{
    "uniprot_canonical_ac": "A4D1S0-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A4D1S0-1|KLRG2_HUMAN Isoform 1 of Killer cell lectin-like receptor subfamily G member 2  OS=Homo sapiens OX=9606 GN=KLRG2 PE=1 SV=3 CANONICAL=A4D1S0-1", 
        "length": 409, 
        "sequence": "MEESWEAAPGGQAGAELPMEPVGSLVPTLEQPQVPAKVRQPEGPESSPSPAGAVEKAAGAGLEPSSKKKPPSPRPGSPRVPPLSLGYGVCPEPPSPGPALVKLPRNGEAPGAEPAPSAWAPMELQVDVRVKPVGAAGGSSTPSPRPSTRFLKVPVPESPAFSRHADPAHQLLLRAPSQGGTWGRRSPLAAARTESGCDAEGRASPAEGSAGSPGSPTCCRCKELGLEKEDAALLPRAGLDGDEKLPRAVTLTGLPMYVKSLYWALAFMAVLLAVSGVVIVVLASRAGARCQQCPPGWVLSEEHCYYFSAEAQAWEASQAFCSAYHATLPLLSHTQDFLGRYPVSRHSWVGAWRGPQGWHWIDEAPLPPQLLPEDGEDNLDINCGALEEGTLVAANCSTPRPWVCAKGTQ"
    }, 
    "uniprot_id": "KLRG2_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20945404", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20945404"
                }
            ], 
            "title": "Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35.", 
            "journal": "The Prostate", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940910.1", 
                    "id": "NP_940910.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Liu X, Cheng I, Plummer SJ, Suarez BK, Casey G, Catalona WJ, Witte JS", 
            "date": "2011"
        }
    ], 
    "uniprot_ac": "A4D1S0", 
    "site_annotation": [
        {
            "end_pos": 397, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 395
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D1S0#A4D1S0-1", 
            "isoform_ac": "A4D1S0-1", 
            "locus": {
                "end_pos": 139453590, 
                "strand": "+", 
                "start_pos": 139483642, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000340940", 
                        "id": "ENST00000340940", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000339356", 
                        "id": "ENSP00000339356", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A4D1S0-1|KLRG2_HUMAN Isoform 1 of Killer cell lectin-like receptor subfamily G member 2  OS=Homo sapiens OX=9606 GN=KLRG2 PE=1 SV=3 CANONICAL=A4D1S0-1", 
                "length": 409, 
                "sequence": "MEESWEAAPGGQAGAELPMEPVGSLVPTLEQPQVPAKVRQPEGPESSPSPAGAVEKAAGAGLEPSSKKKPPSPRPGSPRVPPLSLGYGVCPEPPSPGPALVKLPRNGEAPGAEPAPSAWAPMELQVDVRVKPVGAAGGSSTPSPRPSTRFLKVPVPESPAFSRHADPAHQLLLRAPSQGGTWGRRSPLAAARTESGCDAEGRASPAEGSAGSPGSPTCCRCKELGLEKEDAALLPRAGLDGDEKLPRAVTLTGLPMYVKSLYWALAFMAVLLAVSGVVIVVLASRAGARCQQCPPGWVLSEEHCYYFSAEAQAWEASQAFCSAYHATLPLLSHTQDFLGRYPVSRHSWVGAWRGPQGWHWIDEAPLPPQLLPEDGEDNLDINCGALEEGTLVAANCSTPRPWVCAKGTQ"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D1S0#A4D1S0-2", 
            "isoform_ac": "A4D1S0-2", 
            "locus": {
                "end_pos": 139453523, 
                "strand": "+", 
                "start_pos": 139483642, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000393039", 
                        "id": "ENST00000393039", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000376759", 
                        "id": "ENSP00000376759", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A4D1S0-2|KLRG2_HUMAN Isoform 2 of Killer cell lectin-like receptor subfamily G member 2  OS=Homo sapiens OX=9606 GN=KLRG2 PE=1 SV=3 CANONICAL=A4D1S0-1", 
                "length": 314, 
                "sequence": "MEESWEAAPGGQAGAELPMEPVGSLVPTLEQPQVPAKVRQPEGPESSPSPAGAVEKAAGAGLEPSSKKKPPSPRPGSPRVPPLSLGYGVCPEPPSPGPALVKLPRNGEAPGAEPAPSAWAPMELQVDVRVKPVGAAGGSSTPSPRPSTRFLKVPVPESPAFSRHADPAHQLLLRAPSQGGTWGRRSPLAAARTESGCDAEGRASPAEGSAGSPGSPTCCRCKELGLEKEDAALLPRAGLDGDEKLPRAVTLTDSLRTARTIWISTVGPWRKARWWLQTAALQDPGSVPRGPSDLGSAWSSACQADAAPPTGEAS"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:346689", 
            "resource": "KEGG Pathway", 
            "id": "hsa:346689", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940910.1", 
            "annotation": "Genetic variants in the gene KLRG2 may affect Gleason score at diagnosis and hence the aggressiveness of prostate cancer. GeneRIF: Observational study of gene-disease association. (HuGE Navigator)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940910.1", 
                    "id": "NP_940910.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D4A3B8-1", 
            "protein_name": "RCG27971", 
            "sequence": {
                "length": 389, 
                "sequence": "MEPPQVPAEAPQPRASEDSPRPERTRREAADAQSQELREKSQPPTGSGSPRVPPLSLGYGAFRRLGSCSRELPSPSHSCTEQPRNGEGELEPWTASGEPAPGSWAPVELQVDVRVKPVGAAGASRAPSPAPSTRFLTVPVPESPAFARRSAPTPQWLPRAPSPGSTWSRGSPLAATPTEPIGPAEGCTVPPGSPPCRCRCPCREPGLTKEDDALLQRVGLDGKKLPRAITLIGLPQYMKSLRWALVVMAVLLAVCTVAIVALASRGGAKCQPCPQGWMWSQEHCYYLSEEVQDWESSQAFCSAHQATLPLLNHTQDFLRKYQVTKGSWVGARRGPEGWHWTDGVPLPSQLFLEDSEDHPDFSCGGLEEGRLVALDCSSPRPWVCAKGTK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/52362", 
                    "id": "52362", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "Klrg2", 
            "tax_id": 10116
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [
        {
            "sequence_org": "W", 
            "start_pos": 119, 
            "alt_nt": "A", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "139168032", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "2.0", 
            "sequence_mut": "C", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 119, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
            "sequence_org": "W", 
            "start_pos": 119, 
            "alt_nt": "A", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "139168033", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "2.0", 
            "sequence_mut": "L", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 119, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
            "sequence_org": "G", 
            "start_pos": 138, 
            "alt_nt": "A", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "139167977", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "2.0", 
            "sequence_mut": "C", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 138, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
            "sequence_org": "K", 
            "start_pos": 152, 
            "alt_nt": "G", 
            "chr_id": "7", 
            "ref_nt": "T", 
            "chr_pos": "139167934", 
            "disease": [
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "id": "DOID:9256", 
                        "url": "http://disease-ontology.org/term/DOID:9256", 
                        "resource": "Disease Ontology", 
                        "name": "colorectal cancer", 
                        "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "2.6", 
            "sequence_mut": "T", 
            "subjects_tested": "348", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.6%).", 
            "end_pos": 152, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "9"
        }, 
        {
