{ "uniprot_canonical_ac": "A5I9F0-1", "ptm_annotation": [], "sequence": { "header": "tr|A5I9F0-1|A5I9F0_RAT Isoform 1 of Protein-tyrosine-phosphatase OS=Rattus norvegicus OX=10116 GN=Ptprk PE=1 SV=1 CANONICAL=A5I9F0-1", "length": 1439, "sequence": "MDVAAAALPAFVALWLLSPWPLLGSVQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMVVDSSNHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESRADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLEPNGIITQYEVSYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPSLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEQLHPHRTKREAGTMECYRVPVTYQNSLSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYKGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGVLVFILLLLVVIVIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSLTFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMVWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS" }, "uniprot_id": "A5I9F0_RAT", "enzyme_annotation": [ { "ec": "3.1.3.48", "activity": "" }, { "ec": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17434290", "type": [ "PubMed" ], "id": "17434290" } ], "title": "Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats.", "journal": "Genomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "id": "NP_001025073.2", "database": "RefSeq" } ], "authors": "Wei K., Yamada T., Matsumoto K., Sakai T., Yasutomo K., Tsukumo S., Kose H.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17909891", "type": [ "PubMed" ], "id": "17909891" } ], "title": "A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in the LEC rat.", "journal": "Mamm. Genome", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "id": "NP_001025073.2", "database": "RefSeq" } ], "authors": "Sasaki N., Asano A., Agui T., Jung C.-G., Tsubomatsu K.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18276111", "type": [ "PubMed" ], "id": "18276111" } ], "title": "PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E-cadherin complexes in cancer cells.", "journal": "Cellular signalling", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "id": "NP_001025073.2", "database": "RefSeq" } ], "authors": "Novellino L, De Filippo A, Deho P, Perrone F, Pilotti S, Parmiani G, Castelli C", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18308476", "type": [ "PubMed" ], "id": "18308476" } ], "title": "Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina.", "journal": "Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "id": "NP_001025073.2", "database": "RefSeq" } ], "authors": "Horvat-Brocker A, Reinhard J, Illes S, Paech T, Zoidl G, Harroch S, Distler C, Knyazev P, Ullrich A, Faissner A", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20203423", "type": [ "PubMed" ], "id": "20203423" } ], "title": "Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat.", "journal": "Biomedical research (Tokyo, Japan)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "id": "NP_001025073.2", "database": "RefSeq" } ], "authors": "Iwata R, Sasaki N, Agui T", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8474452", "type": [ "PubMed" ], "id": "8474452" } ], "title": "Cloning and characterization of R-PTP-kappa, a new member of the receptor protein tyrosine phosphatase family with a proteolytically cleaved cellular adhesion molecule-like extracellular region.", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "id": "NP_001025073.2", "database": "RefSeq" } ], "authors": "Jiang YP, Wang H, D'Eustachio P, Musacchio JM, Schlessinger J, Sap J", "date": "1993" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8663237", "type": [ "PubMed" ], "id": "8663237" } ], "title": "Association of human protein-tyrosine phosphatase kappa with members of the armadillo family.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "id": "NP_001025073.2", "database": "RefSeq" } ], "authors": "Fuchs M, Muller T, Lerch MM, Ullrich A", "date": "1996" } ], "uniprot_ac": "A5I9F0", "site_annotation": [ { "end_pos": 102, "annotation": "n_glycosylation_sequon", "start_pos": 100 }, { "end_pos": 1171, "annotation": "n_glycosylation_sequon", "start_pos": 1169 }, { "end_pos": 1321, "annotation": "n_glycosylation_sequon", "start_pos": 1319 }, { "end_pos": 141, "annotation": "n_glycosylation_sequon", "start_pos": 139 }, { "end_pos": 212, "annotation": "n_glycosylation_sequon", "start_pos": 210 }, { "end_pos": 417, "annotation": "n_glycosylation_sequon", "start_pos": 415 }, { "end_pos": 425, "annotation": "n_glycosylation_sequon", "start_pos": 423 }, { "end_pos": 437, "annotation": "n_glycosylation_sequon", "start_pos": 435 }, { "end_pos": 463, "annotation": "n_glycosylation_sequon", "start_pos": 461 }, { "end_pos": 553, "annotation": "n_glycosylation_sequon", "start_pos": 551 }, { "end_pos": 587, "annotation": "n_glycosylation_sequon", "start_pos": 585 }, { "end_pos": 591, "annotation": "n_glycosylation_sequon", "start_pos": 589 }, { "end_pos": 608, "annotation": "n_glycosylation_sequon", "start_pos": 606 }, { "end_pos": 691, "annotation": "n_glycosylation_sequon", "start_pos": 689 }, { "end_pos": 828, "annotation": "n_glycosylation_sequon", "start_pos": 826 }, { "end_pos": 835, "annotation": "n_glycosylation_sequon", "start_pos": 833 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0#A5I9F0-1", "isoform_ac": "A5I9F0-1", "locus": { "end_pos": 17446489, "strand": "+", "start_pos": 