{ "uniprot_canonical_ac": "A2AUU0-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AUU0-1|METL8_MOUSE Isoform 1 of mRNA N(3)-methylcytidine methyltransferase METTL8 OS=Mus musculus OX=10090 GN=Mettl8 PE=1 SV=2 CANONICAL=A2AUU0-1", "length": 281, "sequence": "MNVIWRSCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEDAARKKVEENSATRVAPEEQVKFESDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQNTKEKVGESSWDQVGSSISRTQGTETHCQESFVSPEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNTLQNIPGSFLYCCDFASEAVELVKSHESYSEAQCSAFIHDVCDDGLAYPFPDGILDVVLLVFVLSSIHPDRALFI" }, "uniprot_id": "METL8_MOUSE", "enzyme_annotation": [ { "ec": "2.1.1.-", "activity": "" } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103982.1", "id": "NP_001103982.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15992539", "type": [ "PubMed" ], "id": "15992539" } ], "title": "TIPs are tension-responsive proteins involved in myogenic versus adipogenic differentiation.", "journal": "Dev. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103982.1", "id": "NP_001103982.1", "database": "RefSeq" } ], "authors": "Schuger L., Pan D., Choudhury R., Jakkaraju S., Zhe X.", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18710950", "type": [ "PubMed" ], "id": "18710950" } ], "title": "Effects of the SANT domain of tension-induced/inhibited proteins (TIPs), novel partners of the histone acetyltransferase p300, on p300 activity and TIP-6-induced adipogenesis.", "journal": "Mol. Cell. Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103982.1", "id": "NP_001103982.1", "database": "RefSeq" } ], "authors": "Zhou Y., Schuger L., Aramgam S., Badri K.R., Dhru U.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28655767", "type": [ "PubMed" ], "id": "28655767" } ], "title": "Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103982.1", "id": "NP_001103982.1", "database": "RefSeq" } ], "authors": "Liu X., Xu J., Xu L., Ye F., Dedon P.C., Liang J., Sheng N., Gao Y.G., Fu X.Y., Chionh Y.H., Oo K.S.", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29706498", "type": [ "PubMed" ], "id": "29706498" } ], "title": "The STAT3 Target Mettl8 Regulates Mouse ESC Differentiation via Inhibiting the JNK Pathway.", "journal": "Stem cell reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103982.1", "id": "NP_001103982.1", "database": "RefSeq" } ], "authors": "Gu H, Do DV, Liu X, Xu L, Su Y, Nah JM, Wong Y, Li Y, Sheng N, Tilaye GA, Yang H, Guo H, Yan J, Fu XY", "date": "2018" } ], "uniprot_ac": "A2AUU0", "site_annotation": [ { "end_pos": 187, "annotation": "n_glycosylation_sequon", "start_pos": 185 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0#A2AUU0-1", "isoform_ac": "A2AUU0-1", "locus": { "end_pos": 70966501, "strand": "+", "start_pos": 71018362, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000121586", "id": "ENSMUST00000121586", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000113642", "id": "ENSMUSP00000113642", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AUU0-1|METL8_MOUSE Isoform 1 of mRNA N(3)-methylcytidine methyltransferase METTL8 OS=Mus musculus OX=10090 GN=Mettl8 PE=1 SV=2 CANONICAL=A2AUU0-1", "length": 281, "sequence": "MNVIWRSCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEDAARKKVEENSATRVAPEEQVKFESDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQNTKEKVGESSWDQVGSSISRTQGTETHCQESFVSPEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNTLQNIPGSFLYCCDFASEAVELVKSHESYSEAQCSAFIHDVCDDGLAYPFPDGILDVVLLVFVLSSIHPDRALFI" } }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#A2AUU0-2", "isoform_ac": "A2AUU0-2", "locus": { "end_pos": 70972252, "strand": "+", "start_pos": 71018362, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000148876", "id": "ENSMUST00000148876", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000115855", "id": "ENSMUSP00000115855", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AUU0-2|METL8_MOUSE Isoform 2 of mRNA N(3)-methylcytidine methyltransferase METTL8 OS=Mus musculus OX=10090 GN=Mettl8 PE=1 SV=2 CANONICAL=A2AUU0-1", "length": 304, "sequence": "MNVIWRSCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEDAARKKVEENSATRVAPEEQVKFESDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQNTKEKVGESSWDQVGSSISRTQGTETHCQESFVSPEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNTLQNIPGSFLYCCDFASEAVELVKSHESYSEAQCSAFIHDVCDDGLAYPFPDGILDVVLLVFVLSSIHPDRQVPPCLPNRTCDFYKMSQPPGRGYRPA" } }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#A2AUU0-3", "isoform_ac": "A2AUU0-3", "locus": { "end_pos": 