{
    "uniprot_canonical_ac": "A2VD16-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A2VD16-1|A2VD16_RAT Isoform 1 of Aldo-keto reductase family 1, member C12-like 1  OS=Rattus norvegicus OX=10116 GN=Akr1c12l1 PE=2 SV=1 CANONICAL=A2VD16-1", 
        "length": 323, 
        "sequence": "MSSKHHCVKLNDGHFIPALGFGTSIPNEVPKSKSLEAVHLAIDAGYHHIDTASAYQIEEEIGQAIQSKIKAGVVKREDMFITTKLWCTCFRPELVKPALEKSLKNLQLDYADLYIMHYPVPMKSGDKYLPVDDKGKWLLDTVDFCDTWEMLEKCKDAGLVKSIGVSNFNHKQLERLLNKPGLKYKPVCNQVECHLYMNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLDDPVLCDVAKKNKRSPALIALRYLVQREVVPLAQSFKENEMRENLQVFEFQLSPEDMKTLDGLNKNFRYLSAEFLAGHPEYPFSEEY"
    }, 
    "uniprot_id": "A2VD16_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2VD16", 
                    "id": "A2VD16", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17475203", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17475203"
                }
            ], 
            "title": "Rat NAD+-dependent 3alpha-hydroxysteroid dehydrogenase (AKR1C17): a member of the aldo-keto reductase family highly expressed in kidney cytosol.", 
            "journal": "Archives of biochemistry and biophysics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129216.1", 
                    "id": "NP_001129216.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Sanai M, Endo S, Matsunaga T, Ishikura S, Tajima K, El-Kabbani O, Hara A", 
            "date": "2007"
        }
    ], 
    "uniprot_ac": "A2VD16", 
    "site_annotation": [
        {
            "end_pos": 200, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 198
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2VD16#A2VD16-1", 
            "isoform_ac": "A2VD16-1", 
            "locus": {
                "end_pos": 69588146, 
                "strand": "-", 
                "start_pos": 69598949, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000064884", 
                        "id": "ENSRNOT00000064884", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000059125", 
                        "id": "ENSRNOP00000059125", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2VD16-1|A2VD16_RAT Isoform 1 of Aldo-keto reductase family 1, member C12-like 1  OS=Rattus norvegicus OX=10116 GN=Akr1c12l1 PE=2 SV=1 CANONICAL=A2VD16-1", 
                "length": 323, 
                "sequence": "MSSKHHCVKLNDGHFIPALGFGTSIPNEVPKSKSLEAVHLAIDAGYHHIDTASAYQIEEEIGQAIQSKIKAGVVKREDMFITTKLWCTCFRPELVKPALEKSLKNLQLDYADLYIMHYPVPMKSGDKYLPVDDKGKWLLDTVDFCDTWEMLEKCKDAGLVKSIGVSNFNHKQLERLLNKPGLKYKPVCNQVECHLYMNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLDDPVLCDVAKKNKRSPALIALRYLVQREVVPLAQSFKENEMRENLQVFEFQLSPEDMKTLDGLNKNFRYLSAEFLAGHPEYPFSEEY"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:498790", 
            "resource": "KEGG Pathway", 
            "id": "rno:498790", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129216.1", 
            "annotation": "AKR1C17 is a member of the aldo-keto reductase family highly expressed in kidney cytosol.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129216.1", 
                    "id": "NP_001129216.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZPY8-1", 
            "protein_name": "Aldo-keto reductase family 1, member C13", 
            "sequence": {
                "length": 323, 
                "sequence": "MSSKQHCVKLNDGHFIPALGFGTYKPKEVPKSKSLEAAHLAIDAGYRHIDTAYAYQIEEEIGQAIQSKIKAGVVKREDMFITTKLWCTCFRPELVKPALEKSLKNLQLDYADLYIMHYPVPMKSGDNDFPVDEKGKSLLDTVDFCDTWEMLEKCKDAGLVKSIGVSNFNHKQLERLLNKPGLKYKPVCNQVECHLYLNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVAKKNKRSPALIALRYLVQRGVVPLAQSFKENEMRENLQVFDFQLSPEDMKTLDGLNKNFRYLSAEFLAGHPEYPFSEEY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/121208", 
                    "id": "121208", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "Akr1c13", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q8VC28-1", 
            "protein_name": "Aldo-keto reductase family 1 member C13", 
            "sequence": {
                "length": 323, 
                "sequence": "MSSKQHCVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEEIGQAIQSKIKAGVVKREDLFITTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYPVPMKSGDNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKYKPVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVAKKNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGLNKNFRYLPAEFLVDHPEYPFVEEY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/121208", 
                    "id": "121208", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Akr1c13", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q9JLI0-1", 
            "protein_name": "Aldo-keto reductase a", 
            "sequence": {
                "length": 323, 
                "sequence": "MSSKQHYVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEEIGQAIQSKIKAGVVKREDLFITTKLWCGCFRPELVKPALEKSLKSLQLDYVDLYLIHYPVPMKPGDNESPLDENGKFLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKYKPVCNQVECHLYLNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVAKRNKRSPALIALRYLFQRGIVPLAQSFKENEMRENLQVFEFQLSPEDMKTLDGLNKNFRYLPAEFLADHPEYPFSEEY"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/121208", 
                    "id": "121208", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "gene_name": "Akr1c12", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129216.1", 
        "ac": "NP_001129216.1", 
        "name": "aldo-keto reductase family 1, member C12-like 1", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016229", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "steroid dehydrogenase activity", 
                        "id": "GO:0016229"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004032", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "alditol:NADP+ 1-oxidoreductase activity", 
                        "id": "GO:0004032"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "oxidoreductase activity", 
                        "id": "GO:0016491"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008106", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "alcohol dehydrogenase (NADP+) activity", 
                        "id": "GO:0008106"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047086", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ketosteroid monooxygenase activity", 
                        "id": "GO:0047086"
                    }
                ], 
                "total": 5, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008202", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "steroid metabolic process", 
