{ "uniprot_canonical_ac": "A4Q9E5-1", "ptm_annotation": [], "sequence": { "header": "sp|A4Q9E5-1|TTLL3_MOUSE Isoform 1 of Tubulin monoglycylase TTLL3 OS=Mus musculus OX=10090 GN=Ttll3 PE=1 SV=1 CANONICAL=A4Q9E5-1", "length": 927, "sequence": "MQGVSSALLLSAGQLGPGAAWYRQEGSSECSWLRRSQPSELRTNFSSRWPWPRNSESRRSERLQWPGPASAKPEVASCGDSRRDYSSLPARHLSSARESSMPGALGTVNPQPVRTLVPPTLDEPLPDALRPPDDSLLLWRGLTKGPNHMGRLRNAKIHVERAVKQKKIFMIHGRYPVIRCLLRQRGWVEKKMVHPPGTALPAPQKDLDSSMLGDSDATEDEDEEENEMFRESQLLDLDGFLEFDDLDGIHALMSRMVRNETPYLIWTTRRDVLDCRFLSKDQMINHYARAGSFTTKVGLCLNLRNLPWFDEADADSFFPRCYRLGAEDDKKAFIEDFWLTAARNVLKLVVKLEEKSQSISIQAREEEAPEDTQPKKQEKKLVTVSSDFVDEALSACQEHLSSIAHKDIDKDPNSPLYLSPDDWSQFLQRYYQIVHEGAELRYLEVQVQRCEDILQQLQNVVPQLDMEGDRNIWIVKPGAKSRGRGIMCMNRLDEMLKLVDCNPMLMKDGKWIVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQRHLEASCHRHPMLPPDNMWSSQRFQAHLQEVDAPKAWSSVIVPGMKAAVIHALQTSQDNVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRRLDRSCDTGAFELIYKQPAVEVPQYVGIRLLVEGSTIKKPVPVGHRRTGVRSSLPHLLTQQGSGESKDSGSPTHRSASRKNARAESLEHTEKPEPAAVASVSGKGKKAPFHFPSLHSKAWLPSPRVHRPQGRVLRLQHDQLVGSKALSTTGKALMTLPTAKVLMSFPPHPDLKLAPSMLKPGKVGFELCCTTWRVVLSGGIGEEGHRQRAAPRPSSAPGKGLSSTEPCSKTET" }, "uniprot_id": "TTLL3_MOUSE", "enzyme_annotation": [ { "ec": "6.3.2.-", "activity": "" } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17499049", "type": [ "PubMed" ], "id": "17499049" } ], "title": "A targeted multienzyme mechanism for selective microtubule polyglutamylation.", "journal": "Mol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136204.1", "id": "NP_001136204.1", "database": "RefSeq" } ], "authors": "Janke C., Lacroix B., Rogowski K., van Dijk J., Miro J., Edde B.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19524510", "type": [ "PubMed" ], "id": "19524510" } ], "title": "Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136204.1", "id": "NP_001136204.1", "database": "RefSeq" } ], "authors": "Van Dorsselaer A., Strub J.-M., Thomas D., Gaertig J., Wloga D., Janke C., Rogowski K., van Dijk J., Bre M.-H., Juge F., Levilliers N.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23897886", "type": [ "PubMed" ], "id": "23897886" } ], "title": "Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.", "journal": "The Journal of cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136204.1", "id": "NP_001136204.1", "database": "RefSeq" } ], "authors": "Bosch Grau M, Gonzalez Curto G, Rocha C, Magiera MM, Marques Sousa P, Giordano T, Spassky N, Janke C", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25180231", "type": [ "PubMed" ], "id": "25180231" } ], "title": "Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.", "journal": "The EMBO journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136204.1", "id": "NP_001136204.1", "database": "RefSeq" } ], "authors": "Rocha C, Papon L, Cacheux W, Marques Sousa P, Lascano V, Tort O, Giordano T, Vacher S, Lemmers B, Mariani P, Meseure D, Medema JP, Bieche I, Hahne M, Janke C", "date": "2014" } ], "uniprot_ac": "A4Q9E5", "site_annotation": [ { "end_pos": 261, "annotation": "n_glycosylation_sequon", "start_pos": 259 }, { "end_pos": 46, "annotation": "n_glycosylation_sequon", "start_pos": 44 }, { "end_pos": 574, "annotation": "n_glycosylation_sequon", "start_pos": 572 }, { "end_pos": 666, "annotation": "n_glycosylation_sequon", "start_pos": 