{ "uniprot_canonical_ac": "A3KGF7-1", "ptm_annotation": [], "sequence": { "header": "sp|A3KGF7-1|PLCB2_MOUSE Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1", "length": 1181, "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGSLPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL" }, "uniprot_id": "PLCB2_MOUSE", "enzyme_annotation": [ { "ec": "3.1.4.11", "activity": "" }, { "ec": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2033248", "type": [ "PubMed" ], "id": "2033248" } ], "title": "Expression of phospholipase C isozymes by murine B lymphocytes.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Hempel WM, DeFranco AL", "date": "1991" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30691513", "type": [ "PubMed" ], "id": "30691513" } ], "title": "TrkB expression and dependence divides gustatory neurons into three subpopulations.", "journal": "Neural development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Rios-Pilier J, Krimm RF", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30765691", "type": [ "PubMed" ], "id": "30765691" } ], "title": "PLCbeta2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1.", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Wang L, Zhou Y, Chen Z, Sun L, Wu J, Li H, Liu F, Wang F, Yang C, Yang J, Leng Q, Zhang Q, Xu A, Shen L, Sun J, Wu D, Fang C, Lu H, Yan D, Ge B", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31268747", "type": [ "PubMed" ], "id": "31268747" } ], "title": "Phospholipase C-beta1 potentiates glucose-stimulated insulin secretion.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Hwang HJ, Yang YR, Kim HY, Choi Y, Park KS, Lee H, Ma JS, Yamamoto M, Kim J, Chae YC, Choi JH, Cocco L, Berggren PO, Jang HJ, Suh PG", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31980480", "type": [ "PubMed" ], "id": "31980480" } ], "title": "The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis.", "journal": "ImmunoHorizons", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Howitt MR, Cao YG, Gologorsky MB, Li JA, Haber AL, Biton M, Lang J, Michaud M, Regev A, Garrett WS", "date": "2020" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/32294408", "type": [ "PubMed" ], "id": "32294408" } ], "title": "Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.", "journal": "Immunity", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Perniss A, Liu S, Boonen B, Keshavarz M, Ruppert AL, Timm T, Pfeil U, Soultanova A, Kusumakshi S, Delventhal L, Aydin O, Pyrski M, Deckmann K, Hain T, Schmidt N, Ewers C, Gunther A, Lochnit G, Chubanov V, Gudermann T, Oberwinkler J, Klein J, Mikoshiba K, Leinders-Zufall T, Offermanns S, Schutz B, Boehm U, Zufall F, Bufe B, Kummer W", "date": "2020" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8672127", "type": [ "PubMed" ], "id": "8672127" } ], "title": "Genetic mapping of the human and mouse phospholipase C genes.", "journal": "Mammalian genome : official journal of the International Mammalian Genome Society", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Lyu MS, Park DJ, Rhee SG, Kozak CA", "date": "1996" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8739298", "type": [ "PubMed" ], "id": "8739298" } ], "title": "Expression and immunohistochemical localization of eight phospholipase C isoforms in adult male mouse cerebellar cortex.", "journal": "Acta histochemica", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ], "authors": "Martelli AM, Lach S, Grill V, Gilmour RS, Cocco L, Narducci P, Bareggi R", "date": "1996" } ], "uniprot_ac": "A3KGF7", "site_annotation": [ { "end_pos": 1074, "annotation": "n_glycosylation_sequon", "start_pos": 1072 }, { "end_pos": 326, "annotation": "n_glycosylation_sequon", "start_pos": 324 }, { "end_pos": 571, "annotation": "n_glycosylation_sequon", "start_pos": 569 }, { "end_pos": 866, "annotation": "n_glycosylation_sequon", "start_pos": 864 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7#A3KGF7-1", "isoform_ac": "A3KGF7-1", "locus": { "end_pos": 118709002, "strand": "+", "start_pos": 118728321, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000102524", "id": "ENSMUST00000102524", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000099583", "id": "ENSMUSP00000099583", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A3KGF7-1|PLCB2_MOUSE Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1", "length": 1181, "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGSLPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL" } }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#A3KGF7-2", "isoform_ac": "A3KGF7-2", "locus": {}, "sequence": { "header": "sp|A3KGF7-2|PLCB2_MOUSE Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1", "length": 679, "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITARPRADKWLGGLGS" } }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#A3KGF7-3", "isoform_ac": "A3KGF7-3", "locus": {}, "sequence": { "header": "sp|A3KGF7-3|PLCB2_MOUSE Isoform 3 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1", "length": 702, "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITARPRADKWLGGLGS" } }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#A3KGF7-4", "isoform_ac": "A3KGF7-4", "locus": {}, "sequence": { "header": "sp|A3KGF7-4|PLCB2_MOUSE Isoform 4 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1", "length": 