{ "uniprot_canonical_ac": "A4UUI3-1", "ptm_annotation": [], "sequence": { "header": "tr|A4UUI3-1|A4UUI3_MOUSE Isoform 1 of Guanylate-binding protein 4 OS=Mus musculus OX=10090 GN=Gbp4 PE=1 SV=1 CANONICAL=A4UUI3-1", "length": 631, "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSHTGKSYLMNCLAGQNHVSGTLPTSQRFPSGLHRAVSDQGHLDVVHAPPHQARALVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFVYNSMNTINHQALEQLHYVTELTELIRAKSSPNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGNNPRIQASNSARECIRRFFPNRKCFVFEWPTHDIELIKQLETISEDQLDPTFKESAMAFASYIFTYAKIKTLREGIKVTGNGLGTLVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAASHYSEQMAQRLSLPTDTIQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELLREKNGLFLLKNEEASDKYCQEELDRLSKDLMDNISTFSVPGGHRLYMDMREKIEHDYWQVPRKGVKASEVFQNFLQSQAIIESSILQADTALTAGQKAIAEKHTKKEAAEKEQDLLRQKQKEHQEYMEAQEKRNKENLEQLRRKLEQEREQLIKDHNMMLEKLTKEQKTFREEGYKTQAEELRREIHQLGHNIKEMKQNGDSLVESILRSWFSFISPPSESEKAISSVLSLLRKKDRL" }, "uniprot_id": "A4UUI3_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12396730", "type": [ "PubMed" ], "id": "12396730" } ], "title": "Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro.", "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242934.1", "id": "NP_001242934.1", "database": "RefSeq" } ], "authors": "Nguyen TT, Hu Y, Widney DP, Mar RA, Smith JB", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16689661", "type": [ "PubMed" ], "id": "16689661" } ], "title": "In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.", "journal": "Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242934.1", "id": "NP_001242934.1", "database": "RefSeq" } ], "authors": "Olszewski MA, Gray J, Vestal DJ", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17919070", "type": [ "PubMed" ], "id": "17919070" } ], "title": "In silico and in vitro characterization of mGBP4 splice variants.", "journal": "DNA and cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242934.1", "id": "NP_001242934.1", "database": "RefSeq" } ], "authors": "Konermann C, Kresse A, Beuter-Gunia C, Wurthner J, Degrandi D, Pfeffer K, Beer S", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18025219", "type": [ "PubMed" ], "id": "18025219" } ], "title": "Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.", "journal": "J. Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242934.1", "id": "NP_001242934.1", "database": "RefSeq" } ], "authors": "Pfeffer K., Beer S., Konermann C., Beuter-Gunia C., Degrandi D., Wurthner J., Kresse A., Kurig S.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21551061", "type": [ "PubMed" ], "id": "21551061" } ], "title": "A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection.", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242934.1", "id": "NP_001242934.1", "database": "RefSeq" } ], "authors": "Kim BH, Shenoy AR, Kumar P, Das R, Tiwari S, MacMicking JD", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22095711", "type": [ "PubMed" ], "id": "22095711" } ], "title": "Guanylate binding protein 4 negatively regulates virus-induced type I IFN and antiviral response by targeting IFN regulatory factor 7.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242934.1", "id": "NP_001242934.1", "database": "RefSeq" } ], "authors": "Hu Y, Wang J, Yang B, Zheng N, Qin M, Ji Y, Lin G, Tian L, Wu X, Wu L, Sun B", "date": "2011" } ], "uniprot_ac": "A4UUI3", "site_annotation": [ { "end_pos": 173, "annotation": "n_glycosylation_sequon", "start_pos": 171 }, { "end_pos": 428, "annotation": "n_glycosylation_sequon", "start_pos": 426 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3#A0A0G2JDT5-1", "isoform_ac": "A0A0G2JDT5-1", "locus": { "end_pos": 105125226, "strand": "+", "start_pos": 105137021, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000197799", "id": "ENSMUST00000197799", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000142493", "id": "ENSMUSP00000142493", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JDT5-1|A4UUI3_MOUSE Computationally mapped isoform of Guanylate-binding protein 4 OS=Mus musculus OX=10090 GN=Gbp4 PE=1 SV=1 CANONICAL=A4UUI3-1", "length": 184, "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSHTGKSYLMNCLAGQNHVSGTLPTSQRFPSGLHRAVSDQGHLDVVHAPPHQARALVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFVYNSMNTINHQALEQLHYVTELTELIRAKSSPNPHGIKNSTEFVSFFPDFVW" } }, { "url": "https://www.uniprot.org/uniprot/A4UUI3#A0A0G2JEJ5-1", "isoform_ac": "A0A0G2JEJ5-1", "locus": { "end_pos": 