{ "uniprot_canonical_ac": "A2BGH0-1", "ptm_annotation": [], "sequence": { "header": "sp|A2BGH0-1|BPIB4_MOUSE Isoform 1 of BPI fold-containing family B member 4 OS=Mus musculus OX=10090 GN=Bpifb4 PE=2 SV=1 CANONICAL=A2BGH0-1", "length": 617, "sequence": "MWTAWCVAALSVAAVCGIRQDTTTVLRVTKDVLGNAISGTIQKSDAFRSALREVPVGVGGVPYNDFHVREPPPKYTNGRQLGGNYKYGHIKANDNRAQLGGKYRYGEILDSDGSLRDLRHEDYRPPDSAYHRGSGRYRSAADSSSVGRLYRRELRPGEIPAGVATGALGPGGLLGTGGMLANEGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGRSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLCPIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGDLIDYPLGRPAILPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGAMDIDITDGMFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSEVVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFILEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST" }, "uniprot_id": "BPIB4_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BGH0", "id": "A2BGH0", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14739326", "type": [ "PubMed" ], "id": "14739326" } ], "title": "Phylogenetic and evolutionary analysis of the PLUNC gene family.", "journal": "Protein Sci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BGH0", "id": "A2BGH0", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", "id": "NP_001030047.2", "database": "RefSeq" } ], "authors": "Bingle C.D., Bingle L., Craven C.J., Gillingham P., Havard S., LeClair E.E.", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21787333", "type": [ "PubMed" ], "id": "21787333" } ], "title": "Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily.", "journal": "Biochemical Society transactions", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", "id": "NP_001030047.2", "database": "RefSeq" } ], "authors": "Bingle CD, Seal RL, Craven CJ", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26034043", "type": [ "PubMed" ], "id": "26034043" } ], "title": "Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis.", "journal": "Circulation research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", "id": "NP_001030047.2", "database": "RefSeq" } ], "authors": "Villa F, Carrizzo A, Spinelli CC, Ferrario A, Malovini A, Maciag A, Damato A, Auricchio A, Spinetti G, Sangalli E, Dang Z, Madonna M, Ambrosio M, Sitia L, Bigini P, Cali G, Schreiber S, Perls T, Fucile S, Mulas F, Nebel A, Bellazzi R, Madeddu P, Vecchione C, Puca AA", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28419216", "type": [ "PubMed" ], "id": "28419216" } ], "title": "LAV-BPIFB4 isoform modulates eNOS signalling through Ca2+/PKC-alpha-dependent mechanism.", "journal": "Cardiovascular research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", "id": "NP_001030047.2", "database": "RefSeq" } ], "authors": "Spinelli CC, Carrizzo A, Ferrario A, Villa F, Damato A, Ambrosio M, Madonna M, Frati G, Fucile S, Sciaccaluga M, Capunzo M, Cali G, Milanesi L, Maciag A, Puca AA, Vecchione C", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28852218", "type": [ "PubMed" ], "id": "28852218" } ], "title": "A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling.", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", "id": "NP_001030047.2", "database": "RefSeq" } ], "authors": "Vecchione C, Villa F, Carrizzo A, Spinelli CC, Damato A, Ambrosio M, Ferrario A, Madonna M, Uccellatore A, Lupini S, Maciag A, Ryskalin L, Milanesi L, Frati G, Sciarretta S, Bellazzi R, Genovese S, Ceriello A, Auricchio A, Malovini A, Puca AA", "date": "2017" } ], "uniprot_ac": "A2BGH0", "site_annotation": [ { "end_pos": 277, "annotation": "n_glycosylation_sequon", "start_pos": 275 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2BGH0#A0A668KL61-1", "isoform_ac": "A0A668KL61-1", "locus": { "end_pos": 153940877, "strand": "-", "start_pos": 153963603, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000154281", "id": "ENSMUST00000154281", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000159206", "id": "ENSMUSP00000159206", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A668KL61-1|BPIB4_MOUSE Computationally mapped isoform of BPI fold-containing family B member 4 OS=Mus musculus OX=10090 GN=Bpifb4 PE=2 SV=1 CANONICAL=A2BGH0-1", "length": 