{
    "uniprot_canonical_ac": "A4D1F6-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A4D1F6-1|LRRD1_HUMAN Isoform 1 of Leucine-rich repeat and death domain-containing protein 1  OS=Homo sapiens OX=9606 GN=LRRD1 PE=2 SV=2 CANONICAL=A4D1F6-1", 
        "length": 860, 
        "sequence": "MSEKEGMSEVLEDTISQFRKESRSQSMKEPGFIKETSNLINEASDYLEGKSSNQIYETHPRQNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSSLTGRTAEYQALVNFLSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNFEFLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLIRALTMIGAYEIMDKITALNLFTRAIKF"
    }, 
    "uniprot_id": "LRRD1_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D1F6", 
                    "id": "A4D1F6", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "publication": [], 
    "uniprot_ac": "A4D1F6", 
    "site_annotation": [
        {
            "end_pos": 145, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 143
        }, 
        {
            "end_pos": 219, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 217
        }, 
        {
            "end_pos": 610, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 608
        }, 
        {
            "end_pos": 633, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 631
        }, 
        {
            "end_pos": 651, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 649
        }, 
        {
            "end_pos": 705, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 703
        }, 
        {
            "end_pos": 710, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 708
        }, 
        {
            "end_pos": 775, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 773
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D1F6#A4D1F6-1", 
            "isoform_ac": "A4D1F6-1", 
            "locus": {
                "end_pos": 92144891, 
                "strand": "+", 
                "start_pos": 92165202, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000458448", 
                        "id": "ENST00000458448", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000405987", 
                        "id": "ENSP00000405987", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A4D1F6-1|LRRD1_HUMAN Isoform 1 of Leucine-rich repeat and death domain-containing protein 1  OS=Homo sapiens OX=9606 GN=LRRD1 PE=2 SV=2 CANONICAL=A4D1F6-1", 
                "length": 860, 
                "sequence": "MSEKEGMSEVLEDTISQFRKESRSQSMKEPGFIKETSNLINEASDYLEGKSSNQIYETHPRQNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSSLTGRTAEYQALVNFLSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNFEFLCQKLNLANSETDMPTKSTVSLSERAHQALVIWKTQSNKLSLTAAALRDQLIRALTMIGAYEIMDKITALNLFTRAIKF"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D1F6#A4D1F6-2", 
            "isoform_ac": "A4D1F6-2", 
            "locus": {
                "end_pos": 92142813, 
                "strand": "+", 
                "start_pos": 92159173, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000343318", 
                        "id": "ENST00000343318", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000339642", 
                        "id": "ENSP00000339642", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A4D1F6-2|LRRD1_HUMAN Isoform 2 of Leucine-rich repeat and death domain-containing protein 1  OS=Homo sapiens OX=9606 GN=LRRD1 PE=2 SV=2 CANONICAL=A4D1F6-1", 
                "length": 116, 
                "sequence": "MTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRADERDGLQLHS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D1F6#C9K0I1-1", 
            "isoform_ac": "C9K0I1-1", 
            "locus": {
                "end_pos": 92165026, 
                "strand": "+", 
                "start_pos": 92165202, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000437357", 
                        "id": "ENST00000437357", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000387628", 
                        "id": "ENSP00000387628", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|C9K0I1-1|LRRD1_HUMAN Computationally mapped isoform of Leucine-rich repeat and death domain-containing protein 1  OS=Homo sapiens OX=9606 GN=LRRD1 PE=2 SV=1 CANONICAL=A4D1F6-1", 
                "length": 59, 
                "sequence": "MSEKEGMSEVLEDTISQFRKESRSQSMKEPGFIKETSNLINEASDYLEGKSSNQIYETH"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:401387", 
            "resource": "KEGG Pathway", 
            "id": "hsa:401387", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D4AD14-1", 
            "protein_name": "Leucine-rich repeats and death domain-containing 1", 