            "sequence_org": "P", 
            "start_pos": 156, 
            "alt_nt": "A", 
            "chr_id": "7", 
            "ref_nt": "G", 
            "chr_pos": "139167923", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "2.0", 
            "sequence_mut": "S", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 156, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
            "sequence_org": "R", 
            "start_pos": 163, 
            "alt_nt": "C", 
            "chr_id": "7", 
            "ref_nt": "G", 
            "chr_pos": "139167902", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:2394", 
                            "url": "http://disease-ontology.org/term/DOID:2394", 
                            "resource": "Disease Ontology", 
                            "name": "malignant Ovarian tumor", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2394", 
                            "url": "http://disease-ontology.org/term/DOID:2394", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of ovary", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2394", 
                            "url": "http://disease-ontology.org/term/DOID:2394", 
                            "resource": "Disease Ontology", 
                            "name": "ovarian neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2394", 
                            "url": "http://disease-ontology.org/term/DOID:2394", 
                            "resource": "Disease Ontology", 
                            "name": "ovary neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2394", 
                            "url": "http://disease-ontology.org/term/DOID:2394", 
                            "resource": "Disease Ontology", 
                            "name": "primary ovarian cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2394", 
                            "url": "http://disease-ontology.org/term/DOID:2394", 
                            "resource": "Disease Ontology", 
                            "name": "tumor of the Ovary", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:2394", 
                        "url": "http://disease-ontology.org/term/DOID:2394", 
                        "resource": "Disease Ontology", 
                        "name": "ovarian cancer", 
                        "description": "A female reproductive organ cancer that is located_in the ovary."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "1.1", 
            "sequence_mut": "G", 
            "subjects_tested": "93", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.1%).", 
            "end_pos": 163, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
            "sequence_org": "A", 
            "start_pos": 190, 
            "alt_nt": "T", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "139167821", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "2.0", 
            "sequence_mut": "T", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 190, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
            "sequence_org": "D", 
            "start_pos": 198, 
            "alt_nt": "T", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "139167797", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "2.0", 
            "sequence_mut": "N", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 198, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
            "sequence_org": "G", 
            "start_pos": 214, 
            "alt_nt": "T", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "139167748", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
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            "sequence_mut": "D", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 214, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
            "sequence_org": "G", 
            "start_pos": 339, 
            "alt_nt": "G", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "139138950", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1612", 
                            "url": "http://disease-ontology.org/term/DOID:1612", 
                            "resource": "Disease Ontology", 
                            "name": "breast tumor", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1612", 
                            "url": "http://disease-ontology.org/term/DOID:1612", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of breast", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1612", 
                            "url": "http://disease-ontology.org/term/DOID:1612", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of the breast", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1612", 
                            "url": "http://disease-ontology.org/term/DOID:1612", 
                            "resource": "Disease Ontology", 
                            "name": "mammary cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1612", 
                            "url": "http://disease-ontology.org/term/DOID:1612", 
                            "resource": "Disease Ontology", 
                            "name": "mammary tumor", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1612", 
                            "url": "http://disease-ontology.org/term/DOID:1612", 
                            "resource": "Disease Ontology", 
                            "name": "primary breast cancer", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1612", 
                        "url": "http://disease-ontology.org/term/DOID:1612", 
                        "resource": "Disease Ontology", 
                        "name": "breast cancer", 
                        "description": "A thoracic cancer that originates in the mammary gland."
                    }
                }, 
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "id": "DOID:1324", 
                        "url": "http://disease-ontology.org/term/DOID:1324", 
                        "resource": "Disease Ontology", 
                        "name": "lung cancer", 
                        "description": "A respiratory system cancer that is located_in the lung."
                    }
                }, 
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
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                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
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                    }
                }, 
                {
                    "synonyms": [], 
                    "recommended_name": {
                        "id": "DOID:9256", 
                        "url": "http://disease-ontology.org/term/DOID:9256", 
                        "resource": "Disease Ontology", 
                        "name": "colorectal cancer", 
                        "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