70965519, "strand": "+", "start_pos": 71018362, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000112186", "id": "ENSMUST00000112186", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000107804", "id": "ENSMUSP00000107804", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AUU0-3|METL8_MOUSE Isoform 3 of mRNA N(3)-methylcytidine methyltransferase METTL8 OS=Mus musculus OX=10090 GN=Mettl8 PE=1 SV=2 CANONICAL=A2AUU0-1", "length": 388, "sequence": "MNVIWRSCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEDAARKKVEENSATRVAPEEQVKFESDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQNTKEKVGESSWDQVGSSISRTQGTETHCQESFVSPEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNTLQNIPGSFLYCCDFASEAVELVKSHESYSEAQCSAFIHDVCDDGLAYPFPDGILDVVLLVFVLSSIHPDRMQAVAHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGRCLSENFYVRGDGTRAYFFTKGEIRRMFCEAGLHEKQNLVDHRLQVNRKKQVQMHRVWIQGKFQKPSPWTPQSGN" } }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#A2AUU0-4", "isoform_ac": "A2AUU0-4", "locus": {}, "sequence": { "header": "sp|A2AUU0-4|METL8_MOUSE Isoform 4 of mRNA N(3)-methylcytidine methyltransferase METTL8 OS=Mus musculus OX=10090 GN=Mettl8 PE=1 SV=2 CANONICAL=A2AUU0-1", "length": 358, "sequence": "MNVIWRSCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEDAARKKVEENSATRVAPEEQVKFESDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQNTKEKVGESSWDQVGSSISRTQGTETHCQESFVSPEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNTLQNIPGSFLYCCDFASEAVELVKSHESYSEAQCSAFIHDVCDDGLAYPFPDGILDVVLLVFVLSSIHPDRMQAVAHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGRCLSENFYVRGDGPELISLQKGKSAVCSARLDYTKSKIWLIIACK" } }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#A2AUU0-5", "isoform_ac": "A2AUU0-5", "locus": { "end_pos": 70976096, "strand": "+", "start_pos": 71018362, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000112179", "id": "ENSMUST00000112179", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000107800", "id": "ENSMUSP00000107800", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AUU0-5|METL8_MOUSE Isoform 5 of mRNA N(3)-methylcytidine methyltransferase METTL8 OS=Mus musculus OX=10090 GN=Mettl8 PE=1 SV=2 CANONICAL=A2AUU0-1", "length": 206, "sequence": "MNVIWRSCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEDAARKKVEENSATRVAPEEQVKFESDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQNTKEKVGESSWDQVGSSISRTQGTETHCQESFVSPEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEEHSRILSLLLRLCL" } }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#A2AUU0-6", "isoform_ac": "A2AUU0-6", "locus": {}, "sequence": { "header": "sp|A2AUU0-6|METL8_MOUSE Isoform 6 of mRNA N(3)-methylcytidine methyltransferase METTL8 OS=Mus musculus OX=10090 GN=Mettl8 PE=1 SV=2 CANONICAL=A2AUU0-1", "length": 312, "sequence": "MNVIWRSCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEDAARKKVEENSATRVAPEEQEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNTLQNIPGSFLYCCDFASEAVELVKSHESYSEAQCSAFIHDVCDDGLAYPFPDGILDVVLLVFVLSSIHPDRMQAVAHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGRCLSENFYVRGDGTRAYFFTKGEIRRMFCEAGLHEKQNLVDHRLQVNRKKQVQMHRVWIQGKFQKPSPWTPQSGN" } }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#B0R0U1-1", "isoform_ac": "B0R0U1-1", "locus": { "end_pos": 70965519, "strand": "+", "start_pos": 71051673, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000100037", "id": "ENSMUST00000100037", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000097615", "id": "ENSMUSP00000097615", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B0R0U1-1|METL8_MOUSE Computationally mapped isoform of mRNA N(3)-methylcytidine methyltransferase METTL8 OS=Mus musculus OX=10090 GN=Mettl8 PE=1 SV=1 CANONICAL=A2AUU0-1", "length": 341, "sequence": "MDHMQWSKEEEDAARKKVEENSATRVAPEEQVKFESDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQNTKEKVGESSWDQVGSSISRTQGTETHCQESFVSPEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNTLQNIPGSFLYCCDFASEAVELVKSHESYSEAQCSAFIHDVCDDGLAYPFPDGILDVVLLVFVLSSIHPDRMQAVAHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGRCLSENFYVRGDGTRAYFFTKGEIRRMFCEAGLHEKQNLVDHRLQVNRKKQVQMHRVWIQGKFQKPSPWTPQSGN" } }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#F6Q7P7-1", "isoform_ac": "F6Q7P7-1", "locus": { "end_pos": 70973329, "strand": "+", "start_pos": 