633, "sequence": "MEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMGKNTSKTREPSPGPLTTSPEPSPGPCIPRCPPSEPSSGPCLSDPYSSLDKEL" } }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#E9PYI3-1", "isoform_ac": "E9PYI3-1", "locus": { "end_pos": 118709002, "strand": "+", "start_pos": 118728321, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000159756", "id": "ENSMUST00000159756", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000124364", "id": "ENSMUSP00000124364", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|E9PYI3-1|PLCB2_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Mus musculus OX=10090 GN=Plcb2 PE=1 SV=1 CANONICAL=A3KGF7-1", "length": 1158, "sequence": "MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTYQNQSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFYNFVSYKENVGKDWAEDVLALAKHPMTVNAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKRVEAALGACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHSKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGVAEGSLPSSVPVEEDTGWTAEDRTEVEEEEVVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRLDKQFNPFSVDRIDVVVATTLSITIISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILMPELASLRIAVMEEGSKFLGHRIIPINALHSGYHHLCLRSESNMALTMPALFVFLEMKDYIPDTWADLTVALANPIKYFNAQDKKSVKLKGVTGSLPEKLFSGTPVASQSNGAPVSAGNGSTAPGTKATGEEATKEVTEPQTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTQAAGCKLRPGKGSRKKRTLPCEETVVAPSEPHDRADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESVRAYFKDCFPTEAEDKPERSCEASEESCPQEPLVSKADTQESRL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:18796", "resource": "KEGG Pathway", "id": "mmu:18796", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-112043", "resource": "Reactome", "id": "R-MMU-112043", "name": "PLC beta mediated events" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "resource": "Reactome", "id": "R-MMU-1855204", "name": "Synthesis of IP3 and IP4 in the cytosol" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399997", "resource": "Reactome", "id": "R-MMU-399997", "name": "Acetylcholine regulates insulin secretion" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4086398", "resource": "Reactome", "id": "R-MMU-4086398", "name": "Ca2+ pathway" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416476", "resource": "Reactome", "id": "R-MMU-416476", "name": "G alpha (q) signalling events" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418217", "resource": "Reactome", "id": "R-MMU-418217", "name": "G beta:gamma signalling through PLC beta" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-434316", "resource": "Reactome", "id": "R-MMU-434316", "name": "Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-500657", "resource": "Reactome", "id": "R-MMU-500657", "name": "Presynaptic function of Kainate receptors" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "annotation": "Results show that phospholipase C beta 2 (PLCbeta2) inhibits the virus-induced expression of pro-inflammatory cytokines by interacting with and inhibiting transforming growth factor-beta-activated kinase 1 (TAK1) activation. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#function", "annotation": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7#function", "id": "A3KGF7", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "O89040-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2", "sequence": { "length": 1183, "sequence": "MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKENVGKDWAEDVLALAKHPMTANASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKRVEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQALIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAGQFSGPSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKNKKNQFSGPASPNKKPDGVSEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSGYHHLCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEVTGSLPEKLFSGIPVASQSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPCEETIVVPREVLEGPDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKSFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESMRACFKACFPTEAEEKPERPCEASEESCPQEPLVNKTDTQESRL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/20957", "id": "20957", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Plcb2", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q00722-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2", "sequence": { "length": 1185, "sequence": "MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A3KGF7/", "id": "A3KGF7", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/20957", "id": "20957", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "PLCB2", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "ac": "NP_001277719.1", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform b", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "phosphatidylinositol phospholipase C activity", "id": "GO:0004435" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005543", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "phospholipid binding", "id": "GO:0005543" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004629", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "phospholipase C activity", "id": "GO:0004629" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031683", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "G-protein beta/gamma-subunit complex