            "sequence": {
                "length": 855, 
                "sequence": "MSEDGSNVEPEGLTRSESLEEPEFIDEISDPSNETSPHSGNTDFNQIYESNSSENTEQPSASSTSQLNGNEETNIEIPFSDTNIEEVIPLSNSESPQSSESSETNEAEEYHPVKFPIGRKFRGRTFNGHHKGFDMESDTFTVHLDAKGLQEFPVDIVKVKYVKYLYLDKNQIKTFQGADPGDLLGLETLSLQENGLSSIPQEIQLFHNLKVLNASYNEISHIPKELLQLGNMRQLFLNSNHIESLPSGLENLRYLETLSLGKNRLTHIPDSLCGLKNLKTLNLEYNQLTIFSKSLCFLPKLVSLNLTGNMIGSLPKEVRELKNLENLLMNHNKLTFLAVEIFQLLKIKELHLADNKLEAISPKIENFKELRLLNLDNNLLQSLPKKISHCVNLESLTLSDNNLEELPKKIRKLKNLRQLHANRNKMIKMAEEISHLSKIHSLEFSGNQITHVPIEIKNCKEITRVELNYNNIMYFPVGLCALQSLDYLSFNGNYISEIPVDLSFSKQLLHLELNKNKITIFSEHLCSLTNLEYLDLAKNQIRKIPHCISAMLSLHVLILSDNKFEIFPKELCSLKNLQLLDISENQLHKIPSEISKLKKIQKLNLSNNNFTHFPAELCQLQTLEDLNISQISGKKLTRLPEEVSRMTQLKALNISNNAIKEIPRNIGELRNLITFHASNNQINSLPSSFLSLNVLQSLDLGGNNLTDLPSAIYKLSSLKEINFDDNPLLRPPMEICKGKQMHTITCYLQRADDRDEKILEKIFHIVANNITETKFEFLQQKLHMARSENSVPVKTTTPLNEGIYQALLKWKTEKRVSFTAIALKDQLFRALNMIGAYDIMDKITALNLYTSAIKL"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/18247", 
                    "id": "18247", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A4D1F6/", 
                    "id": "A4D1F6", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "Lrrd1", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q8C0R9-1", 
            "protein_name": "Leucine-rich repeat and death domain-containing protein 1", 
            "sequence": {
                "length": 853, 
                "sequence": "MSEDGSNVEPGGFPRFESLEEPGSEISDLLDEASPYSKSKDSNQIYEANPSKDTEQSAASFTSQLDRNEEKNTGIPFSETNIADIIPLSIEESLQSSGSSETKMAEDYYPVKFPTGRKFRGRIFNGNQKGLDMKSDNFTVNLDAKGLQEFPVDIVKVKYVKYLYLDKNQIKNFQGIDPGDLLGLEILSLQENGLSSIPLEIQLFHNLKILNASYNEISQIPKELLQLENMRQLLLNSNHIDTLPSGLEHLRYLETLSLGKNMLTYIPDSLSSLKNLRILNLEYNQLTIFSKSLCFLPKLNSLNLTGNMIGSLPKEVRELKNLESLLMDHNKLTFLAVEIFQLPKIKELHLADNKLEAISPKIENFKELRLLNLDKNLLQSIPKKISHCVNLESLSLSDNNIEELPKKIRKLKNLRQLHVNRNKMITMTEEISHLSNIHILEFSGNQITHVPIEIKNCRKITRVELNYNNIMYFPVGLCALQSLDYLSFNGNYISEIPVDMSFSKQLLHLELNRNKLTVFSKHLCSLTNLEYLDLAKNQIMTIPSCISAMVSLHVLILSDNKFESFPKELCSLKNLRVLDISENKLQKIPLEISKLKRIQKLNLSNNIFTNFPVELCQLQTLEELNISQTSGKKLTRLPEEVSHMTQLKILNISNNAIKDIPKNIGELRSLVSFYASNNQISSLPSSFLSLEVLQSLDLRGNNMTALPSGIYKLSSLKEINFDDNPLMRPPMEICKGKEMHMITCYLQRADERDEKILEKIFNIVANSITETNFEFLQQKLNMASSANNMPVRPTTPLNERIYQALIKWKAEKDVQFTATALRDKLFRALNMIGAYDIMDKITALNLYTSAIKL"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/18247", 
                    "id": "18247", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A4D1F6/", 
                    "id": "A4D1F6", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Lrrd1", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [
        {
            "sequence_org": "I", 
            "start_pos": 719, 
            "alt_nt": "G", 
            "chr_id": "7", 
            "ref_nt": "T", 
            "chr_pos": "91779971", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:2531", 
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "name": "Hematologic malignancy", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2531", 
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "name": "Hematologic neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2531", 
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "name": "Hematological tumors", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2531", 
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "name": "blood cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2531", 
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "name": "hematopoietic and lymphoid system tumor", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2531", 
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "name": "hematopoietic cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2531", 
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "name": "hematopoietic neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2531", 
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "name": "hematopoietic tumors", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:2531", 
                            "url": "http://disease-ontology.org/term/DOID:2531", 
                            "resource": "Disease Ontology", 
                            "name": "malignant hematopoietic neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:2531", 
                        "url": "http://disease-ontology.org/term/DOID:2531", 
                        "resource": "Disease Ontology", 
                        "name": "hematologic cancer", 
                        "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes."
