{
    "uniprot_canonical_ac": "A2RST1-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2RST1-1|MGST2_MOUSE Isoform 1 of Microsomal glutathione S-transferase 2  OS=Mus musculus OX=10090 GN=Mgst2 PE=2 SV=1 CANONICAL=A2RST1-1", 
        "length": 147, 
        "sequence": "MAGDSSLLAAVSLLSACQQSYFAWRVGRARLKHKIAPPAVTGPLEFERIFRAQQNSLEFYPVFIVMLWMAGWYFNQVFAACLGLLYIYARHKYFWGYAEAAEKRITGFRLSLGILTLLPVLAVLGVASRFLNEYLDFHVAKKLRKPF"
    }, 
    "uniprot_id": "MGST2_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "1.11.1.-", 
            "activity": ""
        }, 
        {
            "ec": "2.5.1.18", 
            "activity": ""
        }, 
        {
            "ec": "2.5.1.18", 
            "activity": "RX + glutathione = HX + R-S-glutathione."
        }, 
        {
            "ec": "4.4.1.20", 
            "activity": "Leukotriene C(4) = leukotriene A(4) + glutathione."
        }
    ], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RST1", 
                    "id": "A2RST1", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26656251", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "26656251"
                }
            ], 
            "title": "Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage.", 
            "journal": "Nat. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RST1", 
                    "id": "A2RST1", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Rubinstein M., Barak S., Dvash E., Har-Tal M., Meir O.", 
            "date": "2015"
        }
    ], 
    "uniprot_ac": "A2RST1", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#A0A0A6YWX7-1", 
            "isoform_ac": "A0A0A6YWX7-1", 
            "locus": {
                "end_pos": 51661249, 
                "strand": "-", 
                "start_pos": 51682470, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000159554", 
                        "id": "ENSMUST00000159554", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000141745", 
                        "id": "ENSMUSP00000141745", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0A6YWX7-1|MGST2_MOUSE Computationally mapped isoform of Microsomal glutathione S-transferase 2  OS=Mus musculus OX=10090 GN=Mgst2 PE=2 SV=1 CANONICAL=A2RST1-1", 
                "length": 82, 
                "sequence": "MAGDSSLLAAVSLLSACQQSYFAWRVGRARLKHKIAPPAVTGPLEFERIFRAQQNSLEFYPVFIVMLWMAGWYFNQGSPVSD"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#A2RST1-1", 
            "isoform_ac": "A2RST1-1", 
            "locus": {
                "end_pos": 51661249, 
                "strand": "-", 
                "start_pos": 51682583, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000099106", 
                        "id": "ENSMUST00000099106", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000096705", 
                        "id": "ENSMUSP00000096705", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2RST1-1|MGST2_MOUSE Isoform 1 of Microsomal glutathione S-transferase 2  OS=Mus musculus OX=10090 GN=Mgst2 PE=2 SV=1 CANONICAL=A2RST1-1", 
                "length": 147, 
                "sequence": "MAGDSSLLAAVSLLSACQQSYFAWRVGRARLKHKIAPPAVTGPLEFERIFRAQQNSLEFYPVFIVMLWMAGWYFNQVFAACLGLLYIYARHKYFWGYAEAAEKRITGFRLSLGILTLLPVLAVLGVASRFLNEYLDFHVAKKLRKPF"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#E0CZ62-1", 
            "isoform_ac": "E0CZ62-1", 
            "locus": {
                "end_pos": 51661249, 
                "strand": "-", 
                "start_pos": 51681869, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000161590", 
                        "id": "ENSMUST00000161590", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000125670", 
                        "id": "ENSMUSP00000125670", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|E0CZ62-1|MGST2_MOUSE Computationally mapped isoform of Microsomal glutathione S-transferase 2  OS=Mus musculus OX=10090 GN=Mgst2 PE=2 SV=1 CANONICAL=A2RST1-1", 
                "length": 77, 
                "sequence": "MAGDSSLLAAVSLLSACQQSYFAWRVGRARLKHKIAPPAVTGPLEFERIFRAHFCSLSGSPVHIRPSQVFLGLCRSR"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-156590", 
            "resource": "Reactome", 
            "id": "R-MMU-156590", 
            "name": "Glutathione conjugation"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5423646", 
            "resource": "Reactome", 
            "id": "R-MMU-5423646", 
            "name": "Aflatoxin activation and detoxification"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#function", 
            "annotation": "Catalyzes several different glutathione-dependent reactions. Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE. Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (By similarity). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2RST1#function", 
                    "id": "A2RST1", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A0G2JU12-1", 
            "protein_name": "Microsomal glutathione S-transferase 2", 
            "sequence": {
                "length": 128, 
                "sequence": "GYFALQVGRVRLKYKIAPPAVTGSLEFERIFRAQQNSLEFYSVFIISLWMAGWYFNQVFATCLGLLYIYARHKYFWGYAEAAEKRIIGFRLSLGILALLTVLAVLGVASRFLDEYLDFHVAKKLKRPF"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2RST1/", 
                    "id": "A2RST1", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "gene_name": "Mgst2", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q99735-1", 
            "protein_name": "Microsomal glutathione S-transferase 2", 
            "sequence": {
                "length": 147, 
                "sequence": "MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFYPIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTLLGALGIANSFLDEYLDLNIAKKLRRQF"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/1811", 
                    "id": "1811", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "gene_name": "MGST2", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778160.2", 
        "ac": "NP_778160.2", 