                        "id": "GO:0008202"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2VD16", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Akr1c12l1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2VD16", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Akr1c12l1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2VD16", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Akr1c17; RGD1559604"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2VD16", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "RGD1559604"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000050243", 
            "id": "ENSRNOG00000050243", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06660", 
            "id": "cd06660", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/498790", 
            "id": "498790", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018170", 
            "id": "IPR018170", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020471", 
            "id": "IPR020471", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023210", 
            "id": "IPR023210", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036812", 
            "id": "IPR036812", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:498790", 
            "id": "rno:498790", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/KNYPFHI/", 
            "id": "KNYPFHI", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1016440at2759", 
            "id": "1016440at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732", 
            "id": "PTHR11732", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00248", 
            "id": "PF00248", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129216.1", 
            "id": "NP_001129216.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1559604", 
            "id": "1559604", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2VD16", 
            "id": "A2VD16", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [
        {
            "synonyms": [], 
            "recommended_name": {
                "id": "DOID:0060074", 
                "url": "http://disease-ontology.org/term/DOID:0060074", 
                "resource": "Disease Ontology", 
                "name": "ductal carcinoma in situ", 
                "description": "A breast carcinoma in situ that is characterized by being non-invasive, not having spread outside of the duct into the surrounding breast tissue, has_material_basis_in abnormally proliferating cells, derives_from epithelial cells."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/0060074#disease-associations", 
                    "id": "0060074", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "synonyms": [
                {
                    "id": "DOID:0080630", 
                    "url": "http://disease-ontology.org/term/DOID:0080630", 
                    "resource": "Disease Ontology", 
                    "name": "precursor B lymphoblastic lymphoma/leukemia", 
                    "description": ""
                }, 
                {
                    "id": "DOID:0080630", 
                    "url": "http://disease-ontology.org/term/DOID:0080630", 
                    "resource": "Disease Ontology", 
                    "name": "B-ALL", 
                    "description": ""
                }
            ], 
            "recommended_name": {
                "id": "DOID:0080630", 
                "url": "http://disease-ontology.org/term/DOID:0080630", 
                "resource": "Disease Ontology", 
                "name": "B-lymphoblastic leukemia/lymphoma", 
                "description": "A B-cell acute lymphoblastic leukemia that is characterized by the presence of too many B-cell lymphoblasts in the blood and bone marrow."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/0080630#disease-associations", 
                    "id": "0080630", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "synonyms": [
                {
                    "id": "MONDO:0013664", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0013664", 
                    "resource": "MONDO", 
                    "name": "46,XY disorder of sex development due to testicular 17,20-desmolase deficiency", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0013664", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0013664", 
                    "resource": "MONDO", 
                    "name": "SRXY8", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0013664", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0013664", 
                    "resource": "MONDO", 
                    "name": "male pseudohermaphroditism due to deficiency of testicular 17,20-desmolase", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0013664", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0013664", 
                    "resource": "MONDO", 
                    "name": "46,XY sex reversal 8; SRXY8", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0013664", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0013664", 
                    "resource": "MONDO", 
                    "name": "46,XY sex reversal type 8", 
                    "description": ""
                }, 
                {
                    "id": "DOID:0111773", 
                    "url": "http://disease-ontology.org/term/DOID:0111773", 
                    "resource": "Disease Ontology", 
                    "name": "SRXY8", 
                    "description": ""
                }, 
                {
                    "id": "DOID:0111773", 
                    "url": "http://disease-ontology.org/term/DOID:0111773", 
                    "resource": "Disease Ontology", 
                    "name": "TDD", 
                    "description": ""
                }, 
                {
                    "id": "DOID:0111773", 
                    "url": "http://disease-ontology.org/term/DOID:0111773", 
                    "resource": "Disease Ontology", 
                    "name": "male pseudohermaphroditism due to deficiency of testicular 17,20-desmolase", 
                    "description": ""
                }
            ], 
            "recommended_name": {
                "id": "DOID:0111773", 
                "url": "http://disease-ontology.org/term/DOID:0111773", 
                "resource": "Disease Ontology", 
                "name": "46,XY sex reversal 8", 