70982184, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000149181", "id": "ENSMUST00000149181", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119863", "id": "ENSMUSP00000119863", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6Q7P7-1|METL8_MOUSE Computationally mapped isoform of mRNA N(3)-methylcytidine methyltransferase METTL8 OS=Mus musculus OX=10090 GN=Mettl8 PE=1 SV=1 CANONICAL=A2AUU0-1", "length": 148, "sequence": "SDANKYWDIFYQTHKNKFFKNRNWLLREFPEILPVNQNTKEKVGESSWDQVGSSISRTQGTETHCQESFVSPEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNTLHPTSPTARPSVLPLFMTCVTTA" } }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#F6W103-1", "isoform_ac": "F6W103-1", "locus": { "end_pos": 70966427, "strand": "+", "start_pos": 70973388, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000140293", "id": "ENSMUST00000140293", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000118026", "id": "ENSMUSP00000118026", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6W103-1|METL8_MOUSE Computationally mapped isoform of mRNA N(3)-methylcytidine methyltransferase METTL8 OS=Mus musculus OX=10090 GN=Mettl8 PE=1 SV=1 CANONICAL=A2AUU0-1", "length": 110, "sequence": "XESYSEAQCSAFIHDVCDDGLAYPFPDGILDVVLLVFVLSSIHPDRMQAVAHRLSRLLKPGGMLLFRDHGRYDNAQLRFKKGRCLSENFYVRGDGTRAYFFTKGMLISLA" } }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#Q8CA70-1", "isoform_ac": "Q8CA70-1", "locus": { "end_pos": 70980063, "strand": "+", "start_pos": 71018362, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000090849", "id": "ENSMUST00000090849", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000088359", "id": "ENSMUSP00000088359", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q8CA70-1|METL8_MOUSE Computationally mapped isoform of mRNA N(3)-methylcytidine methyltransferase METTL8 OS=Mus musculus OX=10090 GN=Mettl8 PE=1 SV=1 CANONICAL=A2AUU0-1", "length": 163, "sequence": "MNVIWRSCICRLRQGKVPHRCQSGVHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEDAARKKVEENSATRVAPEEQEPGSRGRSAPDPDLEEYSKGPGKTEPFPGSNATFRILEVGCGAGNSVFPILNTLQRQKGKEREIATPHHHHQAVPCLASDMACSS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:228019", "resource": "KEGG Pathway", "id": "mmu:228019", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103982.1", "annotation": "METTL8 prohibits the activation of JNK signaling and enhances the differentiation of mouse ESCs. Collectively, our study uncovers a STAT3 target, Mettl8, which regulates mouse ESC differentiation via JNK signaling.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103982.1", "id": "NP_001103982.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#function", "annotation": "Overexpression in lung progenitor cells stimulates smooth muscle-specific gene expression and suppresses adipogenic gene expression.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0#function", "id": "A2AUU0", "database": "UniProtKB" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#function", "annotation": "S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0#function", "id": "A2AUU0", "database": "UniProtKB" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#function", "annotation": "Stimulates adipogenesis.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0#function", "id": "A2AUU0", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103982.1", "annotation": "TIP-6 was identified as a new member of the adipogenic cascade.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103982.1", "id": "NP_001103982.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9H825-1", "protein_name": "mRNA N(3)-methylcytidine methyltransferase METTL8", "sequence": { "length": 291, "sequence": "MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAAARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTLFI" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/11706", "id": "11706", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "gene_name": "METTL8", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103982.1", "ac": "NP_001103982.1", "name": "mRNA N(3)-methylcytidine methyltransferase METTL8 isoform b", "summary": "This locus encodes a member of the methyltransferase family, and is involved in chromatin remodeling. Transcripts from this locus can be induced or inhibited by cell stretch and affect cell differentiation in the myogenic or adipogenic pathways. Multiple transcript variants encoding different isoforms have been found for this gene. Additional splice