{ "uniprot_canonical_ac": "A2RT67-1", "ptm_annotation": [], "sequence": { "header": "sp|A2RT67-1|DEND3_MOUSE Isoform 1 of DENN domain-containing protein 3 OS=Mus musculus OX=10090 GN=Dennd3 PE=1 SV=2 CANONICAL=A2RT67-1", "length": 1274, "sequence": "MAEPAARHLSLPSGLLELCALLGASQDSLRGLEQIAQKRGVKSASSLVPEVLSVFVPPFTTKEDGQVPGASCALGKGRRRSFRKKREKPRMEPWKSHPGDSKGPDSEDVTIPGGVDLLALPQLCFPGCVCVASEPKEDYIHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKSHWEPSVISARCFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAARLSLIPSPPPGPLHLIFNMKPLQVVFPSRADPESPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDHGSVTCSKSSDDNIDIPDVPLLLAQTFIQRVQSLQLHPDLHLAHLSASTDLNEGRARRRAWQQTLNCKIQHITLQLLVGIFREVKNHLNYEHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLNGRMDAFARMDLDTQSEEDRIDRMLISPRRPTVEKMASRKASPLHITHRRMVVSMPNLQDISLPELPPRNSSLRIMDTSNCRSSSPVLKVTPKSTYMFKIPDIHFPLESQCVQAYYTDFVTLLSKAMALLGPGDSLLLARYFYLRGLLHLMQGQLLSALLDFQNLYKTDIGIFPADLVKRTVESMSASERAQAERTPELRRLITEVFDKHGEAPKADDAVKNFELPKKHMQLNDFVKRVQESGIVKDAVIIHRLFDALTFGHEKQIDPETFRDFYTCWKETEAEAQEVSLPALLMEHLDKNECVYKLSSSVKTNRGVGKIAMTQKRLFLLTEGRPGYVEIATFRNIEEVKNSTVAFLLLRIPTLKIKTVAKKEVFEANLKSECDLWHLMVKEMWAGKQLADDHKDPQYVQQALTNVLLMDAVVGTLQSPSAIHAASKLAYFDNMKKKSPMAVPKTTSETLKHKINPSAGETAPQAIEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVFDASSWTVHQHCFKVGSSKVNCMVMAEHNQVWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVHNGKKPSEIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHNDRIWCCTVHKILVVTPQGFVRQELKHPKDASFLAFQLLPEEQQLWAASTGVSELYMWSLKDLDQPPQKTYLQDCSEVTCMIRVKRQIWVGGRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRTLCSAEDRYVLSGAGQEEGKIAIWKVE" }, "uniprot_id": "DEND3_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21718402", "type": [ "PubMed" ], "id": "21718402" } ], "title": "Small GTPase Rab12 regulates constitutive degradation of transferrin receptor.", "journal": "Traffic", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074535.1", "id": "NP_001074535.1", "database": "RefSeq" } ], "authors": "Itoh T., Fukuda M., Matsui T.", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24719330", "type": [ "PubMed" ], "id": "24719330" } ], "title": "Dennd3 functions as a guanine nucleotide exchange factor for small GTPase Rab12 in mouse embryonic fibroblasts.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074535.1", "id": "NP_001074535.1", "database": "RefSeq" } ], "authors": "Fukuda M., Noguchi K., Matsui T.", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25925668", "type": [ "PubMed" ], "id": "25925668" } ], "title": "Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy.", "journal": "EMBO Rep.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" } ], "authors": "Xu J., McPherson P.S., Fotouhi M.", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28249939", "type": [ "PubMed" ], "id": "28249939" } ], "title": "Regulation of DENND3, the exchange factor for the small GTPase Rab12 through an intramolecular interaction.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" } ], "authors": "Xu J., McPherson P.S.", "date": "2017" } ], "uniprot_ac": "A2RT67", "site_annotation": [ { "end_pos": 1100, "annotation": "n_glycosylation_sequon", "start_pos": 1098 }, { "end_pos": 153, "annotation": "n_glycosylation_sequon", "start_pos": 151 }, { "end_pos": 572, "annotation": "n_glycosylation_sequon", "start_pos": 570 }, { "end_pos": 853, "annotation": "n_glycosylation_sequon", "start_pos": 851 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RT67#A2RT67-1", "isoform_ac": "A2RT67-1", "locus": { "end_pos": 73512746, "strand": "-", "start_pos": 