829, "sequence": "MWTAWCVAALSVAAVCGIRQDTTTVLRVTKDVLGNAISGTIQKSDAFRSALREVPVGKARGDGGGPFLGGLLGGSEGSSGGGGGLLGGLLGGSGGGGGDLLGGGLLGGSSSGGGGLLGGGSHGGGLLGGSGGLLGGGSHGGGLLGGSGGLLGGGSHGGGLLGGGSHGGGLLDDDDSHSGGLLGGGGSHGGGLLGGSGGLLGGGSHGGGLLGGSGGLLGGGSHGGGLLGGSGGLLGGGSHGGGLLGGSGGLLGGGRHRYDDYRRAEFPRGVGGVPYNDFHVREPPPKYTNGRQLGGNYKYGHIKANDNRAQLGGKYRYGEILDSDGSLRDLRHEDYRPPDSAYHRGSGRYRSAADSSSVGRLYRRELRPGEIPAGVATGALGPGGLLGTGGMLANEGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGRSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLCPIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGDLIDYPLGRPAILPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGAMDIDITDGMFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSEVVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFILEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST" } }, { "url": "https://www.uniprot.org/uniprot/A2BGH0#A2BGH0-1", "isoform_ac": "A2BGH0-1", "locus": { "end_pos": 153940877, "strand": "-", "start_pos": 153963603, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000109757", "id": "ENSMUST00000109757", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000105379", "id": "ENSMUSP00000105379", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2BGH0-1|BPIB4_MOUSE Isoform 1 of BPI fold-containing family B member 4 OS=Mus musculus OX=10090 GN=Bpifb4 PE=2 SV=1 CANONICAL=A2BGH0-1", "length": 617, "sequence": "MWTAWCVAALSVAAVCGIRQDTTTVLRVTKDVLGNAISGTIQKSDAFRSALREVPVGVGGVPYNDFHVREPPPKYTNGRQLGGNYKYGHIKANDNRAQLGGKYRYGEILDSDGSLRDLRHEDYRPPDSAYHRGSGRYRSAADSSSVGRLYRRELRPGEIPAGVATGALGPGGLLGTGGMLANEGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGRSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLCPIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGDLIDYPLGRPAILPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGAMDIDITDGMFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSEVVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFILEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST" } }, { "url": "https://www.uniprot.org/uniprot/A2BGH0#A2BGH0-2", "isoform_ac": "A2BGH0-2", "locus": { "end_pos": 153943944, "strand": "-", "start_pos": 153963603, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000099181", "id": "ENSMUST00000099181", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000096786", "id": "ENSMUSP00000096786", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2BGH0-2|BPIB4_MOUSE Isoform 2 of BPI fold-containing family B member 4 OS=Mus musculus OX=10090 GN=Bpifb4 PE=2 SV=1 CANONICAL=A2BGH0-1", "length": 403, "sequence": "MAAVASSSLLTACRLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGRSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLCPIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGDLIDYPLGRPAILPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGAMDIDITDGMFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSEVVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFILEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:381399", "resource": "KEGG Pathway", "id": "mmu:381399", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6803157", "resource": "Reactome", "id": "R-MMU-6803157", "name": "Antimicrobial peptides" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", "annotation": "LAV-BPIFB4 isoform modulates eNOS signalling through Ca2+/PKC-alpha-dependent mechanism.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", "id": "NP_001030047.2", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2BGH0#function", "annotation": "May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BGH0#function", "id": "A2BGH0", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", "annotation": "RV-BPIFB4 acts directly on blood pressure homeostasis and may represent a novel biomarker of vascular dysfunction and hypertension. Erratum:[Sci Rep. 2019 Jun 28;9(1):9574. PMID: 31249326] Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", "id": "NP_001030047.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P59827-1", "protein_name": "BPI fold-containing family B member 4", "sequence": { "length": 614, "sequence": "MWMAWCVAALSVVAVCGTSHETNTVLRVTKDVLSNAISGMLQQSDALHSALREVPLGVGDIPYNDFHVRGPPPVYTNGKKLDGIYQYGHIETNDNTAQLGGKYRYGEILESEGSIRDLRNSGYRSAENAYGGHRGLGRYRAAPVGRLHRRELQPGEIPPGVATGAVGPGGLLGTGGMLAADGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGKSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLADVLPDLLCPIVDVVLGLVNDQLGLVDSLIPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGGLIDYPLGWPAVSPKPMPELPPMGDNTKSQLAMSANFLGSVLTLLQKQHALDLDITNGMFEELPPLTTATLGALIPKVFQQYPESCPLIIRIQVLNPPSVMLQKDKALVKVLATAEVMVSQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEKTSLNLRTSNVGNFDIGLMEVLVEKIFDLAFMPAMNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/66971", "id": "66971", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "BPIFB4", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q05704-1", "protein_name": "BPI fold-containing family B member 4", "sequence": { "length": 