{ "uniprot_canonical_ac": "A2RSY1-1", "ptm_annotation": [], "sequence": { "header": "sp|A2RSY1-1|KANL3_MOUSE Isoform 1 of KAT8 regulatory NSL complex subunit 3 OS=Mus musculus OX=10090 GN=Kansl3 PE=1 SV=1 CANONICAL=A2RSY1-1", "length": 903, "sequence": "MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQQENTIESDVPIDVETVTATPVPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTVAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLTQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIVSSGPSSSVFPASRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHVGSEPRDQDAEKKKKPRDLTRRDLAFEIPERGSRPASPAARLPTSPSGSEDLSSVSSSPTSSPKTKVTTVTSTQKSSQIGTSQLLKRHVQRTEAVLTHRQAQAQFAAFLKQNMLVRKAFPPGTSSCLFVPISSESVEDIEKEELRVQLKRHHSSSPLPGAKPSKRPKIKVSLISQGDTVGGPCTLSQGGTPEAAGGKPITMTLGASAGAKELTGLLTTAKSSSSEGGGTASTTPSVASSSATPNAIHTLQSRLVATSPGSSLPGTASASSLLQGLSFSLQDISSKTSGLPGSPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGSLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGATPSEEPNSQMLPSSSQRLPPAP" }, "uniprot_id": "KANL3_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23055939", "type": [ "PubMed" ], "id": "23055939" } ], "title": "A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.", "journal": "PLoS genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297442.1", "id": "NP_001297442.1", "database": "RefSeq" } ], "authors": "Nakano Y, Jahan I, Bonde G, Sun X, Hildebrand MS, Engelhardt JF, Smith RJ, Cornell RA, Fritzsch B, Banfi B", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31576060", "type": [ "PubMed" ], "id": "31576060" } ], "title": "The NSL complex maintains nuclear architecture stability via lamin A/C acetylation.", "journal": "Nature cell biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297442.1", "id": "NP_001297442.1", "database": "RefSeq" } ], "authors": "Karoutas A, Szymanski W, Rausch T, Guhathakurta S, Rog-Zielinska EA, Peyronnet R, Seyfferth J, Chen HR, de Leeuw R, Herquel B, Kimura H, Mittler G, Kohl P, Medalia O, Korbel JO, Akhtar A", "date": "2019" } ], "uniprot_ac": "A2RSY1", "site_annotation": [ { "end_pos": 130, "annotation": "n_glycosylation_sequon", "start_pos": 128 }, { "end_pos": 317, "annotation": "n_glycosylation_sequon", "start_pos": 315 }, { "end_pos": 833, "annotation": "n_glycosylation_sequon", "start_pos": 831 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1#A0A087WPB8-1", "isoform_ac": "A0A087WPB8-1", "locus": { "end_pos": 36365596, "strand": "+", "start_pos": 36367983, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000188528", "id": "ENSMUST00000188528", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000139711", "id": "ENSMUSP00000139711", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WPB8-1|KANL3_MOUSE Computationally mapped isoform of KAT8 regulatory NSL complex subunit 3 OS=Mus musculus OX=10090 GN=Kansl3 PE=1 SV=1 CANONICAL=A2RSY1-1", "length": 84, "sequence": "MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQQENTICGDGHGNSCSTL" } }, { "url": "https://www.uniprot.org/uniprot/A2RSY1#A0A087WQ64-1", "isoform_ac": "A0A087WQ64-1", "locus": { "end_pos": 36365636, "strand": "+", "start_pos": 36367983, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000187628", "id": "ENSMUST00000187628", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000140058", "id": "ENSMUSP00000140058", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WQ64-1|KANL3_MOUSE Computationally mapped isoform of KAT8 regulatory NSL complex subunit 3 OS=Mus musculus OX=10090 GN=Kansl3 PE=1 SV=1 CANONICAL=A2RSY1-1", "length": 90, "sequence": "MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQQENTIVCGLVLFPHLFTVSQTFQ" } }, { "url": "https://www.uniprot.org/uniprot/A2RSY1#A0A087WRK2-1", "isoform_ac": "A0A087WRK2-1", "locus": {}, "sequence": { "header": "tr|A0A087WRK2-1|KANL3_MOUSE Computationally mapped isoform of KAT8 regulatory NSL complex subunit 3 OS=Mus musculus OX=10090 GN=Kansl3 PE=1 SV=1 CANONICAL=A2RSY1-1", "length": 72, "sequence": "MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQQENTM" } }, { "url": "https://www.uniprot.org/uniprot/A2RSY1#A0A0A6YWN0-1", "isoform_ac": "A0A0A6YWN0-1", "locus": { "end_pos": 