73570951, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000043414", "id": "ENSMUST00000043414", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000046774", "id": "ENSMUSP00000046774", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RT67-1|DEND3_MOUSE Isoform 1 of DENN domain-containing protein 3 OS=Mus musculus OX=10090 GN=Dennd3 PE=1 SV=2 CANONICAL=A2RT67-1", "length": 1274, "sequence": "MAEPAARHLSLPSGLLELCALLGASQDSLRGLEQIAQKRGVKSASSLVPEVLSVFVPPFTTKEDGQVPGASCALGKGRRRSFRKKREKPRMEPWKSHPGDSKGPDSEDVTIPGGVDLLALPQLCFPGCVCVASEPKEDYIHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKSHWEPSVISARCFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAARLSLIPSPPPGPLHLIFNMKPLQVVFPSRADPESPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDHGSVTCSKSSDDNIDIPDVPLLLAQTFIQRVQSLQLHPDLHLAHLSASTDLNEGRARRRAWQQTLNCKIQHITLQLLVGIFREVKNHLNYEHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLNGRMDAFARMDLDTQSEEDRIDRMLISPRRPTVEKMASRKASPLHITHRRMVVSMPNLQDISLPELPPRNSSLRIMDTSNCRSSSPVLKVTPKSTYMFKIPDIHFPLESQCVQAYYTDFVTLLSKAMALLGPGDSLLLARYFYLRGLLHLMQGQLLSALLDFQNLYKTDIGIFPADLVKRTVESMSASERAQAERTPELRRLITEVFDKHGEAPKADDAVKNFELPKKHMQLNDFVKRVQESGIVKDAVIIHRLFDALTFGHEKQIDPETFRDFYTCWKETEAEAQEVSLPALLMEHLDKNECVYKLSSSVKTNRGVGKIAMTQKRLFLLTEGRPGYVEIATFRNIEEVKNSTVAFLLLRIPTLKIKTVAKKEVFEANLKSECDLWHLMVKEMWAGKQLADDHKDPQYVQQALTNVLLMDAVVGTLQSPSAIHAASKLAYFDNMKKKSPMAVPKTTSETLKHKINPSAGETAPQAIEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVFDASSWTVHQHCFKVGSSKVNCMVMAEHNQVWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVHNGKKPSEIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHNDRIWCCTVHKILVVTPQGFVRQELKHPKDASFLAFQLLPEEQQLWAASTGVSELYMWSLKDLDQPPQKTYLQDCSEVTCMIRVKRQIWVGGRGLSQGKTRGKIYVMDVEKVTVEKELVAHLDTVRTLCSAEDRYVLSGAGQEEGKIAIWKVE" } }, { "url": "https://www.uniprot.org/uniprot/A2RT67#F6SUD2-1", "isoform_ac": "F6SUD2-1", "locus": { "end_pos": 73557636, "strand": "-", "start_pos": 73565173, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000160267", "id": "ENSMUST00000160267", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000124538", "id": "ENSMUSP00000124538", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6SUD2-1|DEND3_MOUSE Computationally mapped isoform of DENN domain-containing protein 3 OS=Mus musculus OX=10090 GN=Dennd3 PE=1 SV=1 CANONICAL=A2RT67-1", "length": 134, "sequence": "VGTLQSPSAIHAASKLAYFDNMKKKSPMAVPKTTSETLKHKINPSAGETAPQAIEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVFDASSWTVHQHCFKVGSSKVHVLQQTAHGSPFSSHWLGRAQWKEAQ" } }, { "url": "https://www.uniprot.org/uniprot/A2RT67#G3UYA1-1", "isoform_ac": "G3UYA1-1", "locus": { "end_pos": 73512746, "strand": "-", "start_pos": 73568020, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000173292", "id": "ENSMUST00000173292", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000134002", "id": "ENSMUSP00000134002", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|G3UYA1-1|DEND3_MOUSE Computationally mapped isoform of DENN domain-containing protein 3 OS=Mus musculus OX=10090 GN=Dennd3 PE=1 SV=1 CANONICAL=A2RT67-1", "length": 1139, "sequence": "MAEPAARHLSLPSGLLELCALLGASQDSLRGLEQIAQKRGVKSASSLVPEVLSVFVPPFTTKEDGQVPGASCALGKGRRRSFRKKREKPRMEPWKSHPGDSKGPDSEDVTIPGGVDLLALPQLCFPGCVCVASEPKEDYIHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKSHWEPSVISARCFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAARLSLIPSPPPGPLHLIFNMKPLQVVFPSRADPESPIVDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLMAECFVAYLHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDHGSVTCSKSSDDNIDIPDVPLLLAQTFIQRVQSLQLHPDLHLAHLSASTDLNEGRARRRAWQQTLNCKIQHITLQLLVGIFREVKNHLNYEHