPQAAEPIATFYGLRQQAEKDSASTEPYYCLSDFIAPLHSGIRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLDVADLRRLRYKGIRPAPGYPSQPDHTEKLTMWRLADIEQSTGIRLTESLAMAPASAVSGLYFSNLKSKYFAVGKISKDQVEDYALRKNISVAEVEKWLGPILGYDTD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/37280", "id": "37280", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A6H5Y3/", "id": "A6H5Y3", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "MTR", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9Z2Q4-1", "protein_name": "Methionine synthase", "sequence": { "length": 1253, "sequence": "MKKTLQDEIEAILRKRIMVLDGGMGTMIQRYKLSEENFQGQEFKDHSRPLKGNNDILSITQPDVIYQIHKEYLLAGADIIETNTFSSTSIAQADYGLEHLAYRMNKCSADVARKAAEEITLQTGVKRFVAGSLGPTNKTLSVSPSVERPDYRNITFDELVEAYQEQAKGLLDGGVDILLIETIFDTANAKAALFALQKLFEENYASPRPIFISGTIVDKSGRTLSGQTGEAFVTSVSHSDPLCIGLNCALGAAEMRPFIETIGKCTTAYVLCYPNAGLPNTFGDYDETPAMMAMHLKDFAVDGLVNVVGGCCGSTPDHIREIAEAVKNCKPRVPPDSVFEGHMLLSGLEPFRIGPYTNFVNIGERCNVAGSKKFAKLIMAGNYEEALSVAKVQVEMGAQVLDINMDDGMLDGPSAMTKFCNFIASEPDIAKVPLCIDSSNFAVIEAGLKCCQGKCIVNSISLKEGEEDFLEKARKIKKFGAAVVVMAFDEEGQATETDVKVSVCTRAYHLLVEKVGFNPNDIIFDPNILTIGTGMEEHNLYAINFIHATRVIKETLPGVRISGGLSNLSFAFRGMDAIREAMHGVFLYHAIKFGMDMGIVNAGSLPVYDDIHKDLLQLCEDLIWNRDAEATEKLLRYAQTHGKGGKKVIQTDEWRNGSIEERLEYALVKGIEKHIVEDTEEARLNREKYPRPLNIIEGPLMNGMKVVGDLFGAGKMFLPQVIKSARVMKKAVGHLIPFMEKEREEARVLNGSVEEEDPYQGTIVLATVKGDVHDIGKNIVGVVLGCNNFRVIDLGVMTPCDKILQAALDHKADIIGLSGLITPSLDEMIFVAKEMERLAIKIPLLIGGATTSRTHTAVKIAPRYSAPVIHVLDASKSVVVCSQLLDENLKDDYFEEILEEYEDIRQDHYESLKERKYLPLSQARKHSFHIDWLSEPHPVKPTFIGTQVFEDYNLQKLVDYIDWKPFFDVWQLRGKYPNRGFPKIFNDKAVGEEARKVYEDAQNMLSILISRKKLRARGVVGFWPAQSVQDDIHLYAEGAVPQAAEPIATFYGLRQQAEKDSSSTDPYHCLSDFVAPLHSGVRDYLGLFAVACFGVEELSKAYEDDGDDYSSIMVKALGDRLAEAFAEELHERVRRELWAYCGSEQLGVTDLRKLRYEGIRPAPGYPSQPDHTEKLTMWRLANIEQATGIRLTESLAMAPASAVSGLYFSNVKSKYFAVGKISKDQIEDYALRKNMSVAEVEKWLGPILGYDTD" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/37280", "id": "37280", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Mtr", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074597.1", "ac": "NP_001074597.1", "name": "methionine synthase", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008705", "pmid": "11158293", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "methionine synthase activity", "id": "GO:0008705" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "zinc ion binding", "id": "GO:0008270" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016597", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "amino acid binding", "id": "GO:0016597" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008168", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "methyltransferase activity", "id": "GO:0008168" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005542", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "folic acid binding", "id": "GO:0005542" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031419", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "cobalamin binding", "id": "GO:0031419" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009086", "pmid": "11158293", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "methionine biosynthetic process", "id": "GO:0009086" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009235", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "cobalamin metabolic process", "id": "GO:0009235" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006479", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "protein methylation", "id": "GO:0006479" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048678", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "response to axon injury", "id": "GO:0048678" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071732", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "cellular response to nitric oxide", "id": "GO:0071732" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031103", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "name": "axon regeneration", "id": "GO:0031103" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046653", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", 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"url": "http://disease-ontology.org/term/DOID:9352", "resource": "Disease Ontology", "name": "insulin resistance", "description": "" } ], "recommended_name": { "id": "DOID:9352", "url": "http://disease-ontology.org/term/DOID:9352", "resource": "Disease Ontology", "name": "type 2 diabetes mellitus", "description": "A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/9352#disease-associations", "id": "9352", "database": "Alliance of Genome Resources" } ] }, { "synonyms": [ { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "plasma cell myeloma", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "myeloma, plasma cell, malignant", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "medullary plasmacytoma", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "myeloid