664 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5#A4Q9E5-1", "isoform_ac": "A4Q9E5-1", "locus": { "end_pos": 113392497, "strand": "-", "start_pos": 113414239, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000032414", "id": "ENSMUST00000032414", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000032414", "id": "ENSMUSP00000032414", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4Q9E5-1|TTLL3_MOUSE Isoform 1 of Tubulin monoglycylase TTLL3 OS=Mus musculus OX=10090 GN=Ttll3 PE=1 SV=1 CANONICAL=A4Q9E5-1", "length": 927, "sequence": "MQGVSSALLLSAGQLGPGAAWYRQEGSSECSWLRRSQPSELRTNFSSRWPWPRNSESRRSERLQWPGPASAKPEVASCGDSRRDYSSLPARHLSSARESSMPGALGTVNPQPVRTLVPPTLDEPLPDALRPPDDSLLLWRGLTKGPNHMGRLRNAKIHVERAVKQKKIFMIHGRYPVIRCLLRQRGWVEKKMVHPPGTALPAPQKDLDSSMLGDSDATEDEDEEENEMFRESQLLDLDGFLEFDDLDGIHALMSRMVRNETPYLIWTTRRDVLDCRFLSKDQMINHYARAGSFTTKVGLCLNLRNLPWFDEADADSFFPRCYRLGAEDDKKAFIEDFWLTAARNVLKLVVKLEEKSQSISIQAREEEAPEDTQPKKQEKKLVTVSSDFVDEALSACQEHLSSIAHKDIDKDPNSPLYLSPDDWSQFLQRYYQIVHEGAELRYLEVQVQRCEDILQQLQNVVPQLDMEGDRNIWIVKPGAKSRGRGIMCMNRLDEMLKLVDCNPMLMKDGKWIVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQRHLEASCHRHPMLPPDNMWSSQRFQAHLQEVDAPKAWSSVIVPGMKAAVIHALQTSQDNVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRRLDRSCDTGAFELIYKQPAVEVPQYVGIRLLVEGSTIKKPVPVGHRRTGVRSSLPHLLTQQGSGESKDSGSPTHRSASRKNARAESLEHTEKPEPAAVASVSGKGKKAPFHFPSLHSKAWLPSPRVHRPQGRVLRLQHDQLVGSKALSTTGKALMTLPTAKVLMSFPPHPDLKLAPSMLKPGKVGFELCCTTWRVVLSGGIGEEGHRQRAAPRPSSAPGKGLSSTEPCSKTET" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9E5#A4Q9E5-2", "isoform_ac": "A4Q9E5-2", "locus": { "end_pos": 113393147, "strand": "-", "start_pos": 113399186, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000204026", "id": "ENSMUST00000204026", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000145049", "id": "ENSMUSP00000145049", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A4Q9E5-2|TTLL3_MOUSE Isoform 2 of Tubulin monoglycylase TTLL3 OS=Mus musculus OX=10090 GN=Ttll3 PE=1 SV=1 CANONICAL=A4Q9E5-1", "length": 287, "sequence": "MGRLRNAKIHVERAVKQKKIFMIHGRYPVIRCLLRQRGWVEKKMVHPPGTALPAPQKDLDSSMLGDSDATEDEDEEENEMFRESQLLDLDGFLEFDDLDGIHALMSRMVRNETPYLIWTTRRDVLDCRFLSKDQMINHYARAGSFTTKVGLCLNLRNLPWFDEADADSFFPRCYRLGAEDDKKAFIGKGTPIPGLAPSCCLSHRGKEQASPCGLCNPSPFLLPMGLPFISQPWHSEKPREPGLYPVAGSRGGWVGSVWSLDKLLAGPGSTKGNGSLRQSKFLFQHGF" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9E5#A4Q9E5-3", "isoform_ac": "A4Q9E5-3", "locus": {}, "sequence": { "header": "sp|A4Q9E5-3|TTLL3_MOUSE Isoform 3 of Tubulin monoglycylase TTLL3 OS=Mus musculus OX=10090 GN=Ttll3 PE=1 SV=1 CANONICAL=A4Q9E5-1", "length": 704, "sequence": "MDTSSPFYAAGQGEASPPSLPVSISSPSLQSRMVRNETPYLIWTTRRDVLDCRFLSKDQMINHYARAGSFTTKVGLCLNLRNLPWFDEADADSFFPRCYRLGAEDDKKAFIEDFWLTAARNVLKLVVKLEEKSQSISIQAREEEAPEDTQPKKQEKKLVTVSSDFVDEALSACQEHLSSIAHKDIDKDPNSPLYLSPDDWSQFLQRYYQIVHEGAELRYLEVQVQRCEDILQQLQNVVPQLDMEGDRNIWIVKPGAKSRGRGIMCMNRLDEMLKLVDCNPMLMKDGKWIVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQRHLEASCHRHPMLPPDNMWSSQRFQAHLQEVDAPKAWSSVIVPGMKAAVIHALQTSQDNVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRRLDRSCDTGAFELIYKQPAVEVPQYVGIRLLVEGSTIKKPVPVGHRRTGVRSSLPHLLTQQGSGESKDSGSPTHRSASRKNARAESLEHTEKPEPAAVASVSGKGKKAPFHFPSLHSKAWLPSPRVHRPQGRVLRLQHDQLVGSKALSTTGKALMTLPTAKVLMSFPPHPDLKLAPSMLKPGKVGFELCCTTWRVVLSGGIGEEGHRQRAAPRPSSAPGKGLSSTEPCSKTET" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9E5#F6T422-1", "isoform_ac": "F6T422-1", "locus": { "end_pos": 