{ "uniprot_canonical_ac": "A3KGV1-1", "ptm_annotation": [ { "annotation": "Tyrosine phosphorylated (By similarity). Phosphorylated on Ser-95 by TSSK4 (PubMed:26961893).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q2MJU7", "id": "Q2MJU7", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26961893", "id": "26961893", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A3KGV1-1|ODFP2_MOUSE Isoform 1 of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 830, "sequence": "MSASSSGGSPRFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSQKVDELERKLEATSAQNVEFLQVIAKREEAIHQAQLRLEEKTRECGSLARQLESAIEDARRQVEQTKEQALSKERAAQSKILDLETQLSRTKTELGQLRRTRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKASYANVFGDAPYTSSYLTSSPIRSRSPPA" }, "uniprot_id": "ODFP2_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10512203", "type": [ "PubMed" ], "id": "10512203" } ], "title": "Exchangeable gene trap using the Cre/mutated lox system.", "journal": "Cellular and molecular biology (Noisy-le-Grand, France)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106684.1", "id": "NP_001106684.1", "database": "RefSeq" } ], "authors": "Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki M, Miura K, Araki M, Yamamura K", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106684.1", "id": "NP_001106684.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15852003", "type": [ "PubMed" ], "id": "15852003" } ], "title": "Odf2-deficient mother centrioles lack distal/subdistal appendages and the ability to generate primary cilia.", "journal": "Nat. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "authors": "Ishikawa H., Tsukita S., Kubo A., Tsukita S.'", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23386061", "type": [ "PubMed" ], "id": "23386061" } ], "title": "Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.", "journal": "EMBO J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "authors": "Reiter J.F., Garcia-Verdugo J.M., Kodani A., Salome Sirerol-Piquer M., Seol A.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25361759", "type": [ "PubMed" ], "id": "25361759" } ], "title": "Tssk4 is essential for maintaining the structural integrity of sperm flagellum.", "journal": "Mol. Hum. Reprod.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "authors": "Chen S., Fu G., Li H., Wang X., Wang Z., Yu L., Lin G., Wei Y., Saiyin H.", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26961893", "type": [ "PubMed" ], "id": "26961893" } ], "title": "Testis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76.", "journal": "Sci. Rep.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "authors": "Chen S., Fu G., Li H., Wang X., Wang Y., Yu L., Wei Y., Du S.", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30626697", "type": [ "PubMed" ], "id": "30626697" } ], "title": "Cenpj Regulates Cilia Disassembly and Neurogenesis in the Developing Mouse Cortex.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106684.1", "id": "NP_001106684.1", "database": "RefSeq" } ], "authors": "Ding W, Wu Q, Sun L, Pan NC, Wang X", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30787442", "type": [ "PubMed" ], "id": "30787442" } ], "title": "The centrosome protein AKNA regulates neurogenesis via microtubule organization.", "journal": "Nature", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106684.1", "id": "NP_001106684.1", "database": "RefSeq" } ], "authors": "Huttner W.B., Shao W., Shi S.H., Vinopal S., Nguyen L., Tiwari V.K., Broix L., Borrell V., Goetz M., Hauck S.M., Sahu S.K., Wilsch-Braeuninger M., Falk S., De Juan Romero C., Feederle R., Geerlof A., Bradke F., Camargo Ortega G., Chinnappa K., Draganova K., Gavranovic A., Hirst W., Johansson P.A., Jungmann R., Karakaya T., Merl-Pham J., Peyre E., Reber S., Schlichthaerle T., Steininger T.", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30923192", "type": [ "PubMed" ], "id": "30923192" } ], "title": "Epidermal development requires ninein for spindle orientation and cortical microtubule organization.", "journal": "Life science alliance", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106684.1", "id": "NP_001106684.1", "database": "RefSeq" } ], "authors": "Lecland N, Hsu CY, Chemin C, Merdes A, Bierkamp C", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31582806", "type": [ "PubMed" ], "id": "31582806" } ], "title": "Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice.", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106684.1", "id": "NP_001106684.1", "database": "RefSeq" } ], "authors": "Ito C, Akutsu H, Yao R, Yoshida K, Yamatoya K, Mutoh T, Makino T, Aoyama K, Ishikawa H, Kunimoto K, Tsukita S, Noda T, Kikkawa M, Toshimori K", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9045620", "type": [ "PubMed" ], "id": "9045620" } ], "title": "Interactional cloning of the 84-kDa major outer dense fiber protein Odf84. Leucine zippers mediate associations of Odf84 and Odf27.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "authors": "Shao X., van der Hoorn F.A., Oko R., Tarnasky H.A., Schalles U.", "date": "1997" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9740324", "type": [ "PubMed" ], "id": "9740324" } ], "title": "Mouse Odf2 cDNAs consist of evolutionary conserved as well as highly variable sequences and encode outer dense fiber proteins of the sperm tail.", "journal": "Mol. Reprod. Dev.