{ "uniprot_canonical_ac": "A5HK05-1", "ptm_annotation": [ { "annotation": "Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5HK05", "id": "A5HK05", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q92624", "id": "Q92624", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A5HK05-1|APBP2_RAT Isoform 1 of Amyloid protein-binding protein 2 OS=Rattus norvegicus OX=10116 GN=Appbp2 PE=2 SV=1 CANONICAL=A5HK05-1", "length": 585, "sequence": "MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANRAALYGELCALLFAKSHYDEAYKWCVEAMKEITSGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSTGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVNSSPQSTEEVVQSFLMSQNVEGPSC" }, "uniprot_id": "APBP2_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5HK05", "id": "A5HK05", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9843960", "type": [ "PubMed" ], "id": "9843960" } ], "title": "PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094439.1", "id": "NP_001094439.1", "database": "RefSeq" } ], "authors": "Zheng P, Eastman J, Vande Pol S, Pimplikar SW", "date": "1998" } ], "uniprot_ac": "A5HK05", "site_annotation": [ { "end_pos": 527, "annotation": "n_glycosylation_sequon", "start_pos": 525 }, { "end_pos": 563, "annotation": "n_glycosylation_sequon", "start_pos": 561 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A5HK05#A5HK05-1", "isoform_ac": "A5HK05-1", "locus": { "end_pos": 72507703, "strand": "+", "start_pos": 72544868, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000033684", "id": "ENSRNOT00000033684", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000032753", "id": "ENSRNOP00000032753", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5HK05-1|APBP2_RAT Isoform 1 of Amyloid protein-binding protein 2 OS=Rattus norvegicus OX=10116 GN=Appbp2 PE=2 SV=1 CANONICAL=A5HK05-1", "length": 585, "sequence": "MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANRAALYGELCALLFAKSHYDEAYKWCVEAMKEITSGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSTGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVNSSPQSTEEVVQSFLMSQNVEGPSC" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:303396", "resource": "KEGG Pathway", "id": "rno:303396", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A5HK05#function", "annotation": "May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5HK05#function", "id": "A5HK05", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q92624-1", "protein_name": "Amyloid protein-binding protein 2", "sequence": { "length": 585, "sequence": "MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANKAALYGELCALLFAKSHYDEAYKWCIEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSTSPQSTEEVVQSFLISQNVEGPSC" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/31378", "id": "31378", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A5HK05/", "id": "A5HK05", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "APPBP2", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9DAX9-1", "protein_name": "Amyloid protein-binding protein 2", "sequence": { "length": 585, "sequence": "MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANRAALYGELCALLFAKSHYDEAYKWCVEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSSSPQSTEEVVQSFLMAQNVEGPSC" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/31378", "id": "31378", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A5HK05/", "id": "A5HK05", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Appbp2", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094439.1", "ac": "NP_001094439.1", "name": "amyloid protein-binding protein 2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5HK05", "id": "A5HK05", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5HK05", "id": "A5HK05", "database": "UniProtKB" } ], "name": "microtubule", "id": "GO:0005874" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030659", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5HK05", "id": "A5HK05", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle membrane", "id": "GO:0030659" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5HK05", "id": "A5HK05", "database": "UniProtKB" } ], "name": "intracellular protein transport", "id": "GO:0006886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046907", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5HK05", "id": "A5HK05", "database": "UniProtKB" } ], "name": "intracellular transport", "id": "GO:0046907" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A5HK05", "type": "synonym", "resource": "RefSeq", "name": "Appbp2" }, { "url": "https://www.uniprot.org/uniprot/A5HK05", "type": "recommended", "resource": "UniProtKB", "name": "Appbp2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A5HK05", "type": "synonym", "resource": "RefSeq", "name": "PAT1" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000027654", "id": "ENSRNOG00000027654", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/303396", "id": "303396", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "id": "IPR011990", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013026", "id": "IPR013026", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "id": "IPR019734", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042476", "id": "IPR042476", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:303396", "id": "rno:303396", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/LDCCHKL/", "id": "LDCCHKL", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=578212at2759", "id": "578212at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46575", "id": "PTHR46575", "database": "PANTHER" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A5HK05", "id": "PR_A5HK05", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094439.1", "id": "NP_001094439.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1306488", "id": "1306488", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A5HK05", "id": "A5HK05", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 66902.0, "chemical_mass": 66902.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A5HK05", "name": "Appbp2", "locus": { "end_pos": 72503347, "strand": "-", "start_pos": 72545141, "chromosome": "10", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000027654", "id": "ENSRNOG00000027654", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A5HK05#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "APP-BP2" }, { "url": "https://www.uniprot.org/uniprot/A5HK05#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Amyloid beta precursor protein-binding protein 2" }, { "url": "https://www.uniprot.org/uniprot/A5HK05#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Amyloid protein-binding protein 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A5HK05", "type": "synonym", "resource": "RefSeq", "name": "amyloid protein-binding protein 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A5HK05", "type": "synonym", "resource": "RefSeq", "name": "protein interacting with APP tail 1; APP-BP2; amyloid beta precursor protein (cytoplasmic tail) binding protein 2" } ] }