{ "uniprot_canonical_ac": "A4Q9E8-1", "ptm_annotation": [], "sequence": { "header": "sp|A4Q9E8-1|TTLL6_MOUSE Isoform 1 of Tubulin polyglutamylase TTLL6 OS=Mus musculus OX=10090 GN=Ttll6 PE=1 SV=1 CANONICAL=A4Q9E8-1", "length": 822, "sequence": "MLQCLTSESEEGAEEREESSTEDLEELKEFVTLAFVRENTQKRLQNAQQHGKKKRKKKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWGDLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISKPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLDEICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRGIEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWLLEVNHSPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGRFLQQCPNREIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKFFQDNSSLFQNTVASRARELYARQLIQELRQKQEKKVFLKKARKEETQGESAGEQARDKVVRLQRQRQQPKCKTVATCPPKQSLHPVTLVSCTSGLLLNIRGLKKGEISESLEQKDTKEAMLIPCKPVSARNYSSVPDLRSANPSCFEPEFHVPNAKVKEVKSAFMVNIESTAQPITSVESSRDATAPISTSLESLASMSLSTSPECSSPESVHMVSYNHKQQKASFHKPMQEKKSKPLMFSKSRHLDLNCTSMKNDINRQYLMSEILQKVQMKKKRPLFPAPKSQYPTLSKERCPHSRSSSRKKEMNSPSVFVLQASHSRAESLNDLLVVATQARLDPRPSRSHSGTTTRDSSTQDPKHTATA" }, "uniprot_id": "TTLL6_MOUSE", "enzyme_annotation": [ { "ec": "6.-.-.-", "activity": "" } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15890843", "type": [ "PubMed" ], "id": "15890843" } ], "title": "Tubulin polyglutamylase enzymes are members of the TTL domain protein family.", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Edde B", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17499049", "type": [ "PubMed" ], "id": "17499049" } ], "title": "A targeted multienzyme mechanism for selective microtubule polyglutamylation.", "journal": "Mol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "Janke C., Lacroix B., Rogowski K., van Dijk J., Miro J., Edde B.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17971504", "type": [ "PubMed" ], "id": "17971504" } ], "title": "Tissue expression patterns identify mouse cilia genes.", "journal": "Physiological genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "McClintock TS, Glasser CE, Bose SC, Bergman DA", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20530212", "type": [ "PubMed" ], "id": "20530212" } ], "title": "Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.", "journal": "J. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "authors": "Gerlich D.W., Janke C., Guizetti J., Aldrian-Herrada G., Gold N.D., Lacroix B., Rogowski K., van Dijk J.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21074048", "type": [ "PubMed" ], "id": "21074048" } ], "title": "A family of protein-deglutamylating enzymes associated with neurodegeneration.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "authors": "Larroque C., Andrieux A., Bosc C., Janke C., Moutin M.J., Peris L., Magiera M.M., Deloulme J.C., Gold N.D., Lacroix B., Rogowski K., van Dijk J., Bec N., Bosson A., Desagher S., Grau M.B., Holzer M.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22246503", "type": [ "PubMed" ], "id": "22246503" } ], "title": "CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium.", "journal": "Nat. Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "authors": "Attie-Bitach T., Gleeson J.G., Johnson C.A., Logan C.V., Schroth J., Silhavy J.L., Zaki M.S., Boltshauser E., Nelson S.F., Brancati F., Hildebrandt F., Valente E.M., Lee J.H., Glass I.A., Louie C.M., Marsh S.E., Barbot C., Bielas S.L., Lee J.E., Doherty D.A., Setou M., Castroviejo I.P., Cluckey A., Iannicelli M., Ikegami K., Merriman B., Olvera J., Rapin I., Raynes H.R., Schlossman A.M.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26829768", "type": [ "PubMed" ], "id": "26829768" } ], "title": "Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.", "journal": "Nat. Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "authors": "Wang S., Zhu X., Fan Z., Tian Y., Xiong Z., Ye B., Du Y., Xia P.", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", "type": [ "PubMed" ], "id": "27626380" } ], "title": "High-throughput discovery of novel developmental phenotypes.", "journal": "Nature", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28794449", "type": [ "PubMed" ], "id": "28794449" } ], "title": "IL-7Ralpha glutamylation and activation of transcription factor Sall3 promote group 3 ILC development.", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "Liu B, Ye B, Zhu X, Huang G, Yang L, Zhu P, Du Y, Wu J, Meng S, Tian Y, Fan Z", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29593216", "type": [ "PubMed" ], "id": "29593216" } ], "title": "Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y, Fan Z", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/32747782", "type": [ "PubMed" ], "id": "32747782" } ], "title": "Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.", "journal": "Nature structural & molecular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ], "authors": "Mahalingan KK, Keith Keenan E, Strickland M, Li Y, Liu Y, Ball HL, Tanner ME, Tjandra N, Roll-Mecak A", "date": "2020" } ], "uniprot_ac": "A4Q9E8", "site_annotation": [ { "end_pos": 133, "annotation": "n_glycosylation_sequon", "start_pos": 131 }, { "end_pos": 170, "annotation": "n_glycosylation_sequon", "start_pos": 168 }, { "end_pos": 266, "annotation": "n_glycosylation_sequon", "start_pos": 264 }, { "end_pos": 363, "annotation": "n_glycosylation_sequon", "start_pos": 361 }, { "end_pos": 465, "annotation": "n_glycosylation_sequon", "start_pos": 463 }, { "end_pos": 592, "annotation": "n_glycosylation_sequon", "start_pos": 590 }, { "end_pos": 65, "annotation": "n_glycosylation_sequon", "start_pos": 63 }, { "end_pos": 710, "annotation": "n_glycosylation_sequon", "start_pos": 708 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8#A4Q9E8-1", "isoform_ac": "A4Q9E8-1", "locus": { "end_pos": 96133786, "strand": "-", "start_pos": 96158923, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000167258", "id": "ENSMUST00000167258", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000127778", "id": "ENSMUSP00000127778", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4Q9E8-1|TTLL6_MOUSE Isoform 1 of Tubulin polyglutamylase TTLL6 OS=Mus musculus OX=10090 GN=Ttll6 PE=1 SV=1 CANONICAL=A4Q9E8-1", "length": 822, "sequence": "MLQCLTSESEEGAEEREESSTEDLEELKEFVTLAFVRENTQKRLQNAQQHGKKKRKKKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWGDLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISKPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLDEICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRGIEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWLLEVNHSPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGRFLQQCPNREIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKFFQDNSSLFQNTVASRARELYARQLIQELRQKQEKKVFLKKARKEETQGESAGEQARDKVVRLQRQRQQPKCKTVATCPPKQSLHPVTLVSCTSGLLLNIRGLKKGEISESLEQKDTKEAMLIPCKPVSARNYSSVPDLRSANPSCFEPEFHVPNAKVKEVKSAFMVNIESTAQPITSVESSRDATAPISTSLESLASMSLSTSPECSSPESVHMVSYNHKQQKASFHKPMQEKKSKPLMFSKSRHLDLNCTSMKNDINRQYLMSEILQKVQMKKKRPLFPAPKSQYPTLSKERCPHSRSSSRKKEMNSPSVFVLQASHSRAESLNDLLVVATQARLDPRPSRSHSGTTTRDSSTQDPKHTATA" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9E8#A4Q9E8-2", "isoform_ac": "A4Q9E8-2", "locus": { "end_pos": 96135583, "strand": "-", "start_pos": 96158923, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000107680", "id": "ENSMUST00000107680", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000103307", "id": "ENSMUSP00000103307", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4Q9E8-2|TTLL6_MOUSE Isoform 2 of Tubulin polyglutamylase TTLL6 OS=Mus musculus OX=10090 GN=Ttll6 PE=1 SV=1 CANONICAL=A4Q9E8-1", "length": 718, "sequence": "MEMKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWGDLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISKPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLDEICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRGIEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWLLEVNHSPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGRFLQQCPNREIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKFFQDNSSLFQNTVASRARELYARQLIQELRQKQEKKVFLKKARKEETQGESAGEQARDKVVRLQRQRQQPKCKTVATCPPKQSLHPVTLVSCTSGLLLNIRGLKKGEISESLEQKDTKEAMLIPCKPVSARNYSSVPDLRSANPSCFEPEFHVPNAKVKEVKSAFMVNIESTAQPITSVESSRDATAPISTSLESLASMSLSTSPECSSPESVHMVSYNHKQQKASFHKPMQEKKSKPLMFSKSRHLDLNCTSMKNDINRQYLMSEILQKVQMKKKRPLFPAPKSQYPTLSKERCPHSRSSSRKKEMNSPSVFVLQASHSRAESLNDLLVVATQARLDPRPSRSHSGTTTRDSSTQDPKHTATA" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:237930", "resource": "KEGG Pathway", "id": "mmu:237930", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "resource": "Reactome", "id": "R-MMU-8955332", "name": "Carboxyterminal post-translational modifications of tubulin" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8#function", "annotation": "Polyglutamylase which preferentially modifies alpha-tubulin (PubMed:17499049, PubMed:21074048). Mediates tubulin polyglutamylation in cilia (PubMed:22246503). Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (PubMed:17499049, PubMed:21074048). Generates long side-chains (PubMed:20530212). Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS (PubMed:26829768).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8#function", "id": "A4Q9E8", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "annotation": "Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. Erratum:[Nat Struct Mol Biol. 2020 Aug 13;:. PMID: 32792670]", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "annotation": "Ttll6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZJ17-1", "protein_name": "Tubulin tyrosine ligase-like 6", "sequence": { "length": 858, "sequence": "MLQCLTLESEEGAEEREESSTEDLEELKKLVALAFVRENTQKRLQNAQQHGKKKRKKKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWGDLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISKPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNTENLDEICMHLTNYSINKHSSNFIQDAHSGSKRKLSTFNSYMKTHGYDVEQIWRAIEDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWLLEVNHSPSFSTDSKLDKEVKDSLLYDALVLVNLGSCDKKKVLEEERQRGRFLQQCPNREIRMEEVKGFQAVRLQKTEEYEKKNCGGFRLIYPGQNLEKYEKFFQDNSSLFQNTVASRARELYARQLIQELRQKQQNKFFLKKERKEEMQGESAGEQARDKIVRLQRPRQQPKCKPATCPPKQSFHPVNLGSRASSLLLNIRGLKKSETARSLDQKDSKNEVVLIPCKPVSARNYSSVPDLRSSNPSYSELEFHMANSKVKEVKSAFSVNIVSSAQPTAEPSEQLSKVFGYCSQSQVKKTLSDAEFADHLSTSKPITPVETSPDATAPISTSLESLASSLSTTPECSSPESIHMASYNHKQQKASNKPTQEKKSKPLMFSKSRQLDLNCTSMKNDIKKQYLMSEILQKVQMKKKRPLFPVPKTQYPSLSKERYPHGRSSGRKKGMEAHSVVILQSSHSHAESLNDLLVVATQARLDPRPSRSHSGTTTRDSGTQDPKHTATA" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A4Q9E8/", "id": "A4Q9E8", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Ttll6", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q8N841-1", "protein_name": "Tubulin polyglutamylase TTLL6", "sequence": { "length": 843, "sequence": "MPQCPTLESQEGENSEEKGDSSKEDPKETVALAFVRENPGAQNGLQNAQQQGKKKRKKKRLVINLSSCRYESVRRAAQQYGFREGGEDDDWTLYWTDYSVSLERVMEMKSYQKINHFPGMSEICRKDLLARNMSRMLKMFPKDFRFFPRTWCLPADWGDLQTYSRSRKNKTYICKPDSGCQGKGIFITRTVKEIKPGEDMICQLYISKPFIIDGFKFDLRIYVLVTSCDPLRIFVYNEGLARFATTSYSRPCTDNLDDICMHLTNYSINKHSSNFSRDAHSGSKRKLSTFSAYLEDHSYNVEQIWRDIEDVIIKTLISAHPIIRHNYHTCFPNHTLNSACFEILGFDILLDHKLKPWLLEVNHSPSFSTDSRLDKEVKDGLLYDTLVLINLESCDKKKVLEEERQRGQFLQQCCSREMRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLNSEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQPLTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVHLTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPHLISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRSHASAMRDPCMQDQEAYSHCLISGQKGCERS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18229", "id": "18229", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "TTLL6", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "ac": "NP_766387.2", "name": "tubulin polyglutamylase TTLL6", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070740", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "tubulin-glutamic acid ligase activity", "id": "GO:0070740" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015631", "pmid": "21074048", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "tubulin binding", "id": "GO:0015631" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070739", "pmid": "26829768", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "protein-glutamic acid ligase activity", "id": "GO:0070739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "cilium", "id": "GO:0005929" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "microtubule", "id": "GO:0005874" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "ciliary basal body", "id": "GO:0036064" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051013", "pmid": "20530212", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "microtubule