36365573, "strand": "+", "start_pos": 36367983, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000185621", "id": "ENSMUST00000185621", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141616", "id": "ENSMUSP00000141616", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0A6YWN0-1|KANL3_MOUSE Computationally mapped isoform of KAT8 regulatory NSL complex subunit 3 OS=Mus musculus OX=10090 GN=Kansl3 PE=1 SV=1 CANONICAL=A2RSY1-1", "length": 76, "sequence": "MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQQENTIRQEV" } }, { "url": "https://www.uniprot.org/uniprot/A2RSY1#A2RSY1-1", "isoform_ac": "A2RSY1-1", "locus": { "end_pos": 36337634, "strand": "+", "start_pos": 36367983, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000186470", "id": "ENSMUST00000186470", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000140597", "id": "ENSMUSP00000140597", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RSY1-1|KANL3_MOUSE Isoform 1 of KAT8 regulatory NSL complex subunit 3 OS=Mus musculus OX=10090 GN=Kansl3 PE=1 SV=1 CANONICAL=A2RSY1-1", "length": 903, "sequence": "MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQQENTIESDVPIDVETVTATPVPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTVAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLTQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIVSSGPSSSVFPASRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHVGSEPRDQDAEKKKKPRDLTRRDLAFEIPERGSRPASPAARLPTSPSGSEDLSSVSSSPTSSPKTKVTTVTSTQKSSQIGTSQLLKRHVQRTEAVLTHRQAQAQFAAFLKQNMLVRKAFPPGTSSCLFVPISSESVEDIEKEELRVQLKRHHSSSPLPGAKPSKRPKIKVSLISQGDTVGGPCTLSQGGTPEAAGGKPITMTLGASAGAKELTGLLTTAKSSSSEGGGTASTTPSVASSSATPNAIHTLQSRLVATSPGSSLPGTASASSLLQGLSFSLQDISSKTSGLPGSPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGSLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGATPSEEPNSQMLPSSSQRLPPAP" } }, { "url": "https://www.uniprot.org/uniprot/A2RSY1#A2RSY1-2", "isoform_ac": "A2RSY1-2", "locus": { "end_pos": 36337634, "strand": "+", "start_pos": 36367983, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000010597", "id": "ENSMUST00000010597", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000010597", "id": "ENSMUSP00000010597", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RSY1-2|KANL3_MOUSE Isoform 2 of KAT8 regulatory NSL complex subunit 3 OS=Mus musculus OX=10090 GN=Kansl3 PE=1 SV=1 CANONICAL=A2RSY1-1", "length": 877, "sequence": "MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQQENTIESDVPIDVETVTATPVPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTVAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLTQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIVSSGPSSSVFPASRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHVGSEPRDQDAEKKKKPRDLTRRDLAFEIPERGSRPASPAARLPTSPSGSEDLSSVSSSPTSSPKTKVTTVTSTQKSSQIGTSQLLKRHVQRTEAVLTHRQAQVPISSESVEDIEKEELRVQLKRHHSSSPLPGAKPSKRPKIKVSLISQGDTVGGPCTLSQGGTPEAAGGKPITMTLGASAGAKELTGLLTTAKSSSSEGGGTASTTPSVASSSATPNAIHTLQSRLVATSPGSSLPGTASASSLLQGLSFSLQDISSKTSGLPGSPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGSLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGATPSEEPNSQMLPSSSQRLPPAP" } }, { "url": "https://www.uniprot.org/uniprot/A2RSY1#A2RSY1-3", "isoform_ac": "A2RSY1-3", "locus": { "end_pos": 36337634, "strand": "+", "start_pos": 36365570, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000185912", "id": "ENSMUST00000185912", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000140547", "id": "ENSMUSP00000140547", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2RSY1-3|KANL3_MOUSE Isoform 3 of KAT8 regulatory NSL complex subunit 3 OS=Mus musculus OX=10090 GN=Kansl3 PE=1 SV=1 CANONICAL=A2RSY1-1", "length": 778, "sequence": "MNECERHVIFARTDADAPPPPEDWEEHVNRTGWTVAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLTQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIVSSGPSSSVFPASRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHVGSEPRDQDAEKKKKPRDLTRRDLAFEIPERGSRPASPAARLPTSPSGSEDLSSVSSSPTSSPKTKVTTVTSTQKSSQIGTSQLLKRHVQRTEAVLTHRQAQVPISSESVEDIEKEELRVQLKRHHSSSPLPGAKPSKRPKIKVSLISQGDTVGGPCTLSQGGTPEAAGGKPITMTLGASAGAKELTGLLTTAKSSSSEGGGTASTTPSVASSSATPNAIHTLQSRLVATSPGSSLPGTASASSLLQGLSFSLQDISSKTSGLPGSPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGSLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGATPSEEPNSQMLPSSSQRLPPAP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:226976", "resource": "KEGG