617, "sequence": "MWTAWCVAALSVAAVCGIRQDTTTVLRVTKDVLGDAISGTIQKSDAFRSALREVPVGVGGVPYNDFHVREPPPKYTNGRQLGGNYKYGHIEANDNTAQLGGKYRYGEILDSDGSLRDLRHEDYRPSDSAYHRGPGRYRSAADPSSAGRLHRRELRPGEIPAGVATGALGPGGLLGTGGILANEGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGKSLIGFLDIAVEVNITAKVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLANVLPDLLCPIVDVVLGLVNDQLGLVDSLVPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGDLIDYPLGRPAMLPRPQMPELPPMGDNTNSQLAISANFLSSVLTMLQKQGALDIDITDGMFEDLPPLTTSTLGALIPKVFQQYPESRPLTIRIQVPNPPTVTLQKDKALVKVFATSEVVVSQPNDVETTICLIDVDTDLLASFSVEGDKLMIDAKLDKTSLNLRTSNVGNFDVFILEMLVEKIFDLAFMPAMNAILGSGVPLPKILNIDFSNADIDVLEDLLVLST" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/66971", "id": "66971", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Bpifb4", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", "ac": "NP_001030047.2", "name": "BPI fold-containing family B member 4 precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BGH0", "id": "A2BGH0", "database": "UniProtKB" } ], "name": "lipid binding", "id": "GO:0008289" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BGH0", "id": "A2BGH0", "database": "UniProtKB" } ], "name": "extracellular region", "id": "GO:0005576" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BGH0", "id": "A2BGH0", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 2, "name": "Cellular Component" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2BGH0", "type": "synonym", "resource": "RefSeq", "name": "Bpifb4" }, { "url": "https://www.uniprot.org/uniprot/A2BGH0", "type": "recommended", "resource": "UniProtKB", "name": "Bpifb4" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2BGH0", "type": "synonym", "resource": "RefSeq", "name": "Gm1006; Lplunc4" }, { "url": "https://www.uniprot.org/uniprot/A2BGH0", "type": "synonym", "resource": "UniProtKB", "name": "Gm1006" }, { "url": "https://www.uniprot.org/uniprot/A2BGH0", "type": "synonym", "resource": "UniProtKB", "name": "Lplunc4" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074665", "id": "ENSMUSG00000074665", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/381399", "id": "381399", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001124", "id": "IPR001124", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017942", "id": "IPR017942", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017943", "id": "IPR017943", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:381399", "id": "mmu:381399", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2685852", "id": "2685852", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/PESCPLI/", "id": "PESCPLI", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1099604at2759", "id": "1099604at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF01273", "id": "PF01273", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF02886", "id": "PF02886", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2BGH0", "id": "PR_A2BGH0", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6803157", "id": "R-MMU-6803157", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030047.2", "id": "NP_001030047.2", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2BGH0", "id": "A2BGH0", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [ { "residue": "Asn", "site_category": "predicted", "end_pos": 275, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2BGH0#ptm_processing", "id": "A2BGH0", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 275, "glytoucan_ac": "", "type": "N-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 65723.0, "chemical_mass": 65723.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2BGH0", "name": "Bpifb4", "locus": { "end_pos": 153964101, "strand": "+", "start_pos": 153938212, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000074665", "id": "ENSMUSG00000074665", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2BGH0", "type": "synonym", "resource": "RefSeq", "name": "BPI fold-containing family B member 4 precursor" }, { "url": "https://www.uniprot.org/uniprot/A2BGH0#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "BPI fold-containing family B member 4" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2BGH0", "type": "synonym", "resource": "RefSeq", "name": "LBP / BPI / CETP family, N-terminal domain containing protein; long palate, lung and nasal epithelium carcinoma-associated protein 4; ligand-binding protein RY2G5; Novel LBP/BPI/CETP family, N-terminal domain containing protein" }, { "url": "https://www.uniprot.org/uniprot/A2BGH0#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Long palate, lung and nasal epithelium carcinoma-associated protein 4" } ] }