        "name": "microsomal glutathione S-transferase 2 isoform 1", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004364", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glutathione transferase activity", 
                        "id": "GO:0004364"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043295", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glutathione binding", 
                        "id": "GO:0043295"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004464", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "leukotriene-C4 synthase activity", 
                        "id": "GO:0004464"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008047", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "enzyme activator activity", 
                        "id": "GO:0008047"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "identical protein binding", 
                        "id": "GO:0042802"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004602", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glutathione peroxidase activity", 
                        "id": "GO:0004602"
                    }
                ], 
                "total": 6, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005635", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nuclear envelope", 
                        "id": "GO:0005635"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum", 
                        "id": "GO:0005783"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "membrane", 
                        "id": "GO:0016020"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intracellular membrane-bounded organelle", 
                        "id": "GO:0043231"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum membrane", 
                        "id": "GO:0005789"
                    }
                ], 
                "total": 8, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006750", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "glutathione biosynthetic process", 
                        "id": "GO:0006750"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "lipid metabolic process", 
                        "id": "GO:0006629"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019370", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "leukotriene biosynthetic process", 
                        "id": "GO:0019370"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046466", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2RST1", 
                                "id": "A2RST1", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "membrane lipid catabolic process", 
                        "id": "GO:0046466"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RST1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "GST; GST2; MGST; MGST-II"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Gst2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RST1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Mgst2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Mgst2"
        }
    ], 
    "pro_annotation": [], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074604", 
            "id": "ENSMUSG00000074604", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/211666", 
            "id": "211666", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001129", 
            "id": "IPR001129", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001446", 
            "id": "IPR001446", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023352", 
            "id": "IPR023352", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2448481", 
            "id": "2448481", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/HKYFWGY/", 
            "id": "HKYFWGY", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1609516at2759", 
            "id": "1609516at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01124", 
            "id": "PF01124", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-156590", 
            "id": "R-MMU-156590", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5423646", 
            "id": "R-MMU-5423646", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778160.2", 
            "id": "NP_778160.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1", 
            "id": "A2RST1", 
            "database": "UniProtKB"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 16786.0, 
        "chemical_mass": 16786.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1", 
            "name": "Mgst2", 
            "locus": {
                "end_pos": 51682677, 
                "strand": "+", 
                "start_pos": 51660360, 
                "chromosome": "3", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000074604", 
                        "id": "ENSMUSG00000074604", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "1.11.1.-"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "2.5.1.18"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "4.4.1.20"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Glutathione peroxidase MGST2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Leukotriene C4 synthase MGST2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Microsomal GST-2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Microsomal GST-II"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#names_and_taxonomy", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Microsomal glutathione S-transferase 2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2RST1#names_and_taxonomy", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Microsomal glutathione S-transferase II"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RST1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "microsomal GST-2; microsomal GST-II; glutathione peroxidase MGST2; leukotriene C4 synthase MGST2; microsomal glutathione S-transferase II"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2RST1", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "microsomal glutathione S-transferase 2 isoform 1"
        }
    ]
}