                    }
                }, 
                {
                    "synonyms": [
                        {
                            "id": "DOID:363", 
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "name": "CA - cancer of uterus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:363", 
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "name": "Tumour of uterus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:363", 
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of uterus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:363", 
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "name": "malignant uterine tumor", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:363", 
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of uterus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:363", 
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "name": "uterine tumor", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:363", 
                            "url": "http://disease-ontology.org/term/DOID:363", 
                            "resource": "Disease Ontology", 
                            "name": "uterus neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:363", 
                        "url": "http://disease-ontology.org/term/DOID:363", 
                        "resource": "Disease Ontology", 
                        "name": "uterine cancer", 
                        "description": "A female reproductive organ cancer that is located_in the uterus."
                    }
                }, 
                {
                    "synonyms": [
                        {
                            "id": "DOID:1612", 
                            "url": "http://disease-ontology.org/term/DOID:1612", 
                            "resource": "Disease Ontology", 
                            "name": "breast tumor", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1612", 
                            "url": "http://disease-ontology.org/term/DOID:1612", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of breast", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1612", 
                            "url": "http://disease-ontology.org/term/DOID:1612", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of the breast", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1612", 
                            "url": "http://disease-ontology.org/term/DOID:1612", 
                            "resource": "Disease Ontology", 
                            "name": "mammary cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1612", 
                            "url": "http://disease-ontology.org/term/DOID:1612", 
                            "resource": "Disease Ontology", 
                            "name": "mammary tumor", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1612", 
                            "url": "http://disease-ontology.org/term/DOID:1612", 
                            "resource": "Disease Ontology", 
                            "name": "primary breast cancer", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1612", 
                        "url": "http://disease-ontology.org/term/DOID:1612", 
                        "resource": "Disease Ontology", 
                        "name": "breast cancer", 
                        "description": "A thoracic cancer that originates in the mammary gland."
                    }
                }, 
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1F6", 
                    "id": "A4D1F6", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "2.1", 
            "sequence_mut": "L", 
            "subjects_tested": "48", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 2 out of 6 filters: patient freq. (2.1%); num. of cancers (4).", 
            "end_pos": 719, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }, 
        {
            "sequence_org": "E", 
            "start_pos": 124, 
            "alt_nt": "G", 
            "chr_id": "7", 
            "ref_nt": "T", 
            "chr_pos": "91794145", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "Ca lower third oesophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "Ca middle third oesophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "esophagus cancer", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of distal third of esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of lower third of oesophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of middle third of oesophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of proximal third of esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of upper third esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of Distal Third of esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of Proximal Third of esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of abdominal esophagus", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:5041", 
                            "url": "http://disease-ontology.org/term/DOID:5041", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumor of the middle Third of the esophagus", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:5041", 
                        "url": "http://disease-ontology.org/term/DOID:5041", 
                        "resource": "Disease Ontology", 
                        "name": "esophageal cancer", 
                        "description": "A gastrointestinal system cancer that is located_in the esophagus."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1F6", 
                    "id": "A4D1F6", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [], 
            "frequency": "1.0", 
            "sequence_mut": "D", 
            "subjects_tested": "191", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.0%).", 
            "end_pos": 124, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "2"
        }, 
        {
            "sequence_org": "S", 
            "start_pos": 445, 
            "alt_nt": "A", 
            "chr_id": "7", 
            "ref_nt": "C", 
            "chr_pos": "91793183", 
            "disease": [
                {
                    "synonyms": [
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "Thyroid gland neoplasm", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "malignant tumour of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "neoplasm of thyroid gland", 
                            "description": ""
                        }, 
                        {
                            "id": "DOID:1781", 
                            "url": "http://disease-ontology.org/term/DOID:1781", 
                            "resource": "Disease Ontology", 
                            "name": "thyroid neoplasm", 
                            "description": ""
                        }
                    ], 
                    "recommended_name": {
                        "id": "DOID:1781", 
                        "url": "http://disease-ontology.org/term/DOID:1781", 
                        "resource": "Disease Ontology", 
                        "name": "thyroid gland cancer", 
                        "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
                    }
                }
            ], 
            "evidence": [
                {
                    "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1F6", 
                    "id": "A4D1F6", 
                    "database": "BioMuta"
                }
            ], 
            "glycoeffect": [
                "o-glyco-site-loss"
            ], 
            "frequency": "2.0", 
            "sequence_mut": "I", 
            "subjects_tested": "50", 
            "keywords": [
                "biomuta", 
                "somatic", 
                "cancer", 
                "disease"
            ], 
            "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", 
            "end_pos": 445, 
            "minor_allelic_frequency": "", 
            "subjects_positive": "1"
        }
    ], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155000.1", 
        "ac": "NP_001155000.1", 