neoplasm of plasma cell", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "amyloidosis, systemic", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "myeloma, multiple", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "Al amyloidosis", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "plasma cell myeloid neoplasm", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "myelomatosis", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "Kahler's disease", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "Kahler disease", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "myeloma, NOS", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "multiple myeloma/plasma cell myeloma", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "myeloma - multiple", "description": "" }, { "id": "MONDO:0009693", "url": "https://monarchinitiative.org/disease/MONDO:0009693", "resource": "MONDO", "name": "myeloma", "description": "" }, { "id": "DOID:9538", "url": "http://disease-ontology.org/term/DOID:9538", "resource": "Disease Ontology", "name": "plasma cell myeloma", "description": "" } ], "recommended_name": { "id": "DOID:9538", "url": "http://disease-ontology.org/term/DOID:9538", "resource": "Disease Ontology", "name": "multiple myeloma", "description": "A myeloid neoplasm that is located_in the plasma cells in bone marrow." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/9538#disease-associations", "id": "9538", "database": "Alliance of Genome Resources" } ] }, { "synonyms": [ { "id": "MONDO:0013108", "url": "https://monarchinitiative.org/disease/MONDO:0013108", "resource": "MONDO", "name": "leukemia, acute lymphocytic, susceptibility to, 1", "description": "" }, { "id": "MONDO:0013108", "url": "https://monarchinitiative.org/disease/MONDO:0013108", "resource": "MONDO", "name": 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"MONDO:0013108", "url": "https://monarchinitiative.org/disease/MONDO:0013108", "resource": "MONDO", "name": "ALL", "description": "" }, { "id": "MONDO:0013108", "url": "https://monarchinitiative.org/disease/MONDO:0013108", "resource": "MONDO", "name": "leukemia, acute lymphoblastic", "description": "" }, { "id": "DOID:9952", "url": "http://disease-ontology.org/term/DOID:9952", "resource": "Disease Ontology", "name": "ALL", "description": "" }, { "id": "DOID:9952", "url": "http://disease-ontology.org/term/DOID:9952", "resource": "Disease Ontology", "name": "precursor lymphoblastic lymphoma/leukemia", "description": "" }, { "id": "DOID:9952", "url": "http://disease-ontology.org/term/DOID:9952", "resource": "Disease Ontology", "name": "acute lymphoblastic leukaemia", "description": "" }, { "id": "DOID:9952", "url": "http://disease-ontology.org/term/DOID:9952", "resource": "Disease Ontology", "name": "acute lymphocytic leukaemia", "description": "" } ], "recommended_name": { "id": "DOID:9952", "url": "http://disease-ontology.org/term/DOID:9952", "resource": "Disease Ontology", "name": "acute lymphoblastic leukemia", "description": "A acute leukemia that is characterized by over production of lymphoblasts." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/9952#disease-associations", "id": "9952", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [ { "residue": "Thr", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "id": "A6H5Y3", "database": "UniProtKB" } ], "start_pos": "1252", "end_pos": "1252", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 139069.0, "chemical_mass": 139069.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3", "name": "Mtr", "locus": { "end_pos": 12182712, "strand": "-", "start_pos": 12258113, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000021311", "id": "ENSMUSG00000021311", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A6H5Y3#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.1.1.13" }, { "url": "https://www.uniprot.org/uniprot/A6H5Y3#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "5-methyltetrahydrofolate--homocysteine methyltransferase" }, { "url": "https://www.uniprot.org/uniprot/A6H5Y3#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Cobalamin-dependent methionine synthase" }, { "url": "https://www.uniprot.org/uniprot/A6H5Y3#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "MS" }, { "url": "https://www.uniprot.org/uniprot/A6H5Y3#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Methionine synthase" }, { "url": "https://www.uniprot.org/uniprot/A6H5Y3#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Vitamin-B12 dependent methionine synthase" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H5Y3", "type": "synonym", "resource": "RefSeq", "name": "methionine synthase" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A6H5Y3", "type": "synonym", "resource": "RefSeq", "name": "vitamin-B12 dependent methionine synthase; cobalamin-dependent methionine synthase" } ] }