severing", "id": "GO:0051013" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000226", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "microtubule cytoskeleton organization", "id": "GO:0000226" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018095", "pmid": "21074048", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "protein polyglutamylation", "id": "GO:0018095" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018095", "pmid": "26829768", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "protein polyglutamylation", "id": "GO:0018095" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001578", "pmid": "20530212", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "microtubule bundle formation", "id": "GO:0001578" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003353", "pmid": "23897886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "name": "positive regulation of cilium movement", "id": "GO:0003353" } ], "total": 6, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9E8", "type": "synonym", "resource": "RefSeq", "name": "4932418K24Rik; D11Moh43; D11Moh43e; D11Moh44; D11Moh44e; t8130b59" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9E8", "type": "synonym", "resource": "RefSeq", "name": "Ttll6" }, { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "type": "recommended", "resource": "UniProtKB", "name": "Ttll6" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000038756", "id": "ENSMUSG00000038756", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/237930", "id": "237930", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004344", "id": "IPR004344", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013815", "id": "IPR013815", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027754", "id": "IPR027754", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:237930", "id": "mmu:237930", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2683461", "id": "2683461", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/AYPIIKH/", "id": "AYPIIKH", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1251554at2759", "id": "1251554at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12241:SF96", "id": "PTHR12241:SF96", "database": "PANTHER" }, { "url": "https://www.rcsb.org/structure/6VZQ", "id": "6VZQ", "database": "PDB" }, { "url": "https://www.rcsb.org/structure/6VZR", "id": "6VZR", "database": "PDB" }, { "url": "https://www.rcsb.org/structure/6VZS", "id": "6VZS", "database": "PDB" }, { "url": "https://www.rcsb.org/structure/6VZT", "id": "6VZT", "database": "PDB" }, { "url": "https://www.rcsb.org/structure/6VZU", "id": "6VZU", "database": "PDB" }, { "url": "https://www.rcsb.org/structure/6VZV", "id": "6VZV", "database": "PDB" }, { "url": "https://www.rcsb.org/structure/6VZW", "id": "6VZW", "database": "PDB" }, { "url": "http://pfam.xfam.org/family/PF03133", "id": "PF03133", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A4Q9E8", "id": "PR_A4Q9E8", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "id": "R-MMU-8955332", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766387.2", "id": "NP_766387.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "id": "A4Q9E8", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 94507.0, "chemical_mass": 94507.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8", "name": "Ttll6", "locus": { "end_pos": 96165451, "strand": "+", "start_pos": 96133786, "chromosome": "11", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000038756", "id": "ENSMUSG00000038756", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E8#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "6.-.-.-" }, { "url": "https://www.uniprot.org/uniprot/A4Q9E8#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Tubulin polyglutamylase TTLL6" }, { "url": "https://www.uniprot.org/uniprot/A4Q9E8#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Tubulin--tyrosine ligase-like protein 6" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9E8", "type": "synonym", "resource": "RefSeq", "name": "polyglutamylase; tubulin--tyrosine ligase-like protein 6" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9E8", "type": "synonym", "resource": "RefSeq", "name": "tubulin polyglutamylase TTLL6" } ] }