{ "uniprot_canonical_ac": "A2AUQ7-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AUQ7-1|GTA1L_MOUSE Isoform 1 of N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1 OS=Mus musculus OX=10090 GN=Ggta1l1 PE=2 SV=1 CANONICAL=A2AUQ7-1", "length": 319, "sequence": "MQYKKEALLLMLFAVLLALTQRFSYSRTKDHLQKMYACWKDHLEEPHLSTWFDPKKRPDVIATTGWLAPVLWEGTYNREVLEQYYKRLNITIGLAVFATGNFSKEPLRRFIKSADKYFMVGYNVIFYILADSTYNLPYFELGPLRTLKTWRLFEEEMCQDCNLRNMNNMHSKIIQCIQYEVNFLFMMAVNQTFKNNFGVETLGKSVAQLHAWWYFKKPRDFPYERRTKSAAFIPFEKGDFYYHRAIVGGTPLNVLNLIEQYIKGITDDNTNKLVSTFESHLNKYFFINKPARVLSPEYNWDPRFKTPPEIKHIKIAWKP" }, "uniprot_id": "GTA1L_MOUSE", "enzyme_annotation": [ { "ec": "2.4.1.87", "activity": "" }, { "ec": "2.4.1.87", "activity": "UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R." } ], "glycation": [], "keywords": [ "enzyme", "glycosyltransferase-activity", "glycoprotein", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "id": "A2AUQ7", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [], "uniprot_ac": "A2AUQ7", "site_annotation": [ { "end_pos": 103, "annotation": "n_glycosylation_sequon", "start_pos": 101 }, { "end_pos": 192, "annotation": "n_glycosylation_sequon", "start_pos": 190 }, { "end_pos": 91, "annotation": "n_glycosylation_sequon", "start_pos": 89 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7#A2AUQ7-1", "isoform_ac": "A2AUQ7-1", "locus": { "end_pos": 35354382, "strand": "+", "start_pos": 35366278, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000028243", "id": "ENSMUST00000028243", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000028243", "id": "ENSMUSP00000028243", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AUQ7-1|GTA1L_MOUSE Isoform 1 of N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1 OS=Mus musculus OX=10090 GN=Ggta1l1 PE=2 SV=1 CANONICAL=A2AUQ7-1", "length": 319, "sequence": "MQYKKEALLLMLFAVLLALTQRFSYSRTKDHLQKMYACWKDHLEEPHLSTWFDPKKRPDVIATTGWLAPVLWEGTYNREVLEQYYKRLNITIGLAVFATGNFSKEPLRRFIKSADKYFMVGYNVIFYILADSTYNLPYFELGPLRTLKTWRLFEEEMCQDCNLRNMNNMHSKIIQCIQYEVNFLFMMAVNQTFKNNFGVETLGKSVAQLHAWWYFKKPRDFPYERRTKSAAFIPFEKGDFYYHRAIVGGTPLNVLNLIEQYIKGITDDNTNKLVSTFESHLNKYFFINKPARVLSPEYNWDPRFKTPPEIKHIKIAWKP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75859", "resource": "KEGG Pathway", "id": "mmu:75859", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7#function", "annotation": "Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7#function", "id": "A2AUQ7", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "G3V9Q9-1", "protein_name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1", "sequence": { "length": 321, "sequence": "MQYKKETLLLILLAILLALTQRYSRTKDHLQKMYTCWRDHLEEPQLESWFNPKKRPDVIATTGWLAPVLWEGTYDREVLEQYYKRLNITVGLAVFATGNFSSESLRRFIKSANKYFMVGYNVIFYILADGTSNLPYLELGPLRTLKMWRLSGEEMTYEDSNLRNMNNMRYKIMEHIQYEVNFLFVMTANQIIKNHFGVETLGRSVAQLHAWWYFKQPREFPYERRRKASAFIAFEEGDFYYHSAIVGGTPLDVLDLIEHYIKGIIDDRTNELSSTYERHLNKYFFIKKPVRVLSPEYNWDPRFKTPPEIWHIKVAWQPRIT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/86865", "id": "86865", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AUQ7/", "id": "A2AUQ7", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "gene_name": "Ggta1l1", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083739.1", "ac": "NP_083739.1", "name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1 precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016757", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "id": "A2AUQ7", "database": "UniProtKB" } ], "name": "transferase activity, transferring glycosyl groups", "id": "GO:0016757" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "id": "A2AUQ7", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047276", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "id": "A2AUQ7", "database": "UniProtKB" } ], "name": "N-acetyllactosaminide 3-alpha-galactosyltransferase activity", "id": "GO:0047276" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "id": "A2AUQ7", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031982", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "id": "A2AUQ7", "database": "UniProtKB" } ], "name": "vesicle", "id": "GO:0031982" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "id": "A2AUQ7", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032580", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "id": "A2AUQ7", "database": "UniProtKB" } ], "name": "Golgi cisterna membrane", "id": "GO:0032580" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030259", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "id": "A2AUQ7", "database": "UniProtKB" } ], "name": "lipid glycosylation", "id": "GO:0030259" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006486", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "id": "A2AUQ7", "database": "UniProtKB" } ], "name": "protein glycosylation", "id": "GO:0006486" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005975", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "id": "A2AUQ7", "database": "UniProtKB" } ], "name": "carbohydrate metabolic process", "id": "GO:0005975" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUQ7", "type": "synonym", "resource": "RefSeq", "name": "4930568D16Rik" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUQ7", "type": "synonym", "resource": "RefSeq", "name": "Ggta1l1" }, { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "type": "recommended", "resource": "UniProtKB", "name": "Ggta1l1" } ], "pro_annotation": [], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000026882", "id": "ENSMUSG00000026882", "database": "Bgee" }, { "url": "http://www.cazy.org/fam/GT6.html", "id": "GT6", "database": "CAZy" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/75859", "id": "75859", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005076", "id": "IPR005076", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029044", "id": "IPR029044", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75859", "id": "mmu:75859", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1923109", "id": "1923109", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/TPPQIKH/", "id": "TPPQIKH", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1204439at2759", "id": "1204439at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10462", "id": "PTHR10462", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF03414", "id": "PF03414", "database": "Pfam" }, { "url": "http://purl.obolibrary.org/obo/PR_PR_A2AUQ7", "id": "PR_A2AUQ7", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_083739.1", "id": "NP_083739.1", "database": "RefSeq" }, { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "id": "A2AUQ7", "database": "UniProtKB" } ], "expression_disease": [], "glycosylation": [ { "residue": "Asn", "site_category": "predicted", "end_pos": 101, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7#ptm_processing", "id": "A2AUQ7", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 101, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "site_category": "predicted", "end_pos": 89, "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7#ptm_processing", "id": "A2AUQ7", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "start_pos": 89, "glytoucan_ac": "", "type": "N-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 37953.0, "chemical_mass": 37953.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7", "name": "Ggta1l1", "locus": {} } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AUQ7#names_and_taxonomy", "type": "synonym", "resource": "UniProtKB", "name": "2.4.1.87" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUQ7", "type": "synonym", "resource": "RefSeq", "name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1 precursor" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUQ7", "type": "synonym", "resource": "RefSeq", "name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1" }, { "url": "https://www.uniprot.org/uniprot/A2AUQ7#names_and_taxonomy", "type": "recommended", "resource": "UniProtKB", "name": "N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1" } ] }