{ "uniprot_canonical_ac": "A2VD11-1", "ptm_annotation": [], "sequence": { "header": "tr|A2VD11-1|A2VD11_RAT Isoform 1 of Splicing factor YJU2 OS=Rattus norvegicus OX=10116 GN=Yju2 PE=1 SV=1 CANONICAL=A2VD11-1", "length": 313, "sequence": "MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEAYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRMQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLLQHRLSQEQWQQQQEEEDERETVALLEEARYRRLLDDSDSEDEAPPSQPQAAARPNPTAILDEVPKTKRKAEGLCRKAQLAGLVIPKKAKTEANRVSEQVRVPTTGAPESRKVANPAPQTPGASSLSQLGAYGDSEDSDS" }, "uniprot_id": "A2VD11_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD11", "id": "A2VD11", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12477932", "type": [ "PubMed" ], "id": "12477932" } ], "title": "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103143.1", "id": "NP_001103143.1", "database": "RefSeq" } ], "authors": "Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD11", "id": "A2VD11", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A2VD11", "site_annotation": [ { "end_pos": 141, "annotation": "n_glycosylation_sequon", "start_pos": 139 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2VD11#A2VD11-1", "isoform_ac": "A2VD11-1", "locus": { "end_pos": 11100018, "strand": "+", "start_pos": 11108707, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000072357", "id": "ENSRNOT00000072357", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000067468", "id": "ENSRNOP00000067468", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2VD11-1|A2VD11_RAT Isoform 1 of Splicing factor YJU2 OS=Rattus norvegicus OX=10116 GN=Yju2 PE=1 SV=1 CANONICAL=A2VD11-1", "length": 313, "sequence": "MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEAYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRMQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLLQHRLSQEQWQQQQEEEDERETVALLEEARYRRLLDDSDSEDEAPPSQPQAAARPNPTAILDEVPKTKRKAEGLCRKAQLAGLVIPKKAKTEANRVSEQVRVPTTGAPESRKVANPAPQTPGASSLSQLGAYGDSEDSDS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:501285", "resource": "KEGG Pathway", "id": "rno:501285", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2VD11#function", "annotation": "Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD11#function", "id": "A2VD11", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9BW85-1", "protein_name": "Splicing factor YJU2", "sequence": { "length": 323, "sequence": "MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEVYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRVQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLRQHRLSEEERRRQQQEEDEQETAALLEEARKRRLLEDSDSEDEAAPSPLQPALRPNPTAILDEAPKPKRKVEVWEQSVGSLGSRPPLSRLVVVKKAKADPDCSNGQPQAAPTPGAPQNRKEANPTPLTPGASSLSQLGAYLDSDDSNGSN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/6350", "id": "6350", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "YJU2", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9D6J3-1", "protein_name": "Splicing factor YJU2", "sequence": { "length": 314, "sequence": "MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARKETVQNEAYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKRVQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLRQHRMSQEQWQQQQEEEDERETAALLEEARHRRLLEDSESEDEAPPSRPRAAARPNPTAILNEVPQTKRKAEALCSKAQLAGLVVPKKVKTEANGASEQVGVPTAAGAPKSRKADNPTPQTPGTSSLSQLGAYGDSEDSDS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/6350", "id": "6350", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2VD11/", "id": "A2VD11", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "gene_name": "Yju2", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103143.1", "ac": "NP_001103143.1", "name": "coiled-coil domain-containing protein 94", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071006", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD11", "id": "A2VD11", "database": "UniProtKB" } ], "name": "U2-type catalytic step 1 spliceosome", "id": "GO:0071006" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008380", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD11", "id": "A2VD11", "database": "UniProtKB" } ], "name": "RNA splicing", "id": "GO:0008380" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000398", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD11", "id": "A2VD11", "database": "UniProtKB" } ], "name": "mRNA splicing, via spliceosome", "id": "GO:0000398" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2VD11", "type": "synonym", "resource": "RefSeq", "name": "Ccdc94" }, { "url": "https://www.uniprot.org/uniprot/A2VD11", "type": "synonym", "resource": "UniProtKB", "name": "Ccdc94" }, { "url": "https://www.uniprot.org/uniprot/A2VD11", "type": "synonym", "resource": "UniProtKB", "name": "YJU2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2VD11", "type": "synonym", "resource": "RefSeq", "name": "Yju2" }, { "url": "https://www.uniprot.org/uniprot/A2VD11", "type": "recommended", "resource": "UniProtKB", "name": "Yju2" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000047456", "id": "ENSRNOG00000047456", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/501285", "id": "501285", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007590", "id": "IPR007590", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR043701", "id": "IPR043701", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:501285", "id": "rno:501285", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/NTDYECE/", "id": "NTDYECE", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1583452at2759", "id": "1583452at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12111", "id": "PTHR12111", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF04502", "id": "PF04502", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103143.1", "id": "NP_001103143.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1589601", "id": "1589601", "database": "RGD" }, { "url": "https://www.uniprot.org/uniprot/A2VD11", "id": "A2VD11", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 36082.0, "chemical_mass": 36082.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2VD11", "name": "Yju2", "locus": { "end_pos": 11098924, "strand": "-", "start_pos": 11108741, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000047456", "id": "ENSRNOG00000047456", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2VD11#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "Splicing factor YJU2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2VD11", "type": "synonym", "resource": "RefSeq", "name": "coiled-coil domain containing 94" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2VD11", "type": "synonym", "resource": "RefSeq", "name": "coiled-coil domain-containing protein 94" } ] }