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106684.1", "id": "NP_001106684.1", "database": "RefSeq" } ], "authors": "Wolgemuth D.J., Rhee K., Hoyer-Fender S., Petersen C., Brohmann H.", "date": "1998" } ], "uniprot_ac": "A3KGV1", "site_annotation": [ { "end_pos": 269, "annotation": "n_glycosylation_sequon", "start_pos": 267 }, { "end_pos": 792, "annotation": "n_glycosylation_sequon", "start_pos": 790 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1#A3KGV1-1", "isoform_ac": "A3KGV1-1", "locus": { "end_pos": 29890971, "strand": "-", "start_pos": 29930658, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113765", "id": "ENSMUST00000113765", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000109394", "id": "ENSMUSP00000109394", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3KGV1-1|ODFP2_MOUSE Isoform 1 of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 830, "sequence": "MSASSSGGSPRFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSQKVDELERKLEATSAQNVEFLQVIAKREEAIHQAQLRLEEKTRECGSLARQLESAIEDARRQVEQTKEQALSKERAAQSKILDLETQLSRTKTELGQLRRTRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKASYANVFGDAPYTSSYLTSSPIRSRSPPA" } }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#A3KGV1-2", "isoform_ac": "A3KGV1-2", "locus": { "end_pos": 29893047, "strand": "-", "start_pos": 29930658, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113757", "id": "ENSMUST00000113757", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000109386", "id": "ENSMUSP00000109386", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3KGV1-2|ODFP2_MOUSE Isoform 2 of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 806, "sequence": "MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSAASSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSQKVDELERKLEATSAQNVEFLQVIAKREEAIHQAQLRLEEKTRECGSLARQLESAIEDARRQVEQTKEQALSKERAAQSKILDLETQLSRTKTELGQLRRTRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKASYANVFGDAPYTSSYLTSSPIRSRSPPA" } }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#A3KGV1-3", "isoform_ac": "A3KGV1-3", "locus": { "end_pos": 29893047, "strand": "-", "start_pos": 29930658, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000046571", "id": "ENSMUST00000046571", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000049272", "id": "ENSMUSP00000049272", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3KGV1-3|ODFP2_MOUSE Isoform 3 of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 825, "sequence": "MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSAASSQKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSQKVDELERKLEATSAQNVEFLQVIAKREEAIHQAQLRLEEKTRECGSLARQLESAIEDARRQVEQTKEQALSKERAAQSKILDLETQLSRTKTELGQLRRTRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKASYANVFGDAPYTSSYLTSSPIRSRSPPA" } }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#A3KGV1-4", "isoform_ac": "A3KGV1-4", "locus": { "end_pos": 29893047, "strand": "-", "start_pos": 29930658, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113759", "id": "ENSMUST00000113759", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000109388", "id": "ENSMUSP00000109388", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3KGV1-4|ODFP2_MOUSE Isoform 4 of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 826, "sequence": "MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSAASSQKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEKDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSQKVDELERKLEATSAQNVEFLQVIAKREEAIHQAQLRLEEKTRECGSLARQLESAIEDARRQVEQTKEQALSKERAAQSKILDLETQLSRTKTELGQLRRTRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKASYANVFGDAPYTSSYLTSSPIRSRSPPA" } }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#A3KGV1-5", "isoform_ac": "A3KGV1-5", "locus": { "end_pos": 29893047, "strand": "-", "start_pos": 29922431, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113755", "id": "ENSMUST00000113755", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000109384", "id": "ENSMUSP00000109384", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3KGV1-5|ODFP2_MOUSE Isoform 5 of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 652, "sequence": "MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSAASSQKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELARAGARLPR" } }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#A3KGV1-6", "isoform_ac": "A3KGV1-6", "locus": { "end_pos": 29890971, "strand": "-", "start_pos": 29922431, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113764", "id": "ENSMUST00000113764", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000109393", "id": "ENSMUSP00000109393", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3KGV1-6|ODFP2_MOUSE Isoform 6 of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 638, "sequence": "MSASSSGGSPRFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELARAGARLPR" } }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#A3KGV1-7", "isoform_ac": "A3KGV1-7", "locus": {}, "sequence": { "header": "sp|A3KGV1-7|ODFP2_MOUSE Isoform 7 of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 610, "sequence": "MKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELARAGARLPR" } }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#A3KGV2-1", "isoform_ac": "A3KGV2-1", "locus": { "end_pos": 29893047, "strand": "-", "start_pos": 