                "description": "A 46 XY sex reversal characterized by an XY karyotype, phenotypically female genitalia and failure to develop secondary sexual characteristics at puberty including menstruation that has_material_basis_in homozygous or compound heterozygous mutation in AKR1C2 on chromosome 10p15.1."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/0111773#disease-associations", 
                    "id": "0111773", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "synonyms": [
                {
                    "id": "MONDO:0012620", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0012620", 
                    "resource": "MONDO", 
                    "name": "HPC10", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0012620", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0012620", 
                    "resource": "MONDO", 
                    "name": "prostate cancer, hereditary, 10; HPC10", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0012620", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0012620", 
                    "resource": "MONDO", 
                    "name": "prostate cancer, hereditary, 10", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10283", 
                    "url": "http://disease-ontology.org/term/DOID:10283", 
                    "resource": "Disease Ontology", 
                    "name": "NGP - new growth of prostate", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10283", 
                    "url": "http://disease-ontology.org/term/DOID:10283", 
                    "resource": "Disease Ontology", 
                    "name": "hereditary prostate cancer", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10283", 
                    "url": "http://disease-ontology.org/term/DOID:10283", 
                    "resource": "Disease Ontology", 
                    "name": "malignant tumor of the prostate", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10283", 
                    "url": "http://disease-ontology.org/term/DOID:10283", 
                    "resource": "Disease Ontology", 
                    "name": "prostate cancer, familial", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10283", 
                    "url": "http://disease-ontology.org/term/DOID:10283", 
                    "resource": "Disease Ontology", 
                    "name": "prostate neoplasm", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10283", 
                    "url": "http://disease-ontology.org/term/DOID:10283", 
                    "resource": "Disease Ontology", 
                    "name": "prostatic cancer", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10283", 
                    "url": "http://disease-ontology.org/term/DOID:10283", 
                    "resource": "Disease Ontology", 
                    "name": "prostatic neoplasm", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10283", 
                    "url": "http://disease-ontology.org/term/DOID:10283", 
                    "resource": "Disease Ontology", 
                    "name": "tumor of the prostate", 
                    "description": ""
                }
            ], 
            "recommended_name": {
                "id": "DOID:10283", 
                "url": "http://disease-ontology.org/term/DOID:10283", 
                "resource": "Disease Ontology", 
                "name": "prostate cancer", 
                "description": "A male reproductive organ cancer that is located_in the prostate."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/10283#disease-associations", 
                    "id": "10283", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "synonyms": [
                {
                    "id": "MONDO:0013815", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0013815", 
                    "resource": "MONDO", 
                    "name": "FGFR2-related bent bone dysplasia", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0013815", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0013815", 
                    "resource": "MONDO", 
                    "name": "bent bone dysplasia syndrome", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0013815", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0013815", 
                    "resource": "MONDO", 
                    "name": "BBDS", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0013815", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0013815", 
                    "resource": "MONDO", 
                    "name": "bent bone dysplasia (BBD)-FGFR2 type", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0013815", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0013815", 
                    "resource": "MONDO", 
                    "name": "bent bone dysplasia syndrome; BBDS", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0013815", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0013815", 
                    "resource": "MONDO", 
                    "name": "perinatal lethal bent bone dysplasia", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10591", 
                    "url": "http://disease-ontology.org/term/DOID:10591", 
                    "resource": "Disease Ontology", 
                    "name": "gestational hypertension", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10591", 
                    "url": "http://disease-ontology.org/term/DOID:10591", 
                    "resource": "Disease Ontology", 
                    "name": "hypertension induced by pregnancy", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10591", 
                    "url": "http://disease-ontology.org/term/DOID:10591", 
                    "resource": "Disease Ontology", 
                    "name": "pre-eclamptic toxaemia", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10591", 
                    "url": "http://disease-ontology.org/term/DOID:10591", 
                    "resource": "Disease Ontology", 
                    "name": "preeclampsia", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10591", 
                    "url": "http://disease-ontology.org/term/DOID:10591", 
                    "resource": "Disease Ontology", 
                    "name": "preeclampsia/eclampsia", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10591", 
                    "url": "http://disease-ontology.org/term/DOID:10591", 
                    "resource": "Disease Ontology", 