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                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1S0", 
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            ], 
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            "keywords": [
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                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: num. of cancers (4).", 
            "end_pos": 339, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "2"
        }, 
        {
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            "chr_pos": "139138945", 
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                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
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                        "url": "http://disease-ontology.org/term/DOID:1781", 
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                    }
                }
            ], 
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                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1S0", 
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            ], 
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                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 341, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
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                {
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                        {
                            "id": "DOID:1781", 
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                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
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                    ], 
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                }
            ], 
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                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1S0", 
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            ], 
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            "minor_allelic_frequency": "", 
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        }, 
        {
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                {
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                        {
                            "id": "DOID:2394", 
                            "url": "http://disease-ontology.org/term/DOID:2394", 
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                            "description": ""
                        }, 
                        {
                            "id": "DOID:2394", 
                            "url": "http://disease-ontology.org/term/DOID:2394", 
                            "resource": "Disease Ontology", 
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                            "description": ""
                        }, 
                        {
                            "id": "DOID:2394", 
                            "url": "http://disease-ontology.org/term/DOID:2394", 
                            "resource": "Disease Ontology", 
                            "name": "ovarian neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2394", 
                            "url": "http://disease-ontology.org/term/DOID:2394", 
                            "resource": "Disease Ontology", 
                            "name": "ovary neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2394", 
                            "url": "http://disease-ontology.org/term/DOID:2394", 
                            "resource": "Disease Ontology", 
                            "name": "primary ovarian cancer", 
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                        }, 
                        {
                            "id": "DOID:2394", 
                            "url": "http://disease-ontology.org/term/DOID:2394", 
                            "resource": "Disease Ontology", 
                            "name": "tumor of the Ovary", 
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                    ], 
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                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030246", 
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                        ], 
                        "name": "carbohydrate binding", 
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                ], 
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                "name": "Molecular Function"
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            {
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                        ], 
                        "name": "integral component of membrane", 
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                ], 
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                "name": "Cellular Component"
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    "gene_names": [
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            "resource": "RefSeq", 
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    "pro_annotation": [], 
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        {
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        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=24778", 
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            "database": "HGNC"
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        {
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            "id": "IPR001304", 
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        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", 
            "id": "IPR016186", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", 
            "id": "IPR016187", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033992", 
            "id": "IPR033992", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR043318", 
            "id": "IPR043318", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:346689", 
            "id": "hsa:346689", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A4D1S0", 
            "id": "NX_A4D1S0", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/GLPMYVK/", 
            "id": "GLPMYVK", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1201127at2759", 
            "id": "1201127at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47606", 
            "id": "PTHR47606", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00059", 
            "id": "PF00059", 
            "database": "Pfam"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A4D1S0", 
            "id": "A4D1S0", 
            "database": "PHAROS"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A4D1S0", 
            "id": "PR_A4D1S0", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940910.1", 