29901106, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000123335", "id": "ENSMUST00000123335", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000121207", "id": "ENSMUSP00000121207", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A3KGV2-1|ODFP2_MOUSE Computationally mapped isoform of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 69, "sequence": "MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSAASSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITP" } }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#A3KGV3-1", "isoform_ac": "A3KGV3-1", "locus": { "end_pos": 29893047, "strand": "-", "start_pos": 29902246, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000133233", "id": "ENSMUST00000133233", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117628", "id": "ENSMUSP00000117628", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A3KGV3-1|ODFP2_MOUSE Computationally mapped isoform of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 138, "sequence": "MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSAASSQKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEEL" } }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#A3KGV9-1", "isoform_ac": "A3KGV9-1", "locus": { "end_pos": 29890971, "strand": "-", "start_pos": 29922431, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113762", "id": "ENSMUST00000113762", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000109391", "id": "ENSMUSP00000109391", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A3KGV9-1|ODFP2_MOUSE Computationally mapped isoform of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 657, "sequence": "MSASSSGGSPRFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELARAGARLPR" } }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#A3KGW0-1", "isoform_ac": "A3KGW0-1", "locus": { "end_pos": 29889758, "strand": "-", "start_pos": 29922431, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000113767", "id": "ENSMUST00000113767", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000109396", "id": "ENSMUSP00000109396", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A3KGW0-1|ODFP2_MOUSE Computationally mapped isoform of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 701, "sequence": "MGELPTGCRKRRRKRGGAAAGAGLHPPRRLHGTTLASDFNDFIRRRFWAQPCRSWFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRVRDWQKGSHELARAGARLPR" } }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#F6Y325-1", "isoform_ac": "F6Y325-1", "locus": { "end_pos": 29889834, "strand": "-", "start_pos": 29904078, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000137558", "id": "ENSMUST00000137558", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117887", "id": "ENSMUSP00000117887", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6Y325-1|ODFP2_MOUSE Computationally mapped isoform of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 271, "sequence": "XPRRLHGTTLASDFNDFIRRRFWAQPCRSWFPSCGKNGVTSLTQKKVLRTPCGAPSVTVTKSHKRGMKGDTVNVRRSVRVKTKNPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLR" } }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#V9GXZ0-1", "isoform_ac": "V9GXZ0-1", "locus": { "end_pos": 29893047, "strand": "-", "start_pos": 29926083, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000184845", "id": "ENSMUST00000184845", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000139390", "id": "ENSMUSP00000139390", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|V9GXZ0-1|ODFP2_MOUSE Computationally mapped isoform of Outer dense fiber protein 2 OS=Mus musculus OX=10090 GN=Odf2 PE=1 SV=1 CANONICAL=A3KGV1-1", "length": 680, "sequence": "MKDRSSTPPLHVHVDENTPVHVHIKKLPKPSAASSQKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARHVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERIKEEKDFTMLQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGTLLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRCKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKETLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKDKGDLELEIIVLNDRVTDLVNQQQSLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKMLKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRETGGYQRPECRVPTGDCQEGGGNPPGSAAVGGENEGVWVIGEAVGECH" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18286", "resource": "KEGG Pathway", "id": "mmu:18286", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2565942", "resource": "Reactome", "id": "R-MMU-2565942", "name": "Regulation of PLK1 Activity at G2/M Transition" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380259", "resource": "Reactome", "id": "R-MMU-380259", "name": "Loss of Nlp from mitotic centrosomes" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380270", "resource": "Reactome", "id": "R-MMU-380270", "name": "Recruitment of mitotic centrosome proteins and complexes" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380284", "resource": "Reactome", "id": "R-MMU-380284", "name": "Loss of proteins required for interphase microtubule organization from the centrosome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380320", "resource": "Reactome", "id": "R-MMU-380320", "name": "Recruitment of NuMA to mitotic centrosomes" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5620912", "resource": "Reactome", "id": "R-MMU-5620912", "name": "Anchoring of the basal body to the plasma membrane" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854518", "resource": "Reactome", "id": "R-MMU-8854518", "name": "AURKA Activation by TPX2" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106684.1", "annotation": "Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice. GeneRIF: Odf2-deficiency causes sperm neck-midpiece separation, a new type of decapitated and decaudated spermatozoa (DDS), Odf2-DDS, whose semen contains abnormal spermatozoa with immotile tailless headnecks and motile headneckless tails. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106684.1", "id": "NP_001106684.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#function", "annotation": "Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1#function", "id": "A3KGV1", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q5BJF6-1", "protein_name": "Outer dense fiber protein 2", "sequence": { "length": 829, "sequence": "MSASSSGGSPRFPSCGKNGVTSLTQKKVLRAPCGAPSVTVTKSHKRGMKGDTVNVRRSVRVKTKVPWMPPGKSSARPVGCKWENPPHCLEITPPSSEKLVSVMRLSDLSTEDDDSGHCKMNRYDKKIDSLMNAVGCLKSEVKMQKGERQMAKRFLEERKEELEEVAHELAETEHENTVLRHNIERMKEEKDFTILQKKHLQQEKECLMSKLVEAEMDGAAAAKQVMALKDTIGKLKTEKQMTCTDINTLTRQKELLLQKLSTFEETNRTLRDLLREQHCKEDSERLMEQQGALLKRLAEADSEKARLLLLLQDKDKEVEELLQEIQCEKAQAKTASELSKSMESMRGHLQAQLRSKEAENSRLCMQIKNLERSGNQHKAEVEAIMEQLKELKQKGDRDKESLKKAIRAQKERAEKSEEYAEQLHVQLADKDLYVAEALSTLESWRSRYNQVVKEKGDLELEIIVLNDRVTDLVNQQQTLEEKMREDRDSLVERLHRQTAEYSAFKLENERLKASFAPMEDKLNQAHLEVQQLKASVKNYEGMIDNYKSQVMKTRLEADEVAAQLERCDKENKILKDEMNKEIEAARRQFQSQLADLQQLPDILKITEAKLAECQDQLQGYERKNIDLTAIISDLRSRIEHQGDKLEMAREKHQASQKENKQLSLKVDELERKLEATSAQNIEFLQVIAKREEAIHQSQLRLEEKTRECGTLARQLESAIEDARRQVEQTKEHALSKERAAQNKILDLETQLSRTKTELSQLRRSRDDADRRYQSRLQDLKDRLEQSESTNRSMQNYVQFLKSSYANVFGDGPYSTFLTSSPIRSRSPPA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/1907", "id": "1907", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "ODF2", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106684.1", "ac": "NP_001106684.1", "name": "outer dense fiber protein 2 isoform a", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005200", "pmid": "9740324", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "structural constituent of cytoskeleton", "id": "GO:0005200" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017137", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "Rab GTPase binding", "id": "GO:0017137" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "pmid": "23386061", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "centrosome", "id": "GO:0005813" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "pmid": "16920728", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "cilium", "id": "GO:0005929" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005929", "pmid": "16687649", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "cilium", "id": "GO:0005929" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "pmid": "25361759", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "sperm flagellum", "id": "GO:0036126" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036126", "pmid": "27682589", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "sperm flagellum", "id": "GO:0036126" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "pmid": "16297385", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "centriole", "id": "GO:0005814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "pmid": "19625297", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "centriole", "id": "GO:0005814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "pmid": "29487109", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "centriole", "id": "GO:0005814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097539", "pmid": "24947469", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "ciliary transition fiber", "id": "GO:0097539" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001520", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "outer dense fiber", "id": "GO:0001520" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "spindle pole", "id": "GO:0000922" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "microtubule", "id": "GO:0005874" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "ciliary basal body", "id": "GO:0036064" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0120103", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "centriolar subdistal appendage", "id": "GO:0120103" } ], "total": 15, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007275", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "multicellular organism development", "id": "GO:0007275" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007286", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "spermatid development", "id": "GO:0007286" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008104", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "protein localization", "id": "GO:0008104" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902017", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "regulation of cilium assembly", "id": "GO:1902017" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010457", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "centriole-centriole cohesion", "id": "GO:0010457" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044782", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "name": "cilium