Pathway", "id": "mmu:226976", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3214847", "resource": "Reactome", "id": "R-MMU-3214847", "name": "HATs acetylate histones" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1#function", "annotation": "As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1#function", "id": "A2RSY1", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297442.1", "annotation": "Loss of the lysine acetyltransferase MOF or its associated NSL-complex members KANSL2 or KANSL3 leads to a stochastic accumulation of nuclear abnormalities with genomic instability patterns including chromothripsis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297442.1", "id": "NP_001297442.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q3KR73-1", "protein_name": "KAT8 regulatory NSL complex subunit 3", "sequence": { "length": 877, "sequence": "MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQQENTIESDVPIDVETVTATPAPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTVAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLIQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIASSGPSSSVFPASRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMTGAVRSKVLEIHSHFPHKPIILIGWSTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHVGSEPRDQDAEKKKKPRDVARRDLAFEIPERGSRPASPAARLPTSPSGSEDLSSVSSSPTSSPKTKGTTVTSAQKSSQIGTSQLLRRHVQRTDAVLTHRQAQVPISSEPVEEVEKEELRVQLKRHHPSSPLPGAKPSKRPKIKVSLISQGDTVGGPCTLSQGGTPEAAGGKPITMTLGASAGAKELTGLLTTAKSSSSEGGVTASAAPSVASSNATPNAIHTLQSRLVATSPGSSLPGAASASSLLQGLSFSLQDISSKTTGLPGSPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLAATPGGKPTAIHQLLTNGGLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGAAASEEPNSQMLPSSSQRLPPAP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/9949", "id": "9949", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Kansl3", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9P2N6-1", "protein_name": "KAT8 regulatory NSL complex subunit 3", "sequence": { "length": 904, "sequence": "MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRMLFVTPRRQHESTIESDVPIDVETVTSTPMPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTMAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLIQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIASSGPSSSVFPTSRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHMGSEPRDQDAEKKKKPRDVARRDLAFEVPERGSRPASPAAKLPASPSGSEDLSSVSSSPTSSPKTKVTTVTSAQKSSQIGSSQLLKRHVQRTEAVLTHKQAQAQFAAFLKQNMLVRKALPPGTSSCLFVPISSEPPEEGEKEDLRVQLKRHHPSSPLPGSKTSKRPKIKVSLISQGDTAGGPCAPSQGSAPEAAGGKPITMTLGQASAGAKELTGLLTTAKSSSSEGGVSASPVPSVVSSSTAPSALHTLQSRLVATSPGSSLPGATSASSLLQGLSFSLQDISSKTSGLPANPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGGLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGAAPSEESSSQVLPSSSQRLPPAP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/9949", "id": "9949", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "KANSL3", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297442.1", "ac": "NP_001297442.1", "name": "KAT8 regulatory NSL complex subunit 3 isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043995", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "name": "histone acetyltransferase activity (H4-K5 specific)", "id": "GO:0043995" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043996", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "name": "histone acetyltransferase activity (H4-K8 specific)", "id": "GO:0043996" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046972", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "name": "histone acetyltransferase activity (H4-K16 specific)", "id": "GO:0046972" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044545", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "name": "NSL complex", "id": "GO:0044545" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000123", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "name": "histone