        "name": "leucine-rich repeat and death domain-containing protein 1 isoform 1", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046579", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D1F6", 
                                "id": "A4D1F6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of Ras protein signal transduction", 
                        "id": "GO:0046579"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D1F6", 
                                "id": "A4D1F6", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "signal transduction", 
                        "id": "GO:0007165"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4D1F6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "LRRD1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D1F6", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "LRRD1"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
            "id": "ENSG00000240720", 
            "database": "Bgee"
        }, 
        {
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D1F6", 
            "id": "A4D1F6", 
            "database": "BioMuta"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=LRRD1", 
            "id": "LRRD1", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/401387", 
            "id": "401387", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=34300", 
            "id": "34300", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.ebi.ac.uk/intact/interactors/id:A4D1F6*", 
            "id": "A4D1F6", 
            "database": "IntAct"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000488", 
            "id": "IPR000488", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", 
            "id": "IPR001611", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", 
            "id": "IPR003591", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", 
            "id": "IPR032675", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:401387", 
            "id": "hsa:401387", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A4D1F6", 
            "id": "NX_A4D1F6", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/KISHCVM/", 
            "id": "KISHCVM", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=826997at2759", 
            "id": "826997at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00560", 
            "id": "PF00560", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF13855", 
            "id": "PF13855", 
            "database": "Pfam"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A4D1F6", 
            "id": "A4D1F6", 
            "database": "PHAROS"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A4D1F6", 
            "id": "PR_A4D1F6", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155000.1", 
            "id": "NP_001155000.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D1F6", 
            "id": "A4D1F6", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 98035.0, 
        "chemical_mass": 98035.0
    }, 
    "expression_tissue": [
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000007", 
                "uberon": "0000007", 
                "name": "Pituitary gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000007", 
                "uberon": "0000007", 
                "name": "Pituitary gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000178", 
                "uberon": "0000178", 
                "name": "Blood"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000458", 
                "uberon": "0000458", 
                "name": "Endocervix"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000473", 
                "uberon": "0000473", 
                "name": "Testis"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000948", 
                "uberon": "0000948", 
                "name": "Heart"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000955", 
                "uberon": "0000955", 
                "name": "Brain"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000992", 
                "uberon": "0000992", 
                "name": "Ovary"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0000996", 
                "uberon": "0000996", 
                "name": "Vagina"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001043", 
                "uberon": "0001043", 
                "name": "Esophagus"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001150", 
                "uberon": "0001150", 
                "name": "Body of pancreas"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001150", 
                "uberon": "0001150", 
                "name": "Body of pancreas"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001155", 
                "uberon": "0001155", 
                "name": "Colon"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001160", 
                "uberon": "0001160", 
                "name": "Fundus of stomach"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
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            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001161", 
                "uberon": "0001161", 
                "name": "Body of stomach"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001161", 
                "uberon": "0001161", 
                "name": "Body of stomach"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001255", 
                "uberon": "0001255", 
                "name": "Urinary bladder"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0001987", 
                "uberon": "0001987", 
                "name": "Placenta"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002046", 
                "uberon": "0002046", 
                "name": "Thyroid gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002048", 
                "uberon": "0002048", 
                "name": "Lung"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002107", 
                "uberon": "0002107", 
                "name": "Liver"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367", 
                "uberon": "0002367", 
                "name": "Prostate gland"
            }, 
            "present": "no", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002367", 
                "uberon": "0002367", 
                "name": "Prostate gland"
            }, 
            "present": "yes", 
            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0002369", 
                "uberon": "0002369", 
                "name": "Adrenal gland"
            }, 
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            "evidence": [
                {
                    "url": "https://bgee.org/?page=gene&gene_id=ENSG00000240720", 
                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }, 
        {
            "tissue": {
                "url": "http://purl.obolibrary.org/obo/UBERON_0009853", 
                "uberon": "0009853", 
                "name": "Body of uterus"
            }, 
            "present": "no", 
            "evidence": [
                {
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                    "id": "ENSG00000240720", 
                    "database": "Bgee"
                }
            ]
        }
    ], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D1F6", 
            "name": "LRRD1", 
            "locus": {
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                "strand": "-", 
                "start_pos": 92179531, 
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                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000240720", 
                        "id": "ENSG00000240720", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D1F6#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Leucine-rich repeat and death domain-containing protein 1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4D1F6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "leucine-rich repeat and death domain-containing protein 1 isoform 1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4D1F6", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "leucine-rich repeat and death domain-containing protein LOC401387; leucine-rich repeat and death domain-containing protein 1"
        }
    ]
}