113393177, "strand": "-", "start_pos": 113397946, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000205017", "id": "ENSMUST00000205017", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000145044", "id": "ENSMUSP00000145044", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6T422-1|TTLL3_MOUSE Computationally mapped isoform of Tubulin monoglycylase TTLL3 OS=Mus musculus OX=10090 GN=Ttll3 PE=1 SV=1 CANONICAL=A4Q9E5-1", "length": 68, "sequence": "VERAVKQKKIFMIHGRYPVIRCLLRQRGWVEKKMVHPPGTALPAPQKDLDSSMLGDSDATEDVPHGSK" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9E5#F8VQA1-1", "isoform_ac": "F8VQA1-1", "locus": { "end_pos": 113393160, "strand": "-", "start_pos": 113414001, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000203524", "id": "ENSMUST00000203524", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000145329", "id": "ENSMUSP00000145329", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F8VQA1-1|TTLL3_MOUSE Computationally mapped isoform of Tubulin monoglycylase TTLL3 OS=Mus musculus OX=10090 GN=Ttll3 PE=1 SV=1 CANONICAL=A4Q9E5-1", "length": 721, "sequence": "XNAKIHVERAVKQKKIFMIHGRYPVIRCLLRQRGWVEKKMVHPPGTALPAPQKDLDSSMLGDSDATEDEDEEENEMFRESQLLDLDGFLEFDDLDGIHALMSRMVRNETPYLIWTTRRDVLDCRFLSKDQMINHYARAGSFTTKVGLCLNLRNLPWFDEADADSFFPRCYRLGAEDDKKAFIEDFWLTAARNVLKLVVKLEEKSQSISIQAREEEAPEDTQPKKQEKKLVTVSSDFVDEALSACQEHLSSIAHKDIDKDPNSPLYLSPDDWSQFLQRYYQIVHEGAELRYLEVQVQRCEDILQQLQNVVPQLDMEGDRNIWIVKPGAKSRGRGIMCMNRLDEMLKLVDCNPMLMKDGKWIVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQRHLEASCHRHPMLPPDNMWSSQRFQAHLQEVDAPKAWSSVIVPGMKAAVIHALQTSQDNVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRRLDRSCDTGAFELIYKQPAVEVPQYVGIRLLVEGSTIKKPVPVGHRRTGVRSSLPHLLTQQGSGESKDSGSPTHRSASRKNARAESLEHTEKPEPAAVASVSGKGKKAEVAGSLRTLPEVAQLRRGRAGMQTQPLSTSLASIPRPGCLLPVCTDPRAGSSDSNMTSWWALRLCQPQARP" } }, { "url": "https://www.uniprot.org/uniprot/A4Q9E5#H7BX03-1", "isoform_ac": "H7BX03-1", "locus": { "end_pos": 113392497, "strand": "-", "start_pos": 113414239, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000038889", "id": "ENSMUST00000038889", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000037870", "id": "ENSMUSP00000037870", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H7BX03-1|TTLL3_MOUSE Computationally mapped isoform of Tubulin monoglycylase TTLL3 OS=Mus musculus OX=10090 GN=Ttll3 PE=1 SV=1 CANONICAL=A4Q9E5-1", "length": 928, "sequence": "MQGVSSALLLSAGQLGPGAAWYRQEGSSECSWLRRSQPSELRTNFSSRWPWPRNSESRRSERLQWPGPASAKPEVASCGDSRRDYSSLPARHLSSARESSMPGALGTVNPQPVRTLVPPTLDEPLPDALRPPDDSLLLWRGLTKGPNHMGRLRNAKIHVERAVKQKKIFMIHGRYPVIRCLLRQRGWVEKKMVHPPGTALPAPQKDLDSSMLGDSDATEDEDEEENEMFRESQLLDLDGFLEFDDLDGIHALMSRMVRNETPYLIWTTRRDVLDCRFLSKDQMINHYARAGSFTTKVGLCLNLRNLPWFDEADADSFFPRCYRLGAEDDKKAFIAEDFWLTAARNVLKLVVKLEEKSQSISIQAREEEAPEDTQPKKQEKKLVTVSSDFVDEALSACQEHLSSIAHKDIDKDPNSPLYLSPDDWSQFLQRYYQIVHEGAELRYLEVQVQRCEDILQQLQNVVPQLDMEGDRNIWIVKPGAKSRGRGIMCMNRLDEMLKLVDCNPMLMKDGKWIVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQRHLEASCHRHPMLPPDNMWSSQRFQAHLQEVDAPKAWSSVIVPGMKAAVIHALQTSQDNVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRRLDRSCDTGAFELIYKQPAVEVPQYVGIRLLVEGSTIKKPVPVGHRRTGVRSSLPHLLTQQGSGESKDSGSPTHRSASRKNARAESLEHTEKPEPAAVASVSGKGKKAPFHFPSLHSKAWLPSPRVHRPQGRVLRLQHDQLVGSKALSTTGKALMTLPTAKVLMSFPPHPDLKLAPSMLKPGKVGFELCCTTWRVVLSGGIGEEGHRQRAAPRPSSAPGKGLSSTEPCSKTET" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:101100", "resource": "KEGG