{
    "uniprot_canonical_ac": "A3KMN5-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A3KMN5-1|LARGN_MOUSE Isoform 1 of Protein Largen  OS=Mus musculus OX=10090 GN=Prr16 PE=2 SV=1 CANONICAL=A3KMN5-1", 
        "length": 304, 
        "sequence": "MSAKSKGNPSSSSAAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKEQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVRCEEPQRVVPTANPVKTNGTLLRNGGLAGRPNKIPNGDICCIPNSNLDKAPLQSLMHRPEKDRSPQAGPRERVRFNEKVQYHGYCPDCESRYNIKNREVHLHSEPVHPPGKIPHQGPLLHPPPHLPNFPLENGGLGISHSNSFPPPTPATVPPPAAPKPQKTILRKSTTTTV"
    }, 
    "uniprot_id": "LARGN_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A3KMN5", 
                    "id": "A3KMN5", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24656129", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24656129"
                }
            ], 
            "title": "Largen: a molecular regulator of mammalian cell size control.", 
            "journal": "Mol. Cell", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A3KMN5", 
                    "id": "A3KMN5", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074693.1", 
                    "id": "NP_001074693.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Sasaki M., Wakutani Y., Wang F., Inoue S., Li W., Yamamoto K., Sonenberg N., Ikura M., Mak T.W., McCracken S., Wakeham A., Topisirovic I., Alexandrova R., Elia A.J., Gandin V., Haight J., Itsumi M., Lapin V., Mullen P.J., Oo Y.D., Shahinian A., Silvester J.L.", 
            "date": "2014"
        }
    ], 
    "uniprot_ac": "A3KMN5", 
    "site_annotation": [
        {
            "end_pos": 152, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 150
        }, 
        {
            "end_pos": 83, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 81
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A3KMN5#A3KMN5-1", 
            "isoform_ac": "A3KMN5-1", 
            "locus": {
                "end_pos": 51117931, 
                "strand": "-", 
                "start_pos": 51303362, 
                "chromosome": "18", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000116639", 
                        "id": "ENSMUST00000116639", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000112338", 
                        "id": "ENSMUSP00000112338", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A3KMN5-1|LARGN_MOUSE Isoform 1 of Protein Largen  OS=Mus musculus OX=10090 GN=Prr16 PE=2 SV=1 CANONICAL=A3KMN5-1", 
                "length": 304, 
                "sequence": "MSAKSKGNPSSSSAAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKEQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVRCEEPQRVVPTANPVKTNGTLLRNGGLAGRPNKIPNGDICCIPNSNLDKAPLQSLMHRPEKDRSPQAGPRERVRFNEKVQYHGYCPDCESRYNIKNREVHLHSEPVHPPGKIPHQGPLLHPPPHLPNFPLENGGLGISHSNSFPPPTPATVPPPAAPKPQKTILRKSTTTTV"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A3KMN5#A3KMN5-2", 
            "isoform_ac": "A3KMN5-2", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A3KMN5-2|LARGN_MOUSE Isoform 2 of Protein Largen  OS=Mus musculus OX=10090 GN=Prr16 PE=2 SV=1 CANONICAL=A3KMN5-1", 
                "length": 234, 
                "sequence": "MTDSSKTDTLNSSSSGTTASSIEKIKEQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVRCEEPQRVVPTANPVKTNGTLLRNGGLAGRPNKIPNGDICCIPNSNLDKAPLQSLMHRPEKDRSPQAGPRERVRFNEKVQYHGYCPDCESRYNIKNREVHLHSEPVHPPGKIPHQGPLLHPPPHLPNFPLENGGLGISHSNSFPPPTPATVPPPAAPKPQKTILRKSTTTTV"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71373", 
            "resource": "KEGG Pathway", 
            "id": "mmu:71373", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A3KMN5#function", 
            "annotation": "Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration (Probable).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A3KMN5#function", 
                    "id": "A3KMN5", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D4A107-1", 
            "protein_name": "Uncharacterized protein", 
            "sequence": {
                "length": 253, 
                "sequence": "QVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSIEKIKEQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVRCEEPQKAAPTANPLKTNGTLLRNGGLPGRPNKIPNGDICCVPNSNLDKAPLQSLMHRPEKDRSPQAGPRERVRFNEKVQYHGYCPDCETRYNIKNREVHLHSEPVHPPGKLPHYGPVLPPPPHLPTFPLENGGLGISHSNSFPPHTPATVPPPPTAPKPQKTILRKSTTTTV"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A3KMN5/", 
                    "id": "A3KMN5", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q569H4-1", 
            "protein_name": "Protein Largen", 
            "sequence": {
                "length": 304, 
                "sequence": "MSAKSKGNPSSSCPAEGPPAASKTKVKEQIKIIVEDLELVLGDLKDVAKELKEVVDQIDTLTSDLQLEDEMTDSSKTDTLNSSSSGTTASSLEKIKVQANAPLIKPPAHPSAILTVLRKPNPPPPPPRLTPVKCEDPKRVVPTANPVKTNGTLLRNGGLPGGPNKIPNGDICCIPNSNLDKAPVQLLMHRPEKDRCPQAGPRERVRFNEKVQYHGYCPDCDTRYNIKNREVHLHSEPVHPPGKIPHQGPPLPPTPHLPPFPLENGGMGISHSNSFPPIRPATVPPPTAPKPQKTILRKSTTTTV"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A3KMN5/", 
                    "id": "A3KMN5", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/41152", 
                    "id": "41152", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "PRR16", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074693.1", 
        "ac": "NP_001074693.1", 
        "name": "protein Largen", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045793", 
                        "pmid": "24656129", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3KMN5", 
                                "id": "A3KMN5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cell size", 
                        "id": "GO:0045793"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045727", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A3KMN5", 
                                "id": "A3KMN5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of translation", 
                        "id": "GO:0045727"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A3KMN5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "5430406M13Rik; AI607429"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A3KMN5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Prr16"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A3KMN5", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Prr16"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000073565", 
            "id": "ENSMUSG00000073565", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/71373", 
            "id": "71373", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027997", 
            "id": "IPR027997", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:71373", 
            "id": "mmu:71373", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1918623", 
            "id": "1918623", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/LSPVHCC/", 
            "id": "LSPVHCC", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1282387at2759", 
            "id": "1282387at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR15917", 
            "id": "PTHR15917", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF15252", 
            "id": "PF15252", 
            "database": "Pfam"
        }, 
        {
            "url": "http://purl.obolibrary.org/obo/PR_PR_A3KMN5", 
            "id": "PR_A3KMN5", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074693.1", 
            "id": "NP_001074693.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A3KMN5", 
            "id": "A3KMN5", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 32836.0, 
        "chemical_mass": 32836.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A3KMN5", 
            "name": "Prr16", 
            "locus": {
                "end_pos": 51304641, 
                "strand": "+", 
                "start_pos": 51117898, 
                "chromosome": "18", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000073565", 
                        "id": "ENSMUSG00000073565", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A3KMN5#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Proline-rich protein 16"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A3KMN5#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Protein Largen"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A3KMN5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "proline-rich protein 16"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A3KMN5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "protein Largen"
        }
    ]
}