binding", "id": "GO:0031683" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "21606356", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "23010799", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031680", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "G-protein beta/gamma-subunit complex", "id": "GO:0031680" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048015", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "phosphatidylinositol-mediated signaling", "id": "GO:0048015" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050913", "pmid": "15759003", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "sensory perception of bitter taste", "id": "GO:0050913" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "lipid catabolic process", "id": "GO:0016042" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "phospholipase C-activating G protein-coupled receptor signaling pathway", "id": "GO:0007200" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046488", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "phosphatidylinositol metabolic process", "id": "GO:0046488" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001580", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "name": "detection of chemical stimulus involved in sensory perception of bitter taste", "id": "GO:0001580" } ], "total": 6, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KGF7", "type": "synonym", "resource": "RefSeq", "name": "AI550384; B230205M18Rik; B230399N12" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KGF7", "type": "synonym", "resource": "RefSeq", "name": "Plcb2" }, { "url": "https://www.uniprot.org/uniprot/A3KGF7", "type": "recommended", "resource": "UniProtKB", "name": "Plcb2" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040061", "id": "ENSMUSG00000040061", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd13361", "id": "cd13361", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/18796", "id": "18796", "database": "GeneID" }, { "url": 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"database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00168", "id": "PF00168", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00387", "id": "PF00387", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00388", "id": "PF00388", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF08703", "id": "PF08703", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09279", "id": "PF09279", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF17787", "id": "PF17787", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A3KGF7", "id": "PR_A3KGF7", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-112043", "id": "R-MMU-112043", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "id": "R-MMU-1855204", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-399997", "id": "R-MMU-399997", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-4086398", "id": "R-MMU-4086398", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416476", "id": "R-MMU-416476", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418217", "id": "R-MMU-418217", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-434316", "id": "R-MMU-434316", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-500657", "id": "R-MMU-500657", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277719.1", "id": "NP_001277719.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [ { "synonyms": [ { "id": "MONDO:0019182", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "resource": "MONDO", "name": "monogenic obesity", "description": "" }, { "id": "MONDO:0019182", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "resource": "MONDO", "name": "genetic obesity (disease)", "description": "" }, { "id": "MONDO:0019182", "url": "https://monarchinitiative.org/disease/MONDO:0019182", "resource": "MONDO", "name": "genetic obesity", "description": "" } ], "recommended_name": { "id": "DOID:9970", "url": "http://disease-ontology.org/term/DOID:9970", "resource": "Disease Ontology", "name": "obesity", "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness." }, "evidence": [ { "url": "https://www.alliancegenome.org/gene/9970#disease-associations", "id": "9970", "database": "Alliance of Genome Resources" } ] } ], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "id": "A3KGF7", "database": "UniProtKB" } ], "start_pos": "950", "end_pos": "950", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 134546.0, "chemical_mass": 134546.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A3KGF7", "name": "Plcb2", "locus": { "end_pos": 118707517, "strand": "-", "start_pos": 118728438, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000040061", "id": "ENSMUSG00000040061", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KGF7", "type": "synonym", "resource": "RefSeq", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform b" }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2" }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "3.1.4.11" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KGF7", "type": "synonym", "resource": "RefSeq", "name": "PLC-beta-2; phosphoinositide phospholipase C-beta-2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2" }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "PLC-beta-2" }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Phosphoinositide phospholipase C-beta-2" }, { "url": "https://www.uniprot.org/uniprot/A3KGF7#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Phospholipase C-beta-2" } ] }