Pathway", "id": "mmu:101100", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "resource": "Reactome", "id": "R-MMU-8955332", "name": "Carboxyterminal post-translational modifications of tubulin" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136204.1", "annotation": "Decreased levels of TTLL3 expression are linked to the development of colorectal carcinomas. Erratum:[EMBO J. 2014 Nov 18;33(22):2735]", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136204.1", "id": "NP_001136204.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A4Q9E5#function", "annotation": "Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5#function", "id": "A4Q9E5", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136204.1", "annotation": "The TTLL3 was required for stability and maintenance of ependymal cilia, whereas the polyglutamylase TTLL6 was necessary for coordinated beating behavior.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136204.1", "id": "NP_001136204.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9Y4R7-1", "protein_name": "Tubulin monoglycylase TTLL3", "sequence": { "length": 772, "sequence": "MNRLRNAKIYVERAVKQKKIFTIQGCYPVIRCLLRRRGWVEKKMVHRSGPTLLPPQKDLDSSAMGDSDTTEDEDEDEDEEFQPSQLFDFDDLLKFDDLDGTHALMVGLCLNLRNLPWFDEVDANSFFPRCYCLGAEDDKKAFIEDFWLTAARNVLKLVVKSEWKSYPIQAVEEEASGDKQPKKQEKNPVLVSPEFVDEALCACEEYLSNLAHMDIDKDLEAPLYLTPEGWSLFLQRYYQVVHEGAELRHLDTQVQRCEDILQQLQAVVPQIDMEGDRNIWIVKPGAKSRGRGIMCMDHLEEMLKLVNGNPVVMKDGKWVVQKYIERPLLIFGTKFDLRQWFLVTDWNPLTVWFYRDSYIRFSTQPFSLKNLDNSVHLCNNSIQKHLENSCHRHPLLPPDNMWSSQRFQAHLQEMGAPNAWSTIIVPGMKDAVIHALQTSQDTVQCRKASFELYGADFVFGEDFQPWLIEINASPTMAPSTAVTARLCAGVQADTLRVVIDRMLDRNCDTGAFELIYKQPAVEVPQYVGIRLLVEGFTIKKPMAMCHRRMGVRPAVPLLTQRGSGEARHHFPSLHTKAQLPSPHVLRHQGQVLRRQHSKLVGTKALSTTGKALRTLPTAKVFISLPPNLDFKVAPSILKPRKAPALLCLRGPQLEVPCCLCPLKSEQFLAPVGRSRPKANSRPDCDKPRAEACPMKRLSPLKPLPLVGTFQRRRGLGDMKLGKPLLRFPTALVLDPTPNKKKQVKYLGLDSIAVGGSRVDGARPCTPGSTARA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/134361", "id": "134361", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "TTLL3", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136204.1", "ac": "NP_001136204.1", "name": "tubulin monoglycylase TTLL3 isoform 2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070735", "pmid": "19524510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "name": "protein-glycine ligase activity", "id": "GO:0070735" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070736", "pmid": "19524510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "name": "protein-glycine ligase activity, initiating", "id": "GO:0070736" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "name": "ATP binding", "id": "GO:0005524" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "pmid": "19524510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "name": "cilium", "id": "GO:0005929" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "pmid": "19524510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "name": "microtubule