105122909, "strand": "+", "start_pos": 105125554, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000196677", "id": "ENSMUST00000196677", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000142795", "id": "ENSMUSP00000142795", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JEJ5-1|A4UUI3_MOUSE Computationally mapped isoform of Guanylate-binding protein 4 OS=Mus musculus OX=10090 GN=Gbp4 PE=1 SV=1 CANONICAL=A4UUI3-1", "length": 149, "sequence": "MNTINHQALEQLHYVTELTELIRAKSSPNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGNNPRIQASNSARECIRRFFPNRKCFVFEWPTHDIELIKQLETISEDQLDPTFKESAMAFASYIFTYAKIK" } }, { "url": "https://www.uniprot.org/uniprot/A4UUI3#A0A0G2JGT4-1", "isoform_ac": "A0A0G2JGT4-1", "locus": { "end_pos": 105122975, "strand": "+", "start_pos": 105125554, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000199629", "id": "ENSMUST00000199629", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000143689", "id": "ENSMUSP00000143689", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JGT4-1|A4UUI3_MOUSE Computationally mapped isoform of Guanylate-binding protein 4 OS=Mus musculus OX=10090 GN=Gbp4 PE=1 SV=1 CANONICAL=A4UUI3-1", "length": 127, "sequence": "MNTINHQALEQLHYVTELTELIRAKSSPNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGNNPRIQASNSARECIRRFFPNRKCFVFEWPTHDIELIKQLETISEDQL" } }, { "url": "https://www.uniprot.org/uniprot/A4UUI3#A4UUI3-1", "isoform_ac": "A4UUI3-1", "locus": { "end_pos": 105118281, "strand": "+", "start_pos": 105137021, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000100962", "id": "ENSMUST00000100962", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000098522", "id": "ENSMUSP00000098522", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A4UUI3-1|A4UUI3_MOUSE Isoform 1 of Guanylate-binding protein 4 OS=Mus musculus OX=10090 GN=Gbp4 PE=1 SV=1 CANONICAL=A4UUI3-1", "length": 631, "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSHTGKSYLMNCLAGQNHVSGTLPTSQRFPSGLHRAVSDQGHLDVVHAPPHQARALVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFVYNSMNTINHQALEQLHYVTELTELIRAKSSPNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGNNPRIQASNSARECIRRFFPNRKCFVFEWPTHDIELIKQLETISEDQLDPTFKESAMAFASYIFTYAKIKTLREGIKVTGNGLGTLVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAASHYSEQMAQRLSLPTDTIQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELLREKNGLFLLKNEEASDKYCQEELDRLSKDLMDNISTFSVPGGHRLYMDMREKIEHDYWQVPRKGVKASEVFQNFLQSQAIIESSILQADTALTAGQKAIAEKHTKKEAAEKEQDLLRQKQKEHQEYMEAQEKRNKENLEQLRRKLEQEREQLIKDHNMMLEKLTKEQKTFREEGYKTQAEELRREIHQLGHNIKEMKQNGDSLVESILRSWFSFISPPSESEKAISSVLSLLRKKDRL" } }, { "url": "https://www.uniprot.org/uniprot/A4UUI3#A4UUI4-1", "isoform_ac": "A4UUI4-1", "locus": { "end_pos": 105125625, "strand": "+", "start_pos": 105137021, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000196204", "id": "ENSMUST00000196204", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000142528", "id": "ENSMUSP00000142528", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A4UUI4-1|A4UUI3_MOUSE Computationally mapped isoform of Guanylate-binding protein 4 OS=Mus musculus OX=10090 GN=Gbp4 PE=1 SV=1 CANONICAL=A4UUI3-1", "length": 103, "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSHTGKSYLMNCLAGQNHVSLWAPPCSLRPRASGCGACPTPPSQSTGPPGHRGPGRCGKG" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:17472", "resource": "KEGG Pathway", "id": "mmu:17472", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242934.1", "annotation": "GBP4 is a negative regulator of virus-triggered type I interferon (IFN-I) production, interacting as a novel protein targeting interferon regulatory factor (IRF)-7 and inhibiting its function.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242934.1", "id": "NP_001242934.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242934.1", "annotation": "Two splice variants of mGBP4 could be detected. One variant led to a premature stop codon after 312 bp. The second variant resulted in a transcript with a disrupted G2 domain.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242934.1", "id": "NP_001242934.