variants have been described in the literature but they meet nonsense-mediated decay (NMD) criteria and are likely to be degraded as soon as they are transcribed. [provided by RefSeq, Jul 2008]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004402", "pmid": "15992539", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" } ], "name": "histone acetyltransferase activity", "id": "GO:0004402" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008174", "pmid": "28655767", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" } ], "name": "mRNA methyltransferase activity", "id": "GO:0008174" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0052735", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" } ], "name": "tRNA (cytosine-3-)-methyltransferase activity", "id": "GO:0052735" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "15992539", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "15992539", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080009", "pmid": "28655767", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" } ], "name": "mRNA methylation", "id": "GO:0080009" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045444", "pmid": "15992539", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" } ], "name": "fat cell differentiation", "id": "GO:0045444" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016573", "pmid": "15992539", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" } ], "name": "histone acetylation", "id": "GO:0016573" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007519", "pmid": "15992539", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" } ], "name": "skeletal muscle tissue development", "id": "GO:0007519" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUU0", "type": "synonym", "resource": "RefSeq", "name": "BC004636; T; Tip" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUU0", "type": "synonym", "resource": "RefSeq", "name": "Mettl8" }, { "url": "https://www.uniprot.org/uniprot/A2AUU0", "type": "recommended", "resource": "UniProtKB", "name": "Mettl8" }, { "url": "https://www.uniprot.org/uniprot/A2AUU0", "type": "synonym", "resource": "UniProtKB", "name": "Tip" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000041975", "id": "ENSMUSG00000041975", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/228019", "id": "228019", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026113", "id": "IPR026113", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "id": "IPR029063", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041698", "id": "IPR041698", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:228019", "id": "mmu:228019", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2385142", "id": "2385142", "database": "MGI" }, { "url": "http://www.orthodb.org/?query=987359at2759", "id": "987359at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22809", "id": "PTHR22809", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF13649", "id": "PF13649", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2AUU0", "id": "PR_A2AUU0", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103982.1", "id": "NP_001103982.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AUU0", "id": "A2AUU0", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 31670.0, "chemical_mass": 31670.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0", "name": "Mettl8", "locus": { "end_pos": 70964561, "strand": "-", "start_pos": 71055583, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000041975", "id": "ENSMUSG00000041975", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AUU0#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.1.1.-" }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Methyltransferase-like protein 8" }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "Tension-induced/inhibited protein" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUU0", "type": "synonym", "resource": "RefSeq", "name": "mRNA N(3)-methylcytidine methyltransferase METTL8 isoform b" }, { "url": "https://www.uniprot.org/uniprot/A2AUU0#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "mRNA N(3)-methylcytidine methyltransferase METTL8" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUU0", "type": "synonym", "resource": "RefSeq", "name": "tension induced/inhibited protein; methyltransferase-like protein 8; mRNA N(3)-methylcytidine methyltransferase METTL8" } ] }