            "id": "NP_940910.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D1S0", 
            "id": "A4D1S0", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [
        {
            "name": "Prostate cancer [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "NGP - new growth of prostate", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "hereditary prostate cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of the prostate", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "prostate cancer, familial", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "prostate neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "prostatic cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "prostatic neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:10283", 
                            "url": "http://disease-ontology.org/term/DOID:10283", 
                            "resource": "Disease Ontology", 
                            "name": "tumor of the prostate", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:10283", 
                        "url": "http://disease-ontology.org/term/DOID:10283", 
                        "resource": "Disease Ontology", 
                        "name": "prostate cancer", 
                        "description": "A male reproductive organ cancer that is located_in the prostate."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:10283", 
            "significant": "Yes"
        }, 
        {
            "name": "Urinary bladder cancer [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:11054", 
                            "url": "http://disease-ontology.org/term/DOID:11054", 
                            "resource": "Disease Ontology", 
                            "name": "bladder cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:11054", 
                            "url": "http://disease-ontology.org/term/DOID:11054", 
                            "resource": "Disease Ontology", 
                            "name": "tumor of the bladder", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:11054", 
                        "url": "http://disease-ontology.org/term/DOID:11054", 
                        "resource": "Disease Ontology", 
                        "name": "urinary bladder cancer", 
                        "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:11054", 
            "significant": "Yes"
        }, 
        {
            "name": "Thyroid gland cancer [DO disease name]", 
            "trend": "Down", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:1781", 
            "significant": "No"
        }, 
        {
            "name": "Liver cancer [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "Ca liver - primary", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "Resectable malignant neoplasm of Liver", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "hepatic cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "hepatic neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "malignant hepato-biliary neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of liver", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of liver, primary", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of liver", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of liver", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "non-resectable primary hepatic malignant neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "primary liver cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "primary malignant neoplasm of Liver", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "resectable malignant neoplasm of the liver", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3571", 
                            "url": "http://disease-ontology.org/term/DOID:3571", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of liver, not specified as primary or secondary", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:3571", 
                        "url": "http://disease-ontology.org/term/DOID:3571", 
                        "resource": "Disease Ontology", 
                        "name": "liver cancer", 
                        "description": "A hepatobiliary system cancer that is located_in the liver."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:3571", 
            "significant": "No"
        }, 
        {
            "name": "Lung squamous cell carcinoma [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:3907", 
                            "url": "http://disease-ontology.org/term/DOID:3907", 
                            "resource": "Disease Ontology", 
                            "name": "Epidermoid cell carcinoma of the lung", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:3907", 
                        "url": "http://disease-ontology.org/term/DOID:3907", 
                        "resource": "Disease Ontology", 
                        "name": "lung squamous cell carcinoma", 
                        "description": "A non-small cell lung carcinoma that has_material_basis_in the squamous cell."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:3907", 
            "significant": "No"
        }, 
        {
            "name": "Lung adenocarcinoma [DO disease name]", 
            "trend": "Down", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:3910", 
                            "url": "http://disease-ontology.org/term/DOID:3910", 
                            "resource": "Disease Ontology", 
                            "name": "bronchogenic lung adenocarcinoma", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:3910", 
                            "url": "http://disease-ontology.org/term/DOID:3910", 
                            "resource": "Disease Ontology", 
                            "name": "nonsmall cell adenocarcinoma", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:3910", 
                        "url": "http://disease-ontology.org/term/DOID:3910", 
                        "resource": "Disease Ontology", 
                        "name": "lung adenocarcinoma", 
                        "description": "A lung cancer that derives_from epithelial cells of glandular origin."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:3910", 
            "significant": "No"
        }, 
        {
            "name": "Esophageal cancer [DO disease name]", 