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JDV3-1", "protein_name": "Guanylate-binding protein 6", "sequence": { "length": 611, "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLHYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNRLGILVTTYVNAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGEKAIAEERAQKVAAEKEQELLRQKQKEQQEYMEAQEKSHKENLEQLRRKLEQEREQDIKDHDMMLKKLMKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKEALLNGFSTVLFHYLVRYLKHL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128731", "id": "128731", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Gbp6", "tax_id": 10090 }, { "uniprot_canonical_ac": "M0RDF8-1", "protein_name": "Guanylate-binding protein family member 6", "sequence": { "length": 565, "sequence": "VTQPQMAPICLVENHNERLSVNQKAIEILDKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHSGMLGTSQRLPSGLYSAVADQGHLDVVRATPHQAKALVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSLSTINHQALEQLYYVTELTKLIRARSSPNPDGIKNSTEFVSFFPDFVWTVRDFMLELTLNGKNITSDEYLENALKLIPGNSPRIQASNLPRECIRQFFPNRKCFVFDRPTHDKELLQKLETISEDQLDPNFREGTKAFVSYIFTYAKMKTLREGIKVTGNRLGTLVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAVDHYSEQMAQRLRLPTDTLQELLDEHTACEKEAISVFMEHSFKDENQLFLKKLVKLIGEKKGLFVLKNEEASDKYCQEELDRLSKDFMENISTFSVPGGHRLYVDMREKIERDYWQVPRKGVKASEVFQSFLQSQVIIESSILQADTALTAGEKAIAEERTQREAAEKEQELLRQKQREQQQLMEAQEKSNKENLEQLREKLVQERKQLIEEHNMMLEKQLKDQKAYLEE" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A4UUI3/", "id": "A4UUI3", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Gbp6", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q000W5-1", "protein_name": "Guanylate-binding protein 10", "sequence": { "length": 611, "sequence": "MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFIYNSMITINHQALEQLHYVTELTELIRAKSSPNPAGIKNSTEFVSFFPDFVWIVRDFMLELKLNGEDITSDDYLENALKLIPGDKPRMQASNSCRECIRLFFPNRKCFVFDRPTHDKELLQKLDSITEDQLDPKFQEVTKAFVSYIFTYAKIKTLKEGIKVTGNKLGILVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAADHYSEQMAQRLRLPTETLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELIGENKELFLSKNEEASNKYCQEELDRLSKDFMENISTFFVPCGHKLYMDKREKIEHDYWQVPRKGVKASEVFQSFLQSQAFIESSILQADTALTAGKKAIAEERAQKVAAEKEQDLLRQKQKEQQEYMEAQEKSHKENIEQLRRKLMQEREQLIKDHNMMLKKQLKDQKAFLEEGFKKKAEEMNKEIQQLRDVIKDKKRNTDRIKDALLNGFSTVLFHYLVRYLKHL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128731", "id": "128731", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Gbp10", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q6ZN66-1", "protein_name": "Guanylate-binding protein 6", "sequence": { "length": 633, "sequence": "MESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAGQNHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTVRDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPTNDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYVEAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACEREAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMESISAGSFSVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKALTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREHLLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNLADELTAILSAPAKLIGHGVKGVSSLFKKHKLPF" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128731", "id": "128731", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "GBP6", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8BTS3-1", "protein_name": "Guanylate-binding protein 9", "sequence": { "length": 619, "sequence": "MTQPQMAPICLVENHNEQLLVNQEAIEILEKISQPVVVVAIVGLYRTGKSYLMNCLAGQNHGFPLGSTVQSQTKGIWMWCMPHPTKPEHTLVLLDTEGLGDVEKSNPKNDSWIFALSVLLSSTFVYNSMSTINHQALEQLHYVTELTELIRSKSSRNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGYNPRVQASNSARECIRCFFPNRKCFVFDRPTHDRELLQKLETISEDQLDLKFREGTKAFVSYVFTYAKIKTLREGIKVTGNRLGTLVTTYVDAINSGAVPCLDDAMTSVARRENSVAVQKAADHYSEQMAQRLRLPTDTLQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVEIISEKIAFFWLKNEEASNKYCQEELDRLSKDFMDNISTFSVPGGHRIYTDMRKKIERDYWQVPRKGVKACEVFQNFLQSQYIIESSILQADRALTAGEKAIAEERAQKEVAEKEQELLRQKQKEQQEYMEAQEKRNKENLEQLRRKLMQEREQDIKDHDMMLEKQLKDQKAFLEEGFTNKAEEINAEIERLEHNIKDKKENIGPILELIEKAFCAGVFSSLIMVALLTHNPSLLRK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/128731", "id": "128731", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Gbp9", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242934.1", "ac": "NP_001242934.1", "name": "macrophage activation 2 isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "GTPase activity", "id": "GO:0003924" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "GTP