cytoskeleton", "id": "GO:0015630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005930", "pmid": "19524510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "name": "axoneme", "id": "GO:0005930" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "name": "microtubule", "id": "GO:0005874" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "pmid": "23897886", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "name": "cilium assembly", "id": "GO:0060271" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018094", "pmid": "19524510", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "name": "protein polyglycylation", "id": "GO:0018094" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035082", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "name": "axoneme assembly", "id": "GO:0035082" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9E5", "type": "synonym", "resource": "RefSeq", "name": "4833441J24Rik; AI450050" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9E5", "type": "synonym", "resource": "RefSeq", "name": "Ttll3" }, { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "type": "recommended", "resource": "UniProtKB", "name": "Ttll3" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000030276", "id": "ENSMUSG00000030276", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/101100", "id": "101100", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A4Q9E5*", "id": "A4Q9E5", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004344", "id": "IPR004344", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027753", "id": "IPR027753", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:101100", "id": "mmu:101100", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2141418", "id": "2141418", "database": "MGI" }, { "url": "http://www.orthodb.org/?query=1137333at2759", "id": "1137333at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45870:SF1", "id": "PTHR45870:SF1", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF03133", "id": "PF03133", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A4Q9E5", "id": "PR_A4Q9E5", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8955332", "id": "R-MMU-8955332", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136204.1", "id": "NP_001136204.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "id": "A4Q9E5", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 104428.0, "chemical_mass": 104428.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5", "name": "Ttll3", "locus": { "end_pos": 113414587, "strand": "+", "start_pos": 113389260, "chromosome": "6", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000030276", "id": "ENSMUSG00000030276", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A4Q9E5#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "6.3.2.-" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9E5", "type": "synonym", "resource": "RefSeq", "name": "TTL domain protein; tubulin--tyrosine ligase-like protein 3; tubulin monoglycylase TTLL3" }, { "url": "https://www.uniprot.org/uniprot/A4Q9E5#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Tubulin monoglycylase TTLL3" }, { "url": "https://www.uniprot.org/uniprot/A4Q9E5#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Tubulin--tyrosine ligase-like protein 3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A4Q9E5", "type": "synonym", "resource": "RefSeq", "name": "tubulin monoglycylase TTLL3 isoform 2" } ] }