                    "name": "pregnancy associated hypertension", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10591", 
                    "url": "http://disease-ontology.org/term/DOID:10591", 
                    "resource": "Disease Ontology", 
                    "name": "pregnancy toxemia", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10591", 
                    "url": "http://disease-ontology.org/term/DOID:10591", 
                    "resource": "Disease Ontology", 
                    "name": "proteinuric hypertension of pregnancy", 
                    "description": ""
                }, 
                {
                    "id": "DOID:10591", 
                    "url": "http://disease-ontology.org/term/DOID:10591", 
                    "resource": "Disease Ontology", 
                    "name": "toxaemia of pregnancy", 
                    "description": ""
                }
            ], 
            "recommended_name": {
                "id": "DOID:10591", 
                "url": "http://disease-ontology.org/term/DOID:10591", 
                "resource": "Disease Ontology", 
                "name": "pre-eclampsia", 
                "description": "A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/10591#disease-associations", 
                    "id": "10591", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "synonyms": [], 
            "recommended_name": {
                "id": "DOID:1240", 
                "url": "http://disease-ontology.org/term/DOID:1240", 
                "resource": "Disease Ontology", 
                "name": "leukemia", 
                "description": "A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/1240#disease-associations", 
                    "id": "1240", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
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                    "id": "DOID:5603", 
                    "url": "http://disease-ontology.org/term/DOID:5603", 
                    "resource": "Disease Ontology", 
                    "name": "acute T cell leukemia", 
                    "description": ""
                }, 
                {
                    "id": "DOID:5603", 
                    "url": "http://disease-ontology.org/term/DOID:5603", 
                    "resource": "Disease Ontology", 
                    "name": "precursor T-lymphoblastic lymphoma/leukemia", 
                    "description": ""
                }, 
                {
                    "id": "DOID:5603", 
                    "url": "http://disease-ontology.org/term/DOID:5603", 
                    "resource": "Disease Ontology", 
                    "name": "Precursor T Lymphoblastic Leukemia", 
                    "description": ""
                }, 
                {
                    "id": "DOID:5603", 
                    "url": "http://disease-ontology.org/term/DOID:5603", 
                    "resource": "Disease Ontology", 
                    "name": "T Acute Lymphoblastic Leukemia", 
                    "description": ""
                }, 
                {
                    "id": "DOID:5603", 
                    "url": "http://disease-ontology.org/term/DOID:5603", 
                    "resource": "Disease Ontology", 
                    "name": "T-cell acute lymphocytic leukaemia", 
                    "description": ""
                }, 
                {
                    "id": "DOID:5603", 
                    "url": "http://disease-ontology.org/term/DOID:5603", 
                    "resource": "Disease Ontology", 
                    "name": "acute T cell leukaemia", 
                    "description": ""
                }
            ], 
            "recommended_name": {
                "id": "DOID:5603", 
                "url": "http://disease-ontology.org/term/DOID:5603", 
                "resource": "Disease Ontology", 
                "name": "T-cell acute lymphoblastic leukemia", 
                "description": "An acute lymphoblastic leukemia that is characterized by too many T-cell lymphoblasts found in the bone marrow and blood."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/5603#disease-associations", 
                    "id": "5603", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }, 
        {
            "synonyms": [
                {
                    "id": "MONDO:0019182", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182", 
                    "resource": "MONDO", 
                    "name": "monogenic obesity", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0019182", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182", 
                    "resource": "MONDO", 
                    "name": "genetic obesity (disease)", 
                    "description": ""
                }, 
                {
                    "id": "MONDO:0019182", 
                    "url": "https://monarchinitiative.org/disease/MONDO:0019182", 
                    "resource": "MONDO", 
                    "name": "genetic obesity", 
                    "description": ""
                }
            ], 
            "recommended_name": {
                "id": "DOID:9970", 
                "url": "http://disease-ontology.org/term/DOID:9970", 
                "resource": "Disease Ontology", 
                "name": "obesity", 
                "description": "An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness."
            }, 
            "evidence": [
                {
                    "url": "https://www.alliancegenome.org/gene/9970#disease-associations", 
                    "id": "9970", 
                    "database": "Alliance of Genome Resources"
                }
            ]
        }
    ], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 36956.0, 
        "chemical_mass": 36956.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2VD16", 
            "name": "Akr1c12l1", 
            "locus": {
                "end_pos": 69599142, 
                "strand": "+", 
                "start_pos": 69588085, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000050243", 
                        "id": "ENSRNOG00000050243", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2VD16#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Aldo-keto reductase family 1, member C12-like 1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2VD16", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "aldo-keto reductase family 1, member C12-like 1"
        }
    ]
}