binding", "id": "GO:0005525" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle", "id": "GO:0031410" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "pmid": "22095711", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050830", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "defense response to Gram-positive bacterium", "id": "GO:0050830" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001933", "pmid": "22095711", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "negative regulation of protein phosphorylation", "id": "GO:0001933" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042308", "pmid": "22095711", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "negative regulation of protein import into nucleus", "id": "GO:0042308" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031397", "pmid": "22095711", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "negative regulation of protein ubiquitination", "id": "GO:0031397" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071346", "pmid": "18025219", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "cellular response to interferon-gamma", "id": "GO:0071346" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042832", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "defense response to protozoan", "id": "GO:0042832" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050688", "pmid": "22095711", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "regulation of defense response to virus", "id": "GO:0050688" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032687", "pmid": "22095711", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "name": "negative regulation of interferon-alpha production", "id": "GO:0032687" } ], "total": 9, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A4UUI3", "type": "synonym", "resource": "RefSeq", "name": "AW228052; Mag-; Mag-2; Mp; Mpa; Mpa-2; Mpa2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4UUI3", "type": "synonym", "resource": "RefSeq", "name": "Gbp4" }, { "url": "https://www.uniprot.org/uniprot/A4UUI3", "type": "recommended", "resource": "UniProtKB", "name": "Gbp4" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000079363", "id": "ENSMUSG00000079363", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd16269", "id": "cd16269", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/17472", "id": "17472", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003191", "id": "IPR003191", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015894", "id": "IPR015894", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "id": "IPR027417", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR030386", "id": "IPR030386", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036543", "id": "IPR036543", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037684", "id": "IPR037684", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:17472", "id": "mmu:17472", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:97072", "id": "97072", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/NDSFITR/", "id": "NDSFITR", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1027269at2759", "id": "1027269at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF02263", "id": "PF02263", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF02841", "id": "PF02841", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242934.1", "id": "NP_001242934.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A4UUI3", "id": "A4UUI3", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 72042.0, "chemical_mass": 72042.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3", "name": "Gbp4", "locus": { "end_pos": 105115767, "strand": "-", "start_pos": 105139586, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000079363", "id": "ENSMUSG00000079363", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A4UUI3#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Guanylate binding protein 4.1" }, { "url": "https://www.uniprot.org/uniprot/A4UUI3#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Guanylate-binding protein 4" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4UUI3", "type": "synonym", "resource": "RefSeq", "name": "guanylate-binding protein 4 homolog; guanylate nucleotide binding protein 4; macrophage activation 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4UUI3", "type": "synonym", "resource": "RefSeq", "name": "macrophage activation 2 isoform 1" } ] }