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLNGRMDAFARMDLDTQSEEDRIDRMLISPRRPTVEKMASRKASPLHITHRRMVVSMPNLQDISLPELPPRNSSLRIMDTSNCRSSSPVLKVTPKSTYMFKIPDIHFPLESQCVQAYYTDFVTLLSKAMALLGPGDSLLLARYFYLRGLLHLMQGQLLSALLDFQNLYKTDIGIFPADLVKRTVESMSASERAQAERTPELRRLITEVFDKHGEAPKADDAVKNFELPKKHMQLNDFVKRVQESGIVKDAVIIHRLFDALTFGHEKQIDPETFRDFYTCWKETEAEAQEVSLPALLMEHLDKNECVYKLSSSVKTNRGVGKIAMTQKRLFLLTEGRPGYVEIATFRNIEEVKNSTVAFLLLRIPTLKIKTVAKKEVFEANLKSECDLWHLMVKEMWAGKQLADDHKDPQYVQQALTNVLLMDAVVGTLQSPSAIHAASKLAYFDNMKKKSPMAVPKTTSETLKHKINPSAGETAPQAIEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVFDASSWTVHQHCFKVGSSKVNCMVMAEHNQVWVGSEDSVIYIINVHSMSCNKQLTDHRSPVTGLAVHNGKKPSEIYSCSLDGTVIAWNVSTLRVISRFQLSYGDLLSISLHNDRIWCSSLPASLSHGCS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:105841", "resource": "KEGG Pathway", "id": "mmu:105841", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8876198", "resource": "Reactome", "id": "R-MMU-8876198", "name": "RAB GEFs exchange GTP for GDP on RABs" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074535.1", "annotation": "Dennd3 not only functions as a Rab12-GEF but also modulates Akt signaling in mouse embryonic fibroblast cells", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074535.1", "id": "NP_001074535.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2RT67#function", "annotation": "Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation (PubMed:24719330, PubMed:25925668, PubMed:28249939). Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12 (PubMed:25925668). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:21718402, PubMed:24719330). Starvation also induces phosphorylation at Tyr-940, which leads to up-regulated GEF activity and initiates autophagy (PubMed:28249939).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67#function", "id": "A2RT67", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A2RUS2-1", "protein_name": "DENN domain-containing protein 3", "sequence": { "length": 1198, "sequence": "MRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKSLQIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAHLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHLNYEHRVFNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKARLNRRMDAFAQMDLDTQSEEDRINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMPNLQDIAMPELAPRNSSLRLTDTAGCRGSSAVLNVTPKSPYTFKIPEIHFPLESKCVQAYHAHFVSMLSEAMCFLAPDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTVESMSAPEWEGAEQAPELMRLISEILDKPHEASKLDDHVKKFKLPKKHMQLGDFMKRVQESGIVKDASIIHRLFEALTVGQEKQIDPETFKDFYNCWKETEAEAQEVSLPWLVMEHLDKNECVCKLSSSVKTNLGVGKIAMTQKRLFLLTEGRPGYLEISTFRNIEEVRRTTTTFLLRRIPTLKIRVASKKEVFEANLKTECDLWHLMVKEMWAGKKLADDHKDPHYVQQALTNVLLMDAVVGTLQSPGAIYAASKLSYFDKMSNEMPMTLPETTLETLKHKINPSAGEAFPQAVDVLLYTPGHLDPAEKVEDAHPKLWCALSEGKVTVFNASSWTIHQHSFKVGTAKVNCMVMADQNQVWVGSEDSVIYIINVHSMSCNKQLTAHCSSVTDLIVQDGQEAPSNVYSCSMDGMVLVWNVSTLQVTSRFQLPRGGLTSIRLHGGRLWCCTGNSIMVMKMNGSLHQELKIEENFKDTSTSFLAFQLLPEEEQLWAACAGRSEVYIWSLKDLAQPPQRVPLEDCSEINCMIRVKKQVWVGSRGLGQGTPKGKIYVIDAERKTVEKELVAHMDTVRTLCSAEDRYVLSGSGREEGKVAIWKGE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/28254", "id": "28254", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "DENND3", "tax_id": 9606 }, { "uniprot_canonical_ac": "D4A2H4-1", "protein_name": "DENN domain-containing 3", "sequence": { "length": 