acetyltransferase complex", "id": "GO:0000123" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043984", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "name": "histone H4-K16 acetylation", "id": "GO:0043984" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043981", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "name": "histone H4-K5 acetylation", "id": "GO:0043981" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043982", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "name": "histone H4-K8 acetylation", "id": "GO:0043982" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSY1", "type": "synonym", "resource": "RefSeq", "name": "4632411B12Rik; 4932435K23; AI431067; AI647574; C85723; Kiaa1310; mKIAA1310" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSY1", "type": "synonym", "resource": "RefSeq", "name": "Kansl3" }, { "url": "https://www.uniprot.org/uniprot/A2RSY1", "type": "recommended", "resource": "UniProtKB", "name": "Kansl3" }, { "url": "https://www.uniprot.org/uniprot/A2RSY1", "type": "synonym", "resource": "UniProtKB", "name": "Kiaa1310" }, { "url": "https://www.uniprot.org/uniprot/A2RSY1", "type": "synonym", "resource": "UniProtKB", "name": "Nsl3" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000010453", "id": "ENSMUSG00000010453", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/226976", "id": "226976", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2RSY1*", "id": "A2RSY1", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026555", "id": "IPR026555", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029058", "id": "IPR029058", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:226976", "id": "mmu:226976", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1918055", "id": "1918055", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/HFSHKPI/", "id": "HFSHKPI", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=316190at2759", "id": "316190at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13136", "id": "PTHR13136", "database": "PANTHER" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2RSY1", "id": "PR_A2RSY1", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3214847", "id": "R-MMU-3214847", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297442.1", "id": "NP_001297442.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "start_pos": "523", "end_pos": "523", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": "536", "end_pos": "536", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "start_pos": "536", "end_pos": "536", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "Atxn7l3b", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "start_pos": "540", "end_pos": "540", "kinase_uniprot_canonical_ac": "Q3UD01-1" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "start_pos": "540", "end_pos": "540", "kinase_uniprot_canonical_ac": "" }, { "residue": "Ser", "kinase_gene_name": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "id": "A2RSY1", "database": "UniProtKB" } ], "start_pos": "772", "end_pos": "772", "kinase_uniprot_canonical_ac": "" } ], "mass": { "monoisotopic_mass": 96135.0, "chemical_mass": 96135.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2RSY1", "name": "Kansl3", "locus": { "end_pos": 36335730, "strand": "-", "start_pos": 36369181, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000010453", "id": "ENSMUSG00000010453", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSY1", "type": "synonym", "resource": "RefSeq", "name": "KAT8 regulatory NSL complex subunit 3 isoform 1" }, { "url": "https://www.uniprot.org/uniprot/A2RSY1#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "KAT8 regulatory NSL complex subunit 3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSY1", "type": "synonym", "resource": "RefSeq", "name": "NSL complex protein NSL3; non-specific lethal 3 homolog" }, { "url": "https://www.uniprot.org/uniprot/A2RSY1#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "NSL complex protein NSL3" }, { "url": "https://www.uniprot.org/uniprot/A2RSY1#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Non-specific lethal 3 homolog" } ] }