organization", "id": "GO:0044782" } ], "total": 6, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KGV1", "type": "synonym", "resource": "RefSeq", "name": "AI848335; cene; MMTEST2; MMTEST29" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KGV1", "type": "synonym", "resource": "RefSeq", "name": "Odf2" }, { "url": "https://www.uniprot.org/uniprot/A3KGV1", "type": "recommended", "resource": "UniProtKB", "name": "Odf2" }, { "url": "https://www.uniprot.org/uniprot/A3KGV1", "type": "synonym", "resource": "UniProtKB", "name": "Odf84" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026790", "id": "ENSMUSG00000026790", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/18286", "id": "18286", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A3KGV1*", "id": "A3KGV1", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026099", "id": "IPR026099", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18286", "id": "mmu:18286", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1098824", "id": "1098824", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/KASYTNV/", "id": "KASYTNV", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=328077at2759", "id": "328077at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23162", "id": "PTHR23162", "database": "PANTHER" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A3KGV1", "id": "PR_A3KGV1", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2565942", "id": "R-MMU-2565942", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380259", "id": "R-MMU-380259", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380270", "id": "R-MMU-380270", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380284", "id": "R-MMU-380284", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-380320", "id": "R-MMU-380320", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5620912", "id": "R-MMU-5620912", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854518", "id": "R-MMU-8854518", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106684.1", "id": "NP_001106684.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "DOID:10907", "url": "http://disease-ontology.org/term/DOID:10907", "resource": "Disease Ontology", "name": "Microcephalus", "description": "" }, { "id": "DOID:10907", "url": "http://disease-ontology.org/term/DOID:10907", "resource": "Disease Ontology", "name": "microencephaly", "description": "" } ], "recommended_name": { "id": "DOID:10907", "url": "http://disease-ontology.org/term/DOID:10907", "resource": "Disease Ontology", "name": "microcephaly", "description": "A congenital nervous system abnormality that is characterized by a significantly smaller than normal head in infants." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/10907#disease-associations", "id": "10907", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "106", "end_pos": "106", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "109", "end_pos": "109", "kinase_uniprot_canonical_ac": "" }, { "residue": "Thr", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "110", "end_pos": "110", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "115", "end_pos": "115", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "129", "end_pos": "129", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "139", "end_pos": "139", "kinase_uniprot_canonical_ac": "" }, { "residue": "Thr", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "231", "end_pos": "231", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "261", "end_pos": "261", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "632", "end_pos": "632", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "73", "end_pos": "73", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "74", "end_pos": "74", "kinase_uniprot_canonical_ac": "" }, { "residue": "Thr", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "92", "end_pos": "92", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26961893", "id": "26961893", "database": "PubMed" } ], "start_pos": "95", "end_pos": "95", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "id": "A3KGV1", "database": "UniProtKB" } ], "start_pos": "95", "end_pos": "95", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 95541.0, "chemical_mass": 95541.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1", "name": "Odf2", "locus": { "end_pos": 29931746, "strand": "+", "start_pos": 29889221, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000026790", "id": "ENSMUSG00000026790", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A3KGV1#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "84 kDa outer dense fiber protein" }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Cenexin" }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Outer dense fiber of sperm tails protein 2" }, { "url": "https://www.uniprot.org/uniprot/A3KGV1#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Outer dense fiber protein 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KGV1", "type": "synonym", "resource": "RefSeq", "name": "cenexin; 84 kDa outer dense fiber protein; outer dense fiber of sperm tails protein 2; outer dense fiber protein 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KGV1", "type": "synonym", "resource": "RefSeq", "name": "outer dense fiber protein 2 isoform a" } ] }