            "trend": "Up", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "Ca lower third oesophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "Ca middle third oesophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "esophagus cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of distal third of esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of lower third of oesophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of middle third of oesophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of proximal third of esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of upper third esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of Distal Third of esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of Proximal Third of esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of abdominal esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of the middle Third of the esophagus", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:5041", 
                        "url": "http://disease-ontology.org/term/DOID:5041", 
                        "resource": "Disease Ontology", 
                        "name": "esophageal cancer", 
                        "description": "A gastrointestinal system cancer that is located_in the esophagus."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A4D1S0", 
                    "id": "A4D1S0", 
                    "database": "BioXpress"
                }
            ], 
            "url": "http://disease-ontology.org/term/DOID:5041", 
            "significant": "No"
        }
    ], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [
        {
            "residue": "Ser", 
            "kinase_gene_name": "CDC73", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19664994", 
                    "id": "19664994", 
                    "database": "PubMed"
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            "start_pos": "158", 
            "end_pos": "158", 
            "kinase_uniprot_canonical_ac": "Q6P1J9-1"
        }, 
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            "residue": "Ser", 
            "kinase_gene_name": "", 
            "evidence": [
                {
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                    "id": "A4D1S0", 
                    "database": "UniProtKB"
                }
            ], 
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            "end_pos": "158", 
            "kinase_uniprot_canonical_ac": ""
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        {
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            "kinase_gene_name": "CDC73", 
            "evidence": [
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                    "id": "19413330", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19664994", 
                    "id": "19664994", 
                    "database": "PubMed"
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            ], 
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            "end_pos": "204", 
            "kinase_uniprot_canonical_ac": "Q6P1J9-1"
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            "evidence": [
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                    "id": "19413330", 
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            "end_pos": "209", 
            "kinase_uniprot_canonical_ac": "Q6P1J9-1"
        }, 
        {
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            "kinase_gene_name": "CDC73", 
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            ], 
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            "kinase_uniprot_canonical_ac": "Q6P1J9-1"
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            "evidence": [
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                }
            ], 
            "start_pos": "215", 
            "end_pos": "215", 
            "kinase_uniprot_canonical_ac": "Q6P1J9-1"
        }, 
        {
            "residue": "Ser", 
            "kinase_gene_name": "CDC73", 
            "evidence": [
                {
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                }
            ], 
            "start_pos": "260", 
            "end_pos": "260", 
            "kinase_uniprot_canonical_ac": "Q6P1J9-1"
        }, 
        {
            "residue": "Tyr", 
            "kinase_gene_name": "CDC73", 
            "evidence": [
                {
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                    "id": "18491316", 
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            ], 
            "start_pos": "262", 
            "end_pos": "262", 
            "kinase_uniprot_canonical_ac": "Q6P1J9-1"
        }, 
        {
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            "kinase_gene_name": "CDC73", 
            "evidence": [
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                    "id": "18491316", 
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                }
            ], 
            "start_pos": "284", 
            "end_pos": "284", 
            "kinase_uniprot_canonical_ac": "Q6P1J9-1"
        }
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        "chemical_mass": 42851.0
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    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000007", 
                "uberon": "0000007", 
                "name": "Pituitary gland"
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            "present": "no", 
            "evidence": [
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                    "id": "ENSG00000188883", 
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        }, 
        {
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                "uberon": "0000007", 
                "name": "Pituitary gland"
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            "present": "yes", 
            "evidence": [
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                    "id": "ENSG00000188883", 
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        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178", 
                "uberon": "0000178", 
                "name": "Blood"
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            "present": "no", 
            "evidence": [
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                    "id": "ENSG00000188883", 
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        }, 
        {
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                "uberon": "0000178", 
                "name": "Blood"
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            "present": "yes", 
            "evidence": [
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                    "database": "Bgee"
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        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
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            "present": "no", 
            "evidence": [
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                    "id": "ENSG00000188883", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
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}
