{
    "uniprot_canonical_ac": "A4D250-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A4D250-1|BLACE_HUMAN Isoform 1 of B-cell acute lymphoblastic leukemia-expressed protein  OS=Homo sapiens OX=9606 GN=BLACE PE=2 SV=2 CANONICAL=A4D250-1", 
        "length": 179, 
        "sequence": "MMKDIIPASSWASEESTDLQNGSFPLSVAPRSEFPRRRALEDWLLSVFLADQAESEGQLVLERVRDTPPPVTSPRGDGICVSRGKAPSSPGGSTHAWLYLTRHFPWSPFPHGGWTDTSEPCVLETLGGSSLAALRGNSLWVQSSGACAFCVYESLIEQSLPNERFEELLLGPSPGEVMK"
    }, 
    "uniprot_id": "BLACE_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D250", 
                    "id": "A4D250", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/14667812", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "14667812"
                }
            ], 
            "title": "A gene expressed exclusively in acute B lymphoblastic leukemias.", 
            "journal": "Genomics", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D250", 
                    "id": "A4D250", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Boon T., Dupont S., Olive D., Coulie P., Ameye G., De Plaen E., Jost E., Laduron S., Michaux L., Vialle-Castellano A., van Baren N.", 
            "date": "2004"
        }
    ], 
    "uniprot_ac": "A4D250", 
    "site_annotation": [
        {
            "end_pos": 23, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 21
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D250#A4D250-1", 
            "isoform_ac": "A4D250-1", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A4D250-1|BLACE_HUMAN Isoform 1 of B-cell acute lymphoblastic leukemia-expressed protein  OS=Homo sapiens OX=9606 GN=BLACE PE=2 SV=2 CANONICAL=A4D250-1", 
                "length": 179, 
                "sequence": "MMKDIIPASSWASEESTDLQNGSFPLSVAPRSEFPRRRALEDWLLSVFLADQAESEGQLVLERVRDTPPPVTSPRGDGICVSRGKAPSSPGGSTHAWLYLTRHFPWSPFPHGGWTDTSEPCVLETLGGSSLAALRGNSLWVQSSGACAFCVYESLIEQSLPNERFEELLLGPSPGEVMK"
            }
        }
    ], 
    "pathway": [], 
    "function": [], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [
        {
            "sequence_org": "G", 
            "start_pos": 92, 
            "alt_nt": "A", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "155150601", 
            "disease": [
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "id": "DOID:9256", 
                        "url": "http://disease-ontology.org/term/DOID:9256", 
                        "resource": "Disease Ontology", 
                        "name": "colorectal cancer", 
                        "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D250", 
                    "id": "A4D250", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "1.1", 
            "sequence_mut": "*", 
            "subjects_tested": "94", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.1%).", 
            "end_pos": 92, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }
    ], 
    "cluster_types": [], 
    "refseq": {}, 
    "go_annotation": {}, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D250", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "BLACE"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
            "id": "ENSG00000204960", 
            "database": "Bgee"
        }, 
        {
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D250", 
            "id": "A4D250", 
            "database": "BioMuta"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=BLACE", 
            "id": "BLACE", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=20484", 
            "id": "20484", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A4D250", 
            "id": "NX_A4D250", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/CESLTEQ/", 
            "id": "CESLTEQ", 
            "database": "OMA"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A4D250", 
            "id": "A4D250", 
            "database": "PHAROS"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A4D250", 
            "id": "PR_A4D250", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D250", 
            "id": "A4D250", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 19503.0, 
        "chemical_mass": 19503.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000007", 
                "uberon": "0000007", 
                "name": "Pituitary gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178", 
                "uberon": "0000178", 
                "name": "Blood"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178", 
                "uberon": "0000178", 
                "name": "Blood"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000955", 
                "uberon": "0000955", 
                "name": "Brain"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000996", 
                "uberon": "0000996", 
                "name": "Vagina"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043", 
                "uberon": "0001043", 
                "name": "Esophagus"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001150", 
                "uberon": "0001150", 
                "name": "Body of pancreas"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155", 
                "uberon": "0001155", 
                "name": "Colon"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001160", 
                "uberon": "0001160", 
                "name": "Fundus of stomach"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001161", 
                "uberon": "0001161", 
                "name": "Body of stomach"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255", 
                "uberon": "0001255", 
                "name": "Urinary bladder"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001987", 
                "uberon": "0001987", 
                "name": "Placenta"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046", 
                "uberon": "0002046", 
                "name": "Thyroid gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002048", 
                "uberon": "0002048", 
                "name": "Lung"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107", 
                "uberon": "0002107", 
                "name": "Liver"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367", 
                "uberon": "0002367", 
                "name": "Prostate gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000204960", 
                    "id": "ENSG00000204960", 
                    "database": "Bgee"
                }
            ]
        }
    ], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D250", 
            "name": "BLACE", 
            "locus": {
                "end_pos": 155356985, 
                "strand": "-", 
                "start_pos": 155367934, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000204960", 
                        "id": "ENSG00000204960", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D250#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "B-cell acute lymphoblastic leukemia-expressed protein"
        }
    ]
}