18057980, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000020988", "id": "ENSRNOT00000020988", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000020988", "id": "ENSRNOP00000020988", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A5I9F0-1|A5I9F0_RAT Isoform 1 of Protein-tyrosine-phosphatase OS=Rattus norvegicus OX=10116 GN=Ptprk PE=1 SV=1 CANONICAL=A5I9F0-1", "length": 1439, "sequence": "MDVAAAALPAFVALWLLSPWPLLGSVQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMVVDSSNHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESRADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLEPNGIITQYEVSYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPSLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEQLHPHRTKREAGTMECYRVPVTYQNSLSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYKGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGVLVFILLLLVVIVIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSLTFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMVWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360302", "resource": "KEGG Pathway", "id": "rno:360302", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-182971", "resource": "Reactome", "id": "R-RNO-182971", "name": "EGFR downregulation" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "annotation": "Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "id": "NP_001025073.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "annotation": "Ptprk appears to function in parallel with or downstream of Th-POK/cKrox (also known as ZBTB7B), a master regulator of T cell lineage decision.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "id": "NP_001025073.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "annotation": "The Ptprk gene is responsible for the thid mutation in the LEC rat. Results further suggest that RPTPkappa plays a critical role in the development of CD4 SP cells in the thymus.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "id": "NP_001025073.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P35822-1", "protein_name": "Receptor-type tyrosine-protein phosphatase kappa", "sequence": { "length": 1457, "sequence": "MDVAAAALPAFVALWLLYPWPLLGSALGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMVVDSSNHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESRADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLEPNGIITQYEVSYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPSLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEQLHPHRTKREAGAMECYQVPVTYQNALSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYKGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVIVIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSLTFMDQHNFSPRLPNDPLVPTAVLDENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMVWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/55693", "id": "55693", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A5I9F0/", "id": "A5I9F0", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Ptprk", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q15262-1", "protein_name": "Receptor-type tyrosine-protein phosphatase kappa", "sequence": { "length": 1439, "sequence": "MDTTAAAALPAFVALLLLSPWPLLGSAQGQFSAGGCTFDDGPGACDYHQDLYDDFEWVHVSAQEPHYLPPEMPQGSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGLNPGTLNILVRVNKGPLANPIWNVTGFTGRDWLRAELAVSTFWPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCDKSPHFLRLGDVEVNAGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGDGPIILKEVEYRMTSGSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAATEEPEVIPDPAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/55693", "id": "55693", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "PTPRK", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025073.2", "ac": "NP_001025073.2", "name": "receptor-type tyrosine-protein phosphatase kappa precursor", "summary": "involved in the stimulation of neurite outgrowth [RGD, Feb 2006]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "protein kinase binding", "id": "GO:0019901" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "beta-catenin binding", "id": "GO:0008013" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045295", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "gamma-catenin binding", "id": "GO:0045295" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "protein tyrosine phosphatase activity", "id": "GO:0004725" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "cell-cell junction", "id": "GO:0005911" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "cell surface", "id": "GO:0009986" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "axon", "id": "GO:0030424" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "dendrite", "id": "GO:0030425" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "neuronal cell body", "id": "GO:0043025" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031256", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "leading edge membrane", "id": "GO:0031256" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001750", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5I9F0", "id": "A5I9F0", "database": "UniProtKB" } ], "name": "photoreceptor outer segment", "id": "GO:0001750" } ], "total": 9, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "pmid": 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