1278, "sequence": "MAEPSARHLSLPSGLLELCALLGASQDSLRGLEQIAQKRGVNGASSLVPEVLSVFVPPFTTKEDGQVVGASCTLSKGRRRSFRKKREKPRMESWKSHPGDSKGPDSEDVTIPGGVDLLALPQLCFPGGVCVASEPKEDYIHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKSHWEPSMSSARRFVPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAARLSLIPSPPPGPLHLIFNMKPLQVVFPSRADPESPIIDLDLHLPLLCFRPEKVLQILTCILTEQRMVFFSSDWALLTLMAECFVAYVHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDLGSVTCSKSSDEDVDIPDVPLLLAQAFIQRVQSLQLHPDLHLAHLSASTDLNEGRARRRAWQQALNCKIQHITLQLLVGIFREVKNHLNYEHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFHSFLKARLNGRMDAFARMDLDTQSEEDRIDRMLISPRRPTVEKMASRKASPLNIAHRRMVVSMPNLQDISLPELPPRNSSLRIMDTSSCKSSSPVLKVTPKSTYTFKIPEIHFPLVSQCVQAYFTDLVTLLSKAMALLGPGDSLLLARYFYLRGLIHLMQGQLLNALLDFQSLYKTDIRIFPADLVKGMVDSMSASERAQAERTPELRRLITEVFDKQGEAPKVDDAVKNFELPKKHMQLNDFVKRVQESGIVKDTTIIHRLFDALTVGHEKQIDPETFRDFYTCWKETEAEAQEVSLPALLVDHLDRNECVYKLSSSVKTNRGVGKIAMTQKRLFLLPEGRPSYVEIATFRNIEEVKSTTVAFLLLKIPTLKIKTVAKKEVFEANLKSECDLWHLMVKEMWAGKKLADDHKDPQYVQQALTNVLLMDAVVGTLQSSGAIYAASKLAYFDKMKNELPMAVPKTTSETLKHKINPSAGETAPQAIEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVFDASSWTIHQHCFKVGSSKVNCMVMAEHSQVWVGSEDSVIYIINVHSMSCNKQLTDHRSAVTGLAVPSGKKPSAVYSCSLDGTVLAWNVSTLRVISRFQLQHGDLMSISLHNDRVFCCTARSILVVTLQGFVRQELRIQPSEEPSASFLAIQLLPEEQQLWVACTGVSELYIWSLKDLGQPPQKTHLQDCTEVTCMIRVKRQIWVGGRGLSQGKTRGKIYVMDVEKVTLEKELVAHSDTVRTLCSAEDRYVLSGAGGEEGKIAIWKVE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/28254", "id": "28254", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2RT67/", "id": "A2RT67", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Dennd3", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074535.1", "ac": "NP_001074535.1", "name": "DENN domain-containing protein 3 precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017112", "pmid": "21718402", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" } ], "name": "Rab guanyl-nucleotide exchange factor activity", "id": "GO:0017112" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle", "id": "GO:0031410" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032483", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" } ], "name": "regulation of Rab protein signal transduction", "id": "GO:0032483" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008333", "pmid": "21718402", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" } ], "name": "endosome to lysosome transport", "id": "GO:0008333" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044257", "pmid": "21718402", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" } ], "name": "cellular protein catabolic process", "id": "GO:0044257" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RT67", "type": "synonym", "resource": "RefSeq", "name": "AI447457; E030003N15Rik" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RT67", "type": "synonym", "resource": "RefSeq", "name": "Dennd3" }, { "url": "https://www.uniprot.org/uniprot/A2RT67", "type": "recommended", "resource": "UniProtKB", "name": "Dennd3" }, { "url": "https://www.uniprot.org/uniprot/A2RT67", "type": "synonym", "resource": "UniProtKB", "name": "Kiaa0870" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000036661", "id": "ENSMUSG00000036661", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/105841", "id": "105841", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001194", "id": "IPR001194", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "id": "IPR001680", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005112", "id": "IPR005112", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017986", "id": "IPR017986", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "id": "IPR019775", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037516", "id": "IPR037516", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR043153", "id": "IPR043153", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:105841", "id": "mmu:105841", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2146009", "id": "2146009", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/VCIISKF/", "id": "VCIISKF", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=521943at2759", "id": "521943at2759", "database": "OrthoDB" }, { "url": "https://www.rcsb.org/structure/6B3Y", "id": "6B3Y", "database": "PDB" }, { "url": "http://pfam.xfam.org/family/PF02141", "id": "PF02141", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2RT67", "id": "PR_A2RT67", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8876198", "id": "R-MMU-8876198", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074535.1", "id": "NP_001074535.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [ { "sequence_org": "S", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25925668", "id": "25925668", "database": "PubMed" } ], "sequence_mut": "A", "start_pos": 554, "end_pos": 554, "annotation": "Abolishes interaction with 14-3-3 proteins." }, { "sequence_org": "S", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25925668", "id": "25925668", "database": "PubMed" } ], "sequence_mut": "A", "start_pos": 572, "end_pos": 572, "annotation": "Greatly reduces interaction with 14-3-3 proteins." }, { "sequence_org": "Y", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28249939", "id": "28249939", "database": "PubMed" } ], "sequence_mut": "D", "start_pos": 940, "end_pos": 940, "annotation": "Abrogates the intramolecular linker-DENN domain interaction and enhances GEF activity towards Rab12." }, { "sequence_org": "Y", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28249939", "id": "28249939", "database": "PubMed" } ], "sequence_mut": "F", "start_pos": 940, "end_pos": 940, "annotation": "Retains the intramolecular linker-DENN domain interaction and impairs GEF activity towards Rab12." } ], "disease": [], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25925668", "id": "25925668", "database": "PubMed" } ], "start_pos": "554", "end_pos": "554", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" } ], "start_pos": "554", "end_pos": "554", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25925668", "id": "25925668", "database": "PubMed" } ], "start_pos": "572", "end_pos": "572", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" } ], "start_pos": "572", "end_pos": "572", "kinase_uniprot_canonical_ac": "" }, { "residue": "Tyr", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28249939", "id": "28249939", "database": "PubMed" } ], "start_pos": "940", "end_pos": "940", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Tyr", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "id": "A2RT67", "database": "UniProtKB" } ], "start_pos": "940", "end_pos": "940", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 143888.0, "chemical_mass": 143888.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2RT67", "name": "Dennd3", "locus": { "end_pos": 73572242, "strand": "+", "start_pos": 73512560, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000036661", "id": "ENSMUSG00000036661", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RT67", "type": "synonym", "resource": "RefSeq", "name": "DENN domain-containing protein 3 precursor" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RT67", "type": "synonym", "resource": "RefSeq", "name": "DENN domain-containing protein 3" }, { "url": "https://www.uniprot.org/uniprot/A2RT67#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "DENN domain-containing protein 3" } ] }